{"id":55318,"date":"2022-11-18T09:30:44","date_gmt":"2022-11-18T14:30:44","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=55318"},"modified":"2025-11-24T20:59:56","modified_gmt":"2025-11-25T01:59:56","slug":"how-does-nurtec-work","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/how-does-nurtec-work\/","title":{"rendered":"How long does Nurtec take to work?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Before the first migraine-specific drugs hit the pharmaceutical market in 2018, the medications used to treat migraine were meant for other health conditions. Antidepressants, beta blockers, and epilepsy drugs reduced <\/span><span style=\"font-weight: 400;\"> in many people, but no one knew for sure how or why. Many people who live with migraines were left without help when those drugs didn\u2019t work for them.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There is a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/new-migraine-medications\/\"><span style=\"font-weight: 400;\">new generation of migraine medications<\/span><\/a><span style=\"font-weight: 400;\">, which block something called calcitonin gene-related peptide, or CGRP. \u201cDuring a migraine attack, CGRP is released, [then] attaches to and activates receptors in the brain, which propagate pain signals,\u201d says Lauren R. Natbony, MD, medical director of <\/span><span style=\"font-weight: 400;\">Integrative Headache Medicine of New York<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One of these CGRP-targeting medications, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nurtec\"><span style=\"font-weight: 400;\">Nurtec ODT<\/span><\/a><span style=\"font-weight: 400;\"> (rimegepant), was <\/span><span style=\"font-weight: 400;\">approved in 2020 as an abortive treatment<\/span><span style=\"font-weight: 400;\"> for migraine.\u00a0 Abortive means you can take it after a migraine begins to stop symptoms, as a rescue medication to relieve your symptoms. Then, in 2021, <\/span><span style=\"font-weight: 400;\">approval was expanded<\/span><span style=\"font-weight: 400;\"> to include use of Nurtec as a preventive migraine treatment\u2014taken once every other day.\u00a0 When it is taken every other day, it\u2019s been shown to reduce the number of monthly migraine days while causing few side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So how, exactly, does Nurtec work to both treat and prevent migraines\u2026and what should you expect it to do for you? Here\u2019s what you need to know.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Nurtec with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tNurtec 75 mg (8 Disintegrating tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$923.06<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/nurtec#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/nurtec#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$923.06<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/nurtec#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/nurtec#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/nurtec#blog-cta\" class=\"coupon-see-all-btn\">See Nurtec prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"how-does-nurtec-work\">How does Nurtec work?<\/h2>\n<p><span style=\"font-weight: 400;\">Older migraine medications, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/propranolol-hcl\"><span style=\"font-weight: 400;\">propranolol<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sumatriptan\"><span style=\"font-weight: 400;\">sumatriptan<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nortriptyline-hcl\"><span style=\"font-weight: 400;\">nortriptyline<\/span><\/a><span style=\"font-weight: 400;\">, are believed to reduce migraine episodes by working along the central nervous system; they increase low serotonin levels (sometimes considered a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4117050\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">risk factor for migraine<\/span><\/a><span style=\"font-weight: 400;\">), prevent vasodilation, and block certain other receptors that can contribute to migraine. But as an anti-CGRP medication, Nurtec doesn\u2019t do any of these things.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cNurtec works by blocking CGRP receptors like a plug,\u201d says <a href=\"https:\/\/integrativeheadacheny.com\/about-dr-adelene-e-jann\/\">Dr. Natbony<\/a>. \u201cWhen CGRP is released, it cannot bind to and activate the receptor; this prevents CGRP from triggering the cascade of inflammation that results in severe migraine pain.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That\u2019s how Nurtec relieves symptoms of an existing migraine, but what about prevention? The mechanism of action is still similar, says Dr. Natbony, with Nurtec providing a more continuous blockade of CGRP receptors which makes it more difficult for a migraine attack to be triggered.\u00a0<\/span><\/p>\n<h2 id=\"how-to-take-nurtec\">How to take Nurtec<\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking Nurtec to treat a migraine on the spot, it works pretty quickly compared to other abortive treatments. Unfortunately, no migraine medications work immediately (yet!). But you should take Nurtec as soon as you notice a migraine starting for best results, says Joanna Lewis, Pharm.D., of <\/span><a href=\"https:\/\/www.thepharmacistsguide.com\/about\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">The Pharmacist\u2019s Guide<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"when-should-you-take-nurtec\"><span style=\"font-weight: 400;\">When should you take Nurtec?