{"id":54549,"date":"2022-10-19T14:20:57","date_gmt":"2022-10-19T18:20:57","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=54549"},"modified":"2026-03-17T10:08:03","modified_gmt":"2026-03-17T14:08:03","slug":"glyxambi-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/glyxambi-alternatives\/","title":{"rendered":"Glyxambi alternatives: What can I take instead of Glyxambi?"},"content":{"rendered":"

Compare Glyxambi alternatives<\/a>\u00a0| Xigduo XR<\/a> | Janumet<\/a> | Oseni<\/a> | Qtern<\/a> | Rybelsus<\/a> | Natural alternatives<\/a> | How to switch meds<\/a><\/span><\/p>\n

Glyxambi<\/span><\/a> is a <\/span>brand name<\/span> medication that is a combination of two drugs, <\/span>empagliflozin<\/span> and <\/span>linagliptin<\/span>, used to treat <\/span>Type 2 diabetes mellitus<\/span><\/a>. <\/span>Glyxambi<\/span> is the first <\/span>FDA<\/span>-approved combination of a <\/span>sodium glucose co-transporter-2<\/span> (SGLT2) inhibitor, <\/span>empagliflozin<\/span>, and a <\/span>dipeptidyl peptidase-4<\/span> (DPP-4) inhibitor, <\/span>linagliptin<\/span>, in a once-daily tablet taken in the morning. This <\/span>prescription drug<\/span> works to <\/span>lower blood sugar<\/span> (<\/span>glucose<\/span>). <\/span>SGLT2 inhibitors<\/span> remove <\/span>glucose<\/span> through the urine by blocking <\/span>blood glucose<\/span> reabsorption in the kidney, while <\/span>DPP-4 inhibitors<\/span> work by increasing hormones that cause the <\/span>pancreas<\/span> to make more insulin and cause the liver to produce less <\/span>glucose<\/span>. Additionally, <\/span>Glyxambi<\/span> has the additional benefit of reducing the risk of heart attack, stroke, and cardiovascular death in adults with <\/span>Type 2 diabetes mellitus<\/span> and established <\/span>cardiovascular disease<\/span>.<\/span><\/b><\/p>\n

While an effective treatment option for some people, <\/span>Glyxambi<\/span> may not be the best and safest option for all people treating <\/span>Type 2 diabetes<\/span><\/a>. Some of the common side effects of <\/span>Glyxambi<\/span> include <\/span>urinary tract infections<\/span>, nasopharyngitis (inflammation of the nasal passages and the pharynx, or throat), and <\/span>upper respiratory tract infections<\/span>. People may not tolerate or need to avoid these side effects. While there are a variety of diabetes drugs that act in different ways to lower <\/span>blood glucose levels<\/span>, many may be used together and some medications have the convenience of being available in combination tablets. However, not all people will need to take more than one type of medication, like <\/span>Glyxambi<\/span>, to manage <\/span>blood sugar levels<\/span>.<\/span><\/p>\n

RELATED: <\/b>Type 1 diabetes<\/b> vs. <\/b>Type 2 diabetes<\/b>: What\u2019s the difference?<\/b><\/a><\/p>\n

What can I take in place of <\/span>Glyxambi<\/span>?<\/span><\/h2>\n

There are other options available to treat <\/span>Type 2 diabetes mellitus<\/span> that do not improve with <\/span>Glyxambi<\/span>. These alternative prescription medications include other combination tablets, <\/span>SGLT2 inhibitors<\/span><\/a>, <\/span>DPP-4 inhibitors<\/span>, <\/span>GLP-1<\/span> receptor agonists<\/span><\/a>, <\/span>biguanides<\/span><\/a>, <\/span>alpha-glucosidase inhibitors<\/span><\/a>, <\/span>thiazolidinediones<\/span><\/a>, <\/span>bile acid sequestrants<\/span><\/a>, <\/span>meglitinides<\/span><\/a>, and <\/span>sulfonylureas<\/span><\/a>. Additionally, combination medications are available as separate tablets that may be a more cost effective treatment option. For example, <\/span>Glyxambi<\/span> is available as separate medications <\/span>Tradjenta<\/span> (<\/span>linagliptin<\/span>) and <\/span>Jardiance<\/span><\/a> (<\/span>empagliflozin<\/span>). These options may be more suitable for certain individuals due to their different uses, side effect profiles, and dosages.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Glyxambi alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Glyxambi<\/span><\/p>\n

(<\/span>empagliflozin<\/span> and <\/span>linagliptin<\/span>)<\/span><\/td>\n

–<\/span>Type 2 diabetes mellitus<\/span><\/p>\n

-Reduce the risk of cardiovascular death in adults with <\/span>Type 2 diabetes mellitus<\/span> and established <\/span>cardiovascular disease<\/span><\/td>\n

Take 1 tablet by mouth once daily in the morning<\/span><\/td>\nGlyxambi<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Invokamet<\/span><\/p>\n

(canagliflozin and <\/span>metformin<\/span>)<\/span><\/td>\n

–<\/span>Type 2 diabetes mellitus<\/span><\/p>\n

-Reduce the risk of cardiovascular death in adults with <\/span>Type 2 diabetes mellitus<\/span> and established <\/span>cardiovascular disease<\/span><\/p>\n

