{"id":54118,"date":"2022-10-17T13:25:17","date_gmt":"2022-10-17T17:25:17","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=54118"},"modified":"2025-10-15T15:12:44","modified_gmt":"2025-10-15T19:12:44","slug":"pravastatin-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/pravastatin-side-effects\/","title":{"rendered":"Pravastatin side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"> <a href=\"#common\">Common pravastatin side effects<\/a><\/span><span style=\"font-weight: 400;\"> | <\/span><span style=\"font-weight: 400;\"> <a href=\"#serious\">Serious side effects<\/a><\/span><span style=\"font-weight: 400;\"> | <a href=\"#flu\">Flu-like symptoms<\/a> | <\/span><span style=\"font-weight: 400;\"> <a href=\"#chest\">Chest pain<\/a><\/span><span style=\"font-weight: 400;\"> | <\/span><span style=\"font-weight: 400;\"> <a href=\"#muscle\">Muscle pain<\/a><\/span> <span style=\"font-weight: 400;\">| <a href=\"#headache\">Headache<\/a> | <\/span><span style=\"font-weight: 400;\"> <a href=\"#timeline\">Side effects timeline<\/a> | <a href=\"#contraindications\">Contraindications <\/a>| <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#avoid\">How to avoid side effects<\/a><\/span><span style=\"font-weight: 400;\"> | <a href=\"#treat\">How to treat side effects<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">For people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-treatment-and-medications\"><span style=\"font-weight: 400;\">high cholesterol levels<\/span><\/a><span style=\"font-weight: 400;\">, high fat levels, or other <\/span><span style=\"font-weight: 400;\">risk factors<\/span><span style=\"font-weight: 400;\"> for <\/span><span style=\"font-weight: 400;\">cardiovascular<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">heart disease<\/span><span style=\"font-weight: 400;\">, the generic drug <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\"><span style=\"font-weight: 400;\">pravastatin<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">brand name<\/span> <span style=\"font-weight: 400;\">Pravachol<\/span><span style=\"font-weight: 400;\">) is prescribed to reduce <\/span><span style=\"font-weight: 400;\">LDL<\/span><span style=\"font-weight: 400;\"> cholesterol, lower <\/span><span style=\"font-weight: 400;\">triglyceride levels<\/span><span style=\"font-weight: 400;\">, slow the progression of <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7594023\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">atherosclerosis<\/span><\/a><span style=\"font-weight: 400;\">, and decrease the <\/span><span style=\"font-weight: 400;\">risk of heart attack<\/span><span style=\"font-weight: 400;\"> and stroke. To succeed, however, <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> therapy also <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-lower-cholesterol\/\"><span style=\"font-weight: 400;\">requires changes in diet and exercise<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Pravastatin<\/span><span style=\"font-weight: 400;\"> belongs to a class of drugs called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">statins<\/span><\/a><span style=\"font-weight: 400;\">, but <\/span><span style=\"font-weight: 400;\">healthcare professionals<\/span><span style=\"font-weight: 400;\"> may refer to them as <\/span><span style=\"font-weight: 400;\">HMG-CoA reductase inhibitors<\/span><span style=\"font-weight: 400;\">. That\u2019s because <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> and other <\/span><span style=\"font-weight: 400;\">statins<\/span><span style=\"font-weight: 400;\"> (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/simvastatin\/what-is\"><span style=\"font-weight: 400;\">simvastatin<\/span><\/a><span style=\"font-weight: 400;\">) block or inhibit a liver <\/span><span style=\"font-weight: 400;\">enzyme<\/span><span style=\"font-weight: 400;\"> that synthesizes cholesterol, helping to reduce cholesterol and fats. Although most people take statins without a problem, <\/span><span style=\"font-weight: 400;\">there are some important<\/span> <span style=\"font-weight: 400;\">side effects to be aware of<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/low-cholesterol-diet\/\"><b>The best diet for <\/b><b>high cholesterol<\/b><\/a><\/p>\n<h2 id=\"common\">Common side effects of pravastatin<\/h2>\n<p><span style=\"font-weight: 400;\">Muscle pain<\/span><span style=\"font-weight: 400;\"> is the most common complaint in people taking <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\/what-is\"><span style=\"font-weight: 400;\">pravastatin<\/span><\/a><span style=\"font-weight: 400;\">, both <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=99cc0546-bb2d-751e-edfd-1c15a1182e0c\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">in clinical trials<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Pravastatin-Sodium-pravastatin-sodium-3511\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">clinical practice<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/111705\/pravastatin\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Pravastatin<\/span><span style=\"font-weight: 400;\">\u2019s <\/span><span style=\"font-weight: 400;\">common side effects<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upper respiratory infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle inflammation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flu-like symptoms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Nausea and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Elevated muscle enzymes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Elevated liver enzymes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Elevated blood sugar<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Confusion or memory problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acid indigestion<\/span><\/li>\n<\/ul>\n<h2 id=\"serious\">Serious side effects of pravastatin<\/h2>\n<p><span style=\"font-weight: 