{"id":60626,"date":"2023-10-03T10:57:03","date_gmt":"2023-10-03T14:57:03","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60626"},"modified":"2025-08-29T17:16:31","modified_gmt":"2025-08-29T21:16:31","slug":"hydroxyzine-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/hydroxyzine-interactions\/","title":{"rendered":"Hydroxyzine interactions to avoid"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Likely due to its sedating nature, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\"><span style=\"font-weight: 400;\">hydroxyzine hydrochloride<\/span><\/a><span style=\"font-weight: 400;\"> (generic Vistaril) is an antihistamine that may be preferable to newer options like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zyrtec\"><span style=\"font-weight: 400;\">Zyrtec<\/span><\/a><span style=\"font-weight: 400;\"> (cetirizine), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/claritin\"><span style=\"font-weight: 400;\">Claritin<\/span><\/a><span style=\"font-weight: 400;\"> (loratadine), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allegra-allergy\"><span style=\"font-weight: 400;\">Allegra<\/span><\/a><span style=\"font-weight: 400;\"> (fexofenadine), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/xyzal-allergy-24hr\"><span style=\"font-weight: 400;\">Xyzal<\/span><\/a><span style=\"font-weight: 400;\"> (levocetirizine) for the treatment of pruritus (itching), anxiety, and nausea than <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-non-drowsy-allergy-medicine\/\"><span style=\"font-weight: 400;\">non-drowsy antihistamines<\/span><\/a><span style=\"font-weight: 400;\">. However, drowsiness can be a big problem with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\/what-is\"><span style=\"font-weight: 400;\">hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\">, and combining hydroxyzine with other meds that cause sleepiness, like central nervous system (CNS) depressants, is particularly risky. Other medications can also cause adverse effects when taken with hydroxyzine. To keep yourself safe, you should be aware of the prescription drugs, nonprescription medications, and foods that interact with hydroxyzine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Hydroxyzine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tHydroxyzine 25 mg (30 Tablet)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.95<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.95<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl#blog-cta\" class=\"coupon-see-all-btn\">See Hydroxyzine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2 id=\"hydroxyzine-drug-interactions\"><span style=\"font-weight: 400;\">Hydroxyzine drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The potential for <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=89901966-724b-4773-98b8-ea663ceabd53\"><span style=\"font-weight: 400;\">adverse effects with hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\"> alone is noteworthy. Drowsiness and dizziness are fairly common, along with anticholinergic effects like dry mouth, urinary retention, and constipation. Less common but much more serious is the potential for cardiac QT-prolongation, which can precipitate serious heart rhythm problems. The risk of these issues is raised by taking medications with similar side effects.<\/span><\/p>\n<h3 id=\"cns-depressants\"><span style=\"font-weight: 400;\">CNS depressants<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drugs that cause drowsiness are called CNS depressants. Hydroxyzine falls within that broad category, and coupling it with other medications creates more concern for falls and accidents. CNS depressants that interact with hydroxyzine include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">Opiate analgesics<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/oxaydo\/what-is\"><span style=\"font-weight: 400;\">Oxaydo<\/span><\/a><span style=\"font-weight: 400;\"> (oxycodone), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/morphine-sulfate\/what-is\"><span style=\"font-weight: 400;\">morphine<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/hydrocodone-acetaminophen\/what-is\"><span style=\"font-weight: 400;\">hydrocodone-acetaminophen<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">Benzodiazepines<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/xanax\/what-is\"><span style=\"font-weight: 400;\">Xanax<\/span><\/a><span style=\"font-weight: 400;\"> (alprazolam), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ativan\/what-is\"><span style=\"font-weight: 400;\">Ativan<\/span><\/a><span style=\"font-weight: 400;\"> (lorazepam), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/valium\/what-is\"><span style=\"font-weight: 400;\">Valium<\/span><\/a><span style=\"font-weight: 400;\"> (diazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscle-relaxants\"><span style=\"font-weight: 400;\">Muscle relaxants<\/span><\/a><span style=\"font-weight: 400;\">, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fexmid\/what-is\"><span style=\"font-weight: 400;\">Fexmid<\/span><\/a><span style=\"font-weight: 400;\"> (cyclobenzaprine), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metaxalone\/what-is\"><span style=\"font-weight: 400;\">metaxalone<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/robaxin\/what-is\"><span style=\"font-weight: 400;\">Robaxin<\/span><\/a><span style=\"font-weight: 400;\"> (methocarbamol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticonvulsants\"><span style=\"font-weight: 400;\">Anticonvulsants<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/neurontin\/what-is\"><span style=\"font-weight: 400;\">Neurontin<\/span><\/a><span style=\"font-weight: 400;\"> (gabapentin) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lyrica\/what-is\"><span style=\"font-weight: 400;\">Lyrica<\/span><\/a><span style=\"font-weight: 400;\"> (pregabalin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypnotics, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ambien\/what-is\"><span style=\"font-weight: 400;\">Ambien<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lunesta\/what-is\"><span