{"id":60415,"date":"2023-09-26T10:12:27","date_gmt":"2023-09-26T14:12:27","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60415"},"modified":"2024-10-25T10:30:50","modified_gmt":"2024-10-25T14:30:50","slug":"sulfamethoxazole-trimethoprim-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/sulfamethoxazole-trimethoprim-alternatives\/","title":{"rendered":"Sulfamethoxazole-trimethoprim (Bactrim) alternatives: What can I take instead of sulfamethoxazole-trimethoprim?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/sulfamethoxazole-trimethoprim\/what-is\"><span style=\"font-weight: 400;\">Bactrim<\/span><\/a><span style=\"font-weight: 400;\"> (sulfamethoxazole\/ trimethoprim, trimethoprim-sulfamethoxazole, TMP-SMX) is a combination antibiotic. Sulfamethoxazole is a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/sulfonamides\"><span style=\"font-weight: 400;\">sulfonamide antibiotic<\/span><\/a><span style=\"font-weight: 400;\">, and trimethoprim is an additional antimicrobial agent. It was approved by the Food and Drug Administration (FDA) in 1973. This medication was initially used primarily to treat urinary tract infections (UTIs) but has proven to be a versatile product. Bactrim can be used for skin and soft tissue infections and even pneumonia caused by dangerous microorganisms.<\/span><\/p>\n<p><span data-sheets-root=\"1\" data-sheets-value='{&quot;1&quot;:2,&quot;2&quot;:&quot;&quot;}' data-sheets-userformat='{\"2\":6849,\"3\":{\"1\":0},\"9\":1,\"10\":2,\"12\":0,\"14\":{\"1\":2,\"2\":0},\"15\":\"Arial\"}' data-sheets-formula=\"=CONCATENATE(R[0]C[-2],R[0]C[-3],R[0]C[-1])\"><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bactrim has been proven effective against the following types of organisms:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Aerobic gram-positive bacteria:<\/b> <i><span style=\"font-weight: 400;\">s<\/span><\/i><i><span style=\"font-weight: 400;\">treptococcus pneumoniae<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Aerobic gram-negative bacteria:<\/b> <i><span style=\"font-weight: 400;\">Escherichia coli<\/span><\/i><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Klebsiella <\/span><\/i><span style=\"font-weight: 400;\">species, <\/span><i><span style=\"font-weight: 400;\">Enterobacter <\/span><\/i><span style=\"font-weight: 400;\">species, <\/span><i><span style=\"font-weight: 400;\">Haemophilus influenzae, Morganella morganii, Proteus mirabilis, Proteus vulgaris, Shigella flexneri, Shigella sonnei<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Other Microorganisms:<\/b> <i><span style=\"font-weight: 400;\">Pneumocystis jirovecii<\/span><\/i><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Fortunately, the combination of sulfamethoxazole and trimethoprim has been generic for quite some time. Thanks to this, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/what-is-medicaid\/\"><span style=\"font-weight: 400;\">Medicare<\/span><\/a><span style=\"font-weight: 400;\"> and major insurance plans cover it, but it is still affordable even if one is not covered by insurance. With a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/bactrim-ds\"><span style=\"font-weight: 400;\">coupon<\/span><\/a><span style=\"font-weight: 400;\"> from SingleCare, a standard treatment is available generically for less than $10 at most major participating pharmacies. Sulfamethoxazole-trimethoprim may be prescribed under the Bactrim, Bactrim DS, or Septra names.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If someone finds themselves in a situation where Bactrim doesn&#8217;t seem the right choice, other treatment options may be available.<\/span><\/p>\n<h2 id=\"what-can-i-take-in-place-of-sulfamethoxazole-trimethoprim\"><span style=\"font-weight: 400;\">What can I take in place of sulfamethoxazole-trimethoprim?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are some scenarios where <\/span><span style=\"font-weight: 400;\">Bactrim<\/span><span style=\"font-weight: 400;\"> may not be the best choice for an infection or condition, even if it is caused by one of the above organisms. First, there are a significant number of individuals who have a sulfa allergy or hypersensitivity. Typically, this involves an undesirable rash and itching and could lead to a life-threatening emergency reaction. Known as anaphylaxis, it can impair breathing and stop the heart without immediate intervention.