{"id":60381,"date":"2023-09-18T10:56:33","date_gmt":"2023-09-18T14:56:33","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60381"},"modified":"2025-09-12T14:27:23","modified_gmt":"2025-09-12T18:27:23","slug":"cyclobenzaprine-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/cyclobenzaprine-interactions\/","title":{"rendered":"Cyclobenzaprine interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclobenzaprine-hcl\"><span style=\"font-weight: 400;\">Cyclobenzaprine<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription muscle relaxant that is approved by the U.S. Food and Drug Administration (FDA). It\u2019s usually dispensed in pharmacies as a generic medicine, but healthcare providers commonly refer to it by brand names <a href=\"https:\/\/www.singlecare.com\/blog\/flexeril-generic\/\">Flexeril<\/a> (immediate-release tablets), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fexmid\"><span style=\"font-weight: 400;\">Fexmid<\/span><\/a><span style=\"font-weight: 400;\"> (immediate-release tablets), or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amrix\"><span style=\"font-weight: 400;\">Amrix<\/span><\/a><span style=\"font-weight: 400;\"> (extended-release capsules). Flexeril is no longer made in the U.S. as a brand-name drug. Cyclobenzaprine is <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=aa5af84e-428e-47ee-9f4e-41dac29d1979#LINK_a15dfd1d-b239-4778-bf15-a3815af34ceb\"><span style=\"font-weight: 400;\">used<\/span><\/a><span style=\"font-weight: 400;\"> for a short period of time, along with rest and physical therapy, to relieve muscle spasms associated with acute, painful musculoskeletal conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While taking cyclobenzaprine, it is important to be aware of interactions and warnings so you can stay as safe as possible. Continue reading to learn more about how to take cyclobenzaprine safely and avoid interactions.<\/span><\/p>\n<h2 id=\"key-takeaways\"><span style=\"font-weight: 400;\">Key takeaways:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some of the most notable cyclobenzaprine interactions include alcohol, drugs that increase serotonin levels, MAO inhibitors, CNS depressants, and drugs that lower the seizure threshold.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cyclobenzaprine interactions can often result in serotonin syndrome, or they can cause more serious side effects of cyclobenzaprine, such as extreme sedation, slowed breathing, or impairment.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In the event of a cyclobenzaprine interaction, such as serotonin syndrome or CNS depression, seek medical help.<\/span><\/li>\n<\/ul>\n<h2 id=\"cyclobenzaprine-drug-interactions\"><span style=\"font-weight: 400;\">Cyclobenzaprine drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Cyclobenzaprine can interact with various prescription and over-the-counter (OTC) medications, to varying degrees of severity. Before you take cyclobenzaprine, tell your healthcare provider about all the medications you take, including prescription drugs, OTC medicines, vitamins, and supplements. Check with your healthcare provider before starting any new medications while taking cyclobenzaprine.<\/span><\/p>\n<h3 id=\"drugs-that-can-cause-serotonin-syndrome-when-combined-with-cyclobenzaprine\"><span style=\"font-weight: 400;\">Drugs that can cause serotonin syndrome when combined with cyclobenzaprine<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\"><span style=\"font-weight: 400;\">Serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\"> is a life-threatening condition caused by the buildup of serotonin. This can happen when you take more than one medication that increases serotonin level, or if you take too high a dosage of a medicine that increases serotonin. <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/serotonin-syndrome-treatment-and-medications\"><span style=\"font-weight: 400;\">Signs and symptoms<\/span><\/a><span style=\"font-weight: 400;\"> of serotonin syndrome range from mild (such as agitation, anxiety, or diarrhea) to life-threatening (such as a high fever, seizures, irregular heartbeat, and unconsciousness). If you have any of these symptoms, seek emergency medical care.