{"id":54781,"date":"2022-10-24T09:30:15","date_gmt":"2022-10-24T13:30:15","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=54781"},"modified":"2026-04-28T12:19:48","modified_gmt":"2026-04-28T16:19:48","slug":"amitriptyline-for-sleep","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/amitriptyline-for-sleep\/","title":{"rendered":"Does amitriptyline work for sleep?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Everyone experiences the occasional restless night from time to time. However, if you frequently lie awake, struggling to fall asleep or stay asleep, you aren\u2019t alone. In fact, approximately 70 million people in the United States deal with chronic sleep problems, according to the <\/span><span style=\"font-weight: 400;\">Centers for Disease Control and Prevention (CDC).<\/span><span style=\"font-weight: 400;\"> And while there are many different underlying reasons that people may struggle to get a good night\u2019s sleep, many find themselves turning to prescription sleep aids.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\">Amitriptyline<\/a> is a prescription medication that is commonly used off-label to treat chronic insomnia. Read on to learn more about amitriptyline, including what it is, common dosages prescribed for sleep disorders, side effects, and alternative options. <\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/news\/sleep-statistics\/\"><b>Sleep statistics<\/b><\/a><b> | <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/medications-that-cause-insomnia\/\"><b>Medications that cause insomnia<\/b><\/a><\/p>\n<h2 id=\"what-is-amitriptyline\"><span style=\"font-weight: 400;\">What is amitriptyline?<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">Amitriptyline hydrochloride (HCL)<\/span><\/a><span style=\"font-weight: 400;\">, commonly referred to by its brand name Elavil, is a prescription medication that\u2019s been approved by the <\/span><span style=\"font-weight: 400;\">Food and Drug Administration (FDA)<\/span><span style=\"font-weight: 400;\"> for the treatment of depression.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are many off-label uses for amitriptyline as well, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/neuropathy-treatment-and-medications\"><span style=\"font-weight: 400;\">Neuropathic pain<\/span><\/a><span style=\"font-weight: 400;\">, including diabetic neuropathy and postherpetic neuralgia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/fibromyalgia-treatment-and-medications\"><span style=\"font-weight: 400;\">Fibromyalgia<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">Migraines<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Interstitial cystitis (bladder pain syndrome)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/ibs-treatment-and-medications\"><span style=\"font-weight: 400;\">Irritable bowel syndrome<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chronic pain, including back pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/insomnia-treatment-and-medications\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/a><\/li>\n<\/ul>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Amitriptyline with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAmitriptyline 25 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\" class=\"coupon-see-all-btn\">See Amitriptyline prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"how-does-amitriptyline-work\"><span style=\"font-weight: 400;\">How does amitriptyline work?<\/span><\/h2>\n<p><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a682388.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Amitriptyline<\/span><\/a><span style=\"font-weight: 400;\"> is in a drug class known as tricyclic antidepressants. It works by altering the levels of certain chemicals in the brain.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cAmitriptyline increases the serotonin and norepinephrine in our brains, which can have a sedative effect, as well as reduce anxiety, and improve mood,\u201d explains <a href=\"https:\/\/www.instagram.com\/zenfulbrainofficial\/\">Puja Aggarwal<\/a>, MD, a board-certified neurologist and founder of <\/span><span style=\"font-weight: 400;\">Zenful Brain<\/span><span style=\"font-weight: 400;\">. \u201cIt also may work by blocking histamine, which can cause drowsiness.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It increases the levels of serotonin and norepinephrine by <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537225\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">blocking their reabsorption<\/span><\/a><span style=\"font-weight: 400;\">, which leads to increased activity of these neurotransmitters. Increased concentrations of these neurotransmitters are believed to help improve mood, reduce feelings of pain, and ultimately help you fall asleep quicker.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While amitriptyline may start to work as soon as one to two hours of the first dose for some individuals, others may not see improvements until one to two weeks of daily usage, as the drug builds up in their system. Continue taking the medication as prescribed and tell your healthcare provider if you don\u2019t see improvements after a few weeks.\u00a0<\/span><\/p>\n<h2 id=\"amitriptyline-for-sleep\"><span style=\"font-weight: 400;\">Amitriptyline for sleep<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cAmitriptyline can be prescribed to people who have had insomnia for longer than one month, those with depression and insomnia, or people with insomnia and anxiety,\u201d Dr. Aggarwal says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, according to some <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5548844\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">research<\/span><\/a><span style=\"font-weight: 400;\">, the use of amitriptyline may have variable effects on sleep quality\u2014specifically on the stages of slow wave sleep (SWS) and rapid eye movement (REM) sleep.