{"id":58033,"date":"2023-04-16T16:50:24","date_gmt":"2023-04-16T20:50:24","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=58033"},"modified":"2025-11-20T16:58:01","modified_gmt":"2025-11-20T21:58:01","slug":"best-diabetes-drug-for-weight-loss","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/best-diabetes-drug-for-weight-loss\/","title":{"rendered":"What is the best diabetes drug for weight loss?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Weight loss is no easy feat\u2014sometimes, a reduced-calorie diet and exercise are not enough to lead to significant change. And you may not want to take the leap to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/obesity-and-health-insurance\/\"><span style=\"font-weight: 400;\">bariatric surgery<\/span><\/a><span style=\"font-weight: 400;\">. Enter a new(-ish) <\/span><a href=\"https:\/\/utswmed.org\/medblog\/obesity-medication-weight-program\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">class of drugs<\/span><\/a><span style=\"font-weight: 400;\"> originally developed for diabetes with the side effect of weight loss. This drug class is known as glucagon-like peptide-1 (GLP-1) agonists and contains several FDA-approved medications. Drugs in this class, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ozempic-0-25-or-0-5-mg-dose\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trulicity\"><span style=\"font-weight: 400;\">Trulicity<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/victoza\/what-is\"><span style=\"font-weight: 400;\">Victoza<\/span><\/a><span style=\"font-weight: 400;\">, were initially developed to be used along with lifestyle changes like diet and exercise to control blood sugar levels (blood glucose levels) in adults with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/type-2-diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\">. Some of these medications are also used in patients with heart disease (cardiovascular disease) to reduce the risk of cardiovascular events, like a heart attack or stroke. However, as more and more evidence shows that these prescription drugs promote weight loss, health professionals are increasingly prescribing them for the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> use of chronic weight management in patients who do not have diabetes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">What are these drugs, and could they work for you? Continue reading to learn more about GLP-1 agonist drugs, also called GLP-1s or GLP-1 receptor agonists.\u00a0\u00a0<\/span><\/p>\n<h2 id=\"how-do-weight-loss-drugs-work\"><span style=\"font-weight: 400;\">How do weight loss drugs work?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">GLP-1 agonists, such as Ozempic, work in three ways:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">When blood sugar is high, they stimulate insulin secretion (production), which helps control blood sugar.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">When blood sugar is high, they inhibit glucagon secretion (production), which helps control blood sugar.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">They also cause slowed gastric emptying (delayed gastric emptying), which helps control blood sugar\u2014but also helps you feel satisfied with less food and decreases appetite and cravings, which enables you to stick to a healthy eating plan.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These drugs are not stimulants (like <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phentermine-alternatives\/\"><span style=\"font-weight: 400;\">phentermine<\/span><\/a><span style=\"font-weight: 400;\">) and do not speed up your metabolism.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition to GLP-1 agonists, there is also Mounjaro to consider. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> (tirzepatide) is the first <\/span><span style=\"font-weight: 400;\">glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 agonist (also called GLP-1 and GIP receptor agonists) and <\/span><a href=\"https:\/\/beyondtype1.org\/mounjaro-results-obesity-type-2-diabetes\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">works<\/span><\/a><span style=\"font-weight: 400;\"> similarly to GLP-1 agonists. Mounjaro is currently approved with diet and exercise to improve blood sugar control in patients with Type 2 diabetes, but it is <\/span><a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lilly-receives-us-fda-fast-track-designation-tirzepatide\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">being studied<\/span><\/a><span style=\"font-weight: 400;\"> for weight loss. The United States Food and Drug Administration (FDA) has assigned Mounjaro a <\/span><a href=\"https:\/\/www.fda.gov\/patients\/fast-track-breakthrough-therapy-accelerated-approval-priority-review\/fast-track\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fast Track designation<\/span><\/a><span style=\"font-weight: 400;\"> for this use.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Healthcare providers prescribe these medications to people to lose weight, even if they don\u2019t have diabetes. This increased prescribing is because studies have shown people lose a significant amount of weight when they take a drug in the GLP-1 agonist drug class.