{"id":55092,"date":"2022-11-07T23:29:53","date_gmt":"2022-11-08T04:29:53","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=55092"},"modified":"2025-12-19T12:30:57","modified_gmt":"2025-12-19T17:30:57","slug":"metronidazole-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/metronidazole-alternatives\/","title":{"rendered":"Metronidazole alternatives: What can I take instead of metronidazole?"},"content":{"rendered":"

Metronidazole<\/span><\/a> (brand name <\/span>Flagyl<\/span>) is an antibiotic that is used to treat a variety of bacterial and parasitic infections. <\/span>Metronidazole<\/span><\/a> belongs to a group of antibiotics called <\/span>nitroimidazoles<\/span> that work to disrupt the DNA of bacterial and parasitic cells. This medication is primarily used to treat <\/span>infectious diseases<\/span> caused by <\/span>anaerobic bacteria<\/span> (bacteria that survive without oxygen) and single-cell parasites such as amoebas and trichomonas. Depending on the type and severity of infection, <\/span>metronidazole<\/span> is taken by mouth as a tablet or capsule, administered as an injection, or applied topically as a cream, gel, or lotion. Metronidazole is used for a wide range of conditions. Common infections that it can treat include <\/span>bacterial vaginosis<\/span><\/a>, pelvic inflammatory disease (PID), <\/span>trichomoniasis<\/span>, Clostridioides difficile (C. diff), amebiasis (amebic dysentery and liver <\/span>abscess<\/span>), <\/span>giardiasis<\/span>, <\/span>Crohn\u2019s disease<\/span><\/a>, and Helicobacter pylori (H. pylori).<\/span><\/p>\n

RELATED: <\/b>What is <\/b>metronidazole<\/b><\/a>\u00a0<\/b><\/p>\n

While an effective <\/span>treatment option<\/span> for some people, <\/span>metronidazole<\/span> may not be the best and safest option for all people treating bacterial or parasitic infections. <\/span>Metronidazole<\/span> should not be used in <\/span>pregnant women<\/span> during the first trimester of pregnancy. Alcohol should be avoided while using <\/span>metronidazole,<\/span> as this can lead to a <\/span>serious <\/span>drug interaction<\/span><\/a>. Some people may need to switch to a different antibiotic after laboratory results identify a growth of a bacteria or parasite that <\/span>metronidazole<\/span> may not effectively treat. Additionally, an alternative may need to be used due to <\/span>antimicrobial<\/span> resistance. According to the <\/span>Centers for Disease Control and Prevention<\/span> (<\/span>CDC<\/span>)<\/span><\/a>, <\/span>antimicrobial<\/span> resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow. Resistant infections can be difficult, and sometimes impossible, to treat. As the <\/span>incidence<\/span> of this resistance increases, alternative therapies may need to be utilized.<\/span><\/p>\n

RELATED: <\/b>Metronidazole<\/b> side effects<\/b> and how to avoid them<\/b><\/a><\/p>\n

What can I take in place of <\/span>metronidazole<\/span>?<\/span><\/h2>\n

There are other options available to treat bacterial or parasitic infections that do not improve with <\/span>metronidazole<\/span>. These alternative oral prescription medications include other <\/span>nitroimidazoles<\/span> and other <\/span>antibiotics<\/span><\/a>. It\u2019s important that the alternative antibiotic has <\/span>antimicrobial<\/span> activity against the specific infection being treated, as the alternative options vary in their range of activity. These options may be more suitable for certain individuals due to their different uses, <\/span>side effect<\/span> profiles, and dosages.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare metronidazole alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Flagyl<\/span> (<\/span>metronidazole<\/span>)<\/span><\/td>\n\n
    \n
  • Amebiasis<\/span><\/li>\n
  • Anaerobic bacterial infections<\/span><\/li>\n
  • Trichomoniasis<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 500 to 750 mg by mouth every 6 to 12 hours for 5 to 14 days depending on the type of infection<\/span><\/td>\nFlagyl coupons<\/span><\/a><\/td>\n<\/tr>\n
Alinia (nitazoxanide)<\/span><\/td>\n\n
    \n
  • Treatment of diarrhea caused by Cryptosporidium parvum or <\/span>Giardia<\/span> lamblia<\/span><\/li>\n
  • Clostridioides difficile infection<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 500 mg by mouth every 12 hours for 3 days<\/span><\/td>\nAlinia coupons<\/span><\/a><\/td>\n<\/tr>\n
Augmentin (<\/span>amoxicillin<\/span>–<\/span><\/p>\n

