{"id":54824,"date":"2022-10-25T09:30:25","date_gmt":"2022-10-25T13:30:25","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=54824"},"modified":"2025-10-21T16:42:24","modified_gmt":"2025-10-21T20:42:24","slug":"hydroxyzine-for-dogs","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/hydroxyzine-for-dogs\/","title":{"rendered":"Is hydroxyzine safe for dogs?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Just like their human owners, some dogs have seasonal allergies. Others may be allergic to medications, food, or things they encounter out on their adventures\u2014such as bee stings, snake bites, or other traumas that can cause a reaction. There are several over-the-counter and prescription medications that can help your furry friend in the case of an allergic reaction, one of which is <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\"><span style=\"font-weight: 400;\">hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\">. Here we will go over hydroxyzine\u2019s uses, dosage, side effects, and some safety considerations.\u00a0<\/span><\/p>\n<h2 id=\"what-is-hydroxyzine\"><span style=\"font-weight: 400;\">What is hydroxyzine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In humans, hydroxyzine hydrochloride is used both as an antihistamine and as an anti-<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\"> or sleep medication. Its primary function is blocking the effects of histamine in the body. Histamine is what gives us symptoms of an allergic reaction such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itching\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash or hives\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">By blocking histamine\u2019s activity, some antihistamines also cause mild sedation. For this reason, humans and animals feel sleepy while taking antihistamines like hydroxyzine.\u00a0<\/span><\/p>\n<h2 id=\"what-is-hydroxyzine-used-for-in-dogs\"><span style=\"font-weight: 400;\">What is hydroxyzine used for in dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydroxyzine can be prescribed to dogs for a number of reasons, including allergic reactions, motion sickness while traveling, and allergic skin disease such as eczema, also known as atopy when referring to dogs.\u00a0<\/span><\/p>\n<h3 id=\"allergies\"><span style=\"font-weight: 400;\">Allergies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When choosing which drug to give to a dog for an allergic reaction, veterinarians look to the cause of the allergy. <\/span><a href=\"https:\/\/seniortailwaggers.com\/team\/dr-sara-ochoa\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sara Ochoa DVM<\/span><\/a><span style=\"font-weight: 400;\">, a veterinarian at <\/span><a href=\"https:\/\/seniortailwaggers.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">seniortailwaggers.com<\/span><\/a><span style=\"font-weight: 400;\">, says that hydroxyzine can be used for allergic reactions to snake bites, medication, or bee stings. Benadryl is also used, and many vets recommend it first, especially since many owners have it on hand or can get it easily.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cI [prescribe] hydroxyzine in cases where Benadryl does not seem to be helping,\u201d Dr. Ochoa says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As for seasonal allergies, hydroxyzine may not be prescribed as the first medication either. \u201cAllergies in dogs are not largely histamine-mediated and therefore hydroxyzine does not work well for most allergic dogs,\u201d says <\/span><a href=\"https:\/\/seniortailwaggers.com\/team\/dr-jamie-whittenburg\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Jamie Whittenburg, DVM<\/span><\/a><i><span style=\"font-weight: 400;\">, <\/span><\/i><span style=\"font-weight: 400;\">a veterinarian at <\/span><a href=\"https:\/\/seniortailwaggers.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">seniortailwaggers.com<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"atopic-dermatitis\"><span style=\"font-weight: 400;\">Atopic dermatitis<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydroxyzine is often used for allergic skin conditions in dogs such as atopic dermatitis or atopy, also known as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/eczema-treatment-and-medications\"><span style=\"font-weight: 400;\">eczema<\/span><\/a><span style=\"font-weight: 400;\">. This chronic, itchy condition can cause great discomfort to dogs, much like it does for humans. The constant itching can cause dogs to open up wounds in their skin, making them susceptible to infection. Therefore, preventing itching and chewing is an important part of keeping your pet healthy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You may notice your pet seems less anxious when taking an antihistamine, but it might also be because they are in less discomfort. The sedative effect \u201cis also a great side effect to help dogs sleep a little better at night and not itch all night,\u201d Dr. Ochoa says. When your pet will be sleeping better and not scratching or itching throughout the night, they are also giving themselves more time to heal.\u00a0<\/span><\/p>\n<h3 id=\"nausea-and-vomiting\"><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Antihistamines are also antiemetic in dogs, meaning they treat vomiting associated with motion sickness. So, meds like hydroxyzine may be recommended before traveling for both this reason and their sedative or tranquilizing effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because of its sedative effects, hydroxyzine could cause your pet to have sluggish movement, clumsiness, or be more prone to dozing. Keep this in mind when transporting your pet.\u00a0<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Hydroxyzine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tHydroxyzine 25 mg (30 Tablet)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.95<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.95<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\" class=\"coupon-see-all-btn\">See Hydroxyzine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"hydroxyzine-dosage-for-dogs\"><span style=\"font-weight: 400;\">Hydroxyzine dosage for dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Unlike some other antihistamines, hydroxyzine is a prescription medication, so it should only be given at the dose and frequency prescribed by your veterinarian.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The typical dosage of hydroxyzine is 1 mg tablet per pound of body weight twice a day. You should follow the dosing instructions of one to two maximum mg per pound twice a day. The active ingredient, hydroxyzine, will work within three to six hours, most likely hitting its peak effectiveness around three hours. Some short-acting doses might work after an hour.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The medication may come in a pill or a liquid. You should discuss with your vet the best method for getting your pet to take the medication while taking into account your dog\u2019s temperament around medications. You\u2019ll also need to discuss the best time of day, if it should be taken with food, and any other health considerations or medications. Hydroxyzine should be stored at room temperature away from excess heat and moisture. <\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/where-to-fill-pet-prescriptions\/\"><b>Where to fill your pet\u2019s prescriptions<\/b><\/a><\/p>\n<h2 id=\"hydroxyzine-for-dogs-side-effects\"><span style=\"font-weight: 400;\">Hydroxyzine for dogs side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As with all medications, hydroxyzine has several side effects. Common side effects of hydroxyzine include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sedation or drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth, leading to increased drinking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lack of appetite\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Excitability or hyperactivity is a rare side effect of the medication. And tremors or seizures are very rare.