{"id":60512,"date":"2023-09-26T11:04:46","date_gmt":"2023-09-26T15:04:46","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60512"},"modified":"2025-10-22T17:08:36","modified_gmt":"2025-10-22T21:08:36","slug":"metoprolol-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/","title":{"rendered":"Metoprolol interactions to avoid"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Metoprolol is a generic, FDA-approved prescription medication classified as a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/beta-blockers\"><span style=\"font-weight: 400;\">beta blocker<\/span><\/a><span style=\"font-weight: 400;\">. It&#8217;s prescribed to treat hypertension (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypertension-treatments-and-medications\"><span style=\"font-weight: 400;\">high blood pressure<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/chest-pain-causes-treatment\/\"><span style=\"font-weight: 400;\">angina<\/span><\/a><span style=\"font-weight: 400;\"> (chest pain), and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/congestive-heart-failure-treatment-and-medications\"><span style=\"font-weight: 400;\">heart failure<\/span><\/a><span style=\"font-weight: 400;\">, and to improve survival after a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/panic-attack-vs-heart-attack\/\"><span style=\"font-weight: 400;\">heart attack<\/span><\/a><span style=\"font-weight: 400;\">. Brand names for metoprolol include Lopressor (metoprolol tartrate immediate-release tablets), Toprol XL (metoprolol succinate extended-release tablets), and Kapspargo (metoprolol succinate extended-release capsules).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like many medications, metoprolol can interact with other drugs, foods, and substances. These interactions can make metoprolol less effective or increase the risk of side effects. Here\u2019s what you need to know to stay safe while taking metoprolol.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Metoprolol with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tMetoprolol 25 mg (60 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.13<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metoprolol-tartrate#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metoprolol-tartrate#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.13<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metoprolol-tartrate#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metoprolol-tartrate#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metoprolol-tartrate#blog-cta\" class=\"coupon-see-all-btn\">See Metoprolol prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2 id=\"metoprolol-drug-interactions\"><span style=\"font-weight: 400;\">Metoprolol-drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Metoprolol can interact with various prescription and over-the-counter (OTC) medications to varying degrees of severity. Before you take metoprolol, tell your healthcare provider about all the medications you take, including prescription drugs, OTC medicines, vitamins, and supplements. Check with your doctor before starting any new medications while taking metoprolol.<\/span><\/p>\n<h3 id=\"monoamine-oxidase-inhibitors-maois\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors (MAOIs)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drugs in the MAOI class can have an additive effect with beta blockers like metoprolol, which can cause low blood pressure or a slow heartbeat. This can lead to vertigo (a spinning sensation), fainting, or orthostatic hypotension (a drop in blood pressure when you stand up from a sitting or lying down position). If you take an MAOI, your doctor may prescribe a lower dose of metoprolol and monitor you closely. Or, your doctor may choose a different drug to replace the MAOI. Some examples of MAOIs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/azilect\"><span style=\"font-weight: 400;\">Azilect (rasagiline)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/emsam\"><span style=\"font-weight: 400;\">Emsam (selegiline)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/marplan\"><span style=\"font-weight: 400;\">Marplan (isocarboxazid)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/nardil\/what-is\"><span style=\"font-weight: 400;\">Nardil (phenelzine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/parnate\"><span style=\"font-weight: 400;\">Parnate (tranylcypromine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/zyvox\/what-is\"><span style=\"font-weight: 400;\">Zyvox (linezolid)<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"cyp2d6-inhibitors\"><span style=\"font-weight: 400;\">CYP2D6 inhibitors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Metoprolol is metabolized in the body by an enzyme called cytochrome P450 2D6 (CYP2D6). Other medications that inhibit this enzyme can lead to increased levels of metoprolol in the body, which can cause serious side effects. If possible, the combination of interacting drugs should be avoided. If this is not possible, the patient should be closely monitored. Some examples of drugs metabolized by CYP2D6 include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">Antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/paxil\"><span style=\"font-weight: 400;\">Paxil (paroxetine)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/wellbutrin-xl\/what-is\"><span style=\"font-weight: 400;\">Wellbutrin (bupropion)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prozac\"><span style=\"font-weight: 400;\">Prozac (fluoxetine)<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">Zoloft (sertraline)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antipsychotics such as Haldol (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/haloperidol\"><span style=\"font-weight: 400;\">haloperidol<\/span><\/a><span style=\"font-weight: 400;\">) or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/chlorpromazine-hcl\"><span style=\"font-weight: 400;\">chlorpromazine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antiarrhythmics (medicines for an irregular heartbeat) such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/quinidine-sulfate\"><span style=\"font-weight: 400;\">quinidine<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/propafenone-hcl\/what-is\"><span style=\"font-weight: 400;\">propafenone<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antiretrovirals