{"id":58522,"date":"2023-05-23T13:00:15","date_gmt":"2023-05-23T17:00:15","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=58522"},"modified":"2025-10-22T16:21:29","modified_gmt":"2025-10-22T20:21:29","slug":"wellbutrin-and-caffeine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/wellbutrin-and-caffeine\/","title":{"rendered":"Is it safe to mix Wellbutrin and caffeine?"},"content":{"rendered":"

Wellbutrin (<\/span>bupropion<\/span><\/a>) is a prescription antidepressant medication. Though most commonly prescribed to treat depression, it is sometimes prescribed <\/span>off-label<\/span><\/a> for attention-deficit\/hyperactivity disorder (ADHD) or (the 12-hour extended-release form) smoking cessation.\u00a0<\/span><\/p>\n

If you or someone you know is taking Wellbutrin, the underlying condition\u2014depression or ADHD \u2014might already cause sleep problems. On top of that, <\/span>research from Neuropsychopharmacology<\/i><\/span>\u00a0also shows that Wellbutrin has stimulant properties (though it does not contain actual caffeine), which could cause or exacerbate sleep disturbances.\u00a0<\/span><\/p>\n

When you wake up to take your daily dose of Wellbutrin and need an extra jolt of energy after a poor night\u2019s sleep, you might wonder: Does caffeine affect Wellbutrin? Is it safe to mix Wellbutrin and caffeine?<\/span><\/p>\n

Can you drink coffee with Wellbutrin?<\/span><\/h2>\n

It is best to avoid mixing Wellbutrin and caffeine, says <\/span>Sid Khurana<\/span><\/a>, MD, a board-certified psychiatrist and medical director of outpatient services at Nevada Mental Health in Las Vegas.<\/span><\/p>\n

Here\u2019s why:<\/span><\/p>\n

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  1. It could lead to toxicity. <\/b>High doses of caffeine can increase the level of Wellbutrin in the body, raising the risk of toxicity and seizures, according to Dr. Khurana. It can also cause <\/span>irritability, tremor, and increased blood pressure<\/span><\/a>.<\/span><\/li>\n
  2. It could worsen symptoms of anxiety and depression. <\/b>Both caffeine and <\/span>Wellbutrin<\/span><\/a> have stimulant effects, so combining them could worsen symptoms of anxiety and depression, such as over-alertness, jitteriness, or trouble sleeping.\u00a0<\/span><\/li>\n
  3. It could cause sleep difficulties. <\/b>\u201c[Wellbutrin] also has a side effect of insomnia,\u201d Dr. Khurana says. If depression or ADHD has already made sleep difficult, adding Wellbutrin and caffeine could further damage your ability to rest.<\/span><\/li>\n<\/ol>\n

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