{"id":58301,"date":"2023-05-08T12:19:47","date_gmt":"2023-05-08T16:19:47","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=58301"},"modified":"2025-09-18T13:20:23","modified_gmt":"2025-09-18T17:20:23","slug":"tramadol-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tramadol-alternatives\/","title":{"rendered":"Tramadol alternatives: What can I take instead of tramadol?"},"content":{"rendered":"

Tramadol<\/span><\/a> is a commonly prescribed <\/span>opioid pain medication<\/span><\/a>. It is approved by the Food and Drug Administration (FDA) in adults to treat pain that is severe enough to require an opioid medication. It\u2019s typically used when non-opioid medicines are not expected to work (or do not work), or cannot be tolerated. Because of its risk for misuse and abuse, <\/span>tramadol<\/span><\/a> is classified as a Schedule IV <\/span>controlled substance<\/span><\/a> by the DEA. However, tramadol is not the best drug for everyone. Some people may be interested in exploring alternative drugs\u2014perhaps due to side effects or concerns around Tramadol\u2019s status as a controlled substance. The good news is that there are various alternatives that you can discuss with your healthcare provider.<\/span><\/p>\n

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Save up to 80% on Tramadol with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

\n\t\t\t\t
\n\t\t\t\t\tTramadol 50 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23663 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\"Food\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$8.99\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$11.40\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Tramadol prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n

What can I take in place of tramadol?<\/span><\/h2>\n

In addition to typical side effects seen with opioids, such as sedation and respiratory depression (breathing problems), possible side effects of tramadol also include seizures and low blood sugar, among others. Also, as a controlled substance, tramadol poses risks of abuse, diversion, dependence, and withdrawal. For these reasons, alternative painkillers may be more appropriate in certain cases.\u00a0<\/span><\/p>\n

Other options are available to manage pain that either does not improve with tramadol, if side effects like drowsiness and constipation become intolerable, or if drug interactions pose problems. Alternative prescription medications include other opioid analgesics, <\/span>NSAIDs<\/span><\/a>, acetaminophen, and antidepressant serotonin-norepinephrine reuptake inhibitors (<\/span>SNRIs<\/span><\/a>). These options may be more suitable for certain individuals.<\/span>
\n<\/span><\/p>\n

Top 5 tramadol alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to tramadol.<\/span><\/p>\n

1. Belbuca (buprenorphine)<\/span><\/h3>\n

Belbuca<\/span><\/a> is a buccal film that dissolves inside the cheek and contains the active ingredient buprenorphine. It is used to treat pain that is severe and persistent, requiring daily treatment with opioid medicine, and is used when other medicines cannot be used or tolerated. Because Belbuca dissolves in the cheek, it may be an appropriate alternative for people who have trouble swallowing pills. However, it is used every day and is not meant to be taken as needed. The most common side effects of Belbuca include nausea, vomiting, constipation, headache, dizziness, and sleepiness. Belbuca is a Schedule III controlled substance, which means it may have a higher potential for abuse and misuse than tramadol.<\/span><\/p>\n

2. Cymbalta (duloxetine)<\/span><\/h3>\n

Cymbalta<\/span><\/a> is classified as an SNRI. Although it is an antidepressant, it is commonly prescribed for certain pain conditions, such as <\/span>fibromyalgia<\/span><\/a>, chronic musculoskeletal pain, and diabetic peripheral neuropathic pain. Cymbalta is not an opioid medicine, and is not a controlled substance. As with all antidepressants, Cymbalta has a <\/span>black box warning<\/span><\/a> for increased suicidal thoughts and behavior. When initiating Cymbalta, close monitoring for the emergence of such thoughts and behaviors is important. Common side effects of Cymbalta include nausea, constipation, dry mouth, decreased appetite, sleepiness, and excess sweating.<\/span><\/p>\n

3. Aleve (naproxen)<\/span><\/h3>\n

Naproxen<\/span><\/a> is a type of<\/span> NSAID<\/span><\/a> and may be a good alternative to opioid pain medications like tramadol in certain situations. Naproxen is available over the counter in a lower dose and by prescription at higher doses. Since it\u2019s a nonopioid drug, it doesn\u2019t have the common side effects specific to opioids, like constipation and drowsiness.\u00a0<\/span><\/p>\n

NSAIDs like Aleve do come with their own set of potential side effects, though. NSAID use is associated with an<\/span> increased risk of cardiovascular events<\/span><\/a>, including the development of<\/span> high blood pressure<\/span><\/a>. Risk factors for the development of cardiovascular events include age 65 or older,<\/span> higher doses<\/span><\/a>, longer duration and frequency of use, and pre-existing cardiovascular disease or the presence of other risk factors for cardiovascular disease. NSAIDs can also increase bleeding event risk, so while not an opioid, they remain a medication with some risk associated with their use.<\/span><\/p>\n

