{"id":58934,"date":"2023-06-16T10:24:03","date_gmt":"2023-06-16T14:24:03","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=58934"},"modified":"2025-09-12T14:33:39","modified_gmt":"2025-09-12T18:33:39","slug":"cyclobenzaprine-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/cyclobenzaprine-alternatives\/","title":{"rendered":"Top cyclobenzaprine (Fexmid ) alternatives and how to switch your Rx"},"content":{"rendered":"

Did you wake up with a stiff neck or <\/span>neck pain<\/span>? Is your lower back spasming for some reason and causing <\/span>acute low back pain<\/span>? The muscle spasm pain can be searing and intense; it may have you guardedly moving for fear of triggering a jolt. <\/span>Cyclobenzaprine<\/span>, an <\/span>FDA<\/span>-approved prescription medication, has long been a go-to <\/span>muscle relaxant<\/span> for <\/span>short-term<\/span> use for <\/span>muscle spasms<\/span> and <\/span>pain relief<\/span>. Known also by its <\/span>brand name<\/span> Fexmid and former <\/span>brand-name<\/span> Flexeril<\/span><\/a>, <\/span>cyclobenzaprine<\/span> plays a frequent role in acute <\/span>musculoskeletal pain control<\/span><\/a> via either of these regular-release forms or via its <\/span>extended-release<\/span> form, <\/span>Amrix<\/span>. <\/span>Cyclobenzaprine<\/span> shares structural similarities with <\/span>tricyclic antidepressants<\/span>, including <\/span>amitriptyline<\/span><\/a> and <\/span>nortriptyline<\/span><\/a>. However, all forms of the drug have flaws, and you may be interested in an alternative to avoid one of its <\/span>common side effects<\/span>. Despite its notoriety, it is not necessarily effective for everyone. There are many alternatives to get better relief from <\/span>muscle pain<\/span>.<\/span><\/p>\n

RELATED: <\/b>Cyclobenzaprine<\/b> coupons<\/b><\/a> |\u00a0<\/b>What is <\/b>cyclobenzaprine<\/b><\/a><\/p>\n

What can I take in place of <\/span>cyclobenzaprine<\/span>?<\/span><\/h2>\n

Skeletal <\/span>muscle relaxants<\/span><\/a> are a unique and interesting <\/span>drug class<\/span>. There are no conclusive comparison studies to determine which <\/span>muscle relaxant<\/span> is more effective. Costs vary, but a <\/span>SingleCare discount card<\/span><\/a> can help if this is a concern when comparing options. Each member of this drug family has its idiosyncrasies when it comes to <\/span>side effects<\/span>. This means you may be able to choose a <\/span>different <\/span>muscle relaxant<\/span><\/a> even if Fexmid fails you. If not, you could step outside the med class and look at <\/span>nonsteroidal anti-inflammatory medications<\/span><\/a> (<\/span>NSAIDs<\/span>), <\/span>benzodiazepines<\/span><\/a>, or <\/span>analgesics<\/span><\/a>, such as <\/span>acetaminophen<\/span>. You will need more information to take to your <\/span>healthcare provider<\/span> for <\/span>medical advice<\/span>.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare Fexmid (cyclobenzaprine) alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Fexmid (<\/span>cyclobenzaprine<\/span>)<\/span><\/td>\nMuscle spasm<\/span><\/td>\n5 to 10 mg three times daily<\/span><\/td>\nFexmid coupons<\/span><\/a><\/td>\n<\/tr>\n
Amrix<\/span> (<\/span>cyclobenzaprine<\/span> ER)<\/span><\/td>\nMuscle spasm<\/span><\/td>\n15 to 30 mg once daily<\/span><\/td>\nAmrix<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Methocarbamol<\/span><\/td>\nMuscle spasm<\/span>, tetanus<\/span><\/td>\n1000 mg four times daily<\/span><\/td>\nMethocarbamol<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Zanaflex<\/span> (<\/span>tizanidine<\/span>)<\/span><\/td>\nSpasticity<\/span><\/td>\n2 mg every 8 hours<\/span><\/td>\nZanaflex<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Metaxalone<\/span><\/td>\nAcute musculoskeletal pain<\/span><\/td>\n640 mg three times daily<\/span><\/td>\nMetaxalone<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Soma<\/span> (<\/span>carisoprodol<\/span>)<\/span><\/td>\nAcute musculoskeletal pain<\/span><\/td>\n250 mg three times daily and at bedtime<\/span><\/td>\nSoma<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Baclofen<\/span><\/td>\nSpasticity<\/span><\/td>\n5 to 20 mg three times daily<\/span><\/td>\nBaclofen<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Valium<\/span> (<\/span>diazepam<\/span>)<\/span><\/td>\nMuscle spasm<\/span>, seizures, anxiety, acute alcohol withdrawal<\/span><\/td>\n2 to 10 mg three times daily<\/span><\/td>\nValium<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Chlorzoxazone<\/span><\/td>\nMusculoskeletal pain and spasm<\/span><\/td>\n250 to 500 mg three times daily<\/span><\/td>\nChlorzoxazone<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Orphenadrine<\/span><\/td>\nMusculoskeletal pain<\/span><\/td>\n100 mg twice daily<\/span><\/td>\nOrphenadrine<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Dantrium (<\/span>dantrolene<\/span>)<\/span><\/td>\nMusculoskeletal pain<\/span><\/td>\n100 mg three times daily<\/span><\/td>\nDantrium coupons<\/span><\/a><\/td>\n<\/tr>\n
Naprosyn (<\/span>naproxen<\/span>)<\/span><\/td>\nOsteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gout, mild to moderate pain<\/span><\/td>\n250 to 500 mg twice daily<\/span><\/td>\nNaprosyn coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 <\/span>cyclobenzaprine<\/span> alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>cyclobenzaprine<\/span>.<\/span><\/p>\n