\u00a0<\/span><\/p>\n<h2 id=\"what-is-the-best-diabetes-drug-for-weight-loss\"><span style=\"font-weight: 400;\">What is the best diabetes drug for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There is not necessarily one best treatment option for weight loss. There are several effective therapeutic options for weight loss in the GLP-1 agonist drug class. The best diabetes drug for weight loss is the one that works best for you, with the least amount of side effects. To determine which, if any, diabetes drug is best for you, speak with your healthcare provider. The chart below outlines the most common GLP-1 agonists (including Mounjaro) that are prescribed off-label for weight loss. All but Rybelsus are injectable drugs administered subcutaneously (under the skin) of the stomach, upper arm, or thigh with a pen injector device. Although most are injected, they are not to be confused with insulin. <\/span><a href=\"https:\/\/www.health.harvard.edu\/blog\/what-happens-when-a-drug-goes-viral-202302212892\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-novel-dual-targeted-treatment-type-2-diabetes\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> are most frequently in the news, in high demand (leading to shortages), and even viral on social media, but any medication in this drug class may cause appetite and weight loss.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"diabetes-drugs-for-weight-loss\"><span class=\"title\">Diabetes drugs for weight loss<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Medication (active ingredient) and pharmaceutical company manufacturer<\/b><\/td>\n<td><b>Dosage<\/b><\/td>\n<td><b>Without insurance price<\/b><\/td>\n<td><b>SingleCare price<\/b><\/td>\n<td><b>Get coupons<\/b><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/bydureon-bcise\/what-is\"><span style=\"font-weight: 400;\">Bydureon BCise<\/span><\/a><span style=\"font-weight: 400;\"> (exenatide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AstraZeneca Pharmaceuticals<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2 mg subcutaneously (SC) weekly injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1230 for a one-month supply of 4 pens<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$805 for a one-month supply of 4 pens<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/bydureon-bcise\"><span style=\"font-weight: 400;\">Get Bydureon BCise coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/byetta-5-mcg-pen\/what-is\"><span style=\"font-weight: 400;\">Byetta<\/span><\/a><span style=\"font-weight: 400;\"> (exenatide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AstraZeneca Pharmaceuticals<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5 to 10 mcg SC twice a day<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$961 for a one-month supply<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$827 for a one-month supply<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/byetta-5-mcg-pen\"><span style=\"font-weight: 400;\">Get Byetta coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Mounjaro (tirzepatide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Eli Lilly and Co.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Starting dose is 2.5 mg SC weekly for 4 weeks, then 5 mg SC weekly, then may increase by 2.5 mg per week gradually up to a maximum of 15 mg per week if required, under the healthcare provider\u2019s supervision<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1523 for a one-month supply of 4 pens<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1024 for a one-month supply of 4 pens<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro\"><span style=\"font-weight: 400;\">Get Mounjaro coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/ozempic-0-25-or-0-5-mg-dose\/what-is\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><span style=\"font-weight: 400;\"> (semaglutide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Novo Nordisk<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Starting dose is 0.25 mg SC weekly for 4 weeks, then increase to 0.5 mg weekly. A gradual increase to 1 or 2 mg weekly may be required under the healthcare provider\u2019s supervision<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1234 for a one-month supply of 0.25\/0.5 mg doses<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$937 for a one-month supply of 0.25\/0.5 mg doses<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/ozempic-0-25-or-0-5-mg-dose\"><span style=\"font-weight: 400;\">Get Ozempic coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/rybelsus\/what-is\"><span style=\"font-weight: 400;\">Rybelsus<\/span><\/a><span style=\"font-weight: 400;\"> (semaglutide)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Novo Nordisk<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Starting dose is 3 mg by mouth daily for 30 days, then increase to 7 mg daily, and may gradually increase to 14 mg daily if required, under the healthcare provider\u2019s supervision<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1276 for #30, 7 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$832 for #30, 7 mg tablets<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/rybelsus\"><span style=\"font-weight: 400;\">Get Rybelsus\u00a0 coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/trulicity\/what-is\"><span style=\"font-weight: 400;\">Trulicity<\/span><\/a><span style=\"font-weight: 400;\"> (dulaglutide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Eli Lilly and Co.