such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/norvir\"><span style=\"font-weight: 400;\">Norvir (ritonavir)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antihistamines such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/diphenhydramine-interactions\/\"><span style=\"font-weight: 400;\">Benadryl (diphenhydramine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antimalarial drugs such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/plaquenil\"><span style=\"font-weight: 400;\">Plaquenil (hydroxychloroquine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antifungal medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lamisil-at\"><span style=\"font-weight: 400;\">Lamisil (terbinafine)<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"drugs-that-cause-bradycardia-slow-heart-rate\"><span style=\"font-weight: 400;\">Drugs that cause bradycardia (slow heart rate)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Beta blockers like metoprolol slow the heart rate, so if metoprolol is combined with another drug that slows the heart rate, there is an increased risk of bradycardia. The patient will be closely monitored if the combination cannot be avoided. Examples of drugs that cause bradycardia include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/calcium-channel-blockers\"><span style=\"font-weight: 400;\">calcium channel blockers<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/verapamil-side-effects\/\"><span style=\"font-weight: 400;\">verapamil<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cardizem\"><span style=\"font-weight: 400;\">Cardizem (diltiazem)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Catapres (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clonidine\/what-is\"><span style=\"font-weight: 400;\">clonidine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lanoxin (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/digoxin\/what-is\"><span style=\"font-weight: 400;\">digoxin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<h3 id=\"alpha-adrenergic-blockers\"><span style=\"font-weight: 400;\">Alpha-adrenergic blockers<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/alpha-blockers\"><span style=\"font-weight: 400;\">Alpha blockers<\/span><\/a><span style=\"font-weight: 400;\"> lower blood pressure, and beta blockers like metoprolol may potentiate the effect. If you take an alpha blocker, consult your healthcare provider for medical advice.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Different alpha blockers may require different interventions. For example, metoprolol may worsen <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/low-blood-pressure\/\"><span style=\"font-weight: 400;\">orthostatic hypotension<\/span><\/a><span style=\"font-weight: 400;\"> caused by prazosin. But <a href=\"https:\/\/www.singlecare.com\/prescription\/clonidine-hcl\/what-is\">clonidine<\/a> has a different interaction\u2014if you are taking both clonidine and metoprolol, and need to stop taking clonidine, you will need to stop taking metoprolol a few days before you stop taking clonidine, to lower the risk of rebound high blood pressure. Examples of alpha blockers include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardura (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cardura\"><span style=\"font-weight: 400;\">doxazosin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Catapres (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/clonidine-side-effects\/\"><span style=\"font-weight: 400;\">clonidine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Minipress (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/prazosin-without-insurance\/\"><span style=\"font-weight: 400;\">prazosin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">One exception is in people who have an adrenal gland tumor called pheochromocytoma. In these individuals, metoprolol should be used along with an alpha blocker, after the alpha blocker has been started.\u00a0<\/span><\/p>\n<h3 id=\"over-the-counter-cough-cold-and-flu-medicines\"><span style=\"font-weight: 400;\">Over-the-counter cough, cold, and flu medicines<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many over-the-counter (OTC) <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/flu-cold-medicine-interactions\/\"><span style=\"font-weight: 400;\">cough, cold, or flu medications<\/span><\/a><span style=\"font-weight: 400;\"> contain multiple ingredients that can interfere with heart or blood pressure conditions and interfere with your medication. If you need to take an OTC medication, ask your doctor or pharmacist about the safest options based on your medical conditions. Some examples of drugs that may interact with your condition or medication include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decongestants such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phenylephrine-vs-pseudoephedrine\/\"><span style=\"font-weight: 400;\">pseudoephedrine or phenylephrine<\/span><\/a><span style=\"font-weight: 400;\">, which can increase blood pressure and\/or decrease the effect of metoprolol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antihistamines like Benadryl (diphenhydramine), which can increase the risk of metoprolol adverse effects, including low blood pressure and slow heart rate\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs<\/span><\/a><span style=\"font-weight: 400;\"> (NSAIDs) like ibuprofen, aspirin, or naproxen can make metoprolol less effective<\/span><\/li>\n<\/ul>\n<h3 id=\"epipen-epinephrine\"><span style=\"font-weight: 400;\">EpiPen (epinephrine)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/epipen-instructions-information\/\"><span style=\"font-weight: 400;\">Epinephrine<\/span><\/a><span style=\"font-weight: 400;\"> is a life-saving medicine used for severe allergic reactions. Metoprolol should be used with caution in people who have a history of anaphylactic reactions. These individuals may have more severe reactions to allergens while taking metoprolol\u2014and may also be unresponsive to the usual doses of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-get-an-epipen\/\"><span style=\"font-weight: 400;\">epinephrine<\/span><\/a><span style=\"font-weight: 400;\"> used to treat the allergic reaction. Ask your doctor for medical advice if you have a history of allergic reactions.