1. <\/span>Methocarbamol<\/span><\/h3>\n

Brand-name<\/span> oral <\/span>Robaxin<\/span> is not available anymore in the United States, but its generic version, <\/span>methocarbamol<\/span><\/a>, is still available and in use. Like <\/span>cyclobenzaprine<\/span>, <\/span>methocarbamol<\/span> is considered an <\/span>antispasmodic <\/span>skeletal muscle relaxant<\/span><\/a>. They exert their effect by acting on the <\/span>central nervous system<\/span> (CNS)<\/span><\/a>, namely the brain. Both <\/span>methocarbamol<\/span> and <\/span>cyclobenzaprine<\/span> have <\/span>serious <\/span>adverse effects<\/span> to be wary of. They can cause <\/span>drowsiness<\/span>, unsteadiness, and blurred vision, which all contribute to a heightened risk of falls and other injuries. Due to those <\/span>adverse effects<\/span>, they are included in the <\/span>Beers list of medications<\/span><\/a> to generally be avoided in most <\/span>older adults<\/span> over 65 years. However, <\/span>methocarbamol<\/span> does avoid the anticholinergic effects that <\/span>cyclobenzaprine<\/span> can produce, such as <\/span>dry mouth<\/span>, <\/span>constipation<\/span>, and a prolonged QT interval on ECG assessment of heart rhythm.<\/span><\/p>\n

2. <\/span>Zanaflex<\/span><\/h3>\n

Zanaflex<\/span><\/a> and its generic formulation, <\/span>tizanidine<\/span>, can also lead to prolongation of the QT interval, so it will not help if avoiding this potential <\/span>side effect<\/span> is important. However, <\/span>Zanaflex<\/span> is classified as an antispasticity <\/span>muscle relaxant<\/span>, making it a potential choice for those needing relief from muscle <\/span>spasticity<\/span>. Besides its <\/span>adverse effects<\/span> that include <\/span>sedation<\/span>, dizziness, and <\/span>dry mouth<\/span>, the drug also carries the risk of a withdrawal syndrome when it is stopped. The withdrawal symptoms can include elevated <\/span>blood pressure<\/span>, fast heart rate, and hypertonia (elevated muscle tone).\u00a0<\/span><\/p>\n

3. <\/span>Metaxalone<\/span><\/h3>\n

Metaxalone<\/span><\/a> was formerly known by its <\/span>brand-name<\/span> Skelaxin<\/span>. It has some similarities to <\/span>methocarbamol<\/span> and <\/span>cyclobenzaprine<\/span>, in that it is an antispasmodic that likely helps with skeletal <\/span>muscle pain<\/span> by being a CNS depressant that slows brain function. Like <\/span>Zanaflex<\/span>, you have to be careful about a host of potential <\/span>drug interactions<\/span> and <\/span>side effects<\/span> with <\/span>metaxalone<\/span>. Be sure to review your list of prescription medications, <\/span>over-the-counter<\/span> drugs, and <\/span>supplements<\/span> with a <\/span>healthcare provider<\/span> before deciding to start <\/span>metaxalone<\/span> or any of the <\/span>muscle relaxants<\/span>.<\/span><\/p>\n

