{"id":59908,"date":"2023-08-14T11:58:31","date_gmt":"2023-08-14T15:58:31","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=59908"},"modified":"2026-08-31T13:31:05","modified_gmt":"2026-08-31T17:31:05","slug":"pantoprazole-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/pantoprazole-alternatives\/","title":{"rendered":"Pantoprazole alternatives: Other PPIs and lifestyle changes"},"content":{"rendered":"

Pantoprazole<\/a> is a generic prescription medication used to treat gastroesophageal reflux disease (GERD<\/a>), erosive esophagitis, and other conditions related to excess stomach acid, such as peptic ulcers. It belongs to a class of drugs called proton pump inhibitors (PPIs)<\/a>, which reduce stomach acid production by blocking the microscopic pump on the acid producing cells in the stomach. The brand-name version of pantoprazole is Protonix<\/a>.<\/p>\n

Pantoprazole may not be right for everyone because of side effects, cost, or how well it works. Alternatives include other PPIs, some of which are available over the counter, as well as another type of acid reducer called H2 blockers<\/a>.<\/p>\n\t\t\t

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Save up to 80% on Pantoprazole with SingleCare<\/p>\n\t\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t\t

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\n\t\t\t\t\t\tPantoprazole 40 mg (30 Delayed release tablets)\t\t\t\t\t<\/div>\n\t\t\t\t\t
\n\t\t\t\t\t\t23666 - Hampton, VA\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$7.28\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$7.28\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\tSee Pantoprazole prices at all pharmacies<\/a>\n\t\t\t<\/div>\n\t\t\n

Related: <\/b>What\u2019s the best heartburn medicine for you?<\/b><\/a><\/p>\n

What can I take instead of pantoprazole?<\/h2>\n

There are other options available to treat GERD or other stomach acid-related conditions that do not improve with pantoprazole<\/a>. Other PPIs generally provide similar acid suppression when used at equivalent doses, so factors such as cost, dosing, and individual response may help determine which PPI is most suitable. Other alternatives include histamine H2 antagonists (H2 blockers) and antacids. These options have different uses, side effects, dosages, and costs that may make them more suitable for certain people.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u00a0 Compare Protonix (pantoprazole) alternatives<\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Protonix (pantoprazole)<\/b><\/td>\n$638 for 30, 40 mg delayed-release tablets<\/td>\n$439 for 30, 40 mg delayed-release tablets of brand-name Protonix at Kroger<\/td>\nSee latest prices<\/a><\/td>\n<\/tr>\n
Generic Protonix\u00a0<\/b>(pantoprazole)<\/b><\/td>\n$144 for 30, 40 mg delayed-release tablets<\/td>\n$7 for 30, 40 mg delayed-release tablets of generic Protonix at Kroger<\/td>\nSee latest prices<\/a><\/td>\n<\/tr>\n
Prilosec (omeprazole)<\/b><\/td>\n$569 for 30, 10 mg oral powder packets<\/td>\n$12 for 30, 10 mg oral powder packets of generic Prilosec at Kroger<\/td>\nSee latest prices<\/a><\/td>\n<\/tr>\n
Nexium (esomeprazole)<\/b><\/td>\n$1,060 for 90, 40 mg delayed-release capsules<\/td>\n$21 for 90, 40 mg delayed-release capsules of generic Nexium at Kroger<\/td>\nSee latest prices<\/a><\/td>\n<\/tr>\n
Prevacid (lansoprazole)<\/b><\/td>\n$531 for 30, 30 mg delayed-release capsules<\/td>\n$7 for 30, 30 mg delayed-release capsules of generic Prevacid at Kroger<\/td>\nSee latest prices<\/a><\/td>\n<\/tr>\n
Dexilant (dexlansoprazole)<\/b><\/td>\n$470 for 30, 60 mg delayed-release capsules<\/td>\n$82 for 30, 60 mg delayed-release capsules of generic Dexilant at CVS Pharmacy<\/td>\nSee latest prices<\/a><\/td>\n<\/tr>\n
Aciphex<\/b><\/p>\n

(rabeprazole)<\/b><\/td>\n

$1,536 for 30, 20 mg delayed-release tablets<\/td>\n$15 for 30, 20 mg delayed-release tablets of generic Aciphex at Kroger<\/td>\nSee latest prices<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 pantoprazole alternatives<\/h2>\n

