{"id":56948,"date":"2023-02-07T08:21:37","date_gmt":"2023-02-07T13:21:37","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=56948"},"modified":"2026-06-12T14:28:21","modified_gmt":"2026-06-12T18:28:21","slug":"amoxicillin-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/amoxicillin-alternatives\/","title":{"rendered":"Amoxicillin (Amoxil) alternatives: What can I take instead of amoxicillin?"},"content":{"rendered":"

Amoxicillin is a commonly used prescription <\/span>antibiotic<\/span><\/a> that treats a wide range of bacterial infections, including skin infections, middle ear infections, sinus infections, throat infections (pharyngitis), urinary tract infections (UTIs), community-acquired pneumonia, bronchitis, and others. Still, amoxicillin may not be the right medication for any number of reasons, including antibiotic resistance, drug allergies, the type of infection, or drug interactions. Healthcare providers, though, have a wide variety of antibiotics across a spectrum of drug classes that can treat the same bacterial infections as amoxicillin.\u00a0<\/span><\/p>\n

What can I take instead of <\/span>amoxicillin<\/span>?<\/span><\/h2>\n

Amoxicillin<\/span> belongs to the <\/span>penicillin<\/span><\/a> class of <\/span>antibiotics<\/span><\/a>. Other class members could be considered if <\/span>amoxicillin<\/span> is unavailable, including penicillin itself. Unfortunately, penicillins don\u2019t always work because bacteria can be resistant to beta-lactam, the part of the penicillin molecule that kills bacteria. In those cases, the usual alternative to amoxicillin is a single medication containing two antibiotics: amoxicillin with clavulanate, which neutralizes bacterial resistance.<\/span><\/p>\n

Penicillins have a long and celebrated role in medicine, but many people can\u2019t use them due to a drug <\/span>allergy<\/span><\/a>. In these cases, <\/span>cephalosporin<\/span><\/a> antibiotics may be an option if the allergic reaction is only a rash. You can identify cephalosporins because their names all begin with ceph- or cef-.<\/span><\/p>\n

Aside from cephalosporins, the most commonly used substitutes for amoxicillin are <\/span>macrolide antibiotics<\/span><\/a> (drugs that end in \u2013mycin), <\/span>tetracycline antibiotics<\/span><\/a> (drugs that end in \u2013cycline), or <\/span>sulfonamide antibiotics<\/span><\/a> (drugs that start with sulfa). <\/span>Quinolone antibiotics<\/span><\/a> (drugs that end in \u2013oxacin), such as levofloxacin, are also a possible amoxicillin substitute.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare <\/span>amoxicillin alternatives<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Amoxicillin<\/span><\/td>\n$20 per 21, 500 mg capsules of generic amoxicillin<\/span><\/td>\n$9 per 21, 500 mg capsules of generic amoxicillin at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Augmentin<\/span> (<\/span>amoxicillin<\/span>-clavulanic acid<\/span>)<\/span><\/td>\n$766 per 1, 125-31.25 mg\/5 mL, 100 mL bottle<\/span><\/td>\n$11 per 20, 875-125 mg tablets of generic Augmentin at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cephalexin<\/span><\/td>\n$44 per 28, 500 mg capsules of generic cephalexin<\/span><\/td>\n$9 per 28, 500 mg capsules of generic cephalexin at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cefdinir<\/span><\/td>\n$114 per 20, 300 mg capsules of generic cefdinir<\/span><\/td>\n$15 per 20, 300 mg capsules of generic cefdinir at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Zithromax<\/span> (<\/span>azithromycin<\/span>)<\/span><\/td>\n$323 for 1, 500 mg solution<\/span><\/td>\n$6 for 1, 6-tablet box of generic Zithromax at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Doxycycline<\/span> hyclate<\/span><\/td>\n$96 for 14, 100 mg capsules of generic doxycycline<\/span><\/td>\n$8 for 14, 100 mg capsules of generic doxycycline at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Penicillin<\/span> V potassium<\/span><\/td>\n$50 per 28, 500 mg tablets of generic penicillin V potassium<\/span><\/td>\n$10 per 28, 500 mg tablets of generic penicillin V potassium at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cefuroxime axetil<\/span><\/td>\n$174 per 14, 500 mg tablets of generic cefuroxime<\/span><\/td>\n$15 per 14, 500 mg tablets of generic cefuroxime at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cefixime<\/span><\/td>\n$85 for 2, 400 mg capsules of generic cefixime<\/span><\/td>\n$14 for 2, 400 mg capsules of generic cefixime at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Ceftriaxone<\/span> sodium<\/span><\/td>\n$52 per 1, 1 gm solution of generic ceftriaxone<\/span><\/td>\n$7 per 1, 1 gm solution of generic ceftriaxone at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cefprozil<\/span><\/td>\n$86 per 100 mL of 250 mg\/5 mL solution of generic cefprozil<\/span><\/td>\n$29 per 100 mL of 250 mg\/5 mL solution of generic cefprozil at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Clarithromycin<\/span><\/td>\n$148 for 28, 500 mg tablets of generic clarithromycin<\/span><\/td>\n$24 for 28, 500 mg tablets of generic clarithromycin at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cleoc<\/span><\/a>i<\/span>n<\/span><\/a> (<\/span>clindamycin<\/span>)<\/span><\/td>\n$411 for 30, 300 mg capsules<\/span><\/td>\n$9 for 30, 300 mg capsules of generic clindamycin at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Bactrim DS<\/span> (<\/span>sulfamethoxazole-trimethoprim<\/span>)<\/span><\/td>\n$49 for 14, 800-160 mg tablets<\/span><\/td>\n$3 for 14, 800-160 mg tablets of generic Bactrim DS at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 01\/05\/26. The listed price, excluding insurance, refers to the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under \u201cSavings options\u201d to see the latest drug prices.<\/span><\/i><\/small><\/p>\n