style=\"font-weight: 400;\">Lunesta<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">Antidepressants<\/span><\/a><span style=\"font-weight: 400;\">, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prozac\/what-is\"><span style=\"font-weight: 400;\">Prozac<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trazodone-hcl\/what-is\"><span style=\"font-weight: 400;\">trazodone<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Symptoms of combining hydroxyzine with CNS depressants could range from mild sleepiness to difficulty waking up or unsteadiness with walking. Severe symptoms are reasons to seek care immediately. Your healthcare provider may not prescribe hydroxyzine if you take another CNS depressant, or they may prescribe a low dose in order to avoid over-sedation. Your healthcare provider will consider your age and any other medical conditions you have before they prescribe hydroxyzine with a CNS depressant.\u00a0<\/span><\/p>\n<h3 id=\"qt-prolonging-drugs\"><span style=\"font-weight: 400;\">QT-prolonging drugs<\/span><\/h3>\n<p><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/17183-long-q-t-syndrome-lqts\"><span style=\"font-weight: 400;\">QT prolongation<\/span><\/a><span style=\"font-weight: 400;\"> amounts to slowing down the electrical reset after heartbeats. This delay increases the chance of a life-threatening heart arrhythmia developing. Besides hydroxyzine, many different types of medications can prolong the QT interval. A few examples include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/macrolides\"><span style=\"font-weight: 400;\">Macrolide antibiotics<\/span><\/a><span style=\"font-weight: 400;\">, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zithromax\/what-is\"><span style=\"font-weight: 400;\">Zithromax<\/span><\/a><span style=\"font-weight: 400;\"> (azithromycin) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\/what-is\"><span style=\"font-weight: 400;\">clarithromycin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/quinolones\"><span style=\"font-weight: 400;\">Quinolone antibiotics<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/levofloxacin\/what-is\"><span style=\"font-weight: 400;\">levofloxacin<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/moxifloxacin-hcl-in-nacl\/what-is\"><span style=\"font-weight: 400;\">moxifloxacin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/atypical-antipsychotics\"><span style=\"font-weight: 400;\">Antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, including <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/seroquel\/what-is\"><span style=\"font-weight: 400;\">Seroquel<\/span><\/a><span style=\"font-weight: 400;\"> (quetiapine) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/risperdal\/what-is\"><span style=\"font-weight: 400;\">Risperdal<\/span><\/a><span style=\"font-weight: 400;\"> (risperidone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">Antidepressants <\/span><\/a><span style=\"font-weight: 400;\">like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/celexa\/what-is\"><span style=\"font-weight: 400;\">Celexa<\/span><\/a><span style=\"font-weight: 400;\"> (citalopram), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/remeron\/what-is\"><span style=\"font-weight: 400;\">Remeron<\/span><\/a><span style=\"font-weight: 400;\"> (mirtazapine), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/doxepin-hcl\/what-is\"><span style=\"font-weight: 400;\">doxepin<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">With so many types of QT-prolonging drugs, this issue is more common than patients may realize, particularly because mental health medications are often used concurrently. If you take multiple medications, make sure to mention them to your healthcare provider before they prescribe hydroxyzine. They\u2019ll assess the risk of QT prolongation and may end up recommending an electrocardiogram (EKG), a simple in-office test, to measure the QT interval.<\/span><\/p>\n<h3 id=\"anticholinergics\"><span style=\"font-weight: 400;\">Anticholinergics<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Anticholinergics are a category of drugs from many different classes that inhibit the action of the neurotransmitter acetylcholine, which plays a large role in various bodily functions. When the neurotransmitter can\u2019t operate as it should, it can result in <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC487008\/\"><span style=\"font-weight: 400;\">anticholinergic side effects<\/span><\/a><span style=\"font-weight: 400;\">, such as blurred vision, difficulty urinating, constipation, confusion, and agitation. Examples of anticholinergics that may react with hydroxyzine include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antihistamines\"><span style=\"font-weight: 400;\">Antihistamines<\/span><\/a><span style=\"font-weight: 400;\">, both sedating (hydroxyzine and diphenhydramine) and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/non-drowsy-benadryl\/\"><span style=\"font-weight: 400;\">non-drowsy<\/span><\/a><span style=\"font-weight: 400;\"> (cetirizine and loratadine) varieties<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">Antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, such as Seroquel, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zyprexa\/what-is\"><span style=\"font-weight: 400;\">Zyprexa<\/span><\/a><span style=\"font-weight: 400;\"> (olanzapine), and Risperdal<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bladder <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscarinic-antagonists\"><span style=\"font-weight: 400;\">antimuscarinics<\/span><\/a><span style=\"font-weight: 400;\">, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trospium-chloride\/what-is\"><span style=\"font-weight: 400;\">trospium<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ditropan-xl\/what-is\"><span style=\"font-weight: 400;\">Ditropan XL<\/span><\/a><span style=\"font-weight: 400;\"> (oxybutynin XL), and Detrol (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tolterodine-tartrate\/what-is\"><span