{"id":58219,"date":"2023-05-04T09:21:02","date_gmt":"2023-05-04T13:21:02","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=58219"},"modified":"2026-01-22T19:22:51","modified_gmt":"2026-01-23T00:22:51","slug":"contrave-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/contrave-side-effects\/","title":{"rendered":"Contrave side effects explained: What to expect and how to avoid them"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/contrave\"><span style=\"font-weight: 400;\">Contrave<\/span><\/a><span style=\"font-weight: 400;\"> (naltrexone\/bupropion) extended-release tablet is a brand-name medication used for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/contrave-weight-loss\/\"><span style=\"font-weight: 400;\">weight management<\/span><\/a><span style=\"font-weight: 400;\"> along with a reduced-calorie diet and increased physical activity. Contrave reduces food intake by targeting two regions of the brain: the mesolimbic reward system and the hypothalamus. In these areas, Contrave regulates feelings of pleasure when eating to help control cravings and curb hunger. Although it\u2019s effective, it has a higher risk of side effects than <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-weight-loss-pills\/\"><span style=\"font-weight: 400;\">other weight loss medications<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Contrave with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tContrave 8 mg (90 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$613.45<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/contrave#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/contrave#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$613.45<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/contrave#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/contrave#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/contrave#blog-cta\" class=\"coupon-see-all-btn\">See Contrave prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2 id=\"common-side-effects-of-contrave\"><span style=\"font-weight: 400;\">Common side effects of Contrave<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common side effects of Contrave are nausea, headache, and constipation. According to <\/span><a href=\"https:\/\/www.curraxpharma.com\/PI\/contrave-label-current.pdf\/\"><span style=\"font-weight: 400;\">clinical trial data<\/span><\/a><span style=\"font-weight: 400;\">, 24% of patients receiving Contrave discontinued treatment because of an adverse event, as they could not tolerate the weight loss medicine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other side effects of Contrave include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increase in blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increase in heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hot flush<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tremor<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach virus<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Influenza<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ringing in the ears<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Altered taste<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle strain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart palpitations<\/span><\/li>\n<\/ul>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/contrave-vs-phentermine\/\"><b>Contrave vs. phentermine<\/b><\/a><\/p>\n<h2 id=\"serious-side-effects-of-contrave\"><span style=\"font-weight: 400;\">Serious side effects of Contrave<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Contrave has several serious side effects, including a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">boxed warning<\/span><\/a><span style=\"font-weight: 400;\"> for suicidal thoughts and behaviors. Serious side effects of Contrave include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Neuropsychiatric disorders<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Homicidal ideation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suicidality<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression exacerbation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypersensitivity reaction<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stevens-Johnson syndrome (a serious disorder of the skin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erythema multiforme (skin reaction)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anaphylaxis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver toxicity<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe high blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Angle-closure glaucoma<\/span><\/li>\n<\/ul>\n<h3 id=\"nausea\"><span style=\"font-weight: 400;\">Nausea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nausea is the most common side effect of Contrave and happens to about one-third of people taking it. Clinical trial data show the most frequent side effect leading to discontinuation is nausea. Along with nausea, other gastrointestinal (GI) side effects are common with Contrave, such as vomiting. Generally, nausea and other GI side effects are temporary and resolve quickly. Drinking plenty of water and eating a small amount of food with Contrave (such as dry toast) can help manage GI side effects. If symptoms do not improve, it is best to consult with the healthcare team and decide if an over-the-counter (OTC) anti-nausea medication is appropriate.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/nausea-relief-medication-and-home-remedies\/\"><b>28 nausea medications and remedies<\/b><\/a><\/p>\n<h3 id=\"constipation\"><span style=\"font-weight: 400;\">Constipation<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Constipation is the second most common side effect of Contrave and happens to about 19% of people taking it. Like the other GI side effects common with Contrave, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-constipation-last\/\"><span style=\"font-weight: 400;\">constipation is generally temporary<\/span><\/a><span style=\"font-weight: 400;\"> and resolves quickly. While taking Contrave, it is best to stay hydrated and drink plenty of water to help &#8220;get things moving&#8221; again, as water is important for digestion. If symptoms do not improve, it is best to consult your healthcare provider and decide whether an OTC constipation medicine is necessary. However, worsening constipation with severe abdominal pain could indicate a more serious health condition requiring immediate medical attention.