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">An infection may already be resistant to Bactrim if it has been exposed to the drug recently or repeatedly. The prescriber must know the history of any antibiotic therapy before they choose treatment. Inappropriate use of antibiotics can lead to antibiotic resistance. A pathogen can be very adaptive, and because of this, we have to be very careful in how we prescribe and use our relatively small selection of antibiotics.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These options are not intended to be interpreted as medical advice. Only a prescriber can determine which antibiotic, if any, is appropriate for the condition needing treatment. This also does not include all appropriate dosing, uses, risk factors, or drug interactions for each alternative. Most antibiotics have specific dosing for the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/childrens-antibiotics\/\"><span style=\"font-weight: 400;\">pediatric population<\/span><\/a><span style=\"font-weight: 400;\">, but those are not listed here. A pharmacist can provide more information.<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th>&nbsp;<\/p>\n<h2 id=\"compare-sulfamethoxazole-trimethoprim-bactrim-alternatives\">Compare sulfamethoxazole-trimethoprim (Bactrim) alternatives<\/h2>\n<p>&nbsp;<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td>Drug name<\/td>\n<td>Uses<\/td>\n<td>Dosage<\/td>\n<td>Savings options<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bactrim (sulfamethoxazole-trimethoprim)<\/span><\/td>\n<td>UTI, Pneumocystitis pneumonia (PCP), otitis media, bronchitis, pertussis<\/td>\n<td>800 mg\/ 160 mg by mouth twice daily for 3 days to 7 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/bactrim\"><span style=\"font-weight: 400;\">Sulfamethoxazole-trimethoprim coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cipro (ciprofloxacin)<\/span><\/td>\n<td>UTI, Lower respiratory infections (LRTI), skin infections, animal bites, diarrhea, gastroenteritis, sinus infection, gonorrhea<\/td>\n<td>250 mg to 750 mg by mouth twice daily for 3 to 10 days, depending on the diagnosis<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cipro\"><span style=\"font-weight: 400;\">Cipro coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Levaquin (levofloxacin)<\/span><\/td>\n<td>Sinus infection, UTI, bronchitis, community-acquired pneumonia (CAP), skin infections<\/td>\n<td>500 mg to 750 mg by mouth twice daily for 5 days to 10 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/levofloxacin\"><span style=\"font-weight: 400;\">Levaquin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">PenVK (penicillin)<\/span><\/td>\n<td>Pharyngitis, tonsillitis, skin infections, animal bites, scarlet fever<\/td>\n<td>500 mg by mouth two to three times daily for 10 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/penicillin-v-potassium\"><span style=\"font-weight: 400;\">Pen VK coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Amoxil (amoxicillin)<\/span><\/td>\n<td>Pharyngitis, tonsillitis, otitis media, skin infections, UTI<\/td>\n<td>500 mg by mouth every 8 to 12 hours for 10 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\"><span style=\"font-weight: 400;\">Amoxil coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Augmentin (amoxicillin\/ clavulanic acid)<\/span><\/td>\n<td>Otitis media, sinus infection, LRTI, CAP, skin infection, UTI<\/td>\n<td>500 mg\/ 125 mg every 8 hours or 875 mg\/ 125 mg every 12 hours by mouth for 10 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/augmentin\"><span style=\"font-weight: 400;\">Augmentin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Keflex (cephalosporin)<\/span><\/td>\n<td>URI, skin infection, otitis media<\/td>\n<td>250 mg every 6 hours or 500 mg every 12 hours by mouth for 7 to 14 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cephalexin\"><span style=\"font-weight: 400;\">Keflex coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Omnicef (cefdinir)<\/span><\/td>\n<td>Otitis media, bronchitis, sinus infection, CAP, pharyngitis, tonsillitis, skin infections<\/td>\n<td>300 mg by mouth every 12 hours for 5 to 7 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cefdinir\"><span style=\"font-weight: 400;\">Omnicef coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vantin (cefpodoxime)<\/span><\/td>\n<td>CAP, gonorrhea, UTI, skin infections, pharyngitis, tonsillitis, sinus infections<\/td>\n<td>200 mg by mouth every 12 hours for a minimum of 5 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cefpodoxime-proxetil\"><span style=\"font-weight: 400;\">Vantin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vibramycin (doxycycline hyclate)<\/span><\/td>\n<td>Skin