Top 5 <\/span>amoxicillin alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>amoxicillin<\/span>.<\/span><\/p>\n

1. <\/span>Augmentin<\/span><\/h3>\n

Augmentin<\/span><\/a> (<\/span>amoxicillin-clavulanate<\/span>) combines amoxicillin with a beta-lactamase (clavulanate) that neutralizes antibiotic resistance in penicillin-susceptible bacteria. It is typically the first-line treatment when there\u2019s a possibility of drug-resistant bacteria, such as ear, <\/span>sinus<\/span>, or lung infections. It is not given to a patient who has a known penicillin allergy.\u00a0<\/span><\/p>\n\t\t

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Save up to 80% on Augmentin with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

\n\t\t\t\t
\n\t\t\t\t\tAugmentin 875-125 mg (20 Tablets)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$10.84\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$10.84\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Augmentin prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

RELATED: <\/b>Amoxicillin vs. Augmentin: Differences, similarities, and which is better for you<\/b><\/a><\/p>\n

2. <\/span>Cephalexin<\/span><\/h3>\n

Cephalexin<\/span><\/a>, a first-generation cephalosporin, is a good substitute for people with a mild penicillin allergy, such as those who get a minor rash with prior <\/span>amoxicillin<\/span> use. For other infections, it may be the choice. <\/span>Cephalexin<\/span> is a common pick for <\/span>strep throat<\/span><\/a> and skin infections like cellulitis.<\/span><\/p>\n

RELATED: <\/b>Cephalexin vs. Amoxicillin: Differences, similarities, and which is better for you<\/b><\/a><\/p>\n

3. Cefdinir<\/span><\/h3>\n

Advancing to a third-generation antibiotic like <\/span>cefdinir<\/span><\/a> can provide broader spectrum coverage, including <\/span>acute middle ear infections<\/span> and <\/span>pneumonia<\/span><\/a>, even when <\/span>amoxicillin<\/span> has been ineffective. These agents can also be effective for <\/span>urinary tract infections<\/span>, a condition for which <\/span>amoxicillin<\/span> is not often chosen. The once-daily dosing of cefdinir is also nice. Unfortunately, killing more bacteria also erodes the beneficial bacteria in the intestinal tract, so <\/span>healthcare providers<\/span> typically recommend avoiding a more potent antibiotic than necessary.\u00a0<\/span><\/p>\n

RELATED: <\/b>Cefdinir vs. amoxicillin: Differences, similarities, and which is better for you<\/b><\/a><\/p>\n

4. Zithromax<\/span><\/h3>\n

Zithromax<\/span><\/a> (azithromycin) has been a popular choice for <\/span>strep throat<\/span> and other respiratory tract <\/span>infections<\/span> for those who are allergic to <\/span>penicillin<\/span>. The macrolide drug\u2019s once-daily <\/span>dosing<\/span><\/a> and five-day treatment course have won it plenty of fans. Unfortunately, more recently, macrolide resistance rates have tempered enthusiasm, so Zithromax is not a recommended first choice for most folks with <\/span>acute bacterial <\/span>sinusitis<\/span><\/a> or <\/span>acute otitis media<\/span><\/a>.<\/span><\/p>\n