400;\">Pravastatin<\/span><span style=\"font-weight: 400;\">\u2019s <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Pravastatin-Sodium-pravastatin-sodium-3511\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most <\/span><span style=\"font-weight: 400;\">serious side effects<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Kidney damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle damage (<\/span><span style=\"font-weight: 400;\">rhabdomyolysis<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Autoimmune damage and death of muscle tissues<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/pancreatitis-treatment-and-medications\"><span style=\"font-weight: 400;\">Swollen pancreas<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood disorders<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lung disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tendon rupture<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/lupus-treatment-and-medications\"><span style=\"font-weight: 400;\">Lupus<\/span><\/a><span style=\"font-weight: 400;\">-like symptoms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe <\/span><span style=\"font-weight: 400;\">allergic reactions\u00a0<\/span><\/li>\n<\/ul>\n<h3 id=\"flu\">Flu-like symptoms<\/h3>\n<p><span style=\"font-weight: 400;\">In clinical trials, the incidence of flu symptoms among participants taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> was 9%\u2014about 1 in 11 people. <\/span><a href=\"https:\/\/medscimonit.com\/abstract\/index\/idArt\/420832\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">In some cases<\/span><\/a><span style=\"font-weight: 400;\">, these flu symptoms are not caused by infection but are a reaction to the medication. If flu symptoms are experienced, talk to the prescribing <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider. This is to make sure the medication is not affecting the liver or muscles.<\/span><\/p>\n<h3 id=\"chest\">Chest pain<\/h3>\n<p><span style=\"font-weight: 400;\">Chest pain<\/span><span style=\"font-weight: 400;\"> is a <\/span><span style=\"font-weight: 400;\">common side effect<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. Approximately 10% of clinical trial participants experienced <\/span><span style=\"font-weight: 400;\">chest pain<\/span><span style=\"font-weight: 400;\">, but so did 9.8% of participants not taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. Chest pain can be a symptom of a serious heart problem, so always talk to a <\/span><span style=\"font-weight: 400;\">healthcare professional<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"muscle\">Muscle pain<\/h3>\n<p><span style=\"font-weight: 400;\">Muscle pain<\/span><span style=\"font-weight: 400;\"> is the most <\/span><span style=\"font-weight: 400;\">common side effect<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">, affecting 1% to 6% of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> users. <\/span><span style=\"font-weight: 400;\">Some muscle pain may just be bothersome, but it could also<\/span><span style=\"font-weight: 400;\"> be a symptom of muscle damage. Tell the prescribing <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider immediately if you are experiencing new or worsening muscle pain or weakness while taking pravastatin.\u00a0<\/span><\/p>\n<h3 id=\"headache\">Headache<\/h3>\n<p><span style=\"font-weight: 400;\">Headache occurred in 3.5% to 7.5% of participants who took pravastatin in clinical trials . However, 4.6% of participants not taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> also complained of headaches. If headaches are bothersome or getting worse, get <\/span><span style=\"font-weight: 400;\">medical advice<\/span><span style=\"font-weight: 400;\"> from a <\/span><span style=\"font-weight: 400;\">healthcare professional<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"timeline\">How soon do side effects start?<\/h2>\n<p><span style=\"font-weight: 400;\">Pravastatin<\/span><span style=\"font-weight: 400;\"> begins working with the first dose, though it may take some time for cholesterol and fat levels to change. Some of the <\/span><span style=\"font-weight: 400;\">common side effects<\/span><span style=\"font-weight: 400;\"> can occur early in treatment such as <\/span><span style=\"font-weight: 400;\">muscle pain<\/span><span style=\"font-weight: 400;\">, fatigue, and dizziness. Some <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> may take weeks or months to occur, particularly <\/span><span style=\"font-weight: 400;\">serious side effects<\/span><span style=\"font-weight: 400;\"> such as <\/span><span style=\"font-weight: 400;\">liver problems<\/span><span style=\"font-weight: 400;\"> or serious muscle damage. <\/span><span style=\"font-weight: 400;\">Allergic reactions<\/span><span style=\"font-weight: 400;\"> can happen right after the first dose, but severe skin reactions may occur later in treatment.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long do <\/span><span style=\"font-weight: 400;\">pravastatin<\/span> <span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many <\/span><span style=\"font-weight: 400;\">common side effects<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> improve over time, but some may not. Most <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, however, typically go away after the drug has been discontinued. It takes the body about two hours to clear half a dose of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">, so many <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> will feel better the day after the drug is stopped. Some <\/span><span style=\"font-weight: 400;\">side effects,<\/span><span style=\"font-weight: 400;\"> such as <\/span><span style=\"font-weight: 400;\">liver damage<\/span><span style=\"font-weight: 400;\"> or muscle damage, may take weeks or months to improve. Others, such as some rare but serious side effects, may have lifelong consequences.