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While taking cyclobenzaprine, you may need to avoid the medications below or be carefully monitored if you need to take both medications. Or, your healthcare provider may decide to prescribe a different drug than cyclobenzaprine. Examples of drugs that can cause serotonin syndrome when combined with cyclobenzaprine include, but are not limited to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\"><span style=\"font-weight: 400;\">Selective serotonin reuptake inhibitor (SSRI) antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> used for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety,<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\/what-is\"><span style=\"font-weight: 400;\">Lexapro (escitalopram)<\/span><\/a><span style=\"font-weight: 400;\">, Paxil (paroxetine), Zoloft (sertraline), or Prozac (fluoxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/ssris-vs-snris\/\"><span style=\"font-weight: 400;\">Serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> such as Cymbalta (duloxetine) or Effexor (venlafaxine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> such as Elavil (amitriptyline) or Pamelor (nortriptyline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/news\/opioid-epidemic-statistics-legislation\/\"><span style=\"font-weight: 400;\">Opioid pain medications<\/span><\/a><span style=\"font-weight: 400;\"> such as Ultram (tramadol), OxyContin (oxycodone), or Demerol (meperidine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wellbutrin (bupropion)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/triptans\"><span style=\"font-weight: 400;\">Triptans<\/span><\/a><span style=\"font-weight: 400;\"> for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraine,<\/span><\/a><span style=\"font-weight: 400;\"> such as Imitrex (sumatriptan) or Maxalt (rizatriptan)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/st-johns-wort\/\"><span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Verapamil<\/span><\/li>\n<\/ul>\n<h3 id=\"monoamine-oxidase-inhibitors-maois\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors (MAOIs)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">We mentioned <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">MAOIs<\/span><\/a><span style=\"font-weight: 400;\"> briefly in the above section as a class of medications that can cause serotonin syndrome when taken with cyclobenzaprine. Additionally, the prescribing information indicates that an MAOI drug should never be taken while taking cyclobenzaprine or within 14 days of the last dose of cyclobenzaprine. The combination could cause high fever, seizures, or even death. If you take an MAOI, your healthcare provider will not prescribe cyclobenzaprine. You can ask about an alternative medication that will be safer to take with an MAOI, or ask if there is an alternative to the MAOI. Examples of MAOIs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/azilect\"><span style=\"font-weight: 400;\">Azilect (rasagiline)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Emsam (selegiline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Marplan (isocarboxazid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nardil (phenelzine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Parnate (tranylcypromine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/zyvox\/what-is\"><span style=\"font-weight: 400;\">Zyvox (linezolid)<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"central-nervous-system-cns-depressants\"><span style=\"font-weight: 400;\">Central nervous system (CNS) depressants<\/span><\/h3>\n<p><a href=\"https:\/\/nida.nih.gov\/publications\/drugfacts\/prescription-cns-depressants\"><span style=\"font-weight: 400;\">CNS depressants<\/span><\/a><span style=\"font-weight: 400;\"> cause a slowing down of the central nervous system. Cyclobenzaprine is a CNS depressant. Taking it with another CNS depressant should be avoided because it can worsen the adverse effects and cause impairment and extreme sedation. In some cases, it can cause slowed breathing, coma, or even death. Make sure you tell your healthcare provider if you take a CNS depressant, or ask your healthcare provider or pharmacist if you are not sure if any of your medications are CNS depressants. Your healthcare provider may decide to recommend a lower dose of cyclobenzaprine\u2014or prescribe a different drug altogether.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition to muscle relaxants, other examples of CNS depressants include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drugs for anxiety (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">benzodiazepines<\/span><\/a><span style=\"font-weight: 400;\">) such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/xanax\"><span style=\"font-weight: 400;\">Xanax (alprazolam)<\/span><\/a><span style=\"font-weight: 400;\"> or Valium (diazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drugs that help with sleeping, such as Ambien (zolpidem)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/barbiturates\"><span style=\"font-weight: 400;\">Barbiturates<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phenobarbital-without-insurance\/\"><span style=\"font-weight: 400;\">phenobarbital<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioid pain medications such as Vicodin (hydrocodone\/acetaminophen) or oxycodone<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Older antihistamines like <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/diphenhydramine-interactions\/\"><span style=\"font-weight: 400;\">Benadryl (diphenhydramine)<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"medications-that-lower-the-seizure-threshold\"><span style=\"font-weight: 400;\">Medications that lower the seizure threshold<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Cyclobenzaprine is <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513362\/\"><span style=\"font-weight: 400;\">chemically similar to tricyclic antidepressants<\/span><\/a><span style=\"font-weight: 400;\">. These drugs are known to lower the seizure threshold, making you more likely to have a seizure, and should be used with caution in people who have seizures. Talk to your healthcare provider if you have a history of seizures, and make sure your healthcare provider knows about all the medications you take. If there is a possibility of a drug interaction, your healthcare provider may prescribe a different medication. Other drugs that can lower the seizure threshold include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bupropion, including drugs that contain bupropion such as Auvelity (bupropion\/dextromethorphan)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tramadol, including drugs that contain tramadol such as Ultracet (tramadol\/acetaminophen)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/li>\n<\/ul>\n<h2 id=\"other-cyclobenzaprine-interactions\"><span style=\"font-weight: 400;\">Other cyclobenzaprine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In addition to drug-drug interactions, it\u2019s always important to know if your medication interacts with certain foods, drinks, supplements, or medical conditions. Although cyclobenzaprine does not have any notable food interactions, there are some other interactions and precautions to be aware of.<\/span><\/p>\n<h3 id=\"cyclobenzaprine-and-alcohol\"><span style=\"font-weight: 400;\">Cyclobenzaprine and alcohol\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol is a CNS depressant, like cyclobenzaprine. Combining alcohol with cyclobenzaprine can result in the complications described above such as impairment and extreme sedation\u2014and in some cases, it can cause slowed breathing, coma, or even death. Avoid alcohol while taking cyclobenzaprine. If you do drink alcohol, talk to your healthcare provider. They may recommend a different medication.\u00a0\u00a0<\/span><\/p>\n<h3 id=\"cyclobenzaprine-and-dietary-supplements\"><span style=\"font-weight: 400;\">Cyclobenzaprine and dietary supplements<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">St. John\u2019s wort is a dietary supplement used for depression. It increases serotonin levels and should not be combined with cyclobenzaprine because the combination could cause serotonin syndrome. The same type of interaction is possible with the supplement SAMe, a supplement that is used for depression. If you take a supplement that causes drowsiness, such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/sleep-aids-guide\/\"><span style=\"font-weight: 400;\">valerian<\/span><\/a><span style=\"font-weight: 400;\"> or kava, check with your healthcare professional before combining it with cyclobenzaprine.<\/span><\/p>\n<h3 id=\"cyclobenzaprine-and-cannabis\"><span style=\"font-weight: 400;\">Cyclobenzaprine and cannabis<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While taking cyclobenzaprine, avoid cannabis or CBD. The combination with cyclobenzaprine could cause additive CNS depressant effects.\u00a0<\/span><\/p>\n<h3 id=\"cyclobenzaprine-and-illicit-drugs\"><span style=\"font-weight: 400;\">Cyclobenzaprine and illicit drugs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Cyclobenzaprine should not be taken along with illicit drugs like cocaine, because it can increase the risk of serotonin syndrome or other complications.\u00a0<\/span><\/p>\n<h3 id=\"cyclobenzaprine-and-certain-health-conditions\"><span style=\"font-weight: 400;\">Cyclobenzaprine and certain health conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before taking cyclobenzaprine, tell your physician about all of your medical conditions and medical history as well as family history. Cyclobenzaprine is not safe for everyone. You should not take this medication if you:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are allergic to cyclobenzaprine or any ingredient in the medication<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Currently, take an MAOI (wait at least 14 days after stopping an MAOI before taking cyclobenzaprine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have recently had a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cardiac-arrest-vs-heart-attack\/\"><span style=\"font-weight: 400;\">heart attack<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have certain heart or heart rhythm conditions, such as heart block or congestive heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have an overactive thyroid (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/hypothyroidism-vs-hyperthyroidism\/\"><span style=\"font-weight: 400;\">hyperthyroidism<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Cyclobenzaprine may be prescribed with caution and close monitoring in individuals with certain medical conditions, such as liver disease, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/living-with-glaucoma\/\"><span style=\"font-weight: 400;\">glaucoma<\/span><\/a><span style=\"font-weight: 400;\">, or bladder problems.