{"id":58371,"date":"2023-05-09T13:06:23","date_gmt":"2023-05-09T17:06:23","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=58371"},"modified":"2025-10-06T13:46:14","modified_gmt":"2025-10-06T17:46:14","slug":"benzonatate-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/benzonatate-alternatives\/","title":{"rendered":"Benzonatate (Tessalon Perles) alternatives: What can I take instead of benzonatate?"},"content":{"rendered":"

A cough can definitely be a nuisance at school or work and be disruptive overnight, but since the COVID-19 pandemic, a cough can earn some sideways looks in public, too. More than ever, it would be nice if a medication could quiet or resolve a cough. <\/span>Benzonatate<\/span><\/a> has been an option for many years. Better known by its brand name, Tessalon Pearles, benzonatate stands apart from liquid cough suppressants by being a capsule, a feature that has won it fans. However, the drug has some serious potential for harm, particularly if it falls into the wrong hands. It is best to know about this potential and understand what alternatives exist for benzonatate<\/span>.<\/span><\/p>\n\t\t

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Save up to 80% on Benzonatate with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t Benzonatate 100 mg (30 Capsules)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23663 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t
\n\t\t\t\"Food\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$10.17\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$10.24\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Benzonatate prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

What can I take instead of benzonatate?<\/span><\/h2>\n

Benzonatate is thought to reduce cough by anesthetizing stretch receptors in the chest wall and pleura (lung lining). Adults must always be cautious about swallowing the capsules whole. Chewing the capsule could lead to numbness of the throat, which can put one at risk of aspiration. Children could be at risk of this adverse effect, but they are also at higher risk of other adverse effects of benzonatate, like confusion, hallucinations, and dizziness.\u00a0<\/span><\/p>\n

Fatal cases of overdose leading to convulsions and cardiac arrest from accidental ingestion in children have been reported. Signs of overdose can occur within 15 minutes and with as little as one or two capsules in very young children. Accordingly, the Food and Drug Administration (FDA) has only approved benzonatate for those over 10 years of age and <\/span>explicitly warns<\/span><\/a> about the need to store this drug in a child-resistant container out of reach of children.<\/span><\/p>\n

If these concerns have created hesitations about benzonatate, other mechanisms and options for cough suppression exist. Dextromethorphan is an N-methyl-D-aspartate (NMDA) receptor antagonist that can reduce the sensitivity of cough receptors. <\/span>Opioids<\/span><\/a>, like <\/span>morphine<\/span><\/a> and <\/span>codeine<\/span><\/a>, may reduce coughing by inhibiting the cough center in the brain.\u00a0<\/span><\/p>\n

