{"id":56609,"date":"2023-01-19T09:43:14","date_gmt":"2023-01-19T14:43:14","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=56609"},"modified":"2025-10-20T11:35:19","modified_gmt":"2025-10-20T15:35:19","slug":"zoloft-weight-gain","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/zoloft-weight-gain\/","title":{"rendered":"Does Zoloft cause weight gain?"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/jxMSrZsGgEI?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">Zoloft<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\/what-is\"><span style=\"font-weight: 400;\">sertraline<\/span><\/a><span style=\"font-weight: 400;\">) is a prescription medication that belongs to the selective serotonin reuptake inhibitor (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\"><span style=\"font-weight: 400;\">SSRI<\/span><\/a><span style=\"font-weight: 400;\">) class of antidepressants. Zoloft is often prescribed as part of a treatment plan, which may include other methods such as cognitive behavioral therapy, to treat major depressive disorder (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\">) or other mental health conditions, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/ocd-treatment-and-medications\"><span style=\"font-weight: 400;\">Obsessive-compulsive disorder<\/span><\/a><span style=\"font-weight: 400;\"> (OCD)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">Panic disorder<\/span><\/a><span style=\"font-weight: 400;\"> (PD)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/ptsd-treatment-and-medications\"><span style=\"font-weight: 400;\">Post-traumatic stress disorder<\/span><\/a><span style=\"font-weight: 400;\"> (PTSD)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Social anxiety disorder (SAD)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Premenstrual dysphoric disorder (PMDD)<\/span><\/li>\n<\/ul>\n<p><span data-sheets-root=\"1\"><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zoloft is a popular antidepressant medication. As of 2022, nearly <\/span><span style=\"font-weight: 400;\">40 million prescriptions<\/span><span style=\"font-weight: 400;\"> have been written for this medication. Many patients want to know if Zoloft will cause weight gain. In fact, one of the <\/span><span style=\"font-weight: 400;\">most common reasons<\/span><span style=\"font-weight: 400;\"> why people stop taking SSRIs is because of <a href=\"https:\/\/www.singlecare.com\/\/blog\/rapid-weight-gain-causes\">weight gain<\/a>. Zoloft may cause weight gain with long-term use. It may also cause a slight weight loss in children. Continue reading to learn more about Zoloft and its effect on body weight.<\/span><\/p>\n<h2 id=\"does-zoloft-cause-weight-gain\"><span style=\"font-weight: 400;\">Does Zoloft cause weight gain?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because everyone is different in their symptoms of depression or anxiety, as well as side effects and response to medication, weight changes due to Zoloft will vary by individual. One person may gain weight while another may lose. Some people eat more when they are depressed, and when they start taking Zoloft and feeling better, they may return to a normal diet and lose weight. On the other hand, some people experience appetite loss when depressed and eat less. Then, when taking Zoloft and starting to feel better, they may start to eat more and gain weight.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While it is difficult to know how each person will respond to Zoloft in terms of weight gain, we can look at the results of some clinical studies.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">One<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4850471\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\u00a0study<\/span><\/a><span style=\"font-weight: 400;\"> looked at weight gain in adults after two years of antidepressant use. In this study, people who took sertraline gained an average of 5.9 pounds after two years.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/bariatrictimes.com\/psychiatric-medications-and-weight-gain-a-review\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">review of many studies<\/span><\/a><span style=\"font-weight: 400;\"> published in 2017 noted that a small weight loss may occur with short-term use of SSRIs, including Zoloft\u2014in an 8-week study, individuals who took Zoloft lost an average of 1.58 pounds. However, short-term use of SSRIs is very unusual, because most people take SSRIs for at least 6 months\u2014or much longer. The review noted one particular<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11105740\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\u00a0study<\/span><\/a><span style=\"font-weight: 400;\">, which looked at people who took an SSRI for up to 32 weeks and found sertraline to cause a weight gain of 1% (this would equate to a 1.8-pound weight gain for someone who weighs 180 pounds). And 4.2% of individuals who took Zoloft gained more than 7% of body weight (which would equate to at least 12.6 extra pounds for someone who weighs 180 pounds).\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In terms of <\/span><span style=\"font-weight: 400;\">children<\/span><span style=\"font-weight: 400;\">, Zoloft may affect growth hormones, which may slow growth and cause weight loss. Children who take Zoloft will have their height and weight monitored regularly.