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What are the long-term <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Pravastatin<\/span><span style=\"font-weight: 400;\"> therapy is intended to last for months or years\u2014even for a lifetime. While there are no <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> specifically caused by long-term use, some of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">\u2019s severe <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> can be cumulative if the drug is continued. These include <\/span><span style=\"font-weight: 400;\">liver damage<\/span><span style=\"font-weight: 400;\">, autoimmune reactions, and muscle damage.<\/span><\/p>\n<h2 id=\"contraindications\">Pravastatin contraindications<\/h2>\n<p><span style=\"font-weight: 400;\">People who have a known allergy to <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> will not be prescribed this drug. Because of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">\u2019s possible effects on the liver and muscles, <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> is also contraindicated in people with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Active <\/span><span style=\"font-weight: 400;\">liver disease<\/span><span style=\"font-weight: 400;\"> or elevated liver <\/span><span style=\"font-weight: 400;\">enzymes<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The <\/span><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\"> has prohibited the use of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> in <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=99cc0546-bb2d-751e-edfd-1c15a1182e0c\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">pregnancy and <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><\/a><span style=\"font-weight: 400;\"> because of the risk to the fetus or the nursing infant. People who may become pregnant are advised to use <\/span><span style=\"font-weight: 400;\">birth control<\/span><span style=\"font-weight: 400;\"> while taking pravastatin, and the drug will be stopped if they become pregnant.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Pravastatin<\/span><span style=\"font-weight: 400;\"> has been tested in children and is <\/span><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\">-approved to treat children 8 years of age and older for congenital <\/span><span style=\"font-weight: 400;\">high cholesterol<\/span><span style=\"font-weight: 400;\"> (hypercholesterolemia). In clinical trials, children taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> experienced roughly the same rate of <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> as adults. Female teens of reproductive age are advised to use <\/span><span style=\"font-weight: 400;\">birth control<\/span><span style=\"font-weight: 400;\"> because of the possible hazards to a fetus.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Seniors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People 65 and older experience most <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> at the same rate as younger adults. However, muscle problems are more common in older adults, so extra caution is needed when taking pravastatin.\u00a0<\/span><\/p>\n<h2 id=\"warnings\">Pravastatin warnings<\/h2>\n<p><span style=\"font-weight: 400;\">As with all <\/span><span style=\"font-weight: 400;\">prescription drugs<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> may cause more problems in some people than others. Here are the issues to consider.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Cautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Pravastatin<\/span><span style=\"font-weight: 400;\"> may worsen some pre-existing conditions, so it\u2019s used with caution and extra monitoring in people with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems in the past<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chronic alcohol abuse<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Underactive <\/span><span style=\"font-weight: 400;\">thyroid<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drug abuse and physical dependence are not considered risks of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> treatment. There are no withdrawal symptoms when the drug is discontinued. However, <\/span><span style=\"font-weight: 400;\">cholesterol levels<\/span><span style=\"font-weight: 400;\"> will rapidly rise unless another cholesterol-lowering drug is substituted.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Call a <\/span><span style=\"font-weight: 400;\">poison control center<\/span><span style=\"font-weight: 400;\"> or contact a <\/span><span style=\"font-weight: 400;\">healthcare professional<\/span><span style=\"font-weight: 400;\"> if an overdose of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> is suspected. The maximum dosage is 80 mg per day for adults, but the <a href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\/dosage\">daily dosage may vary<\/a> based on age and other health conditions. Never exceed the dosage prescribed by a <\/span><span style=\"font-weight: 400;\">healthcare professional<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2 id=\"interactions\">Pravastatin interactions<\/h2>\n<p><span style=\"font-weight: 400;\">Some drugs interfere with the body\u2019s ability to break down <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">, increasing the risk of <\/span><span style=\"font-weight: 400;\">serious side effects<\/span><span style=\"font-weight: 400;\"> such as muscle and <\/span><span style=\"font-weight: 400;\">liver problems<\/span><span style=\"font-weight: 400;\">. These drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/macrolides\"><span style=\"font-weight: 400;\">Macrolide antibiotics<\/span><\/a><span style=\"font-weight: 400;\">, especially <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\"><span style=\"font-weight: 