RELATED: <\/b>Azithromycin vs. amoxicillin: Differences, similarities, and which is better for you<\/b><\/a><\/p>\n

5. Doxycycline<\/span><\/h3>\n

Sinusitis<\/span>, pneumonia, and Lyme disease are all treated with <\/span>doxycycline<\/span><\/a>. These uses make this tetracycline antibiotic an option in many cases where <\/span>amoxicillin<\/span> cannot be used or is ineffective. The <\/span>downsides of tetracyclines<\/span><\/a> are worth noting. Stomach upset and sun sensitivity are common side effects, and there is concern about dental staining with long treatment courses in young children.<\/span><\/p>\n

RELATED: <\/b>Why you should take probiotics with antibiotics<\/b><\/a><\/p>\n

Amoxicillin over-the-counter alternatives<\/span><\/h2>\n

Antibiotics sold over the counter are primarily used on the skin to prevent bacterial infections after wounds or burns. These antibiotics cannot treat many common or serious skin infections. including badly infected wounds, acne, rosacea, cellulitis, or similar infections. Most importantly, these antibiotics should <\/span>never<\/span><\/i> be ingested or used inside the ear, mouth, nose, or anus to treat a bacterial infection inside the body.\u00a0<\/span><\/p>\n

Natural alternatives to amoxicillin<\/span><\/h2>\n

A number of natural supplements or foods have antibacterial properties. Studies on <\/span>garlic<\/span><\/a>, <\/span>honey<\/span><\/a>, <\/span>oregano<\/span><\/a>, and <\/span>clove<\/span><\/a> have identified antimicrobial compounds in these foods, including sulfur compounds (garlic), eugenol (clove), and hydrogen peroxide (honey). Studies on other herbs, such as <\/span>ginger<\/span><\/a>, suggest they may help suppress microbial activity. Taken in moderation, all these substances are safe additions to a healthy diet and may help prevent bacterial infections or manage very mild bacterial infections. They have not been shown to be an effective treatment for bacterial infections that require FDA-approved antibiotics.\u00a0<\/span><\/p>\n

How to switch to an <\/span>amoxicillin alternative<\/span><\/h2>\n

Finding an alternative to <\/span>amoxicillin<\/span> is quite possible, whether you need a different option due to allergy, ineffectiveness, adverse effects, or <\/span>cost<\/span><\/a>. The selection process must consider the type of bacteria and the antibiotic’s potency. Your <\/span>clinicians<\/span> will review your list of prescription medications, over-the-counter drugs, and supplements to look for drug interactions and allergies. When it is all said and done, you can expect to be started on a different antibiotic and be on your way to feeling better.<\/span><\/p>\n

Choosing the right treatment for a viral infection<\/span><\/h2>\n

Antibiotics like amoxicillin do not treat viral infections. Unfortunately, viruses are much harder to fight off with drugs. The first step is to get a diagnosis and medical advice from a healthcare professional. Once the infection has been identified, the doctor may prescribe an appropriate antiviral drug, but often they won\u2019t. Some viruses aren\u2019t treatable with antivirals, and instead, supportive care is suggested. Others, like the cold virus, will resolve in a few days without treatment. Some viruses, like influenza or COVID-19, are treatable, but initial antiviral treatment is reserved only for people at risk for serious infection or complications.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Amoxicillin is a commonly used prescription antibiotic that treats a wide range of bacterial infections, including skin infections, middle ear infections, sinus infections, throat infections (pharyngitis), urinary tract infections (UTIs), community-acquired pneumonia, bronchitis, and others. Still, amoxicillin may not be the right medication for any number of reasons, including antibiotic resistance, drug allergies, the type […]<\/p>\n","protected":false},"author":133,"featured_media":56956,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715],"coauthors":[20732],"class_list":["post-56948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","wpautop"],"acf":[],"yoast_head":"\nTop amoxicillin (Amoxil) alternatives and how to switch your Rx | SingleCare<\/title>\n<meta name=\"description\" content=\"Augmentin, cephalexin, cefdinir, Zithromax, and Vibramycin are some amoxicillin (Amoxil) alternatives. 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