An unexpected option is the gamma-aminobutyric acid (GABA) analogs gabapentin and pregabalin, both of which have limited evidence of effectiveness for cough, possibly due to an effect on the central nervous system. Nebulizing an anesthetic drug, such as lidocaine or tetracaine, can provide an inhaled option for cough suppression. More commonly, the expectorant guaifenesin is used for colds to loosen up a cough. Attempts at treating cough with <\/span>antihistamines<\/span><\/a> like diphenhydramine or decongestants like pseudoephedrine are seen in the setting of allergies or colds. While they may be effective against the underlying cause, they are not <\/span>antitussives<\/span><\/a> or cough suppressants. The following table provides antitussive alternatives to benzonatate.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Tessalon Perles (benzonatate) alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Benzonatate<\/span><\/a><\/td>\n$65 per 30, 100 mg capsules<\/span><\/td>\n$10 per 30, 100 mg capsules of generic benzonatate<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Delsym Cough and Sore throat (acetaminophen-dextromethorphan)\u00a0<\/span><\/td>\n$20 per 1, 180 mL bottle of 650 mg-20 mg\/20 mL solution<\/span><\/td>\n$13 per 1, 180 mL bottle of 650 mg-20 mg\/20 mL solution of brand-name Delsym Cough and Sore throat<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Mucinex DM (guaifenesin-dextromethorphan)<\/span><\/td>\n$24 per 1, 20-tablet box of 12-hour extended-release tablets<\/span><\/td>\n$12 per 1, 20-tablet box of 12-hour extended-release tablets of branded generic Mucus Relief DM<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
G Tussin AC (<\/span>guaifenesin-codeine<\/span><\/a>)<\/span><\/td>\n$19 per 1, 118 mL bottle of 100 mg-10 mg\/5 mL solution<\/span><\/td>\n$12 per 1, 118 mL bottle of 100 mg-10 mg\/5 mL solution of generic guaifenesin-codeine<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Promethazine-codeine<\/span><\/td>\n$23 per 1, 120 mL bottle of 6.25 mg-10 mg\/5 mL solution<\/span><\/td>\n$15 per 1, 120 mL bottle of 6.25 mg\/10 mg\/5 mL solution of generic promethazine-codeine<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Promethazine-dextromethorphan<\/span><\/a><\/td>\n$43 per 1 bottle of 6.25 mg-15 mg\/5 mL syrup<\/span><\/td>\n$5 per 1 bottle of of 6.25 mg-15 mg\/5 mL syrup of generic promethazine-dextromethorphan<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Hycodan (hydrocodone-homatropine<\/a>)<\/span><\/td>\n$42 per 1 bottle of 5 mg-1.5 mg\/5 mL liquid<\/span><\/td>\n$40 per 30, 5 mg-1.5 mg tablets of generic hydrocodone-homatropine<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Neurontin<\/span><\/a> (<\/span>gabapentin<\/span><\/a>)<\/span><\/td>\n$790 per 90, 300 mg capsules<\/span><\/td>\n$9 per 90, 300 mg capsules of generic gabapentin<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 benzonatate alternatives<\/span><\/h2>\n

The following are some of the most common prescription alternatives to benzonatate.<\/span><\/p>\n

1. Guaifenesin-codeine<\/span><\/h3>\n

Suppressing a cough is not easy, and treatment attempts often fail. Sometimes, stopping the cough is not advisable, so consult a healthcare provider about using cough suppressants. A prescription is needed for some of these drugs, including benzonatate and opiates. Codeine, like other opiates, is on the <\/span>controlled substance list<\/span><\/a> of the Drug Enforcement Administration (DEA) based on its habit-forming potential. Be aware of other common side effects of codeine, such as drowsiness and constipation. According to a review in the journal Chest, <\/span>evidence<\/span><\/a> supporting codeine\u2019s effectiveness for cough is limited, but it has been used traditionally, often in combination with guaifenesin (<\/span>guaifenesin-codeine<\/span><\/a>). Adding guaifenesin may help to thin mucus, while codeine suppresses the cough.<\/span><\/p>\n

2. Promethazine-codeine<\/span><\/h3>\n

Codeine provides the cough-suppressing action of promethazine-codeine. Promethazine adds an antihistamine effect to the mix, which could provide relief from a runny nose and nasal congestion. The problem is that both drugs cause drowsiness, and warnings about promethazine note the risk of dangerous respiratory depression. Use in children, seniors, and those with underlying health problems is usually avoided.<\/span><\/p>\n

3. Promethazine-dextromethorphan<\/span><\/h3>\n

Providing another prescription treatment option for cough, promethazine-dextromethorphan leverages promethazine\u2019s antihistamine action for cold symptoms to go along with a proven cough suppressant, dextromethorphan. Dextromethorphan is available in numerous over-the-counter products, but this combination provides a way to obtain the anti-tussive with a prescription. Of course, the same warnings about promethazine apply, thus limiting its use.<\/span><\/p>\n

4. Hycodan<\/span><\/h3>\n

Hycodan<\/span><\/a> is another opiate combination drug with a history of use for coughing. That use is dwindling. Hycodan combines hydrocodone, an opiate with the typical narcotic adverse effects, and homatropine, an anticholinergic with all the side effect concerns surrounding that drug class. Put them together, and Hycodan\u2019s possible side effects include sedation, constipation, dizziness, urinary retention, and dry mouth.<\/span><\/p>\n