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Starting dose is 0.75 mg SC weekly, and may gradually increase to 1.5 mg weekly if required, up to the highest dose of 4.5 mg if needed, under the healthcare provider\u2019s supervision<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1256 for a one-month supply of 4 pen injectors\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$804 for a one-month supply of 4 pen injectors\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/trulicity\"><span style=\"font-weight: 400;\">Get Trulicity coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/victoza\/what-is\"><span style=\"font-weight: 400;\">Victoza<\/span><\/a><span style=\"font-weight: 400;\"> (liraglutide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Novo Nordisk<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Starting dose 0.6 mg SC daily for one week, then 1.2 mg SC daily, may gradually increase to a maximum dose of 1.8 mg daily if required, under the healthcare provider\u2019s supervision<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1496 for a one-month supply<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1015 for a one-month supply<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/victoza\"><span style=\"font-weight: 400;\">Get Victoza coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">*This chart does not include GLP-1 agonists specifically approved for weight loss (not diabetes), including Saxenda and Wegovy.<\/span><\/p>\n<h2 id=\"benefits-of-glp-1-drugs-for-weight-loss\"><span style=\"font-weight: 400;\">Benefits of GLP-1 drugs for weight loss<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Generally, people taking a GLP-1 can expect to lose <\/span><a href=\"https:\/\/www.niddk.nih.gov\/health-information\/professionals\/diabetes-discoveries-practice\/new-in-medications-for-weight-management\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">3 to 5% of body weight<\/span><\/a><span style=\"font-weight: 400;\"> at the dosage for diabetes. This means someone who weighs 200 pounds may lose about 6 to 10 pounds. However, higher doses may lead to more weight loss.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although any GLP-1 drug can promote weight loss, let\u2019s look at some clinical studies and their findings.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/diabetes.medicinematters.com\/tirzepatide\/type-2-diabetes\/a-quick-guide-to-the-surpass-and-surmount-trials\/18478154\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">SURPASS-1 clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> studied Mounjaro in people with diabetes and found that the medication reduced hemoglobin A1C (a measure of long-term blood sugar control) and resulted in significant weight loss of about 14 to 19 pounds. Additional SURPASS trials confirmed that Mounjaro reduced A1C levels and promoted considerable weight loss.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In the <\/span><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2206038\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">SURMOUNT-1 clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> for Mounjaro, people who had obesity or were overweight but did not have diabetes took either Mounjaro or a placebo (inactive medication). Participants\u2019 mean weight loss percentage after 72 weeks was 15% with 5 mg weekly doses, 20% with 10 mg weekly doses, and 21% with 15 mg doses, compared to 3% in participants who received a placebo. Eighty-five percent of participants lost 5% or more of their body weight, compared to 35% who took a placebo. Additional SURMOUNT trials are still in progress.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The SUSTAIN trials studied semaglutide, the ingredient in injectable Ozempic and oral Rybelsus. It\u2019s also the ingredient in Wegovy, which is approved for weight loss but not diabetes. The first <\/span><a href=\"https:\/\/diabetes.medicinematters.com\/semaglutide\/type-2-diabetes\/sustain-1-high-degree-of-glycemic-control-with-semaglutide-in-ty\/12004944\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">SUSTAIN trial<\/span><\/a><span style=\"font-weight: 400;\"> found that semaglutide, injected once weekly, significantly decreased A1C. People who took semaglutide lost about eight to 10 pounds over 30 weeks, compared to about 2 pounds in those who took a placebo. <\/span><a href=\"https:\/\/diabetes.medicinematters.com\/semaglutide\/type-2-diabetes\/a-quick-guide-to-the-sustain-trials\/12206922\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Additional SUSTAIN trials<\/span><\/a><span style=\"font-weight: 400;\"> confirmed that semaglutide significantly reduces A1C and weight (some participants lost up to about 13 pounds, or 15 pounds with a higher dose) and lowers cardiovascular risk.