\u00a0<\/span><\/p>\n<h2 id=\"other-metoprolol-interactions\"><span style=\"font-weight: 400;\">Other metoprolol interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In addition to drug-drug interactions, it\u2019s always important to know if your medication interacts with certain foods, drinks, or medical conditions. While metoprolol has no notable food interactions, it is recommended to be taken with or just after a meal. Here are some other interactions and warnings to be aware of.\u00a0<\/span><\/p>\n<h3 id=\"metoprolol-and-alcohol\"><span style=\"font-weight: 400;\">Metoprolol and alcohol\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol and metoprolol can both cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metoprolol-side-effects\/\"><span style=\"font-weight: 400;\">dizziness, lightheadedness, and low blood pressure<\/span><\/a><span style=\"font-weight: 400;\">. Combining them may increase these effects. If you drink alcohol, talk to your provider. People taking Kapspargo should avoid alcohol entirely, as it may cause the drug to release too quickly.<\/span><\/p>\n<h3 id=\"metoprolol-and-caffeine\"><span style=\"font-weight: 400;\">Metoprolol and caffeine\u00a0<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/caffeine-and-beta-blockers\/\"><span style=\"font-weight: 400;\">Caffeine<\/span><\/a><span style=\"font-weight: 400;\"> may reduce the effectiveness of beta blockers like metoprolol and raise your heart rate or blood pressure. Small amounts may be okay, depending on your health condition. Ask your provider what\u2019s safe for you.<\/span><\/p>\n<h3 id=\"metoprolol-and-certain-medical-conditions\"><span style=\"font-weight: 400;\">Metoprolol and certain medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before taking metoprolol, tell your physician about all of your medical conditions and medical history, as well as your family history. Metoprolol is not safe for everyone. You should not take this medication if you:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are allergic to metoprolol, any beta blocker, or any ingredient in the medication<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have severe <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/low-heart-rate-causes\"><span style=\"font-weight: 400;\">bradycardia<\/span><\/a><span style=\"font-weight: 400;\"> (slow heart rate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have second-degree or third-degree <\/span><a href=\"https:\/\/www.hopkinsmedicine.org\/health\/conditions-and-diseases\/heart-block\"><span style=\"font-weight: 400;\">heart block<\/span><\/a><span style=\"font-weight: 400;\"> (interference with electrical signals that tell your heart when to beat)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are in <\/span><a href=\"https:\/\/www.nhlbi.nih.gov\/health\/cardiogenic-shock\"><span style=\"font-weight: 400;\">cardiac shock<\/span><\/a><span style=\"font-weight: 400;\"> (a life-threatening emergency where the heart cannot pump enough blood and oxygen to the brain and other organs)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/21686-acute-heart-failure\"><span style=\"font-weight: 400;\">decompensated heart failure<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have sick sinus syndrome (heart rhythm problems caused by the heart\u2019s pacemaker), unless you have a permanent pacemaker<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a severe <\/span><a href=\"https:\/\/www.cdc.gov\/heartdisease\/PAD.htm\"><span style=\"font-weight: 400;\">peripheral arterial circulatory disorder<\/span><\/a><span style=\"font-weight: 400;\"> (a narrowing or blockage of the vessels that carry blood from the heart to the legs)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Metoprolol may not be appropriate for people with certain other medical conditions. Tell your healthcare provider if you have any medical conditions, including if you are pregnant or breastfeeding.<\/span><\/p>\n<h2 id=\"how-to-minimize-metoprolol-interactions\"><span style=\"font-weight: 400;\">How to minimize metoprolol interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Here are some tips to minimize the risk of metoprolol interactions:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Before taking metoprolol, make sure your doctor knows your full medical history and all of the medications you take, so they can screen for drug interactions or other potential problems. While taking metoprolol, do not start any new medications unless approved by your doctor. Keep an <\/span><a href=\"https:\/\/www.ahrq.gov\/health-literacy\/improve\/pharmacy\/medicine-list.html\"><span style=\"font-weight: 400;\">updated list<\/span><\/a><span style=\"font-weight: 400;\"> of your medications with you.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metoprolol may cause fatigue and dizziness. Do not drive or operate machinery until you know how metoprolol affects you.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoid or limit alcohol while taking metoprolol. If you drink alcohol, consult your doctor for medical advice.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Know the possible side effects of metoprolol\u2014side effects can worsen if you take an interacting drug. Common side effects include tiredness, dizziness, constipation or diarrhea, depression, shortness of breath, low blood pressure, slow heart rate, and nightmares. Report side effects to your doctor, or get emergency medical help for severe symptoms. You should also get emergency medical help if you experience symptoms of an allergic reaction, such as hives, trouble breathing, or swelling of the face, lips, tongue, or throat.\u00a0<\/span><\/li>\n<\/ol>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-metoprolol-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about metoprolol interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because there are various potential metoprolol interactions, this article does not provide a complete list. It is important to communicate with your healthcare provider about all of your medical conditions and the medications you take. This will help minimize the risk of interactions and ensure proper management and monitoring.