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cThe best time to take it\u2026is as soon as you feel a migraine attack coming on,\u201d Dr. Lewis recommends. \u201cSometimes people wait until the pain becomes unbearable, but it\u2019s actually best to take the medication as soon as [it starts].\u201d<\/span><\/p>\n<h3 id=\"how-long-does-nurtec-take-to-work\"><span style=\"font-weight: 400;\">How long does Nurtec take to work?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">As far as how you\u2019ll feel after taking a dose, Dr. Natbony says many people will experience some amount of pain relief and what she calls \u201cfreedom from functional disability\u201d around 60 minutes post-dose. In other words, after one hour most people are able to gradually begin resuming their daily activities. You might not be completely symptom-free at that point, but you\u2019ll typically keep improving from there, with most people feeling significantly better about <\/span><a href=\"https:\/\/www.nurtec.com\/faq\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">two hours after taking Nurtec<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking Nurtec regularly to prevent migraine, you can expect fairly quick results, too, says Dr. Natbony: \u201cIn clinical trials, there was a 30% drop in migraines within the first week [when Nurtec was taken preventively].\u201d<\/span><\/p>\n<h3 id=\"nurtec-side-effects\"><span style=\"font-weight: 400;\">Nurtec side effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The other bit of good news is regarding side effects, which Dr. Lewis says are usually relatively mild; nausea and stomach pain are the most commonly reported side effects, but have only been found to occur in <\/span><a href=\"https:\/\/www.nurtec.com\/side-effects\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">fewer than 3% of people taking Nurtec<\/span><\/a><span style=\"font-weight: 400;\">. Nurtec is not safe for you if you have severe kidney or liver impairment.<\/span><\/p>\n<h3 id=\"how-long-does-nurtec-last\"><span style=\"font-weight: 400;\">How long does Nurtec last?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nurtec has a long half-life, says Dr. Natbony, which allows it to prevent and treat symptoms for about 48 hours at a time.\u00a0<\/span><\/p>\n<h3 id=\"how-often-do-you-take-nurtec\"><span style=\"font-weight: 400;\">How often do you take Nurtec?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you take it as an abortive medication, it can relieve your symptoms <\/span><i><span style=\"font-weight: 400;\">and <\/span><\/i><span style=\"font-weight: 400;\">keep them away for a while. If you\u2019re using it preventively, you\u2019ll still only need to take it every two days because of how long it stays active in your system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cFor preventive use, take Nurtec at the same time every other day,\u201d advises Dr. Lewis. \u201cTaking it in the morning or evening does not matter, [but if you get nauseated] from the medication, take it in the evening.\u201d<\/span><\/p>\n<h2 id=\"how-do-you-know-if-you-need-nurtec\">How do you know if you need Nurtec?<\/h2>\n<p><span style=\"font-weight: 400;\">Nurtec is generally recommended for people with <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3258393\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">episodic migraine<\/span><\/a><span style=\"font-weight: 400;\">, or people who have no more than 14 migraine days per month. It\u2019s a good option for people who haven\u2019t had success with other types of migraine medications, who have struggled with the side effects of other migraine medications, or who want to combine their preventive and abortive medications into one convenient drug.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to Dr. Lewis, Nurtec may also work well for people who can\u2019t take triptans because of the side effects or co-existing cardiovascular disease, as well as for people who regularly have nausea and\/or vomiting with their migraine attacks.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cBecause Nurtec dissolves under the tongue, it does not go through the stomach to be absorbed,\u201d says Dr. Lewis, \u201cwhich can result in quicker relief and better pain relief for those who are having a hard time keeping medication down due to nausea.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ultimately, though, you should always talk to your doctor about whether Nurtec is right for you. While it works for many people, it\u2019s not right for everyone\u2014and Dr. Lewis notes that it has several drug interactions, so make sure you let your prescribing doctor know about all the other medications and supplements you take.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Before the first migraine-specific drugs hit the pharmaceutical market in 2018, the medications used to treat migraine were meant for other health conditions. Antidepressants, beta blockers, and epilepsy drugs reduced in many people, but no one knew for sure how or why. Many people who live with migraines were left without help when those drugs [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":55177,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,4316],"coauthors":[8860],"class_list":["post-55318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-migraine","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How Nurtec works and how to take it for best results<\/title>\n<meta name=\"description\" content=\"As one of the new generation migraine drugs, Nurtec works differently than other migraine medications. 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