infections, cellulitis, animal bites, skin ulcers, UTI, URI, LRTI, acne, gastroenteritis<\/td>\n<td>100 mg by mouth every 12 hours for 7 to 10 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/vibramycin\"><span style=\"font-weight: 400;\">Vibramycin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ery-Tab (erythromycin)<\/span><\/td>\n<td>Acne, LRTIs, CAP, URIs, Legionnaires disease, chlamydia<\/td>\n<td>250 mg every 6 hours or 333 mg every 8 hours by mouth for 7 to 10 days, depending on the infection<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin-base\"><span style=\"font-weight: 400;\">Ery-Tab coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zithromax (azithromycin)<\/span><\/td>\n<td>CAP, bronchitis, pharyngitis, tonsillitis, sinus infection, otitis media, conjunctivitis (eye infection), skin infection, pelvic inflammatory disease<\/td>\n<td>500 mg by mouth on day 1, followed by 250 mg by mouth once daily for 4 additional days<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zithromax\"><span style=\"font-weight: 400;\">Zithromax coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Biaxin (clarithromycin)<\/span><\/td>\n<td>Bronchitis, CAP, sinusitis, skin infections, otitis media,<\/td>\n<td>250 mg to 500 mg by mouth twice daily for 5 to 7 days, depending on the diagnosis<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\"><span style=\"font-weight: 400;\">Biaxin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cleocin (clindamycin)<\/span><\/td>\n<td>Sepsis, LRTIs, CAP, intra-abdominal infections, bone and joint infections, skin infections<\/td>\n<td>150 mg to 450 mg by mouth every 6 hours for 7 to 10 days, depending on the diagnosis<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cleocin\"><span style=\"font-weight: 400;\">Cleocin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Macrobid (nitrofurantoin)<\/span><\/td>\n<td>UTI, UTI prophylaxis<\/td>\n<td>100 mg by mouth every 12 hours for 7 days<\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/macrobid\"><span style=\"font-weight: 400;\">Macrobid coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 id=\"other-alternatives-to-sulfamethoxazole-trimethoprim\"><span style=\"font-weight: 400;\">Other alternatives to sulfamethoxazole-trimethoprim<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avelox (moxifloxacin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Duricef (cefadroxil)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ancef (cefazolin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cefzil (cefprozil)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rocephin (ceftriaxone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suprax (cefixime)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Spectracef (cefditoren)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Minocin (minocycline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urex (methenamine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Proloprim (trimethoprim)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Macrodantin (nitrofurantoin)<\/span><\/li>\n<\/ul>\n<h2 id=\"top-5-sulfamethoxazole-trimethoprim-alternatives\"><span style=\"font-weight: 400;\">Top 5 sulfamethoxazole-trimethoprim alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are multiple classes of antibiotics, and within each class, there are multiple products to choose from. Each class uniquely fights bacterial infections, and each product may have unique bacterial coverage. A healthcare provider may utilize laboratory tests, including blood or tissue samples, to determine the most effective products for the infection. Other antibiotics available include quinolones or fluoroquinolones, beta-lactams, macrolides, and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/aminoglycosides\"><span style=\"font-weight: 400;\">aminoglycosides<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The following are some of the most common alternatives to sulfamethoxazole-trimethoprim.<\/span><\/p>\n<h3 id=\"1-penicillin-antibiotics\">1. Penicillin antibiotics<\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/penicillins\"><span style=\"font-weight: 400;\">Penicillin<\/span><\/a><span style=\"font-weight: 400;\"> was the <\/span><a href=\"https:\/\/www.drugs.com\/drug-class\/natural-penicillins.