4. Celebrex (celecoxib)<\/span><\/h3>\n

NSAID use can result in<\/span> gastrointestinal (GI) ulceration and bleeding<\/span><\/a>. Celebrex, though, has been found to be associated with as much as a<\/span> 20% lower risk of bleeding compared to other NSAIDs<\/span><\/a>, and it may be safer than other NSAIDs in patients requiring long-term use (greater than six months). Celebrex is FDA approved for osteoarthritis, rheumatoid arthritis, acute pain, painful menstrual periods, and ankylosing spondylitis. Common side effects include stomach pain, indigestion, gas, diarrhea, and dizziness.<\/span><\/p>\n

5. Voltaren gel (diclofenac 1%)<\/span><\/h3>\n

A<\/span> topical pain reliever<\/span><\/a> alternative to tramadol is <\/span>Voltaren gel<\/span><\/a>. Voltaren is an NSAID, like naproxen or celecoxib, and it is now available over the counter. The topical application allows for the avoidance of some of the safety concerns observed with oral NSAIDs, but it does carry the same NSAID warnings as the oral agents regarding increased risk of gastrointestinal and cardiovascular adverse events, so it should always be used at the lowest dose for the shortest duration of time possible. The gel may work as well as oral NSAIDs for arthritis pain and acute musculoskeletal pain (like sprains and strains). However, it comes with a higher risk of<\/span> localized adverse events<\/span><\/a>, such as rash, compared to oral NSAIDs.<\/span><\/p>\n

NSAID prices and pain management resources<\/b><\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare tramadol alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Tramadol\u00a0<\/b><\/td>\n\n
    \n
  • Pain that is severe enough to require an opioid pain medicine, when other medicines cannot be used<\/span><\/li>\n<\/ul>\n<\/td>\n
Tramadol coupons<\/span><\/a><\/td>\n<\/tr>\n
Belbuca<\/b> (buprenorphine)<\/b><\/td>\n\n
    \n
  • Pain that is severe and persistent that requires extended treatment with a daily opioid pain medicine, when other medicines cannot be used<\/span><\/li>\n<\/ul>\n<\/td>\n
Belbuca coupons<\/span><\/a><\/td>\n<\/tr>\n
Cymbalta<\/b> (duloxetine)<\/b><\/td>\n\n
    \n
  • Fibromyalgia<\/span><\/li>\n
  • Generalized anxiety disorder<\/span><\/li>\n
  • Major depressive disorder<\/span><\/li>\n
  • Chronic musculoskeletal pain<\/span><\/li>\n
  • Neuropathic pain associated with diabetes mellitus<\/span><\/li>\n<\/ul>\n<\/td>\n
Cymbalta coupons<\/span><\/a><\/td>\n<\/tr>\n
Aleve (naproxen)<\/b><\/td>\n\n
    \n
  • Anti-inflammatory<\/span><\/li>\n
  • Dysmenorrhea (painful menstrual periods)<\/span><\/li>\n
  • Fever<\/span><\/li>\n
  • Gout pain<\/span><\/li>\n<\/ul>\n<\/td>\n
Aleve coupons<\/span><\/a><\/td>\n<\/tr>\n
Celebrex (celecoxib)<\/b><\/td>\n\n
    \n
  • Osteoarthritis<\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n
  • Pain and inflammation<\/span><\/li>\n
  • Dysmenorrhea\u00a0<\/span><\/li>\n
  • Ankylosing spondylitis<\/span><\/li>\n<\/ul>\n<\/td>\n
Celebrex coupons<\/span><\/a><\/td>\n<\/tr>\n
Voltaren gel (diclofenac 1% gel)<\/b><\/td>\n\n
    \n
  • Osteoarthritis<\/span><\/li>\n
  • Pain<\/span><\/li>\n<\/ul>\n<\/td>\n
Voltaren coupons<\/span><\/a><\/td>\n<\/tr>\n
Hydrocodone\/ acetaminophen (APAP)<\/b><\/td>\n\n
    \n
  • Pain management<\/span><\/li>\n<\/ul>\n<\/td>\n
Hydrocodone\/APAP coupons<\/span><\/a><\/td>\n<\/tr>\n
MS Contin<\/b> (extended-release morphine)<\/b><\/td>\n\n
    \n
  • Chronic pain (including chronic cancer pain) in opioid-tolerant individuals<\/span><\/li>\n<\/ul>\n<\/td>\n
MS Contin coupons<\/span><\/a><\/td>\n<\/tr>\n
Dilaudid<\/b> \u00a0(hydromorphone)<\/b><\/td>\n\n
    \n
  • Pain that is severe enough to require an opioid pain medicine, when other medicines cannot be used<\/span><\/li>\n<\/ul>\n<\/td>\n
Dilaudid coupons<\/span><\/a><\/td>\n<\/tr>\n
Roxicodone<\/b> (oxycodone)<\/b><\/td>\n\n
    \n
  • Pain that is severe enough to require an opioid pain medicine, when other medicines cannot be used<\/span><\/li>\n<\/ul>\n<\/td>\n
Roxicodone coupons<\/span><\/a><\/td>\n<\/tr>\n
Percocet<\/b> \u00a0(oxycodone\/acetaminophen)<\/b><\/td>\n\n
    \n
  • Pain that is severe enough to require an opioid pain medicine, when other medicines cannot be used<\/span><\/li>\n<\/ul>\n<\/td>\n
Percocet coupons<\/span><\/a><\/td>\n<\/tr>\n
OxyContin<\/b> \u00a0(extended-release oxycodone)<\/b><\/td>\n\n
    \n
  • Persistent and severe pain that requires extended treatment with a daily opioid pain medicine, when other medicines cannot be used<\/span><\/li>\n<\/ul>\n<\/td>\n
Oxycontin coupons<\/span><\/a><\/td>\n<\/tr>\n
Motrin, Advil (ibuprofen)<\/b><\/td>\n\n
    \n
  • Anti-inflammatory<\/span><\/li>\n
  • Dysmenorrhea<\/span><\/li>\n
  • Fever<\/span><\/li>\n
  • Migraine<\/span><\/li>\n
  • Pain<\/span><\/li>\n<\/ul>\n<\/td>\n
Ibuprofen coupons<\/span><\/a><\/td>\n<\/tr>\n
Tylenol (acetaminophen)<\/b><\/td>\n\n
    \n
  • Pain<\/span><\/li>\n
  • Fever<\/span><\/li>\n<\/ul>\n<\/td>\n
Tylenol coupons<\/span><\/a><\/td>\n<\/tr>\n
Meloxicam<\/b><\/td>\n\n
    \n
  • Osteoarthritis<\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Meloxicam coupons<\/span><\/a><\/td>\n<\/tr>\n
Indocin (indomethacin)<\/b><\/td>\n\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Osteoarthritis<\/span><\/li>\n
  • Rheumatoid arthritis\u00a0<\/span><\/li>\n
  • Bursitis\/tendinitis<\/span><\/li>\n
  • Gout<\/span><\/li>\n<\/ul>\n<\/td>\n
Indocin coupons<\/span><\/a><\/td>\n<\/tr>\n
Lidoderm (lidocaine patch)<\/b><\/td>\n\n
    \n
  • Pain (localized)<\/span><\/li>\n
  • Postherpetic neuralgia<\/span><\/li>\n<\/ul>\n<\/td>\n
Lidoderm coupons<\/span><\/a><\/td>\n<\/tr>\n
Feldene (piroxicam)<\/b><\/td>\n\n
    \n
  • Osteoarthritis<\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Feldene coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Natural alternatives to tramadol<\/span><\/h2>\n