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our weight management newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Weight Management Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"side-effects-of-diabetes-medications-for-weight-loss\"><span style=\"font-weight: 400;\">Side effects of diabetes medications for weight loss<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">With any drug comes a risk of side effects. The most common side effects of Ozempic and other <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/glp-1-agonists\"><span style=\"font-weight: 400;\">GLP-1 agonist<\/span><\/a><span style=\"font-weight: 400;\"> medications are <\/span><a href=\"https:\/\/www.uptodate.com\/contents\/glucagon-like-peptide-1-based-therapies-for-the-treatment-of-type-2-diabetes-mellitus\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">gastrointestinal side effects<\/span><\/a><span style=\"font-weight: 400;\">, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation or diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indigestion\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reflux<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Burping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These side effects can range from mild to severe and may gradually disappear as your body adjusts to the medication. If these side effects are troublesome and persist, consult your healthcare provider.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other common side effects may include injection site reactions and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/diabetic-retinopathy\/\"><span style=\"font-weight: 400;\">diabetic retinopathy<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The risk of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/low-blood-sugar-symptoms\"><span style=\"font-weight: 400;\">hypoglycemia<\/span><\/a><span style=\"font-weight: 400;\"> (low blood sugar) is low unless a GLP-1 agonist is combined with insulin or certain oral diabetes drugs such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/glipizide\/what-is\"><span style=\"font-weight: 400;\">glipizide<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/glimepiride\"><span style=\"font-weight: 400;\">glimepiride<\/span><\/a><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/glyburide\/what-is\"><span style=\"font-weight: 400;\">glyburide<\/span><\/a><span style=\"font-weight: 400;\">. In this case, close monitoring of blood glucose levels is required, and a dosage adjustment of insulin or the oral diabetes drug may be necessary.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">All GLP-1 agonists (this includes tirzepatide, or the brand name Mounjaro) have a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black box warning<\/span><\/a><span style=\"font-weight: 400;\">, the most serious warning required by the FDA. The warning states that GLP-1 agonist medications have caused thyroid cancer in animal studies. It is not known if this applies to humans. People with a personal or family history of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/thyroid-nodules\/\"><span style=\"font-weight: 400;\">medullary thyroid carcinoma<\/span><\/a><span style=\"font-weight: 400;\"> (MTC) or who have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not take a GLP-1 agonist. All individuals who take a GLP-1 agonist should be alert to symptoms of a thyroid tumor, including hoarseness, a lump in the neck, and difficulty swallowing or breathing.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other serious side effects may include pancreas, gallbladder, and kidney problems, including kidney failure. In rare cases, severe allergic reactions may occur. Patients who experience symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, should seek emergency medical help.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is not a complete list of side effects, and others may occur. Consult your healthcare provider for more information and questions about side effects.\u00a0<\/span><\/p>\n<h2 id=\"who-should-take-diabetes-weight-loss-drugs\"><span style=\"font-weight: 400;\">Who should take diabetes weight loss drugs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you want to take a diabetes medication, such as Ozempic, for weight loss, visit your healthcare provider. Together, you can determine if you are an appropriate candidate for this medication. Candidates may include people with a body mass index (BMI) of 30 kg\/m<\/span><span style=\"font-weight: 400;\">2<\/span><span style=\"font-weight: 400;\"> or higher, or people with a BMI of 27 kg\/m<\/span><span style=\"font-weight: 400;\">2 <\/span><span style=\"font-weight: 400;\">or higher, with a weight-related medical condition like high cholesterol or blood pressure.