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hydroxyzine is usually a short-acting medication and will clear the system within 24 hours.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If your dog is showing any of the following possible side effects, they may be responding poorly to the medication, it may be interacting with another of their medications, they may have overdosed, or they may be allergic to hydroxyzine. If you notice any of the following, seek emergency veterinary advice:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Major behavior changes, such as being more energetic or significantly lethargic\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting or diarrhea\u00a0\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of consciousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizure\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble breathing<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Dr. Ochoa says to observe your pet closely when they start the new medication for signs that they are not tolerating it well. Ask your vet if you have concerns about any side effects noted.\u00a0<\/span><\/p>\n<h2 id=\"is-hydroxyzine-safe-for-dogs\"><span style=\"font-weight: 400;\">Is hydroxyzine safe for dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Veterinarians find hydroxyzine to be an effective antihistamine for dogs, and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12050832\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">studies show<\/span><\/a><span style=\"font-weight: 400;\"> it is a good option for dogs with eczema. Much like with people, not every drug works well for every dog or every condition, so you may need to work out a treatment plan with your vet.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One important consideration when planning out your dog\u2019s best course of treatment is whether or not they are taking any other medications. If your pet is already on an anti-anxiety or sedative medication, the sedative effects of hydroxyzine could have a compounding effect.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cYour dog\u2019s veterinarian should always be kept apprised of any medications your dog is taking so that adverse drug reactions may be avoided,\u201d Dr. Whittenburg says. Include a list of any medications, vitamins, or supplements along with your pet\u2019s health history when you visit your veterinarian.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, hydroxyzine should be used cautiously in pets that have glaucoma, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/high-blood-pressure-in-dogs\/\"><span style=\"font-weight: 400;\">high blood pressure<\/span><\/a><span style=\"font-weight: 400;\">, trouble urinating, enlarged prostate, intestinal blockages, and kidney or heart disease.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our allergies newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Allergies Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"alternative-treatments\"><span style=\"font-weight: 400;\">Alternative treatments<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In addition to other antihistamines like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-itch-relief\"><span style=\"font-weight: 400;\">Benadryl<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/diphenhydramine-hcl\"><span style=\"font-weight: 400;\">diphenhydramine<\/span><\/a><span style=\"font-weight: 400;\">) or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zyrtec-allergy\"><span style=\"font-weight: 400;\">Zyrtec<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allergy-cetirizine\"><span style=\"font-weight: 400;\">cetirizine<\/span><\/a><span style=\"font-weight: 400;\">), your veterinarian might want you to try other medications for your dog\u2019s allergies either before or after trying hydroxyzine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThere are many newer generation drugs that work much better than hydroxyzine for dog allergies,\u201d Dr. Whittenburg says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other pet medications veterinarians recommend for allergies in canines include Apoquel and Cytopoint. Apoquel is given in tablet form once a day while Cytopoint is a monthly injection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other medications your vet may try to help your <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/allergy-medicine-for-dogs-cats\/\"><span style=\"font-weight: 400;\">pet\u2019s allergies<\/span><\/a><span style=\"font-weight: 400;\"> include steroids or allergy shots, sometimes called immunotherapy, something humans often also get to combat allergies long-term.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some supplements are potentially helpful for dogs with allergies and eczema, but, again, do discuss any new vitamins or supplements with your vet before adding them into your pet\u2019s diet. Coconut, fish, or other oils that make your pet\u2019s hair and skin healthier might reduce itchiness.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You might also make lifestyle adjustments to help your dog, such as:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Figuring out what is causing the irritation or allergy for your dog and eliminating it from your environment<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Adjusting your walk routine or route to avoid certain triggers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changing your household cleaning products<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cleaning more thoroughly to eliminate dust or mold.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">You might have to even give up your favorite perfume or laundry detergent if it\u2019s exacerbating your pet\u2019s allergies. Additionally, smoking is not good for a pet prone to allergies, so avoiding cigarettes will benefit your health and your pet\u2019s. Ask your vet about recommended pet bathing products or procedures to help alleviate itchy skin and not open up any sensitive, healing wounds.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Just like their human owners, some dogs have seasonal allergies. Others may be allergic to medications, food, or things they encounter out on their adventures\u2014such as bee stings, snake bites, or other traumas that can cause a reaction. There are several over-the-counter and prescription medications that can help your furry friend in the case of [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":54455,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7956],"tags":[7969],"coauthors":[20599],"class_list":["post-54824","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pets","tag-dogs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Hydroxyzine for dogs: Side effects, dosage, and uses<\/title>\n<meta name=\"description\" content=\"Hydroxyzine is an antihistamine that may be prescribed for allergies, motion sickness, or eczema in dogs. 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