The following are some of the most common alternatives to pantoprazole.<\/p>\n

1. Omeprazole (Prilosec)<\/h3>\n

Omeprazole<\/a> is one of the most commonly used PPIs<\/a> and works similarly to pantoprazole by reducing stomach acid production by blocking acid-producing cells. Unlike pantoprazole, prescription omeprazole is FDA approved to treat stomach and duodenal ulcers<\/a> and, when used with certain antibiotics, to treat H. pylori<\/i> infection in adults with peptic ulcer disease.<\/p>\n

Omeprazole is available both by prescription and over the counter. Prescription omeprazole delayed-release capsules come in 10 mg, 20 mg, and 40 mg strengths, while OTC Prilosec<\/a> contains 20 mg of omeprazole. For people who have difficulty swallowing capsules, prescription omeprazole capsules can be opened and mixed with one tablespoon of applesauce<\/a>. Prescription omeprazole should be taken 30 to 60 minutes before meals.<\/p>\n

Omeprazole has similar common side effects as pantoprazole, including nausea, diarrhea, vomiting, abdominal pain, headache, and flatulence. Because pantoprazole is only available by prescription, omeprazole may be a suitable alternative for people looking for an OTC treatment option.<\/p>\n

Related: <\/b>Pantoprazole vs. omeprazole<\/b><\/a><\/p>\n

2. Esomeprazole (Nexium)<\/h3>\n

Esomeprazole<\/a> is another PPI that works similarly to pantoprazole by reducing stomach acid. Also available under the brand name Nexium<\/a>, esomeprazole comes in both prescription and over-the-counter (OTC) forms. For people who have difficulty swallowing capsules, prescription esomeprazole capsules can be opened and mixed with one tablespoon of applesauce<\/a>. Prescription esomeprazole should be taken about one hour before meals.<\/p>\n

Like other PPIs, esomeprazole has similar common side effects, including headache, diarrhea, nausea, abdominal pain, and flatulence. It may be a suitable pantoprazole alternative for people who have not had adequate symptom relief with pantoprazole or who prefer an OTC treatment option.<\/p>\n

Related: <\/b>Nexium side effects and how to avoid them<\/b><\/a><\/p>\n

3. Lansoprazole (Prevacid)<\/h3>\n

Lansoprazole<\/a>, also available under the brand name Prevacid<\/a>, is another PPI that reduces stomach acid. Lansoprazole is available both by prescription and over the counter. It also comes in different dosage forms, including an orally disintegrating tablet (ODT) that dissolves on the tongue.<\/p>\n

For people who have difficulty swallowing capsules, lansoprazole capsules can be opened and mixed<\/a> with one tablespoon of applesauce, cottage cheese, yogurt, or strained pears. The capsule contents can also be mixed with about 60 mL of apple, orange, or tomato juice. Prescription lansoprazole should be taken before meals as with the other PPIs.<\/p>\n

Lansoprazole has similar common side effects as other PPIs, including diarrhea, abdominal pain, nausea, and constipation. Its different dosage forms may make it a suitable alternative for people who have difficulty swallowing capsules, while OTC availability may be convenient for people treating frequent heartburn.<\/p>\n

Related: <\/b>How much is lansoprazole without insurance?<\/b><\/a><\/p>\n

4. Dexlansoprazole (Dexilant)<\/h3>\n

Dexlansoprazole<\/a> is another PPI alternative that is also available under the brand name Dexilant<\/a>. Like pantoprazole, dexlansoprazole is available only by prescription. For adults and children who have difficulty swallowing capsules, dexlansoprazole capsules can be opened and mixed with one tablespoon of applesauce<\/a>. Dexlansoprazole can be taken any time of day without regard to meals, as it is the only PPI with a dual delayed-release<\/a> mechanism, meaning the medication is released at two different times. This may be a suitable alternative for people who prefer a more flexible dosing schedule.<\/p>\n

Related: <\/b>Dexilant side effects and how to avoid them<\/b><\/a><\/p>\n

5. Rabeprazole (Aciphex)<\/h3>\n

Rabeprazole<\/a> is another PPI available under the brand name Aciphex<\/a>. Like pantoprazole, rabeprazole requires a prescription. For most conditions, rabeprazole tablets can be taken with or without food, although specific instructions depend on the condition being treated<\/a>. Rabeprazole may be a suitable alternative for people who have not had adequate improvement with pantoprazole.<\/p>\n

Natural alternatives to pantoprazole<\/h2>\n

Lifestyle and dietary changes may help lessen reflux and heartburn symptoms alongside medication. The American College of Gastroenterology<\/a> recommends or suggests several lifestyle changes for managing GERD.<\/p>\n

Recommended lifestyle modifications include:<\/p>\n