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">first <\/span><\/a><span style=\"font-weight: 400;\">commercially available antibiotic, dating back to the 1940s. It was discovered accidentally by a scientist who left an uncovered petri dish of <\/span><i><span style=\"font-weight: 400;\">staphylococcus aureus<\/span><\/i><span style=\"font-weight: 400;\"> out where it grew mold. It was noted that the bacteria was not growing near the mold spores, and the mold substance was isolated and named penicillin. Penicillins are effective against gram-positive and gram-negative bacteria. Unfortunately, because this class of antibiotics has been around for quite some time, the antimicrobial resistance to penicillin is a growing concern. Some formulations have a beta-lactamase inhibitor that helps fight resistance but can still occur. It is important not to &ldquo;underdose&rdquo; this class of drugs when used, as this can propagate resistance more. Penicillins are commonly used for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ear-infection-treatment-and-medications\"><span style=\"font-weight: 400;\">otitis media<\/span><\/a><span style=\"font-weight: 400;\"> (ear infections), <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/upper-respiratory-infection-symptoms\"><span style=\"font-weight: 400;\">upper respiratory tract infections<\/span><\/a><span style=\"font-weight: 400;\"> (URI), and some <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/uti-treatment-and-medications\"><span style=\"font-weight: 400;\">urinary tract infections<\/span><\/a><span style=\"font-weight: 400;\"> (UTIs). Penicillin allergies are possible, and penicillin should not be taken if an allergic reaction to penicillin or a related product has occurred. This can include rashes, itching, or anaphylaxis.<\/span><\/p>\n<p><b>Examples:<\/b><span style=\"font-weight: 400;\"> PenVK (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/penicillin-v-potassium\/what-is\"><span style=\"font-weight: 400;\">penicillin potassium<\/span><\/a><span style=\"font-weight: 400;\">), Amoxil (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\/what-is\"><span style=\"font-weight: 400;\">amoxicillin<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/augmentin\/what-is\"><span style=\"font-weight: 400;\">Augmentin<\/span><\/a><span style=\"font-weight: 400;\"> (amoxicillin\/ clavulanic acid)<\/span><\/p>\n<h3 id=\"2-cephalosporin-antibiotics\">2. Cephalosporin antibiotics<\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/cephalosporins\"><span style=\"font-weight: 400;\">Cephalosporins<\/span><\/a><span style=\"font-weight: 400;\"> come in multiple generations: first-generation, second-generation, third-generation, and fourth-generation. As each generation advanced, they offered more sophisticated mechanisms to fight bacterial infections. The differences between the generations affect dosing, absorption, administration length, and bacterial coverage spectrum. In general, cephalosporins are used to treat ear infections, skin infections, URIs, UTIs, and bone infections. If there is an allergy to penicillins, there is a possibility of also being allergic to cephalosporins. It&#8217;s important to discuss this potential risk with your healthcare provider or pharmacist<\/span><\/p>\n<p><b>Examples:<\/b><span style=\"font-weight: 400;\"> Keflex (cephalosporin), Omnicef (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cefdinir\/what-is\"><span style=\"font-weight: 400;\">cefdinir<\/span><\/a><span style=\"font-weight: 400;\">), Vantin (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cefpodoxime-proxetil\/what-is\"><span style=\"font-weight: 400;\">cefpodoxime<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h3 id=\"3-macrolide-antibiotics\">3. Macrolide antibiotics<\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/macrolides\"><span style=\"font-weight: 400;\">Macrolide antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> are primarily effective against gram-positive bacteria. They block protein synthesis in the bacterial cell, stopping the continued growth of the bacteria. Macrolides are effective against certain <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/std-symptoms\"><span style=\"font-weight: 400;\">sexually transmitted infections<\/span><\/a><span style=\"font-weight: 400;\"> or diseases (STI or STD), skin infections, ear infections, and eye infections. Patients with hepatic impairment or liver disease may not be good candidates for macrolide therapy.