{"id":58387,"date":"2023-05-10T09:30:14","date_gmt":"2023-05-10T13:30:14","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=58387"},"modified":"2026-04-09T18:14:40","modified_gmt":"2026-04-09T22:14:40","slug":"signs-your-antidepressant-dose-is-too-high","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/signs-your-antidepressant-dose-is-too-high\/","title":{"rendered":"5 signs your antidepressant dose is too high"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Antidepressants are medications commonly used to <\/span><span style=\"font-weight: 400;\">relieve symptoms of depression<\/span><span style=\"font-weight: 400;\"> or anxiety. They are only available with a prescription, so a patient\u2019s healthcare provider decides the dosage. Still, sometimes finding the right dose takes time. Everyone\u2019s body chemistry is unique, and many <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> can take weeks or months to reach full effectiveness.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fortunately, there are several indications to help you and your healthcare provider know if your antidepressant dose needs to be changed. Keeping a record of side effects to share with your healthcare provider can help them pinpoint the best dose. Here are some signs your antidepressant dose is too high.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/best-antidepressant\/\"><b>What\u2019s the best antidepressant for me?<\/b><\/a><\/p>\n<h2 id=\"5-signs-your-antidepressant-dose-is-too-high\"><span style=\"font-weight: 400;\">5 signs your antidepressant dose is too high<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Experiencing some symptoms while your body adjusts to a new medication is common, but there are a few red flags that could indicate your dose is too high.\u00a0<\/span><\/p>\n<h3 id=\"1-serotonin-syndrome\"><span style=\"font-weight: 400;\">1. Serotonin syndrome<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cAntidepressants work by helping increase neurotransmitters or chemicals in the brains, such as serotonin,\u201d says <a href=\"https:\/\/www.kavitadesai.ca\/about\">Kavita Desai<\/a>, Pharm.D., founder of wellness company <\/span><span style=\"font-weight: 400;\">Revivele<\/span><span style=\"font-weight: 400;\">. But if an antidepressant dose is too high, serotonin levels can get too high, too, causing serotonin to build up in the body. This is known as serotonin syndrome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Symptoms of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482377\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\"> range from very mild to life-threatening and typically arise within 24 hours of taking the antidepressant in question.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Desai says less severe symptoms include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mild tremors\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restlessness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Severe, potentially <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/serotonin-syndrome\/symptoms-causes\/syc-20354758\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">life-threatening symptoms<\/span><\/a><span style=\"font-weight: 400;\"> of serotonin syndrome include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle rigidity<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Losing consciousness\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are several different types of antidepressants that have the potential to cause serotonin syndrome. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Selective serotonin reuptake inhibitors (SSRIs)<\/b><span style=\"font-weight: 400;\">, including Prozac (fluoxetine), Paxil (paroxetine), Lexapro (escitalopram), Celexa (citalopram), Viibryd (vilazodone<\/span><span style=\"font-weight: 400;\"> HCl)<\/span><span style=\"font-weight: 400;\">, and Zoloft (sertraline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/snris\"><b>Serotonin-norepinephrine reuptake inhibitors<\/b><\/a><b> (SNRIs)<\/b><span style=\"font-weight: 400;\">, including Cymbalta (duloxetine), Fetzima (levomilnacipran), Savella (milnacipran), Pristiq (<a href=\"https:\/\/www.singlecare.com\/prescription\/desvenlafaxine-er\/what-is\">desvenlafaxine<\/a>), and Effexor XR (venlafaxine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><b>Tricyclic antidepressants<\/b><\/a><b> (TCAs)<\/b><span style=\"font-weight: 400;\">, including Elavil (amitriptyline) and Pamelor (nortriptyline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bupropion<\/b><span style=\"font-weight: 400;\">, which is sold under the brand names Wellbutrin SR, Wellbutrin XL, and Zyban<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lithium<\/b><span style=\"font-weight: 400;\">, sold as Lithobid, a mood-stabilizing drug<\/span><\/li>\n<\/ul>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/resources\/antidepressants\">Save on common antidepressants<\/a><\/p>\n<h3 id=\"2-emotional-blunting\"><span style=\"font-weight: 400;\">2. Emotional blunting<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Emotional blunting is when you experience a lack of all emotions, from happiness to sadness.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIndividuals describe feeling like \u2018zombies\u2019 or not being able to share their feelings or experiences with others,\u201d explains <\/span><a href=\"https:\/\/www.linkedin.com\/in\/kristen-roye-psyd-8487b6a\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Kristen Roye<\/span><\/a><span style=\"font-weight: 400;\">, Psy.D., a psychologist and vice president of clinical operations at <\/span><a href=\"https:\/\/www.destinationsforteens.com\/about-destinations-for-teens\/destinations-staff\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Destinations for Teens<\/span><\/a><span style=\"font-weight: 400;\">. She adds that some people experience emotional blunting as <\/span><a href=\"https:\/\/www.merckmanuals.com\/home\/mental-health-disorders\/dissociative-disorders\/depersonalization-derealization-disorder\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">depersonalization<\/span><\/a><span style=\"font-weight: 400;\">, a sense of being an external observer of reality.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Thus, symptoms of emotional blunting include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inability to feel happy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inability to feel sad<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Feeling detached from those around you<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Social withdrawal<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lack of motivation at work or school<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lack of sexual interest<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty concentrating<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Emotional blunting can indicate that your antidepressant is not working properly, but it can also be a sign of worsening depression, according to Dr. Desai. It is important to tell your healthcare provider about feeling numb or detached so that the cause can be pinpointed and addressed.