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metoprolol is a generic, FDA-approved prescription medication classified as a beta blocker. It&#8217;s prescribed to treat hypertension (high blood pressure), angina (chest pain), and heart failure, and to improve survival after a heart attack. Brand names for metoprolol include Lopressor (metoprolol tartrate immediate-release tablets), Toprol XL (metoprolol succinate extended-release tablets), and Kapspargo (metoprolol succinate extended-release [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":60514,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[814,737],"coauthors":[10668],"class_list":["post-60512","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-interactions","tag-heart-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Metoprolol interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Metoprolol (Lopressor) interacts with MAOIs, CYP2D6 inhibitors, alpha blockers, and alcohol. Here\u2019s what you should not take with metoprolol to minimize the chance of side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Metoprolol interactions to avoid\" \/>\n<meta property=\"og:description\" content=\"Metoprolol (Lopressor) interacts with MAOIs, CYP2D6 inhibitors, alpha blockers, and alcohol. Here\u2019s what you should not take with metoprolol to minimize the chance of side effects.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-26T15:04:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-22T21:08:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/metoprolol-interactions.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Karen Berger, Pharm.D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karen Berger, Pharm.D.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"Metoprolol interactions to avoid\",\"datePublished\":\"2023-09-26T15:04:46+00:00\",\"dateModified\":\"2025-10-22T21:08:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/\"},\"wordCount\":1348,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/metoprolol-interactions.png\",\"keywords\":[\"Drug interactions\",\"Heart health\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/\",\"name\":\"Metoprolol interactions to avoid | SingleCare\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/metoprolol-interactions.png\",\"datePublished\":\"2023-09-26T15:04:46+00:00\",\"dateModified\":\"2025-10-22T21:08:36+00:00\",\"description\":\"Metoprolol (Lopressor) interacts with MAOIs, CYP2D6 inhibitors, alpha blockers, and alcohol. Here\u2019s what you should not take with metoprolol to minimize the chance of side effects.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/metoprolol-interactions.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/09\\\/metoprolol-interactions.png\",\"width\":1920,\"height\":1080,\"caption\":\"Rx pill bottle and prescription pad: Metoprolol interactions\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/metoprolol-interactions\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Metoprolol interactions to avoid\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\",\"name\":\"Christie Falzone\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"caption\":\"Christie Falzone\"},\"description\":\"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/cfalzone\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Metoprolol interactions to avoid | SingleCare","description":"Metoprolol (Lopressor) interacts with MAOIs, CYP2D6 inhibitors, alpha blockers, and alcohol. Here\u2019s what you should not take with metoprolol to minimize the chance of side effects.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/","og_locale":"en_US","og_type":"article","og_title":"Metoprolol interactions to avoid","og_description":"Metoprolol (Lopressor) interacts with MAOIs, CYP2D6 inhibitors, alpha blockers, and alcohol. Here\u2019s what you should not take with metoprolol to minimize the chance of side effects.","og_url":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2023-09-26T15:04:46+00:00","article_modified_time":"2025-10-22T21:08:36+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/metoprolol-interactions.png","type":"image\/png"}],"author":"Karen Berger, Pharm.D.","twitter_card":"summary_large_image","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Karen Berger, Pharm.D.","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/"},"author":{"name":"Christie Falzone","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e"},"headline":"Metoprolol interactions to avoid","datePublished":"2023-09-26T15:04:46+00:00","dateModified":"2025-10-22T21:08:36+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/"},"wordCount":1348,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/metoprolol-interactions.png","keywords":["Drug interactions","Heart health"],"articleSection":["Drug Info"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/","url":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/","name":"Metoprolol interactions to avoid | SingleCare","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/metoprolol-interactions.png","datePublished":"2023-09-26T15:04:46+00:00","dateModified":"2025-10-22T21:08:36+00:00","description":"Metoprolol (Lopressor) interacts with MAOIs, CYP2D6 inhibitors, alpha blockers, and alcohol. Here\u2019s what you should not take with metoprolol to minimize the chance of side effects.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/metoprolol-interactions.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/09\/metoprolol-interactions.png","width":1920,"height":1080,"caption":"Rx pill bottle and prescription pad: Metoprolol interactions"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/metoprolol-interactions\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Metoprolol interactions to avoid"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e","name":"Christie Falzone","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7","url":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","caption":"Christie Falzone"},"description":"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.","url":"https:\/\/www.singlecare.com\/blog\/author\/cfalzone\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/60512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/133"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=60512"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/60512\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/60514"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=60512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=60512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=60512"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=60512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}