<\/span><\/p>\n<p><b>Examples:<\/b> <a href=\"https:\/\/www.singlecare.com\/prescription\/zithromax\/what-is\"><span style=\"font-weight: 400;\">Zithromax<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/azithromycin\/what-is\"><span style=\"font-weight: 400;\">azithromycin<\/span><\/a><span style=\"font-weight: 400;\">), Biaxin (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\/what-is\"><span style=\"font-weight: 400;\">clarithromycin<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ery-tab\/what-is\"><span style=\"font-weight: 400;\">Ery-Tab<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin-base\/what-is\"><span style=\"font-weight: 400;\">erythromycin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h3 id=\"4-urinary-antiinfectives\">4. Urinary antiinfectives<\/h3>\n<p><span style=\"font-weight: 400;\">Urinary antiinfectives are a unique class because their effectiveness stems from their high concentration in the urine. They are antibiotics used against bacteria responsible for UTIs and are highly concentrated in the urine. Patients with liver or kidney disease may not be able to take these medications as they could experience toxicity. Do not take these if <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/antibiotics-safe-in-pregnancy\/\"><span style=\"font-weight: 400;\">pregnant<\/span><\/a><span style=\"font-weight: 400;\"> and in the last month of a pregnancy.<\/span><\/p>\n<p><b>Examples:<\/b> <a href=\"https:\/\/www.singlecare.com\/prescription\/macrobid\/what-is\"><span style=\"font-weight: 400;\">Macrobid<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nitrofurantoin-monohyd-macro\/what-is\"><span style=\"font-weight: 400;\">nitrofurantoin monohyd macro<\/span><\/a><span style=\"font-weight: 400;\"> ), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/macrodantin\/what-is\"><span style=\"font-weight: 400;\">Macrodantin<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nitrofurantoin-macrocrystal\/what-is\"><span style=\"font-weight: 400;\">nitrofurantoin macrocrystal<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h3 id=\"5-quinolone-or-fluoroquinolone-antibiotics\">5. Quinolone or Fluoroquinolone antibiotics<\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/quinolones\"><span style=\"font-weight: 400;\">Fluoroquinolone antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> have potentially severe adverse effects and are rarely used as a first-line treatment for infections. Their prevalence of use greatly decreased after the retrospective correlation to a few severe adverse reactions once these drugs had been on the market for several years. They can cause QT prolongation and tendon weakness, leading to debilitating injuries. However, they are very effective against various bacteria types and may need to be considered if other antibiotics are not working. It is imperative to use the shortest course possible when prescribing fluoroquinolones. Cipro (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ciprofloxacin-for-uti\/\"><span style=\"font-weight: 400;\">ciprofloxacin<\/span><\/a><span style=\"font-weight: 400;\">) covers some organisms responsible for UTIs and may be the best option when Bactrim is not treated adequately.<\/span><\/p>\n<p><b>Examples: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/cipro\/what-is\"><span style=\"font-weight: 400;\">Cipro<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ciprofloxacin-hcl\/what-is\"><span style=\"font-weight: 400;\">ciprofloxacin<\/span><\/a><span style=\"font-weight: 400;\">), Levaquin (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/levofloxacin\/what-is\"><span style=\"font-weight: 400;\">levofloxacin<\/span><\/a><span style=\"font-weight: 400;\">), Avelox (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/moxifloxacin-hcl\/what-is\"><span style=\"font-weight: 400;\">moxifloxacin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h2 id=\"natural-alternatives-to-sulfamethoxazole-trimethoprim\">Natural alternatives to sulfamethoxazole-trimethoprim<\/h2>\n<p><span style=\"font-weight: 400;\">There are no natural antibiotics available to purchase off the shelf. Natural alternatives for fighting infections are aimed more at early intervention, detection, and prevention.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/uti-causes\"><span style=\"font-weight: 400;\">urinary tract infections<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37068952\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cranberry products<\/span><\/a><span style=\"font-weight: 400;\"> have been shown to have value in symptomatic relief and prevention. The acidic environment created in the urine after ingesting cranberry products is thought to create an environment where it is hard for the bacteria to continue to grow and spread. The body&rsquo;s natural immune system can continue its attack on the infection. Good genital hygiene helps prevent conditions that could make UTIs more common. This includes washing with mild soap and water and good cleaning habits after urinating.