<\/span><\/p>\n<h3 id=\"why-does-zoloft-cause-weight-gain\"><span style=\"font-weight: 400;\">Why does Zoloft cause weight gain?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Weight gain due to Zoloft (or any SSRI antidepressant) is thought to possibly be <\/span><a href=\"https:\/\/www.ccjm.org\/content\/ccjom\/70\/7\/314.full.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">due to several factors<\/span><\/a><span style=\"font-weight: 400;\">, including:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">By affecting serotonin receptor activity, which may regulate appetite and weight<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">By increasing appetite, especially carbohydrate cravings<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">By improving symptoms of depression, and helping appetite return to normal in those who had appetite loss<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"other-ssris-and-weight-gain\"><span style=\"font-weight: 400;\">Other SSRIs and weight gain<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">SSRI weight gain can occur with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/ssri-weight-gain-statistics\/\"><span style=\"font-weight: 400;\">other SSRIs<\/span><\/a><span style=\"font-weight: 400;\"> besides Zoloft. A <\/span><a href=\"https:\/\/www.bmj.com\/content\/361\/bmj.k1951\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> in the <\/span><i><span style=\"font-weight: 400;\">British Medical Journal (BMJ)<\/span><\/i><span style=\"font-weight: 400;\"> looked at the long-term use of antidepressants and weight gain. The study found that those who took an antidepressant had an increased risk of at least a 5% increase in weight, as opposed to individuals who did not take an antidepressant. Weight gain increased in the second and third years of treatment. The study researchers concluded that antidepressant use increased the risk of weight gain over at least 5 years.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5629701\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">4-year study<\/span><\/a><span style=\"font-weight: 400;\"> concluded that SSRI use was associated with weight gain\u2014in combination with certain lifestyle factors including a Western diet, lack of activity, and smoking.\u00a0 <\/span><\/p>\n<p><span style=\"font-weight: 400;\">The review of studies (mentioned in the section above) noted that some individuals gain what is considered to be an \u201cextreme\u201d amount of weight, which is more than 7% of body weight. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/paxil\"><span style=\"font-weight: 400;\">Paxil<\/span><\/a><span style=\"font-weight: 400;\"> (paroxetine)<\/span><span style=\"font-weight: 400;\"> caused the most weight gain. In the study, 25.5% of people who took Paxil, 6.8% of people who took <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prozac\/what-is\"><span style=\"font-weight: 400;\">Prozac<\/span><\/a><span style=\"font-weight: 400;\"> (fluoxetine)<\/span><span style=\"font-weight: 400;\">, and 4.2% of people who took Zoloft (sertraline) gained more than 7% of body weight.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another study also concludes that <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/paxil\/what-is\"><span style=\"font-weight: 400;\">Paxil<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/paxil\/what-is\"><span style=\"font-weight: 400;\">(paroxetine)<\/span><\/a><span style=\"font-weight: 400;\"> may be <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10926053\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most likely<\/span><\/a><span style=\"font-weight: 400;\"> to cause greater weight gain than other SSRIs during long-term treatment. Interestingly \u2014bupropion, which is not an SSRI, also known by its brand name, Wellbutrin, is an antidepressant that may cause weight loss\u2014and is one ingredient in the weight-loss drug Contrave.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25467076\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">One study<\/span><\/a><span style=\"font-weight: 400;\"> examined adults using antidepressants for 6 to 36 months and found that 55% of people gained weight. Of these, almost 41% gained 7% or more of their weight compared to baseline. The study found <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/celexa\"><span style=\"font-weight: 400;\">Celexa<\/span><\/a><span style=\"font-weight: 400;\"> (citalopram)<\/span><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\"><span style=\"font-weight: 400;\">Lexapro<\/span><\/a><span style=\"font-weight: 400;\"> (escitalopram)<\/span><span style=\"font-weight: 400;\">, Paxil (paroxetine), and Zoloft (sertraline) to be associated with significant weight gain\u2014but not Prozac (fluoxetine). The study also found some serotonin-norepinephrine reuptake inhibitors (SNRIs) to cause weight gain, including <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cymbalta\"><span style=\"font-weight: 400;\">Cymbalta (duloxetine)<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr\"><span style=\"font-weight: 400;\">Effexor<\/span><\/a><span style=\"font-weight: 400;\"> (venlafaxine)<\/span><span style=\"font-weight: 400;\">.