{"id":60499,"date":"2023-09-26T10:02:33","date_gmt":"2023-09-26T14:02:33","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60499"},"modified":"2025-04-17T18:31:32","modified_gmt":"2025-04-17T22:31:32","slug":"paxlovid-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/","title":{"rendered":"Paxlovid interactions to avoid"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> is an oral <\/span><span style=\"font-weight: 400;\">antiviral<\/span><span style=\"font-weight: 400;\"> medication developed to treat COVID-19. The drug consists of two active ingredients, nirmatrelvir and <\/span><span style=\"font-weight: 400;\">ritonavir<\/span><span style=\"font-weight: 400;\">, which work as protease inhibitors to reduce the spread and number of viruses in the body. <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> can be a useful drug that can decrease the risk of <\/span><span style=\"font-weight: 400;\">hospitalization<\/span><span style=\"font-weight: 400;\"> or death in <\/span><span style=\"font-weight: 400;\">high-risk<\/span><span style=\"font-weight: 400;\"> individuals with COVID-19. However, it doesn\u2019t come without the risk of <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\">, which could decrease its effectiveness or cause harmful side effects.\u00a0<\/span><\/p>\n<h2 id=\"paxlovid-drug-interactions\"><b>Paxlovid<\/b><b>&#8211;<\/b><b>drug interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">, developed by <\/span><span style=\"font-weight: 400;\">Pfizer<\/span><span style=\"font-weight: 400;\"> and granted initial <\/span><span style=\"font-weight: 400;\">Emergency Use Authorization<\/span><span style=\"font-weight: 400;\"> and subsequent approval by the <\/span><span style=\"font-weight: 400;\">Food and Drug Administration<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\">) for COVID-19, is associated with several <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK585126\/\"><span style=\"font-weight: 400;\">drug-drug interactions<\/span><\/a><span style=\"font-weight: 400;\">. Let\u2019s explore the various drugs, including both prescription and over-the-counter (OTC) medications, that can interact with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3 id=\"statins\"><b>Statins<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> can interact with HMG-CoA reductase inhibitors, also known as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">statins<\/span><\/a><span style=\"font-weight: 400;\">, which are used to manage high cholesterol levels. <\/span><span style=\"font-weight: 400;\">Ritonavir<\/span><span style=\"font-weight: 400;\"> in <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> blocks the <\/span><span style=\"font-weight: 400;\">enzyme<\/span><span style=\"font-weight: 400;\"> that processes <\/span><span style=\"font-weight: 400;\">statins<\/span><span style=\"font-weight: 400;\">, which can lead to increased statin blood levels. Increased <\/span><span style=\"font-weight: 400;\">statin<\/span><span style=\"font-weight: 400;\"> levels may cause increased statin side effects like muscle pain, weakness, and fatigue. Examples of <\/span><span style=\"font-weight: 400;\">statins<\/span><span style=\"font-weight: 400;\"> that can interact with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zocor (<\/span><span style=\"font-weight: 400;\">simvastatin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lipitor (<\/span><span style=\"font-weight: 400;\">atorvastatin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mevacor (<\/span><span style=\"font-weight: 400;\">lovastatin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Crestor (<\/span><span style=\"font-weight: 400;\">rosuvastatin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<h3 id=\"calcium-channel-blockers\"><b>Calcium channel blockers<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Another interaction involves <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/calcium-channel-blockers\"><span style=\"font-weight: 400;\">calcium channel blockers<\/span><\/a><span style=\"font-weight: 400;\">, which treat high blood pressure (hypertension) and chest pain. <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> can increase the <\/span><span style=\"font-weight: 400;\">concentrations<\/span><span style=\"font-weight: 400;\"> of these drugs, potentially leading to side effects like dangerously low blood pressure, dizziness, and fatigue. <\/span><span style=\"font-weight: 400;\">Calcium channel blockers<\/span><span style=\"font-weight: 400;\"> often do not need to be discontinued while taking <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. However, a decrease in the dosage of the <\/span><span style=\"font-weight: 400;\">calcium channel blocker<\/span><span style=\"font-weight: 400;\"> is usually recommended to avoid potential side effects. Some common <\/span><span style=\"font-weight: 400;\">calcium channel blockers<\/span><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Norvasc (<\/span><span style=\"font-weight: 400;\">amlodipine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Procardia (<\/span><span style=\"font-weight: 400;\">nifedipine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardizem (<\/span><span style=\"font-weight: 400;\">diltiazem<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Calan (<\/span><span style=\"font-weight: 400;\">verapamil<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Plendil (felodipine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardene (nicardipine)<\/span><\/li>\n<\/ul>\n<h3 id=\"anticoagulants-and-antiplatelet-agents\"><b>Anticoagulants<\/b><b> and antiplatelet agents<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may also interact with blood thinners, like <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">anticoagulants<\/span><\/a><span style=\"font-weight: 400;\"> and antiplatelet agents, which are used to prevent blood clots. <\/span><span style=\"font-weight: 400;\">Ritonavir<\/span><span style=\"font-weight: 400;\"> can affect the metabolism of these drugs, potentially increasing their blood levels and the risk of bleeding problems. Examples of <\/span><span style=\"font-weight: 400;\">anticoagulant<\/span><span style=\"font-weight: 400;\"> medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coumadin (<\/span><span style=\"font-weight: 400;\">warfarin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xarelto (<\/span><span style=\"font-weight: 400;\">rivaroxaban<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eliquis (<\/span><span style=\"font-weight: 400;\">apixaban<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pradaxa (dabigatran)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Examples of antiplatelet agents include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Plavix (<\/span><span style=\"font-weight: 400;\">clopidogrel<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Brilinta (<\/span><span style=\"font-weight: 400;\">ticagrelor<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<h3 id=\"antiarrhythmic-drugs\"><b>Antiarrhythmic<\/b><b> drugs<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> can interact with certain <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antiarrhythmics\"><span style=\"font-weight: 400;\">antiarrhythmic<\/span><span style=\"font-weight: 400;\"> drugs<\/span><\/a><span style=\"font-weight: 400;\"> used to treat irregular heartbeats. The interaction may cause an increased risk of life-threatening heart rhythm problems. <\/span><span style=\"font-weight: 400;\">In general, using <\/span><span style=\"font-weight: 400;\">antiarrhythmic<\/span><span style=\"font-weight: 400;\"> drugs with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> is <\/span><span style=\"font-weight: 400;\">contraindicated<\/span><span style=\"font-weight: 400;\">, meaning they should not be taken together at all. <\/span><span style=\"font-weight: 400;\">Examples of these <\/span><span style=\"font-weight: 400;\">antiarrhythmics<\/span><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cordarone (<\/span><span style=\"font-weight: 400;\">amiodarone<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quinidex (<\/span><span style=\"font-weight: 400;\">quinidine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lanoxin (<\/span><span style=\"font-weight: 400;\">digoxin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tambocor (flecainide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rythmol (propafenone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Multaq (dronedarone)<\/span><\/li>\n<\/ul>\n<h3 id=\"cardiovascular-agents\"><b>Cardiovascular agents<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Some heart medications should not be taken with Paxlovid because the interaction can cause serious side effects. Combining Paxlovid with Inspra (eplerenone) should be avoided because the interaction can cause high levels of eplerenone and an increased risk of <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9580069\/\"><span style=\"font-weight: 400;\">high potassium levels<\/span><\/a><span style=\"font-weight: 400;\">. Combining Paxlovid with Corlanor (ivabradine) can increase levels of ivabradine and lead to a slow heart rate or other heart problems.\u00a0<\/span><\/p>\n<h3 id=\"psychiatric-medications\"><b>Psychiatric medications<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Certain <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/medication-for-anxiety-and-depression\/\"><span style=\"font-weight: 400;\">mental health medications<\/span><\/a><span style=\"font-weight: 400;\">, such as antipsychotics and benzodiazepines, may interact with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. Taking a benzodiazepine with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may lead to increased blood levels of the benzodiazepine, which can lead to sedation and respiratory depression, especially with high doses. Benzodiazepines include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Valium (<\/span><span style=\"font-weight: 400;\">diazepam<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Versed (<\/span><span style=\"font-weight: 400;\">midazolam<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Klonopin (<\/span><span style=\"font-weight: 400;\">clonazepam<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Halcion (<\/span><span style=\"font-weight: 400;\">triazolam<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Certain antipsychotics, such as <\/span><span style=\"font-weight: 400;\">lurasidone<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">pimozide<\/span><span style=\"font-weight: 400;\">, should be avoided in combination with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> due to the risk of potentially dangerous <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4345877\/\"><span style=\"font-weight: 400;\">heart rhythm problems<\/span><\/a><span style=\"font-weight: 400;\">. In some cases, the dosage of the antipsychotic drug may need to be reduced while taking <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. Antipsychotic medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clozaril (<\/span><span style=\"font-weight: 400;\">clozapine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orap (<\/span><span style=\"font-weight: 400;\">pimozide<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Latuda (<\/span><span style=\"font-weight: 400;\">lurasidone<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seroquel (<\/span><span style=\"font-weight: 400;\">quetiapine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In addition, <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may affect the levels of certain antidepressants. It can decrease the levels of bupropion and increase the levels of <\/span><span style=\"font-weight: 400;\">trazodone<\/span><span style=\"font-weight: 400;\">, which may require changes in dosages.