400;\">clarithromycin<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin\"><span style=\"font-weight: 400;\">erythromycin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hiv-treatment-and-medications\"><span style=\"font-weight: 400;\">HIV\/AIDS<\/span><\/a><span style=\"font-weight: 400;\"> drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some cancer drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The immune suppressant <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclosporine\"><span style=\"font-weight: 400;\">cyclosporine<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some cholesterol drugs can cause <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> when combined with <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. These include <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/fibrates\"><span style=\"font-weight: 400;\">fibrates<\/span><\/a><span style=\"font-weight: 400;\"> like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/gemfibrozil\"><span style=\"font-weight: 400;\">gemfibrozil<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fenofibrate\"><span style=\"font-weight: 400;\">fenofibrate<\/span><\/a><span style=\"font-weight: 400;\">. These drugs increase the risk of muscle damage when taken with <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. Bile acid sequestrants like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cholestyramine\"><span style=\"font-weight: 400;\">cholestyramine<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/colestipol-hcl\"><span style=\"font-weight: 400;\">colestipol<\/span><\/a><span style=\"font-weight: 400;\"> will interfere with the body\u2019s ability to absorb <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">, decreasing its therapeutic benefits. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/niacin\"><span style=\"font-weight: 400;\">Niacin<\/span><\/a><span style=\"font-weight: 400;\"> is another cholesterol treatment that is avoided with <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Niacin<\/span><span style=\"font-weight: 400;\"> (vitamin B3) is used to raise \u201cgood\u201d cholesterol (<\/span><span style=\"font-weight: 400;\">HDL<\/span><span style=\"font-weight: 400;\">), but there\u2019s an increased risk of muscle damage when it\u2019s taken with <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. This may also occur with red yeast rice, a supplement sometimes taken to improve cholesterol levels.<\/span><\/p>\n<h2 id=\"avoid\">How to avoid pravastatin side effects<\/h2>\n<p><span style=\"font-weight: 400;\">Most people won\u2019t have adverse effects with <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">, but there are also ways to decrease this risk..<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Give the prescriber a complete medical history<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, make sure the prescriber knows about all medical conditions past and present. Some may increase the risk for <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> when taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. The prescriber will especially need to know about:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypothyroidism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy and pregnancy plans or potential<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><span style=\"font-weight: 400;\"> plans<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Drug interactions<\/span><span style=\"font-weight: 400;\"> can worsen the <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">, so tell the prescribing <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider about all <\/span><span style=\"font-weight: 400;\">prescription drugs<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">over-the-counter<\/span><span style=\"font-weight: 400;\"> medications, and <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\"> that are being taken.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Take <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> as instructed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Follow all the directions when taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. This pill should be taken once per day at night. If a dose is missed, take it when it\u2019s remembered. However, if it\u2019s almost time for the <\/span><span style=\"font-weight: 400;\">next dose<\/span><span style=\"font-weight: 400;\">, then skip the <\/span><span style=\"font-weight: 400;\">missed dose<\/span><span style=\"font-weight: 400;\"> to avoid taking too much medicine at once. Just take the <\/span><span style=\"font-weight: 400;\">next dose<\/span><span style=\"font-weight: 400;\"> as scheduled.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Keep all follow-up appointments\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid <\/span><span style=\"font-weight: 400;\">serious side effects<\/span><span style=\"font-weight: 400;\">, the <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider will schedule regular follow-up visits and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cholesterol-test\/\"><span style=\"font-weight: 400;\">blood tests<\/span><\/a><span style=\"font-weight: 400;\">. These follow-up visits and tests can help spot problems before they become serious. During these visits, tell the <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider about any <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, particularly <\/span><span style=\"font-weight: 400;\">muscle pain<\/span><span style=\"font-weight: 400;\"> or weakness.