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.sleepfoundation.org\/stages-of-sleep\" target=\"_blank\" rel=\"noopener\"><b>Slow wave sleep (SWS)<\/b><\/a><b>: <\/b><span style=\"font-weight: 400;\">SWS includes stages 3 and 4 of non-REM sleep. This is the period when you are in your deepest sleep, and when the body physically recovers and grows. Your immune system is also strengthened during this time.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.sleepfoundation.org\/stages-of-sleep\/rem-sleep\" target=\"_blank\" rel=\"noopener\"><b>Rapid eye movement (REM) sleep<\/b><\/a><b>:<\/b><span style=\"font-weight: 400;\"> REM sleep follows after SWS. The majority of your dreams will occur in this stage. REM sleep plays an important role in memory consolidation, emotional processing, and brain development. This is when your brain processes everything you learned and experienced during the day.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Amitriptyline, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7866255\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">and many other antidepressant medications<\/span><\/a><span style=\"font-weight: 400;\">, may suppress REM sleep and have variable effects on SWS. When REM sleep is shortened, you may experience problems with mood and memory, which can lead to a decline in mental health and cause feelings of anxiety or depression in some individuals. Your body also may not have time to repair itself. So while you may fall asleep quicker, your body and brain may not be able to function at their highest levels and you may be left feeling tired, sore, or ultimately become sick as a result of a weakened immune system\u2014although not everyone who takes amitriptyline will experience these side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you do choose to use amitriptyline for sleep, it\u2019s recommended that you take it shortly before bedtime. However, you can move this up an hour or two if you find that you are waking groggy in the morning.\u00a0<\/span><\/p>\n<h2 id=\"amitriptyline-dosage-for-sleep\"><span style=\"font-weight: 400;\">Amitriptyline dosage for sleep<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\"><span style=\"font-weight: 400;\">Amitriptyline<\/span><\/a><span style=\"font-weight: 400;\"> is most commonly prescribed in tablet form, with tablet strengths ranging from 10 mg to 150 mg. However, the amitriptyline dosage for sleep generally starts at 10 mg.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThe amitriptyline dose should start at the lower doses of 10 mg to 25 mg for sleep,\u201d says Dr. Aggarwal. \u201cIf the initial low dose doesn\u2019t help, your prescribing healthcare provider can slowly increase the dose until you find one that works well to help with your insomnia.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThe prescribed dose of amitriptyline can also depend on factors like age, medical history, and other medical conditions,\u201d adds Sean Ormond, MD, a dual-board certified anesthesiologist and interventional pain physician at <\/span><a href=\"https:\/\/atlaspainspecialists.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Atlas Pain Specialists<\/span><\/a><span style=\"font-weight: 400;\"> in Phoenix, Arizona.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Amitriptyline with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAmitriptyline 25 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl#blog-cta\" class=\"coupon-see-all-btn\">See Amitriptyline prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"amitriptyline-side-effects\"><span style=\"font-weight: 400;\">Amitriptyline side effects\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like any medication, there is a risk of side effects for individuals who take amitriptyline. While some side effects are common and may not be cause for concern, others can be serious and require medical attention.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of amitriptyline include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other side effects of amitriptyline may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea or vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sexual problems, such as decreased sex drive or impotence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In some cases, these side effects can improve with continued use. However, if you experience prolonged or bothersome side effects and would like to discontinue use of the amitriptyline, you should consult your healthcare provider first. Depending on your dose, they will likely advise you to wean off the drug slowly to avoid additional side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In rare cases, serious side effects can occur. Serious side effects of amitriptyline include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast or irregular heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain or difficulty breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thoughts of harming yourself or others<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itching or hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of your hands, face, mouth, or throat\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of bone fractures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe dizziness or feeling lightheaded<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you experience any of these serious side effects, contact a healthcare professional immediately for medical advice.