4. <\/span>Baclofen<\/span><\/h3>\n

Known by its <\/span>brand-name<\/span> Lioresal<\/span>, the antispasticity drug <\/span>baclofen<\/span><\/a> acts on the CNS in a manner similar to gamma amino-butyric acid (GABA). Its use tends to be more for <\/span>spasticity<\/span> in the setting of CNS lesions such as multiple <\/span>sclerosis<\/span> (MS), <\/span>cerebral palsy<\/span>, and <\/span>spinal cord injuries<\/span>. Although CNS depression can occur, it may be less than with other <\/span>muscle relaxants<\/span>. Like all medications, <\/span>side effects<\/span> can occur with the use of <\/span>Baclofen<\/span>. However, a withdrawal syndrome, including hallucinations and seizures, can occur with abrupt discontinuation of <\/span>baclofen<\/span>. You should have the <\/span>medical advice<\/span> of the prescribing healthcare professional before starting or stopping one of these drugs.<\/span><\/p>\n

5. Naprosyn<\/span><\/h3>\n

You might be surprised to see <\/span>Naprosyn<\/span><\/a> on this list, being that it is a non-steroidal anti-inflammatory drug (<\/span>NSAID<\/span>) commonly used for <\/span>musculoskeletal conditions<\/span> and not a <\/span>muscle relaxant<\/span>. The reason is that <\/span>NSAIDs<\/span> have more evidence to back their effectiveness, particularly for back pain, no pun intended. In fact, one emergency room <\/span>study<\/span><\/a> found that adding <\/span>metaxalone<\/span>, <\/span>Zanaflex<\/span>, or <\/span>baclofen<\/span> to the <\/span>NSAID<\/span> ibuprofen<\/span> did not provide better relief of acute <\/span>lower back pain<\/span> than the <\/span>NSAID<\/span> alone at one week after the presentation. <\/span>NSAIDs<\/span> have their own list of <\/span>adverse effects<\/span> for sure, but they do avoid the <\/span>side effects<\/span> of <\/span>drowsiness<\/span> and instability that can arise from <\/span>cyclobenzaprine<\/span> and its fellow <\/span>muscle relaxants<\/span>.\u00a0<\/span><\/p>\n

Neither <\/span>cyclobenzaprine<\/span> nor <\/span>NSAIDs<\/span> are on the Drug Enforcement Agency\u2019s (DEA) controlled substance list. <\/span>Soma<\/span>, opiates, <\/span>tramadol<\/span>, and <\/span>Valium<\/span> are some of the controlled substances with significant abuse potential that are used for musculoskeletal pain. Just because <\/span>cyclobenzaprine<\/span> is not risky enough to be on the DEA list does not mean that it has no abuse potential.<\/span><\/p>\n

Natural alternatives to <\/span>cyclobenzaprine<\/span><\/h2>\n

The cautionary notes on <\/span>cyclobenzaprine<\/span> have probably left you wanting to turn over every stone in looking into alternatives. Natural remedies are popular, particularly for nocturnal leg cramps, a type of <\/span>muscle spasm<\/span> we have all likely experienced. Everyone seems to have their opinion on what works, but studies have not proven many to be effective. <\/span>B-complex vitamins<\/span><\/a> and vitamin E might be helpful. If you are deficient in magnesium, then a magnesium <\/span>supplement<\/span> may help with leg cramps, but otherwise, it will likely be ineffective, according to a <\/span>published review<\/span><\/a>. There seems to be no perfect pill for <\/span>muscle spasms<\/span>. Non-pharmacological options like stretching and <\/span>physical therapy<\/span> may be something to consider for <\/span>muscle pains<\/span>.<\/span><\/p>\n

How to switch to a <\/span>cyclobenzaprine<\/span> alternative<\/span><\/h2>\n

Whether you are interested in an alternative because <\/span>cyclobenzaprine<\/span> has been ineffective or has been causing <\/span>adverse effects<\/span>, you now know what else is out there. Taking that information with you, you should have an appointment with your medical provider to discuss it. You certainly do not want to make any changes on your own. As a team, you both can settle on a decision after considering all the options.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Did you wake up with a stiff neck or neck pain? Is your lower back spasming for some reason and causing acute low back pain? The muscle spasm pain can be searing and intense; it may have you guardedly moving for fear of triggering a jolt. Cyclobenzaprine, an FDA-approved prescription medication, has long been a […]<\/p>\n","protected":false},"author":133,"featured_media":58935,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[808,4350],"coauthors":[20732],"class_list":["post-58934","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-pain-management","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nTop Fexmid (cyclobenzaprine) alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Methocarbamol, Zanaflex, metaxalone, baclofen, and Naprosyn are some cyclobenzaprine alternatives. 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