\u00a0<\/span><\/p>\n<h3 id=\"erectile-dysfunction-ed-medications\"><b>Erectile dysfunction (ED)<\/b><b> medications<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> can interact with medications used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/erectile-dysfunction-treatment-and-medications\"><span style=\"font-weight: 400;\">ED<\/span><\/a><span style=\"font-weight: 400;\">. The co-administration of <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may lead to elevated blood levels of these ED drugs, which can increase the risk of <\/span><span style=\"font-weight: 400;\">adverse effects<\/span><span style=\"font-weight: 400;\"> like low blood pressure, a prolonged and painful erection (priapism), and vision changes. Some common <\/span><span style=\"font-weight: 400;\">ED<\/span><span style=\"font-weight: 400;\"> medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viagra (<\/span><span style=\"font-weight: 400;\">sildenafil<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cialis (<\/span><span style=\"font-weight: 400;\">tadalafil<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Levitra (<\/span><span style=\"font-weight: 400;\">vardenafil<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stendra (avanafil)<\/span><\/li>\n<\/ul>\n<h3 id=\"migraine-medications\"><b>Migraine medications<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">A <\/span><span style=\"font-weight: 400;\">drug interaction<\/span><span style=\"font-weight: 400;\"> is also possible with medications prescribed to <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">treat migraines<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> could increase blood levels of these medications, potentially leading to increased side effects. For example, taking ergot derivatives like <\/span><span style=\"font-weight: 400;\">dihydroergotamine<\/span><span style=\"font-weight: 400;\"> and ergotamine with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> could lead to ergot <\/span><span style=\"font-weight: 400;\">toxicity with symptoms like <\/span><span style=\"font-weight: 400;\">nausea, dizziness, and increased blood pressure<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Examples of migraine medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Migranal (<\/span><span style=\"font-weight: 400;\">dihydroergotamine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ergomar (ergotamine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Relpax (eletriptan)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ubrelvy (ubrogepant)<\/span><\/li>\n<\/ul>\n<h3 id=\"opioids-and-opioid-antagonists\"><b>Opioids and opioid antagonists<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">There is a potential interaction between Paxlovid and certain <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">opioid pain medications<\/span><\/a><span style=\"font-weight: 400;\">. Taking Paxlovid can increase the levels of opioids, which may lead to serious side effects such as severe respiratory depression. In addition, taking Paxlovid with the opioid antagonist naloxegol is not recommended due to the risk of opioid withdrawal symptoms. Some examples of opioids include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Duragesic (fentanyl)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zohydro ER (hydrocodone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oxycontin (oxycodone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Demerol (meperidine)<\/span><\/li>\n<\/ul>\n<h3 id=\"hormonal-contraceptives\"><b>Hormonal <\/b><b>contraceptives<\/b><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/contraceptives\"><span style=\"font-weight: 400;\">Birth control pills<\/span><\/a><span style=\"font-weight: 400;\"> like those containing <\/span><span style=\"font-weight: 400;\">ethinyl estradiol<\/span><span style=\"font-weight: 400;\"> may interact with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. This interaction can alter the <\/span><span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\">&#8216;s effectiveness, leading to an increased risk of unintended pregnancy. It\u2019s recommended to use other forms of <\/span><span style=\"font-weight: 400;\">contraception<\/span><span style=\"font-weight: 400;\">, such as condoms, during treatment with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. In addition, non-oral <\/span><span style=\"font-weight: 400;\">contraceptives<\/span><span style=\"font-weight: 400;\"> should be continued until one menstrual cycle after stopping <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. Common hormonal <\/span><span style=\"font-weight: 400;\">contraceptives<\/span><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yaz (drospirenone and ethinyl estradiol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ortho Tri-Cyclen (norgestimate and ethinyl estradiol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Femynor (norgestimate and ethinyl estradiol)<\/span><\/li>\n<\/ul>\n<h3 id=\"immunosuppressants\"><b>Immunosuppressants<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may interact with immunosuppressants commonly used to prevent organ rejection after transplantation. Elevated blood levels of these drugs could increase the <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8754454\/\"><span