<\/span><\/p>\n<h3 id=\"3-an-increase-in-suicidal-thoughts\"><span style=\"font-weight: 400;\">3. An increase in suicidal thoughts<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">New or increasing suicidal thoughts or behaviors can indicate that your antidepressant dose is too high. It could also be a sign that your antidepressant is not working properly since these drugs are intended to relieve such symptoms of depression.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In 2004, the <\/span><a href=\"https:\/\/journalofethics.ama-assn.org\/article\/antidepressants-and-fdas-black-box-warning-determining-rational-public-policy-absence-sufficient\/2012-06\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">U.S. Food and Drug Administration<\/span><\/a><span style=\"font-weight: 400;\"> (FDA) began requiring a \u201c<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black box warning<\/span><\/a><span style=\"font-weight: 400;\">\u201d on antidepressants. The warning indicates that the antidepressant can increase the risk of suicidal behaviors and ideations in adolescents.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33351435\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Suicidal ideation<\/span><\/a><span style=\"font-weight: 400;\"> is not always accompanied by action. The term can include any sort of preoccupation, desire, or plan focused on death or suicide. Do not hesitate to contact your healthcare provider about suicidal ideations just because it is a known side effect. This is a life-threatening symptom that should be addressed through a change in dose or medication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you or someone you are with has suicidal thoughts, with or without taking antidepressants, you should take them seriously. Help is available 24\/7 in the United States thanks to a national suicide prevention network of crisis centers. Contact the Suicide &amp; Crisis Lifeline by phone at 988. Support is free and confidential.<\/span><\/p>\n<h3 id=\"4-sleep-problems\"><span style=\"font-weight: 400;\">4. Sleep problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Trouble sleeping is a common sign that an antidepressant dose is too high, according to Desai.<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5548844\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research<\/span><\/a><span style=\"font-weight: 400;\"> suggests that some antidepressants have a negative effect on sleep and that sometimes adjusting the dosage or drug type mitigates the problem. Disrupted sleep can occur in the form of insomnia, restless leg syndrome, sleep apnea, and even nightmares.\u00a0<\/span><\/p>\n<h3 id=\"5-feeling-physically-off\"><span style=\"font-weight: 400;\">5. Feeling physically \u201coff\u201d<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both Dr. Desai and Roye said taking too much of an antidepressant can cause physical side effects too.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cSome physical signs that you may have the incorrect dose include [but are not limited to] weight gain, memory loss, and sexual dysfunction,\u201d says Roye.<\/span><\/p>\n<p><a href=\"https:\/\/www.health.harvard.edu\/womens-health\/when-an-ssri-medication-impacts-your-sex-life\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sexual dysfunction<\/span><\/a><span style=\"font-weight: 400;\"> could mean low libido, difficulty staying aroused, or difficulty reaching orgasm. Gastrointestinal discomfort in the form of nausea or low appetite can indicate that the antidepressant dose is too high, adds Dr. Desai.\u00a0<\/span><\/p>\n<h2 id=\"what-to-do-if-your-antidepressant-dose-is-too-high\"><span style=\"font-weight: 400;\">What to do if your antidepressant dose is too high<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you notice signs that your antidepressant might be too high, the first step is to contact a healthcare professional.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThere is a dance to be done, and the right balance must be found between relief of symptoms and avoidance of adverse reactions,\u201d Roye says. \u201cIf you experience any adverse reactions, it is essential to discuss these concerns with your doctor or mental health provider immediately.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are several reasons to work with a healthcare provider to determine the correct prescription medication dose. Changing the dose on your own can have dangerous, even life-threatening, consequences. Higher doses can raise the risk of serious side effects, for instance. A low dose might not be enough to treat major depressive disorder.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are not experiencing severe side effects, it is also important to give a new antidepressant time to work, according to Dr. Desai. \u201cIt is generally recommended to wait four to six weeks after starting an antidepressant or changing doses to really know if it will work,\u201d she says. \u201c&#8230; [But] if you are having severe side effects, especially suicidal thoughts, even before four weeks have passed, then I would recommend calling your doctor immediately.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The bottom line: If you think your antidepressant dose needs to be adjusted, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ask-a-doctor-about-antidepressants\/\"><span style=\"font-weight: 400;\">talk to your healthcare provider<\/span><\/a><span style=\"font-weight: 400;\">. Changing your dose without the guidance of a healthcare provider can result in serious side effects.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antidepressants are medications commonly used to relieve symptoms of depression or anxiety. They are only available with a prescription, so a patient\u2019s healthcare provider decides the dosage. Still, sometimes finding the right dose takes time. Everyone\u2019s body chemistry is unique, and many antidepressants can take weeks or months to reach full effectiveness.\u00a0 Fortunately, there are [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":58145,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[451,788,450],"coauthors":[20942],"class_list":["post-58387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-depression","tag-drug-safety","tag-mental-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>5 signs your antidepressant dose is too high<\/title>\n<meta name=\"description\" content=\"Signs that your antidepressant medication is too high include serotonin syndrome, emotional blunting, increased suicidal thoughts, and sleep problems. 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