clavulanate)<\/span><\/td>\n

\n
    \n
  • Lower respiratory tract infections<\/span><\/li>\n
  • Ear infections<\/span><\/li>\n
  • Sinus infections<\/span><\/li>\n
  • Skin infections<\/span><\/li>\n
  • Urinary tract infections<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 500 mg\/125 mg to 875 mg\/125 mg by mouth every 12 hours for 3 to 10 days depending on type of infection<\/span><\/td>\nAugmentin coupons<\/span><\/a><\/td>\n<\/tr>\n
Cleocin (<\/span>clindamycin<\/span>)<\/span><\/td>\n\n
    \n
  • Anaerobic infections<\/span><\/li>\n
  • Serious respiratory tract infections<\/span><\/li>\n
  • Serious skin and soft tissue infections<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 150 to 450 mg by mouth every 6 to 12 hours depending on type of infection\u00a0<\/span><\/td>\nCleocin coupons<\/span><\/a><\/td>\n<\/tr>\n
Dificid (fidaxomicin)<\/span><\/td>\n\n
    \n
  • Clostridioides difficile infection<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 200 mg by mouth twice daily for 10 days<\/span><\/td>\nDificid coupons<\/span><\/a><\/td>\n<\/tr>\n
Humatin (paromomycin)\u00a0<\/span><\/td>\n\n
    \n
  • Intestinal amebiasis<\/span><\/li>\n
  • Hepatic coma<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 25 to 35 mg per kg by mouth daily divided in three doses for 5 to 10 days depending on type of infection<\/span><\/td>\nHumatin coupons<\/span><\/a><\/td>\n<\/tr>\n
Solosec (secnidazole)<\/span><\/td>\n\n
    \n
  • Bacterial vaginosis<\/span><\/li>\n
  • Trichomoniasis<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 2 grams by mouth once daily for one dose<\/span><\/td>\nSolosec coupons<\/span><\/a><\/td>\n<\/tr>\n
Tinidazole<\/span><\/td>\n\n
    \n
  • Amebiasis<\/span><\/li>\n
  • Bacterial vaginosis<\/span><\/li>\n
  • Giardiasis<\/span><\/li>\n
  • Trichomoniasis<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 2 grams by mouth once daily for 1 to 5 days depending on type of infection<\/span><\/td>\nTinidazole<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Vancocin (vancomycin)<\/span><\/td>\n\n
    \n
  • Clostridioides difficile infection<\/span><\/li>\n
  • Enterocolitis<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 125 to 500 mg by mouth four times daily for 10 to 14 days depending on type of infection<\/span><\/td>\nVancocin coupons<\/span><\/a><\/td>\n<\/tr>\n
Xifaxan<\/span><\/td>\n\n
    \n
  • Traveler\u2019s Diarrhea caused by noninvasive strains of Escherichia coli\u00a0<\/span><\/li>\n
  • Hepatic Encephalopathy<\/span><\/li>\n
  • Irritable Bowel Syndrome with Diarrhea<\/span><\/li>\n
  • Recurrent Clostridioides difficile infection<\/span><\/li>\n<\/ul>\n<\/td>\n
Take 200 to 550 mg by mouth two to three times daily for 3 to 20 days depending on condition<\/span><\/td>\nXifaxan coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 <\/span>metronidazole<\/span> alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>metronidazole<\/span>.<\/span><\/p>\n