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition to people with diabetes or who need to lose weight, these medications should also be considered in individuals who do not have heart disease but are at high risk for heart disease, such as those with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/blood-pressure-levels\/\"><span style=\"font-weight: 400;\">high blood pressure<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/obesity-statistics\/\"><span style=\"font-weight: 400;\">obesity<\/span><\/a><span style=\"font-weight: 400;\">. A new study published in February 2023 found that most Americans with Type 2 diabetes are candidates for newer medications such as GLP-1s (or a medication from another drug class called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/sglt2-inhibitors\"><span style=\"font-weight: 400;\">SGLT2 inhibitors<\/span><\/a><span style=\"font-weight: 400;\">), but few are taking them. Although 82% of adults in the U.S. with Type 2 diabetes qualified for a GLP-1 or SGLT2 medication, only about 10% of those took one of the drugs.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/diabetes.org\/newsroom\/press-releases\/american-diabetes-association-announces-transition-chief-scientific-and\"><span style=\"font-weight: 400;\">Dr. Robert Gabbay<\/span><\/a><span style=\"font-weight: 400;\">, former chief medical officer and chief scientific officer of the <\/span><a href=\"https:\/\/diabetes.org\/\"><span style=\"font-weight: 400;\">American Diabetes Association<\/span><\/a><span style=\"font-weight: 400;\"> (ADA), notes that certain diabetes drugs, including GLP-1s, can significantly lower the risk of heart and kidney disease.<\/span><\/p>\n<h2 id=\"who-should-not-take-diabetes-weight-loss-drugs\"><span style=\"font-weight: 400;\">Who should NOT take diabetes weight loss drugs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Certain individuals should not take medications like Ozempic, Wegovy, or Mounjaro for weight loss (or diabetes). People who should not use these medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Individuals who are allergic to the specific medication or any drug in the GLP-1 agonist class<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Individuals with a history or family history of medullary thyroid carcinoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Individuals with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Individuals with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/type-1-vs-type-2-diabetes\/\"><span style=\"font-weight: 400;\">Type 1 diabetes<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In some cases, a GLP-1 agonist may or may not be appropriate and, if prescribed, must be used with caution. This includes people with kidney problems, pancreas problems, diabetic retinopathy, and women of childbearing age.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Healthcare professionals will review medical conditions, medical and family history, health concerns, and other factors to consider appropriate candidates for diabetes medication for weight loss.\u00a0<\/span><\/p>\n<h2 id=\"does-insurance-cover-weight-loss-drugs\"><span style=\"font-weight: 400;\">Does insurance cover weight loss drugs?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Private insurance companies, Medicaid, or Medicare prescription plans may or may not cover these medications. Prior authorization may sometimes be required before a coverage determination is made.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You can contact your insurance provider for the most up-to-date coverage information on these drugs.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If your insurance does not cover your weight loss medication, you can always use a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">free SingleCare card or coupon<\/span><\/a><span style=\"font-weight: 400;\"> to save up to 80% off the cost of your medicine. What\u2019s more, SingleCare discounts are reusable, so you can use them on your refills to save considerably throughout the year.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/es\/recursos\/mejor-medicamento-para-la-diabetes-que-hace-bajar-de-peso\"><span style=\"font-weight: 400;\">Lea este art\u00edculo en espa\u00f1ol aqu\u00ed.<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Weight loss is no easy feat\u2014sometimes, a reduced-calorie diet and exercise are not enough to lead to significant change. And you may not want to take the leap to bariatric surgery. Enter a new(-ish) class of drugs originally developed for diabetes with the side effect of weight loss. This drug class is known as glucagon-like [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":58034,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[10298,21067,9825],"coauthors":[10668],"class_list":["post-58033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-diabetes","tag-glp-1-drugs","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Best diabetes drug for weight loss: Benefits and side effects<\/title>\n<meta name=\"description\" content=\"Diabetes drugs for weight loss include Ozempic, Mounjaro, Rybelsus, and Trulicity. 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