-Reduce the risk of end-stage <\/span>kidney disease<\/span>, doubling of serum creatinine, cardiovascular death, and hospitalization for <\/span>heart failure<\/span> in adults with <\/span>Type 2 diabetes mellitus<\/span> and diabetic nephropathy<\/span><\/td>\n

Take 1 tablet tablet by mouth twice daily with meals<\/span><\/td>\nInvokamet coupons<\/span><\/a><\/td>\n<\/tr>\n
Janumet<\/span><\/p>\n

(sitagliptin and <\/span>metformin<\/span>)<\/span><\/td>\n

Type 2 diabetes mellitus<\/span><\/td>\nTake 1 tablet tablet by mouth twice daily with meals<\/span><\/td>\nJanumet coupons<\/span><\/a><\/td>\n<\/tr>\n
Jentadueto<\/span><\/p>\n

(<\/span>linagliptin<\/span> and <\/span>metformin<\/span>)<\/span><\/td>\n

Type 2 diabetes mellitus<\/span><\/td>\nTake 1 tablet tablet by mouth twice daily with meals<\/span><\/td>\nJentadueto coupons<\/span><\/a><\/td>\n<\/tr>\n
Kazano<\/span><\/p>\n

(alogliptin and <\/span>metformin<\/span>)<\/span><\/td>\n

Type 2 diabetes mellitus<\/span><\/td>\nTake 1 tablet tablet by mouth twice daily with meals<\/span><\/td>\nKazano coupons<\/span><\/a><\/td>\n<\/tr>\n
Metformin<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\nTake 850 to 1,000 mg tablet by mouth twice daily with meals<\/span><\/td>\nMetformin<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Oseni<\/span><\/p>\n

(alogliptin and <\/span>pioglitazone<\/span>)<\/span><\/td>\n

Type 2 diabetes mellitus<\/span><\/td>\nTake 1 tablet by mouth once daily<\/span><\/td>\nOseni coupons\u00a0<\/span><\/a><\/td>\n<\/tr>\n
Qtern<\/span><\/p>\n

(dapagliflozin and saxagliptin)<\/span><\/td>\n

Type 2 diabetes mellitus<\/span><\/td>\nTake 1 tablet by mouth once daily in the morning<\/span><\/td>\nQtern coupons<\/span><\/a><\/p>\n

 <\/td>\n<\/tr>\n

Rybelsus<\/span><\/td>\nType 2 diabetes mellitus<\/span><\/td>\nTake 7 to 14 mg tablet by mouth once daily<\/span><\/td>\nRybelsus coupons\u00a0<\/span><\/a><\/p>\n

 <\/td>\n<\/tr>\n

Segluromet<\/span><\/p>\n

(ertugliflozin and <\/span>metformin<\/span>)<\/span><\/td>\n

Type 2 diabetes mellitus<\/span><\/td>\nTake 1 tablet tablet by mouth twice daily with meals<\/span><\/td>\nSegluromet coupons<\/span><\/a><\/p>\n

 <\/td>\n<\/tr>\n

Steglujan<\/span><\/p>\n

(ertugliflozin and sitagliptin)<\/span><\/td>\n

Type 2 diabetes mellitus<\/span><\/td>\nTake 1 tablet by mouth once daily in the morning<\/span><\/td>\nSteglujan coupons<\/span><\/a><\/p>\n

 <\/td>\n<\/tr>\n

Synjardy<\/span><\/p>\n

(<\/span>empagliflozin<\/span> and <\/span>metformin<\/span>)<\/span><\/td>\n

–<\/span>Type 2 diabetes mellitus<\/span><\/p>\n

-Reduce the risk of cardiovascular death in adults with <\/span>Type 2 diabetes mellitus<\/span> and established <\/span>cardiovascular disease<\/span><\/td>\n

Take 1 tablet tablet by mouth twice daily with meals<\/span><\/td>\nSynjardy <\/span>coupons<\/span><\/a><\/p>\n

 <\/td>\n<\/tr>\n

Xigduo XR<\/span><\/p>\n

(dapagliflozin and extended- release <\/span>metformin<\/span>)<\/span><\/td>\n

–<\/span>Type 2 diabetes mellitus<\/span><\/p>\n

-Reduce the risk of hospitalization for <\/span>heart failure<\/span> in adults with <\/span>Type 2 diabetes mellitus<\/span> and established <\/span>cardiovascular disease<\/span> or multiple cardiovascular <\/span>risk factors<\/span><\/p>\n

-Reduce the risk of cardiovascular death and hospitalization for <\/span>heart failure<\/span> in adults with <\/span>heart failure<\/span> (NYHA class II-IV) with reduced ejection fraction<\/span><\/p>\n

-Reduce the risk of sustained estimated glomerular filtration rate decline, end-stage <\/span>kidney disease<\/span>, cardiovascular death, and hospitalization for <\/span>heart failure<\/span> in adults with chronic <\/span>kidney disease<\/span> at risk of progression<\/span><\/td>\n

Take 1 tablet by mouth once daily in the morning with food<\/span><\/td>\nXigduo XR coupons<\/span><\/a><\/p>\n

 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Other alternatives to <\/span>Glyxambi<\/span><\/h3>\n

For people seeking other <\/span>prescription drug<\/span> options to treat <\/span>type 2 diabetes<\/span>, there are a variety of oral and injectable options.<\/span><\/p>\n

Alpha-glucosidase Inhibitors<\/span><\/p>\n