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/effects-of-high-cholesterol\/\"><b>Why you should monitor your cholesterol<\/b><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">4. Don\u2019t drink too much alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">An occasional drink is okay, but drinking too much alcohol raises the risk of hurting the liver when taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"treat\">How to treat side effects of pravastatin<\/h2>\n<p><span style=\"font-weight: 400;\">Minor <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> caused by <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> can be managed with a few home solutions or <\/span><span style=\"font-weight: 400;\">over-the-counter<\/span><span style=\"font-weight: 400;\"> medications. However, other <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> may be symptoms of a more serious problem so will need medical attention.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Flu symptoms<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Flu symptoms may be a sign of the flu, but it could also be a side effect of <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\">. Contact the prescribing <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider if you\u2019re taking <\/span><span style=\"font-weight: 400;\">pravastatin and you feel feverish or have body aches<\/span><span style=\"font-weight: 400;\">. A <\/span><span style=\"font-weight: 400;\">blood test<\/span><span style=\"font-weight: 400;\"> may be needed to make sure everything is okay.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Muscle problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Stop taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> and contact the prescriber if muscles start to hurt or become weak. It may not be serious, but the <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider will need to do <\/span><span style=\"font-weight: 400;\">blood tests<\/span><span style=\"font-weight: 400;\"> to see if there\u2019s a problem. Symptoms include weakness, aches, and pain, especially in the legs, hips, shoulders, and back. You may find it hard to lift your arms or climb stairs. Severe muscle damage can damage the kidneys, so immediate medical help is needed if <\/span><span style=\"font-weight: 400;\">muscle problems<\/span><span style=\"font-weight: 400;\"> are accompanied by <\/span><span style=\"font-weight: 400;\">dark urine<\/span><span style=\"font-weight: 400;\">, blood in the urine, or fever.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Liver problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Discontinue the medicine and contact a <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> provider if there are signs of <\/span><span style=\"font-weight: 400;\">liver problems<\/span><span style=\"font-weight: 400;\"> such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dark urine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pale or clay-colored stools<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tiredness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yellowing<\/span><span style=\"font-weight: 400;\"> of the skin or eyes<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A variety of <\/span><span style=\"font-weight: 400;\">allergic reactions<\/span><span style=\"font-weight: 400;\"> to <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> are possible, including severe <\/span><span style=\"font-weight: 400;\">allergic reactions<\/span><span style=\"font-weight: 400;\">, swelling, and skin reactions. These may be potentially fatal, so stop taking <\/span><span style=\"font-weight: 400;\">pravastatin<\/span><span style=\"font-weight: 400;\"> and immediately get medical help if you experience:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of the face, mouth, throat, or neck<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low <\/span><span style=\"font-weight: 400;\">blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lightheadedness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fainting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Racing heartbeats<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin blisters<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Peeling skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Burning eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sore mouth and throat<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Sources<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/medscimonit.com\/abstract\/index\/idArt\/420832\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Flu-like response on <\/span><span style=\"font-weight: 400;\">statins<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Medical Science Monitor<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/111701\/pravastatin\/Adult-Dosing\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Pravastatin<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.pdr.net\/drug-summary\/Pravastatin-Sodium-pravastatin-sodium-3511\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Pravastatin sodium<\/span><span style=\"font-weight: 400;\"> drug summary<\/span><\/a><span style=\"font-weight: 400;\">, Prescriber\u2019s Digital Reference<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=99cc0546-bb2d-751e-edfd-1c15a1182e0c\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Pravastatin sodium<\/span><span style=\"font-weight: 400;\"> tablet prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Common pravastatin side effects | Serious side effects | Flu-like symptoms | Chest pain | Muscle pain | Headache | Side effects timeline | Contraindications | Warnings | Interactions | How to avoid side effects | How to treat side effects For people with high cholesterol levels, high fat levels, or other risk factors for [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":54651,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752],"coauthors":[8861],"class_list":["post-54118","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Pravastatin side effects and how to avoid them<\/title>\n<meta name=\"description\" content=\"Flu-like symptoms, chest pain, muscle pain, and headache are common pravastatin side effects. 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