1. <\/span>Tinidazole<\/span><\/h3>\n

Tinidazole<\/span><\/a> is a generic medication that belongs to the same group of antibiotics, <\/span>nitroimidazoles<\/span>, as <\/span>metronidazole<\/span>. <\/span>Tinidazole<\/span> can be used for a variety of infections, including amebiasis, <\/span>bacterial vaginosis<\/span>, <\/span>giardiasis<\/span>, and <\/span>trichomoniasis<\/span>. This medication is available as an oral tablet that should be taken with food, as this helps to prevent an upset stomach. <\/span>Tinidazole<\/span> has a convenient dosing schedule as it is often given as one <\/span>single dose<\/span>, but may be given once daily up to five days, depending on the condition being treated. This may be a suitable alternative for people who are unable to tolerate <\/span>metronidazole,<\/span> as it has fewer reported <\/span>side effects<\/span>. The most common <\/span>side effects<\/span> include metallic\/bitter taste, nausea, and weakness or fatigue.<\/span><\/p>\n

2. Solosec<\/span><\/h3>\n

Solosec<\/span><\/a> (secnidazole) is currently only available as a brand-name medication and belongs to the same group of antibiotics, <\/span>nitroimidazoles<\/span>, as <\/span>metronidazole<\/span>. Solosec is used to treat sexually transmitted infections (<\/span>STIs<\/span>), formerly called <\/span>sexually transmitted diseases<\/span> (<\/span>STDs<\/span>), such as <\/span>bacterial vaginosis<\/span> and <\/span>trichomonas vaginalis<\/span>. This medication is available as a packet of oral granules that can be sprinkled onto applesauce, yogurt, or pudding. Solosec has a convenient dosing schedule, as only one dose is needed. The most common <\/span>side effects<\/span> include vaginal yeast infection, headache, nausea, diarrhea, and abdominal pain.<\/span><\/p>\n

3. Cleocin (<\/span>clindamycin<\/span>)<\/span><\/h3>\n

Cleocin<\/span><\/a> is the brand name of the generic medication <\/span>clindamycin<\/span> and belongs to a group of antibiotics called lincosamides. Like <\/span>metronidazole<\/span>, <\/span>clindamycin<\/span> is effective at treating <\/span>anaerobic bacterial<\/span> infections. <\/span>Clindamycin<\/span> is used to treat a wide variety of infections, including skin and soft tissue infections, lower respiratory tract infections, bone and joint infections, and <\/span>bacterial vaginosis<\/span>. This medication is available as an oral capsule and an oral solution. <\/span>Clindamycin<\/span> has a potential risk of causing a of Clostridioides difficile (C. diff)-associated diarrhea.<\/span><\/p>\n

RELATED:<\/b> 8 antibiotics that cause C.Diff<\/b><\/a><\/p>\n

4. Vancocin (vancomycin)<\/span><\/h3>\n

Vancocin<\/span><\/a> is the brand name of the generic medication vancomycin and belongs to a group of antibiotics called glycopeptides. When used as the oral formulation, vancomycin is typically used to treat Clostridioides difficile (C.diff) infections (previously referred to as <\/span>Clostridium difficile<\/span>) and enterocolitis. Vancomycin oral formulations include a capsule and solution. Common <\/span>side effects<\/span> include stomach pain, nausea, diarrhea, flatulence, and vomiting.<\/span><\/p>\n

5. Alinia (nitazoxanide)<\/span><\/h3>\n

Alinia<\/span><\/a> is the brand name of the generic medication nitazoxanide and is an antiprotozoal. This type of medication fights infections caused by <\/span>protozoa<\/span> that feed on organic tissues and other microorganisms. Alinia can be used to treat <\/span>giardiasis<\/span> and Clostridioides difficile (C.diff). These infections can cause diarrhea and inflammation of the colon (<\/span>colitis<\/span>). This medication is available as an oral tablet and oral solution, and should be taken with food. Common <\/span>side effects<\/span> include nausea, abdominal pain, urine discoloration, and headache.<\/span><\/p>\n

Natural alternatives to <\/span>metronidazole<\/span><\/h2>\n

It is not recommended to replace <\/span>metronidazole<\/span> and other antibiotics with natural therapies. It\u2019s important for people taking prescription therapies to know that certain <\/span>supplements<\/span> or herbal treatments may lead to an increased risk of <\/span>drug interactions<\/span> or <\/span>adverse effects<\/span> if used without the guidance of a <\/span>healthcare<\/span> provider.<\/span><\/p>\n