<\/span><\/p>\n<p><b>RELATED:<\/b><a href=\"https:\/\/www.singlecare.com\/blog\/home-remedies-for-constipation\/\"><b> 24 home remedies for constipation<\/b><\/a><\/p>\n<h3 id=\"headache\"><span style=\"font-weight: 400;\">Headache<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Aside from GI side effects, a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/types-of-headaches\/\"><span style=\"font-weight: 400;\">headache<\/span><\/a><span style=\"font-weight: 400;\"> is the next most common side effect of Contrave and happens in about 18% of people. This side effect is typically short-term. While taking Contrave, it is best to stay hydrated and drink plenty of water, which can help manage this side effect. If headache symptoms do not improve or become more severe, seek medical attention, as this could be a sign of a more serious problem, such as a hypertensive event (dangerously high blood pressure).<\/span><\/p>\n<h3 id=\"insomnia\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some people taking Contrave may have trouble falling asleep, staying asleep, or getting good quality sleep. Insomnia is another common side effect of Contrave and happens in about 9% of people. Taking Contrave around bedtime may increase the risk of this side effect. Some tips for avoiding or managing insomnia include taking the evening Contrave dose before dinner and practicing good sleep hygiene. If symptoms do not improve, it is best to consult with the healthcare team and decide whether an OTC or prescription sleep aid is appropriate.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-sleep-better\/\"><b>21 ways to sleep better tonight<\/b><\/a><\/p>\n<h2 id=\"contrave-side-effects-first-week-what-to-expect\"><span style=\"font-weight: 400;\">Contrave side effects first week: What to expect<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">People who start taking Contrave are more likely to experience side effects at the start of treatment. Side effects may be more noticeable <\/span><a href=\"https:\/\/contrave.com\/what-to-expect\/\"><span style=\"font-weight: 400;\">during the first four weeks<\/span><\/a><span style=\"font-weight: 400;\">, since Contrave is started at a low dose and gradually increased to the standard dose over the course of one month. Gradually increasing the dose can help prevent or lessen the severity of side effects. The most common side effects of Contrave during the start of treatment are nausea, vomiting, and constipation.<\/span><\/p>\n<h2 id=\"how-long-do-contrave-side-effects-last\"><span style=\"font-weight: 400;\">How long do Contrave side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Generally, most side effects of Contrave are temporary and resolve quickly as the body adjusts to the new medication, like nausea and other GI side effects. However, if a side effect continues to be bothersome or becomes more severe, it\u2019s best to consult with a healthcare provider for medical advice.<\/span><\/p>\n<h2 id=\"what-are-the-long-term-side-effects-of-contrave\"><span style=\"font-weight: 400;\">What are the long-term side effects of Contrave?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Once Contrave is stopped, related side effects should resolve. However, some possible disease-related concerns could persist, such as liver problems, kidney problems, or narrow-angle glaucoma.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/resources\/weight-loss\"><b>Weight Loss Coupons &amp; Resources<\/b><\/a><\/p>\n<h2 id=\"contrave-contraindications\"><span style=\"font-weight: 400;\">Contrave contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Certain people should not take Contrave as it could cause serious harm. The groups of people who have contraindications to Contrave include those who:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have uncontrolled hypertension (high blood pressure)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have seizure disorder or a history of seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use other bupropion-containing products, including Aplenzin, Forfivo XL, Wellbutrin SR, and Wellbutrin XL<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have bulimia or anorexia nervosa, which increases the risk of seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use opioids or are experiencing acute opioid withdrawal<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are taking monoamine oxidase inhibitors (MAOI); at least 14 days should elapse between discontinuation of MAOI and initiation of treatment with Contrave<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have an allergy to or a history of allergic reactions to bupropion or naltrexone<\/span><\/li>\n<\/ul>\n<h3 id=\"pregnancy-and-nursing\"><span style=\"font-weight: 400;\">Pregnancy and nursing<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Medications for weight loss therapy are not recommended during pregnancy or for women who are <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/alcohol-medications-when-breastfeeding\/\"><span style=\"font-weight: 400;\">breastfeeding<\/span><\/a><span style=\"font-weight: 400;\">. Due to the potential for fetal harm associated with weight loss during pregnancy, you should not take Contrave when pregnant.<\/span><\/p>\n<h3 id=\"children\"><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Contrave is not recommended for use in children. The Food and Drug Administration (FDA) has not approved the use of Contrave for anyone under 18.