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although SSRIs and SNRIs may cause weight gain, other types of antidepressants may cause weight gain as well. For example, tricyclic antidepressants such as <\/span><span style=\"font-weight: 400;\">Elavil <\/span><span style=\"font-weight: 400;\">(amitriptyline)<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">Pamelor<\/span><span style=\"font-weight: 400;\"> (nortriptyline)<\/span><span style=\"font-weight: 400;\"> are <\/span><span style=\"font-weight: 400;\">well-known for causing weight gain<\/span><span style=\"font-weight: 400;\">. And <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16649829\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Remeron<\/span><\/a><span style=\"font-weight: 400;\"> (mirtazapine)<\/span><span style=\"font-weight: 400;\">, which is classified as a tetracyclic antidepressant, is known for causing significant increases in body weight and body fat.\u00a0<\/span><\/p>\n<h2 id=\"how-to-avoid-zoloft-weight-gain\"><span style=\"font-weight: 400;\">How to avoid Zoloft weight gain\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Not everyone will gain weight when taking Zoloft or an SSRI, especially if you are aware and proactive. Here are some tips to help avoid weight gain while taking Zoloft\u2014or any antidepressant:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">First, do not stop taking Zoloft suddenly, even if you start to gain weight. Stopping an SSRI suddenly can cause withdrawal symptoms\u2014as well as worsen depression or anxiety. If you have any concerns about your medication, consult your doctor first. You and your healthcare professional will need to consider all options regarding which medication is best and the possibility of weight gain. For example, a weight gain of 3 pounds over several years can be considered insignificant when compared to living with symptoms of depression. However, a larger weight gain caused by an antidepressant could lead to other health problems like high blood pressure, which could require either lifestyle changes or a change to a different drug.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you have gained weight, ask your healthcare professional if there could be another cause. The SSRI may not necessarily be the culprit of weight gain. Another medical condition could be the cause.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Talk to your healthcare professional, or consult a registered dietician, about lifestyle changes, such as incorporating a healthy diet of nutritious foods and an exercise plan that will fit into your life. According to the Centers for Disease Control and Prevention (CDC), adults should get <\/span><a href=\"https:\/\/www.cdc.gov\/physical-activity-basics\/guidelines\/adults.html\"><span style=\"font-weight: 400;\">at least 150 minutes<\/span><\/a><span style=\"font-weight: 400;\"> of moderate-intensity physical activity every week, plus two strength-training sessions. This can be done, for example, by walking for 30 minutes, 5 days per week, and adding in two strength-training workouts. You can walk outside, or even around a mall\u2014or check YouTube for thousands of free exercise videos, including walking videos. In addition to helping avoid weight gain, this benefits overall health, too.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Keep track of your weight while taking Zoloft. This way, you can see if there is a pattern of weight gain, and make changes if necessary.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If weight gain becomes a problem, or you do not want to take a medication that may make you gain weight, ask your healthcare provider for medical advice about trying a different medication\u2014such as bupropion\u2014with a lower risk of weight gain.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Ask your healthcare professional for other ideas that are personalized to your individual needs. Working together with your healthcare team, you will be able to find the treatment that works best for your depression or anxiety\u2014while also minimizing weight gain.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zoloft (sertraline) is a prescription medication that belongs to the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. Zoloft is often prescribed as part of a treatment plan, which may include other methods such as cognitive behavioral therapy, to treat major depressive disorder (depression) or other mental health conditions, including: Obsessive-compulsive disorder (OCD) Panic disorder [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":56610,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8029],"tags":[9777,451,450],"coauthors":[10668],"class_list":["post-56609","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-education","tag-anxiety","tag-depression","tag-mental-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Does Zoloft cause weight gain? | SingleCare<\/title>\n<meta name=\"description\" content=\"Zoloft may cause weight gain with long-term use. 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