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are pregnant or breastfeeding, consult your healthcare provider for professional medical advice.\u00a0<\/span><\/p>\n<h3 id=\"cyclobenzaprine-and-older-adults\"><span style=\"font-weight: 400;\">Cyclobenzaprine and older adults<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The American Geriatrics Society&#8217;s Criteria for Potentially Inappropriate Medication Use in Older Adults outlines medications that may not be safe for older adults (generally 65 years or older). <\/span><a href=\"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/full\/10.1111\/jgs.18372\"><span style=\"font-weight: 400;\">Cyclobenzaprine is on the list<\/span><\/a><span style=\"font-weight: 400;\"> because it can cause troublesome side effects such as dry mouth, constipation, drowsiness, dizziness (which can increase the risk of fractures due to falls), and confusion. Experts note that cyclobenzaprine is poorly tolerated by older adults due to these side effects and that the lower doses prescribed for older adults are not always effective. Talk with your healthcare provider for professional medical advice.<\/span><\/p>\n<h2 id=\"how-to-minimize-cyclobenzaprine-interactions\"><span style=\"font-weight: 400;\">How to minimize cyclobenzaprine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Here are some tips to minimize the risk of cyclobenzaprine interactions:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Before taking cyclobenzaprine, make sure your healthcare provider knows your full medical history and all of the medications you take, so they can screen for drug interactions or other potential problems. While taking cyclobenzaprine, do not start any new medications unless approved by your healthcare provider. Keep an <\/span><a href=\"https:\/\/www.ahrq.gov\/health-literacy\/improve\/pharmacy\/medicine-list.html\"><span style=\"font-weight: 400;\">updated list<\/span><\/a><span style=\"font-weight: 400;\"> of your medications with you.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cyclobenzaprine often causes drowsiness. Do not drive or operate machinery until you know how cyclobenzaprine affects you.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoid alcohol while taking cyclobenzaprine. If you drink alcohol, talk to your healthcare provider about an alternative medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Know the possible warning signs of interactions, like serotonin syndrome or CNS depression, as described above. Get emergency medical help for these symptoms. You should also get emergency medical help if you have any symptoms of an allergic reaction, such as hives, trouble breathing, or swelling of the face, lips, tongue, or throat.\u00a0<\/span><\/li>\n<\/ol>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-cyclobenzaprine-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about cyclobenzaprine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because there are so many potential cyclobenzaprine interactions, this article does not provide a complete list. It is important to communicate with your healthcare provider about all of your medical conditions and the medications you take. This will help minimize the risk of interactions and ensure proper management and monitoring.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cyclobenzaprine is a prescription muscle relaxant that is approved by the U.S. Food and Drug Administration (FDA). It\u2019s usually dispensed in pharmacies as a generic medicine, but healthcare providers commonly refer to it by brand names Flexeril (immediate-release tablets), Fexmid (immediate-release tablets), or Amrix (extended-release capsules). Flexeril is no longer made in the U.S. as [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":60382,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[814],"coauthors":[10668],"class_list":["post-60381","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Meds to not mix with cyclobenzprine<\/title>\n<meta name=\"description\" content=\"Cyclobenzaprine (Flexeril) interacts with antidepressants, MAOIs, CNS depressants, and alcohol. Here\u2019s what you should not take with cyclobenzaprine to avoid side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/cyclobenzaprine-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cyclobenzaprine interactions to avoid\" \/>\n<meta property=\"og:description\" content=\"Cyclobenzaprine (Flexeril) interacts with antidepressants, MAOIs, CNS depressants, and alcohol. 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