\u00a0<\/span><\/p>\n<h2 id=\"contrave-warnings\"><span style=\"font-weight: 400;\">Contrave warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Contrave has a boxed warning, the most severe type of warning mandated by the FDA, for suicidal thoughts and behavior. This risk should be considered and discussed with the provider before starting therapy with Contrave. The <\/span><a href=\"https:\/\/988lifeline.org\/\"><span style=\"font-weight: 400;\">Suicide and Crisis Lifeline<\/span><\/a><span style=\"font-weight: 400;\"> provides support 24\/7 via 9-8-8, a toll-free hotline.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some health conditions may get worse or cause serious side effects in people taking Contrave, so treatment will require more careful monitoring in older adults and people with any of the following conditions:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney or liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bipolar disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes mellitus<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardiovascular disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Narrow-angle glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Psychiatric disorders<\/span><\/li>\n<\/ul>\n<h3 id=\"overdose\"><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking too much Contrave can lead to an overdose and result in serious problems, including seizures, convulsions, coma, respiratory failure, and death. Immediate emergency medical care is required if an overdose is suspected. Other symptoms of a Contrave overdose include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Racing heart<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of consciousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperactive reflexes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stiff or rigid muscles<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The maximum dosage of Contrave is four tablets a day. Each tablet contains 8 mg of naltrexone hydrochloride and 90 mg of bupropion hydrochloride.<\/span><\/p>\n<h2 id=\"contrave-interactions\"><span style=\"font-weight: 400;\">Contrave interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Taking Contrave with certain drugs may cause a dangerous drug interaction. Contrave should not be taken with or used with caution in the following:<\/span><\/p>\n<ul>\n<li><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><b>Monoamine oxidase inhibitors (MAOIs)<\/b><\/a><span style=\"font-weight: 400;\">: Examples include isocarboxazid, phenelzine, transdermal selegiline, and tranylcypromine, as they can increase the risk for hypertensive reactions.<\/span><\/li>\n<li><b>Drugs that are metabolized by the CYP2D6 isozyme<\/b><span style=\"font-weight: 400;\">: Examples include certain antidepressants (SSRIs and many tricyclics), antipsychotics (such as haloperidol, risperidone, and thioridazine), beta blockers (such as metoprolol), and Type 1C antiarrhythmics (such as propafenone and flecainide).<\/span><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><b>Opioid analgesics<\/b><\/a><span style=\"font-weight: 400;\">: People taking Contrave may not fully benefit from treatment with opioid-containing medicines.<\/span><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/drug-classes\/dopamine-agonists\"><b>Dopaminergic drugs<\/b><\/a><span style=\"font-weight: 400;\">: Medications such as levodopa and amantadine can increase the chance of CNS toxicity.<\/span><\/li>\n<li><b>Alcohol and caffeine: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/contrave-and-alcohol\/\"><span style=\"font-weight: 400;\">Alcohol<\/span><\/a><span style=\"font-weight: 400;\"> and caffeine may increase the adverse effects, including a greater chance of seizures, and alcohol tolerance may decrease during treatment.<\/span><\/li>\n<li><b>Drugs that lower the seizure threshold<\/b><span style=\"font-weight: 400;\">: Examples include antipsychotics, antidepressants, theophylline, or systemic corticosteroids.<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-avoid-contrave-side-effects\"><span style=\"font-weight: 400;\">How to avoid Contrave side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While some Contrave side effects are common, there are tips for avoiding and minimizing side effects:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take Contrave as directed:<\/b> <span style=\"font-weight: 400;\">Contrave dosing should be increased slowly over the course of one month according to a specific schedule. Take tablets whole and do not cut, chew, or crush them. A helpful dosing tip is to take the morning dose with breakfast and the evening dose before dinner.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tell your healthcare provider about all your medical conditions and medications you\u2019re taking:<\/b> <span style=\"font-weight: 400;\">You can prevent unnecessary side effects of Contrave by letting your healthcare provider know about all of your medical conditions and any medications you\u2019re taking. This includes prescription drugs, OTC drugs, and dietary supplements. Doing so can prevent dangerous drug interactions that may increase adverse events.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drink plenty of water:<\/b> <span style=\"font-weight: 400;\">Staying hydrated can help with common side effects like nausea, headache, and constipation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Do not take Contrave with high-fat meals: <\/b><span style=\"font-weight: 400;\">Taking Contrave with high-fat meals may increase the risk of seizures. Other <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/food-to-avoid-contrave\/\"><span style=\"font-weight: 400;\">foods to avoid on Contrave<\/span><\/a><span style=\"font-weight: 400;\"> include processed foods, caffeine, and foods high in refined sugar.