5. Neurontin<\/span><\/h3>\n

As a medication typically used for seizures or neuropathic pain, <\/span>Neurontin<\/span><\/a> (gabapentin) is undoubtedly an unexpected member of this list. Its presence is based on <\/span>guidelines<\/span><\/a> for the treatment of chronic cough. Those guidelines mention gabapentin because <\/span>clinical trials<\/span><\/a> have found it helpful. This recommendation is only for chronic, unexplained coughs and not for the typical cough related to colds.<\/span><\/p>\n

Over-the-counter cough medications<\/span><\/h2>\n

Delsym<\/span><\/a> is one of the brand-name versions of dextromethorphan, and unlike benzonatate, it is available over the counter (OTC). Like many <\/span>OTC cough<\/span><\/a> and cold remedies, it is available in numerous variations, each with different ingredients for the worst common cold symptoms. The cough suppressant in Delsym products is dextromethorphan, a drug with modest support from clinical trials. While modest, the experimental proof is more robust than with benzonatate, and unlike benzonatate, dextromethorphan has dosing guidelines for children when needed.\u00a0<\/span><\/p>\n

Dextromethorphan has its own obstacles, including drug interactions that can lead to <\/span>serotonin syndrome<\/span><\/a>. Caution with or avoidance of concurrent serotonergic medications is advisable, including certain antidepressants, nausea drugs, and migraine relievers. Be advised that dextromethorphan can also be <\/span>habit-forming and has abuse potential<\/span><\/a>.<\/span><\/p>\n

If the drug interaction potential of dextromethorphan and the adverse effect potential of benzonatate have you looking for other options, Mucinex<\/a> may meet your needs. Mucinex is one of the brand-name forms of guaifenesin, a safe OTC drug that is thought to thin bronchial mucus, making it easier to cough out or expectorate. As such, guaifenesin is a cough medicine but not a cough suppressant. Under the Mucinex brand umbrella, though, is an assortment of products. Each combines a different set of cough and cold symptom relievers. For example, <\/span>Mucinex DM<\/span><\/a> includes the cough suppressant dextromethorphan with the expectorant guaifenesin.<\/span><\/p>\n

Natural alternatives to benzonatate<\/span><\/h2>\n

By now, there may be an interest in steering clear of benzonatate and a few other antitussives. If that\u2019s the case, but a troublesome <\/span>cough is still keeping you up<\/span><\/a>, <\/span>natural remedies<\/span><\/a> could be an option. Throat lozenges or topical ointments with <\/span>menthol or aromatic essential oils<\/span><\/a> could help. Honey is another reasonable choice for a natural solution. A systematic <\/span>review<\/span><\/a> found evidence that honey is probably as effective as dextromethorphan in children. Adding honey to tea may create a soothing solution for a cough.<\/span><\/p>\n

How to switch to a benzonatate alternative<\/span><\/h2>\n

Perhaps one of the above ideas is appealing as an alternative to benzonatate. However, before settling on any option, seek medical advice from a healthcare provider. Make sure to know what is causing the cough and whether suppressing the cough is advisable. If so, talk with the professional about the pros and cons of the different antitussives, particularly how each might affect any underlying health conditions or interact with prescription drugs, OTC medications, and supplements. Finally, discuss the cost differences with a local pharmacist and show them a <\/span>SingleCare discount card<\/span><\/a> for help getting the lowest price. Putting a healthcare team into action will help lead to feeling better as quickly as possible.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A cough can definitely be a nuisance at school or work and be disruptive overnight, but since the COVID-19 pandemic, a cough can earn some sideways looks in public, too. More than ever, it would be nice if a medication could quiet or resolve a cough. Benzonatate has been an option for many years. Better […]<\/p>\n","protected":false},"author":133,"featured_media":58372,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[11169],"coauthors":[20732],"class_list":["post-58371","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-cold-flu","wpautop"],"acf":[],"yoast_head":"\nTop Tessalon Perles (benzonatate) alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Delsym, Mucinex, codeine, Hycodan, and Neurontin are some benzonatate alternatives. 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