The management of pain should be approached from all angles, and non-pharmacologic and more natural approaches may provide some real relief. Depending on the source of the pain,<\/span> physical therapy<\/span><\/a> may be one way to help manage it, especially for chronic pain after injuries or surgeries. By employing therapeutic exercise, physical therapy aims to achieve optimal neuromuscular and skeletal function. Other holistic approaches, such as<\/span> acupuncture<\/span><\/a> or the use of<\/span> aromatherapy<\/span><\/a> with different essential oils like peppermint oil or lavender oil, may also provide some pain relief and are generally safe, natural options to try. Turmeric is a spice with an active component known to have anti-inflammatory properties, and turmeric supplements may provide natural pain relief. Other natural products, such as <\/span>magnesium supplements<\/span><\/a> or <\/span>topical capsaicin<\/span><\/a>, may also reduce inflammation over time. Talk to your healthcare provider before trying any natural remedies.\u00a0<\/span><\/p>\n

RELATED: <\/b>13 home remedies for pain relief<\/b><\/a><\/p>\n

How to switch to a tramadol alternative<\/span><\/h2>\n

If you find it necessary to switch to a tramadol alternative, whether because of side effects or because treatment isn\u2019t working, it\u2019s important to taper your dosage under the direct supervision of a healthcare provider. This will help you avoid unwanted side effects and minimize withdrawal symptoms\u2014particularly if you\u2019ve been taking opioids long-term. Chronic opioid use can cause increased pain sensitivity, which is another reason why tapering doses slowly under the guidance of your healthcare provider is so important.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Tramadol is a commonly prescribed opioid pain medication. It is approved by the Food and Drug Administration (FDA) in adults to treat pain that is severe enough to require an opioid medication. It\u2019s typically used when non-opioid medicines are not expected to work (or do not work), or cannot be tolerated. Because of its risk […]<\/p>\n","protected":false},"author":133,"featured_media":58303,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[3344,808,4350],"coauthors":[10869],"class_list":["post-58301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-opioids","tag-pain-management","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nTop tramadol alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Tramadol doesn't work for everyone. 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