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Monitor body weight loss: <\/b>Contrave can usually be discontinued once you\u2019ve achieved a weight loss of &lt;4% to 5% of baseline after three months. Once you stop taking Contrave, you should continue a healthy diet and regular physical activity to manage your weight.<\/li>\n<\/ol>\n<h2 id=\"how-to-treat-the-side-effects-of-contrave\"><span style=\"font-weight: 400;\">How to treat the side effects of Contrave<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most of the side effects of Contrave are temporary and resolve quickly as the body adjusts to the new medication. However, there are some tips to help treat side effects and lessen their severity if they are bothersome. If a side effect continues and becomes more severe, it\u2019s best to consult with your healthcare provider.<\/span><\/p>\n<h3 id=\"nausea-treatment\"><span style=\"font-weight: 400;\">Nausea treatment<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To help with nausea, it\u2019s important to drink plenty of water and eat a small amount of food with Contrave (such as dry toast). If symptoms do not improve, it is best to consult with a healthcare provider and decide whether an OTC anti-nausea medication (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dramamine\"><span style=\"font-weight: 400;\">Dramamine<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pepto-bismol\"><span style=\"font-weight: 400;\">Pepto Bismol<\/span><\/a><span style=\"font-weight: 400;\">) is appropriate.<\/span><\/p>\n<h3 id=\"constipation-treatment\"><span style=\"font-weight: 400;\">Constipation treatment<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">As another common GI side effect, drinking plenty of water and staying hydrated can help treat constipation associated with Contrave, as water is vital for digestion. If symptoms do not improve, it is best to consult a provider and decide whether an OTC constipation medicine (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/senna\"><span style=\"font-weight: 400;\">Senna<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dulcolax-stool-softener\"><span style=\"font-weight: 400;\">Dulcolax<\/span><\/a><span style=\"font-weight: 400;\">) is necessary.<\/span><\/p>\n<h3 id=\"headache-treatment\"><span style=\"font-weight: 400;\">Headache treatment<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some headaches can be successfully treated with OTC pain reliever medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tylenol\"><span style=\"font-weight: 400;\">Tylenol<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/acetaminophen\"><span style=\"font-weight: 400;\">(acetaminophen)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/advil\"><span style=\"font-weight: 400;\">Advil<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/motrin-ib\"><span style=\"font-weight: 400;\">Motrin<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">(ibuprofen)<\/span><\/a><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/aleve\"><span style=\"font-weight: 400;\">Aleve<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/naproxen\"><span style=\"font-weight: 400;\">(naproxen)<\/span><\/a><span style=\"font-weight: 400;\">. Similar to the treatment of some GI side effects, staying hydrated and drinking plenty of water can also help treat headaches. Some other useful techniques include resting in a darkened room or placing a cold pack on the forehead.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/types-of-headaches\/\"><b>8 types of headaches and how to treat them<\/b><\/a><\/p>\n<h3 id=\"insomnia-treatment\"><span style=\"font-weight: 400;\">Insomnia treatment<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Trouble sleeping, like difficulty falling asleep and staying asleep or getting good quality sleep, can be a bothersome side effect of Contrave. Taking the evening dose of Contrave before dinner and practicing good sleep hygiene can help treat insomnia. If symptoms do not improve, it is best to consult a healthcare provider and decide whether an OTC sleep aid (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/melatonin\"><span style=\"font-weight: 400;\">melatonin<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/unisom-sleeptabs\"><span style=\"font-weight: 400;\">Unisom<\/span><\/a><span style=\"font-weight: 400;\">) or a prescription sleep aid is appropriate.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/sleep-diet\/\"><b>The best diet for sleep<\/b><\/a><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Contrave is generally safe when used as directed, but side effects can occur. If they become bothersome, talk to your healthcare provider. They may recommend a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/contrave-alternatives\/\"><span style=\"font-weight: 400;\">Contrave alternative<\/span><\/a><span style=\"font-weight: 400;\"> that may be more effective, and using your <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">free SingleCare prescription discount card<\/span><\/a><span style=\"font-weight: 400;\"> can help you save.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/contrave-savings\/\"><b>How to save on Contrave<\/b><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Contrave (naltrexone\/bupropion) extended-release tablet is a brand-name medication used for weight management along with a reduced-calorie diet and increased physical activity. Contrave reduces food intake by targeting two regions of the brain: the mesolimbic reward system and the hypothalamus. In these areas, Contrave regulates feelings of pleasure when eating to help control cravings and curb [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":58220,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,9825],"coauthors":[20740],"class_list":["post-58219","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Contrave side effects: What to expect and how to reduce them<\/title>\n<meta name=\"description\" content=\"Nausea, constipation, and headache are common Contrave side effects. 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