\u00a0<\/span><\/p>\n<h2 id=\"alternative-to-amitriptyline-for-sleep\"><span style=\"font-weight: 400;\">Alternative to amitriptyline for sleep<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s important to tell your healthcare provider every medication you are taking prior to starting amitriptyline, as certain drug interactions can occur. Amitriptyline also may not be an option for everyone, including individuals with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart problems, such as heart rhythm abnormalities or increased heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioid or benzodiazepine addiction<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/amitriptyline-and-pregnancy\/\"><span style=\"font-weight: 400;\">Pregnant or breastfeeding<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bipolar disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of epilepsy or seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver or kidney disease<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In addition, while amitriptyline is commonly prescribed by healthcare providers for the treatment of insomnia, there isn\u2019t a lot of research to support the effectiveness of amitriptyline for sleep.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThere is actually not much proof that amitriptyline has any beneficial effect on sleep or insomnia,\u201d explains Dr. Ormond. He adds that there are alternatives to amitriptyline that are more effective for treating insomnia.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Aggarwal shares that common alternatives to amitriptyline for sleep-related concerns include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/melatonin\"><b>Melatonin:<\/b><\/a><span style=\"font-weight: 400;\"> This over-the-counter, natural supplement can help you fall asleep, but you may develop a tolerance and need higher doses over time. Possible side effects include headaches and dizziness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/zolpidem-tartrate\"><b>Zolpidem tartrate (Ambien):<\/b><\/a><span style=\"font-weight: 400;\"> This medication acts on benzodiazepine receptors. It can cause significant side effects, including daytime grogginess, nightmares, and confusion. This medication does have the potential to be abused.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/trazodone-hcl\"><b>Trazodone HCL<\/b><\/a><b>:<\/b><span style=\"font-weight: 400;\"> This is an antidepressant that is commonly prescribed off-label for insomnia. Common side effects include daytime sleepiness, dry mouth, and dizziness. With continued use, a tolerance to the medication can be built up.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/eszopiclone\"><b>Eszopiclone (Lunesta):<\/b><\/a><span style=\"font-weight: 400;\"> This medication acts on the same brain receptors as the benzodiazepines to promote sleep. It\u2019s advised to avoid high-fat meals with this medication, as the effectiveness can decrease. You should also ensure you have at least seven to eight hours to sleep after taking the medication to reduce the risk of daytime drowsiness the next day.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antihistamines\"><b>Antihistamines<\/b><\/a><b> (<\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/diphenhydramine-hcl\"><b>Diphenhydramine<\/b><\/a><b>, <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\"><b>Hydroxyzine<\/b><\/a><b>):<\/b><span style=\"font-weight: 400;\"> These medications can be used for short-term insomnia, but can cause dry mouth, dry eyes, and daytime sleepiness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><b>Benzodiazepines<\/b><\/a><b> (<\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/lorazepam\"><b>Lorazepam<\/b><\/a><b>, <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/clonazepam\"><b>Clonazepam<\/b><\/a><b>, <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/valium\"><b>Valium<\/b><\/a><b>): <\/b><span style=\"font-weight: 400;\">This class of medications can cause sedation and decrease anxiety for better sleep. However, they are not ideal for long-term treatment of insomnia. Unfortunately, there is a risk of substance use disorder and withdrawal symptoms associated with benzodiazepines.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you are experiencing side effects from taking amitriptyline, or just want to try another medication, talk to your healthcare provider about other treatment options. They will help identify which drugs may be an option to help with your sleepless nights. It\u2019s important to find the medication that works best for you, as it can vary by person and may require that you try several options.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Regardless of the medication you and your healthcare provider decide is the right fit for you, SingleCare\u2019s <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">prescription drug savings card<\/span><\/a><span style=\"font-weight: 400;\"> can help you save up to 80% off your next prescription medication. You can use the <\/span><a href=\"https:\/\/www.singlecare.com\/\"><span style=\"font-weight: 400;\">free search tool<\/span><\/a><span style=\"font-weight: 400;\"> to compare prices at pharmacies nearby to be sure you\u2019re getting the best price. Simply enter the name of your medication and your location to get started.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Everyone experiences the occasional restless night from time to time. However, if you frequently lie awake, struggling to fall asleep or stay asleep, you aren\u2019t alone. In fact, approximately 70 million people in the United States deal with chronic sleep problems, according to the Centers for Disease Control and Prevention (CDC). And while there are [&hellip;]<\/p>\n","protected":false},"author":94,"featured_media":54388,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[451,12752,8905,816],"coauthors":[20916],"class_list":["post-54781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-depression","tag-medication-side-effects","tag-seasonal","tag-sleep","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Amitriptyline for sleep: Dosage and alternatives<\/title>\n<meta name=\"description\" content=\"Amitriptyline is a depression medication prescribed off-label for sleep in people with insomnia. 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