Natural remedies to take alongside prescription antibiotics include probiotics and prebiotics. <\/span>Probiotics<\/span><\/a> replenish the natural <\/span>gastrointestinal<\/span> (GI) flora with nonpathogenic organisms. When taking antibiotics, there is a disruption of the GI flora that normally acts as a barrier to infection and aids in the digestion of carbohydrates, which can cause antibiotic-associated diarrhea (AAD). <\/span>Clinical trials<\/span><\/a> have shown that taking probiotics for the entire course of antibiotic treatment can help prevent diarrhea.<\/span><\/p>\n

Prebiotics<\/span><\/a> are a type of dietary fiber that the bacteria in the gut feed on to promote <\/span>gut health<\/span><\/a>. Foods that are rich in prebiotics include asparagus, sugar beet, garlic, onion, wheat, honey, banana, barley, tomato, rye, soybean, peas, and beans.<\/span><\/p>\n

RELATED: <\/b>Why you should take probiotics with antibiotics<\/b><\/a><\/p>\n

How to switch to a <\/span>metronidazole<\/span> alternative<\/span><\/h2>\n

2. Do not suddenly stop taking <\/span>metronidazole<\/span><\/h3>\n

Before stopping <\/span>metronidazole<\/span>, make a care plan with the <\/span>healthcare<\/span> team to avoid further progression of the infection. Once a plan has been made, <\/span>metronidazole<\/span> can be safely discontinued and replaced with the new <\/span>antimicrobial<\/span> treatment if appropriate.<\/span><\/p>\n

3. Complete the course of antibiotic treatment<\/span><\/h3>\n

It\u2019s important to follow the directions on the prescription for antibiotics, as the number of days of therapy has been chosen based on the type of infection determined through <\/span>treatment guidelines<\/span>. Even if a person is feeling better after a few days, that doesn\u2019t mean all of the infection is actually gone. If treatment stops too soon, and the infection comes back, the remaining bacteria may become resistant to the antibiotic that was previously taken.\u00a0<\/span><\/p>\n

RELATED: <\/b>What happens if you don\u2019t finish antibiotics?<\/b><\/a><\/p>\n

Misuse and overuse of antibiotics have contributed to a phenomenon known as <\/span>antibiotic resistance<\/span><\/a>. This resistance develops when potentially harmful bacteria change in a way that reduces or eliminates the effectiveness of antibiotics. As the <\/span>prevalence<\/span> of <\/span>infectious diseases<\/span> like sexually transmitted infections (<\/span>STIs<\/span>) increases, drug resistance is a major threat to <\/span>treatment options<\/span>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Metronidazole (brand name Flagyl) is an antibiotic that is used to treat a variety of bacterial and parasitic infections. Metronidazole belongs to a group of antibiotics called nitroimidazoles that work to disrupt the DNA of bacterial and parasitic cells. This medication is primarily used to treat infectious diseases caused by anaerobic bacteria (bacteria that survive […]<\/p>\n","protected":false},"author":133,"featured_media":55097,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,4350],"coauthors":[20740],"class_list":["post-55092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nTop metronidazole alternatives and how to switch your Rx | SingleCare<\/title>\n<meta name=\"description\" content=\"Tinidazole, Solosec, Cleocin, Vancocin, and Alinia are some metronidazole alternatives. 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1. Discuss all health conditions with a <\/span>healthcare<\/span> provider<\/span><\/h3>\n

Before switching from <\/span>metronidazole<\/span> to an alternative, it\u2019s important that the prescribing doctor has reviewed all health conditions. Alternatives may have serious <\/span>side effects<\/span> or precautions that need to be avoided. It\u2019s best to seek <\/span>medical advice<\/span> prior to changing medication therapy. If the reason for seeking an alternative to metronidazole is cost, SingleCare can help. Using a <\/span>SingleCare discount card<\/span><\/a> can create a prescription savings of up to 80%.\u00a0<\/span><\/p>\n