style=\"font-weight: 400;\">risks of <\/span><span style=\"font-weight: 400;\">adverse events<\/span><\/a><span style=\"font-weight: 400;\">, such as kidney damage. It\u2019s generally recommended to avoid combining these immunosuppressants with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">, although <\/span><span style=\"font-weight: 400;\">certain immunosuppressants<\/span><span style=\"font-weight: 400;\"> may be used with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> if the dosage is adjusted and side effects are monitored. Examples of these immunosuppressants include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prograf (<\/span><span style=\"font-weight: 400;\">tacrolimus<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rapamune (<\/span><span style=\"font-weight: 400;\">sirolimus<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sandimmune (<\/span><span style=\"font-weight: 400;\">cyclosporine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zortress (everolimus)<\/span><\/li>\n<\/ul>\n<h3 id=\"anticonvulsants\"><b>Anticonvulsants<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Certain <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticonvulsants\"><span style=\"font-weight: 400;\">anticonvulsants<\/span><\/a><span style=\"font-weight: 400;\"> can interact with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">, decreasing the levels of <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> in the body. This interaction may lead to decreased effectiveness and potential viral resistance to <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. It\u2019s recommended to avoid taking anticonvulsants with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. The anticonvulsants in question include:<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Luminal (<\/span><span style=\"font-weight: 400;\">phenobarbital<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dilantin (<\/span><span style=\"font-weight: 400;\">phenytoin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tegretol (<\/span><span style=\"font-weight: 400;\">carbamazepine<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mysoline (primidone)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is a general guide and may not cover all the interactions of <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. Those who take medications other than <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> should consult their prescribing <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> for possible <\/span><span style=\"font-weight: 400;\">dose adjustments<\/span><span style=\"font-weight: 400;\"> or alternative options when prescribed <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2 id=\"paxlovid-food-interactions\"><b>Paxlovid food<\/b><b> interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">According to the <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/217188s010lbl.pdf\"><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\"> label<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> can be taken with or without food. Eating a high-fat meal did not significantly affect the blood levels of nirmatrelvir. However, studies have shown that eating a meal may decrease the levels of <\/span><span style=\"font-weight: 400;\">ritonavir<\/span><span style=\"font-weight: 400;\"> by <\/span><a href=\"https:\/\/jiasociety.biomedcentral.com\/articles\/10.1186\/1758-2652-11-S1-P247\"><span style=\"font-weight: 400;\">around 20%<\/span><\/a><span style=\"font-weight: 400;\">, which could lead to decreased effectiveness of the drug.\u00a0<\/span><\/p>\n<h3 id=\"paxlovid-and-grapefruit\"><b>Paxlovid<\/b><b> and grapefruit<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Although this interaction isn\u2019t mentioned on the drug label, grapefruit may prevent your body from <\/span><a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/grapefruit-juice-and-some-drugs-dont-mix\"><span style=\"font-weight: 400;\">breaking down Paxlovid properly<\/span><\/a><span style=\"font-weight: 400;\">, increasing the risk of side effects. It&#8217;s best to avoid grapefruit and grapefruit juice while taking Paxlovid.<\/span><\/p>\n<h3 id=\"paxlovid-and-alcohol\"><b>Paxlovid<\/b><b> and alcohol<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">There\u2019s no known direct interaction between Paxlovid and alcohol, but alcohol can <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7944101\/\"><span style=\"font-weight: 400;\">weaken your immune system<\/span><\/a><span style=\"font-weight: 400;\"> and worsen side effects. Limiting or avoiding alcohol is recommended.<\/span><\/p>\n<h3 id=\"paxlovid-and-caffeine\"><b>Paxlovid<\/b><b> and caffeine<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Caffeine may <\/span><a href=\"https:\/\/go.drugbank.com\/drugs\/DB00503\"><span style=\"font-weight: 400;\">increase side effects<\/span><\/a><span style=\"font-weight: 400;\"> for some people on Paxlovid. Moderate intake, like a cup of coffee, is generally safe.<\/span><\/p>\n<h3 id=\"dietary-recommendations\"><b>Dietary recommendations<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">For people with or at risk of infection with the <\/span><span style=\"font-weight: 400;\">coronavirus<\/span><span style=\"font-weight: 400;\">, it may be beneficial to consider <\/span><a href=\"https:\/\/www.emro.who.int\/nutrition\/covid-19\/nutrition-advice-for-adults-during-the-covid-19-outbreak.html\"><span style=\"font-weight: 400;\">dietary recommendations<\/span><\/a><span style=\"font-weight: 400;\">. Maintaining a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats is recommended to support the immune system. <\/span><span style=\"font-weight: 400;\">Healthcare providers<\/span><span style=\"font-weight: 400;\"> may also recommend staying well-hydrated by drinking water and avoiding excessive caffeine or sugar to maintain optimal health.