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taking immune-boosting supplements such as vitamin C, zinc, and D will boost the body&rsquo;s natural ability to fight infections.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Good hygiene habits such as bathing and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-wash-your-hands\/\"><span style=\"font-weight: 400;\">handwashing<\/span><\/a><span style=\"font-weight: 400;\"> help prevent the spread of bacteria responsible for infections.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Once a bacterial infection occurs, it may be difficult for the body to eradicate. Delaying treatment with an antibiotic can be dangerous and leave the infection harder to treat. Seek help immediately for open and oozing wounds, fever, inflamed and warm skin, and symptoms that do not resolve independently in a reasonable amount of time (ear pain, sinus pain, etc.).<\/span><\/p>\n<h2 id=\"how-to-switch-to-a-sulfamethoxazole-trimethoprim-alternative\">How to switch to a sulfamethoxazole-trimethoprim alternative<\/h2>\n<p><span style=\"font-weight: 400;\">Suppose one is being treated for a bacterial infection with Bactrim or another form of sulfamethoxazole\/trimethoprim. In that case, a healthcare provider will prescribe it as a multi-day regimen (typically 7, 10, or 14). While taking this antibiotic, if the symptoms worsen, contact the healthcare provider immediately, as they may need to make a fast change in therapy. If one <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/finish-antibiotics\/\"><span style=\"font-weight: 400;\">completes their prescribed course<\/span><\/a><span style=\"font-weight: 400;\"> and experiences no worsening of symptoms but still does not see improvement, and if the symptoms persist, it is advisable to schedule a follow-up with the prescriber. Prolonging the treatment with the same medication or considering an alternative might be necessary. The crucial step is to engage in a conversation with the prescriber. If uncertainty remains about the effectiveness of the medication, a pharmacist can provide assistance and address concerns or liaise with the prescriber. Clinicians want to completely treat the infection to decrease the likelihood of it returning and being harder to treat.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fortunately, most antibiotics have coverage on Medicare and commercial drug insurance plans. If paying out of pocket or uninsured, use a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare prescription discount card<\/span><\/a><span style=\"font-weight: 400;\"> to find the lowest price for antibiotics and save from the hassle of going from pharmacy to pharmacy when not feeling well.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bactrim (sulfamethoxazole\/ trimethoprim, trimethoprim-sulfamethoxazole, TMP-SMX) is a combination antibiotic. Sulfamethoxazole is a sulfonamide antibiotic, and trimethoprim is an additional antimicrobial agent. It was approved by the Food and Drug Administration (FDA) in 1973. This medication was initially used primarily to treat urinary tract infections (UTIs) but has proven to be a versatile product. Bactrim can [&hellip;]<\/p>\n","protected":false},"author":145,"featured_media":60425,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,15103],"coauthors":[10437],"class_list":["post-60415","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-drug-pricing","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Top sulfamethoxazole-trimethoprim (Bactrim) alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Penicillin antibiotics, cephalosporin antibiotics, macrolide antibiotics, urinary antiinfectives, quinolone or fluoroquinolone antibiotics are some sulfamethoxazole-trimethoprim alternatives. Get the full list here, including natural antibiotics.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/sulfamethoxazole-trimethoprim-alternatives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sulfamethoxazole-trimethoprim (Bactrim) alternatives: What can I take instead of sulfamethoxazole-trimethoprim?\" \/>\n<meta property=\"og:description\" content=\"Penicillin antibiotics, cephalosporin antibiotics, macrolide antibiotics, urinary antiinfectives, quinolone or fluoroquinolone antibiotics are some sulfamethoxazole-trimethoprim alternatives. 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