style=\"font-weight: 400;\">tolterodine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inhaled antimuscarinics, including <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/spiriva-respimat\/what-is\"><span style=\"font-weight: 400;\">Spiriva Respimat<\/span><\/a><span style=\"font-weight: 400;\"> (tiotropium), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/atrovent-hfa\/what-is\"><span style=\"font-weight: 400;\">Atrovent HFA<\/span><\/a><span style=\"font-weight: 400;\"> (ipratropium), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/incruse-ellipta\/what-is\"><span style=\"font-weight: 400;\">Incruse Ellipta<\/span><\/a><span style=\"font-weight: 400;\"> (umeclidinium)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tricyclic antidepressants, such as doxepin, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">amitriptyline<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nortriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">nortriptyline<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Higher doses of hydroxyzine and anticholinergics result in more severe side effects, and older adults are more susceptible. If you are experiencing adverse effects and are taking hydroxyzine with or without another anticholinergic, contact your healthcare provider immediately for instructions.<\/span><\/p>\n<h2 id=\"hydroxyzine-food-interactions\"><span style=\"font-weight: 400;\">Hydroxyzine food interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fortunately, hydroxyzine does not have serious interactions with most foods. You can take it with or without a meal. However, do not take hydroxyzine and grapefruit together. Grapefruit and grapefruit juice can slow the way the drug metabolizes in the body, resulting in higher levels of hydroxyzine that can cause an increased risk of QT-prolongation.<\/span><\/p>\n<h2 id=\"other-hydroxyzine-interactions\"><span style=\"font-weight: 400;\">Other hydroxyzine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Drinks are a different story, and unlike foods, certain drinks can have a notable interaction with this antihistamine.<\/span><\/p>\n<h3 id=\"hydroxyzine-interactions-with-alcohol\"><span style=\"font-weight: 400;\">Hydroxyzine interactions with alcohol\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Without a doubt, alcohol is a CNS depressant. Drinking with hydroxyzine can compound your risk of drowsiness, increase your risk of falls, and affect your judgment.\u00a0<\/span><\/p>\n<h3 id=\"hydroxyzine-and-caffeine\"><span style=\"font-weight: 400;\">Hydroxyzine and caffeine<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The effects of combining hydroxyzine and caffeine depend on your reason for taking the medication. For example, taking hydroxyzine for anxiety and drinking <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/hydroxyzine-and-caffeine\/\"><span style=\"font-weight: 400;\">caffeinated beverages<\/span><\/a><span style=\"font-weight: 400;\"> doesn\u2019t make much sense; by taking hydroxyzine for its sedating effects, you counteract it with the stimulation from caffeine. On the other hand, if you are taking hydroxyzine for itching, caffeine may offset the tiredness side effect well.<\/span><\/p>\n<h3 id=\"hydroxyzine-cannabis-and-illicit-drugs\"><span style=\"font-weight: 400;\">Hydroxyzine, cannabis, and illicit drugs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The concern about combining hydroxyzine, cannabis, and illicit drugs is similar to the concern about taking it with alcohol. Combining CNS depressants worsens their effects, especially in regard to increased sedation.<\/span><\/p>\n<h3 id=\"hydroxyzine-and-herbal-supplements\"><span style=\"font-weight: 400;\">Hydroxyzine and herbal supplements<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Plant-based products can fall under CNS depressants like kratom, anticholinergics like Jimson weed, or QT-prolongers like berberine. Just because they are found in nature does not mean that herbs cannot harm you or interact with drugs like hydroxyzine.<\/span><\/p>\n<h2 id=\"how-to-minimize-hydroxyzine-interactions\"><span style=\"font-weight: 400;\">How to minimize hydroxyzine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Awareness and communication are your biggest allies in staying safe during medical treatment. Please be aware of the risks of drug interactions anytime you take a new pill, whether prescribed or over the counter. Review your complete medication list with your healthcare provider and discuss any concerns about additive side effects.<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-hydroxyzine-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about hydroxyzine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Asking about drug interactions when you are first prescribed hydroxyzine is wise. You and your healthcare provider can review your medication list for any concerns. If you have been taking hydroxyzine and are about to start a new prescription or nonprescription pill, stop and ask your healthcare provider or pharmacist for medical advice about any interactions. They\u2019ll be glad you asked, and as a result, you will be safer.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Likely due to its sedating nature, hydroxyzine hydrochloride (generic Vistaril) is an antihistamine that may be preferable to newer options like Zyrtec (cetirizine), Claritin (loratadine), Allegra (fexofenadine), and Xyzal (levocetirizine) for the treatment of pruritus (itching), anxiety, and nausea than non-drowsy antihistamines. However, drowsiness can be a big problem with hydroxyzine, and combining hydroxyzine with [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":60629,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,814],"coauthors":[20732],"class_list":["post-60626","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Hydroxyzine interactions to avoid<\/title>\n<meta name=\"description\" content=\"Hydroxyzine HCl interacts with CNS depressants, QT-prolonging drugs, anticholinergics, and more. 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