\u00a0<\/span><\/p>\n<h2 id=\"other-paxlovid-interactions\"><b>Other <\/b><b>Paxlovid<\/b><b> interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may also interact with herbal or dietary supplements and other OTC medicines. <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may interact with other substances, including:<\/span><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>St. John&#8217;s wort<\/b><span style=\"font-weight: 400;\">: Taking this herbal supplement with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may lead to reduced blood levels of <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">. As a result, <\/span><span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><span style=\"font-weight: 400;\"> may decrease the effectiveness of <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cannabis<\/b><span style=\"font-weight: 400;\">: While specific interactions between <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> and cannabis are not well-established, ritonavir in Paxlovid may affect the <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8298645\/\"><span style=\"font-weight: 400;\">metabolism of THC and CBD in cannabis<\/span><\/a><span style=\"font-weight: 400;\">. Mixing Paxlovid and cannabis use could lead to increased <\/span><span style=\"font-weight: 400;\">concentrations<\/span><span style=\"font-weight: 400;\"> and more potent effects of THC and CBD.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Cough and cold medicines<\/b><span style=\"font-weight: 400;\">: These medicines should generally be safe to take with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> when taken as directed. However, some cough and cold medicines may contain dextromethorphan, a cough suppressant. <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> may slightly increase the levels of dextromethorphan in the body and increase the risk of side effects.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Consult your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> about any supplements or other substances you are taking before starting treatment with <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"how-to-minimize-paxlovid-interactions\"><b>How to minimize <\/b><b>Paxlovid<\/b><b> interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The best way to reduce the risk of Paxlovid interactions is to be aware of potential interactions with other medications or supplements you may be taking. Keep an <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/medication-list-template\/\"><span style=\"font-weight: 400;\">updated list<\/span><\/a><span style=\"font-weight: 400;\"> at all times and relay all medications you take to your healthcare provider so they can determine whether there\u2019s a risk of drug interactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition, pay attention to how you feel during treatment. If you notice any unusual side effects or changes in your health, contact your healthcare provider. They can help determine if these symptoms are related to drug interactions and make changes to your treatment plan as needed.<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-paxlovid-interactions\"><b>When to talk to a <\/b><b>healthcare provider<\/b><b> about <\/b><b>Paxlovid<\/b><b> interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">You should talk to a <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> about <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> interactions during the initial visit when they prescribe the medication. You can also consult your local pharmacist if you have concerns about <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In general, you should talk to <\/span><span style=\"font-weight: 400;\">healthcare providers<\/span><span style=\"font-weight: 400;\"> about <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> interactions if you:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take any prescription or over-the-counter medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use any dietary supplements or herbal products<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have any medical conditions or a history of certain illnesses, including kidney or renal impairment, liver problems such as hepatitis, and human immunodeficiency virus 1 (HIV-1)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Experience any unexpected side effects or changes in health<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This article does not provide a complete list of <\/span><span style=\"font-weight: 400;\">Paxlovid<\/span><span style=\"font-weight: 400;\"> interactions. Discuss your overall medical history, including medical conditions and other medications you take, with your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> before starting treatment. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paxlovid is an oral antiviral medication developed to treat COVID-19. The drug consists of two active ingredients, nirmatrelvir and ritonavir, which work as protease inhibitors to reduce the spread and number of viruses in the body. Paxlovid can be a useful drug that can decrease the risk of hospitalization or death in high-risk individuals with [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":60500,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[14636,814],"coauthors":[8669],"class_list":["post-60499","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-coronavirus","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Paxlovid interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Paxlovid interacts with statins, calcium channel blockers, ED medications, and hormonal contraceptives. Here\u2019s what you should not take with Paxlovid to avoid side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Paxlovid interactions to avoid\" \/>\n<meta property=\"og:description\" content=\"Paxlovid interacts with statins, calcium channel blockers, ED medications, and hormonal contraceptives. Here\u2019s what you should not take with Paxlovid to avoid side effects.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-26T14:02:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-17T22:31:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/paxlovid-interactions.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Gerardo Sison, Pharm.D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gerardo Sison, Pharm.D.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"Paxlovid interactions to avoid\",\"datePublished\":\"2023-09-26T14:02:33+00:00\",\"dateModified\":\"2025-04-17T22:31:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/\"},\"wordCount\":1663,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/paxlovid-interactions.png\",\"keywords\":[\"COVID-19\",\"Drug interactions\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/\",\"name\":\"Paxlovid interactions to avoid | SingleCare\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/paxlovid-interactions.png\",\"datePublished\":\"2023-09-26T14:02:33+00:00\",\"dateModified\":\"2025-04-17T22:31:32+00:00\",\"description\":\"Paxlovid interacts with statins, calcium channel blockers, ED medications, and hormonal contraceptives. Here\u2019s what you should not take with Paxlovid to avoid side effects.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/paxlovid-interactions.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/paxlovid-interactions.png\",\"width\":1920,\"height\":1080,\"caption\":\"Rx pill bottle and prescription pad: Paxlovid interactions\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/paxlovid-interactions\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Paxlovid interactions to avoid\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\",\"name\":\"Christie Falzone\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"caption\":\"Christie Falzone\"},\"description\":\"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/cfalzone\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Paxlovid interactions to avoid | SingleCare","description":"Paxlovid interacts with statins, calcium channel blockers, ED medications, and hormonal contraceptives. Here\u2019s what you should not take with Paxlovid to avoid side effects.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/","og_locale":"en_US","og_type":"article","og_title":"Paxlovid interactions to avoid","og_description":"Paxlovid interacts with statins, calcium channel blockers, ED medications, and hormonal contraceptives. Here\u2019s what you should not take with Paxlovid to avoid side effects.","og_url":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2023-09-26T14:02:33+00:00","article_modified_time":"2025-04-17T22:31:32+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/paxlovid-interactions.png","type":"image\/png"}],"author":"Gerardo Sison, Pharm.D.","twitter_card":"summary_large_image","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Gerardo Sison, Pharm.D.","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/"},"author":{"name":"Christie Falzone","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e"},"headline":"Paxlovid interactions to avoid","datePublished":"2023-09-26T14:02:33+00:00","dateModified":"2025-04-17T22:31:32+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/"},"wordCount":1663,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/paxlovid-interactions.png","keywords":["COVID-19","Drug interactions"],"articleSection":["Drug Info"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/","url":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/","name":"Paxlovid interactions to avoid | SingleCare","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/paxlovid-interactions.png","datePublished":"2023-09-26T14:02:33+00:00","dateModified":"2025-04-17T22:31:32+00:00","description":"Paxlovid interacts with statins, calcium channel blockers, ED medications, and hormonal contraceptives. Here\u2019s what you should not take with Paxlovid to avoid side effects.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/paxlovid-interactions.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/paxlovid-interactions.png","width":1920,"height":1080,"caption":"Rx pill bottle and prescription pad: Paxlovid interactions"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/paxlovid-interactions\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Paxlovid interactions to avoid"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e","name":"Christie Falzone","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7","url":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","caption":"Christie Falzone"},"description":"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.","url":"https:\/\/www.singlecare.com\/blog\/author\/cfalzone\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/60499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/133"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=60499"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/60499\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/60500"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=60499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=60499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=60499"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=60499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}