{"id":60632,"date":"2023-10-03T11:16:51","date_gmt":"2023-10-03T15:16:51","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60632"},"modified":"2025-11-03T15:53:47","modified_gmt":"2025-11-03T20:53:47","slug":"wellbutrin-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/wellbutrin-alternatives\/","title":{"rendered":"Wellbutrin (bupropion) alternatives: What can I take instead of Wellbutrin?"},"content":{"rendered":"

Wellbutrin<\/span><\/a> is a brand-name prescription drug that treats <\/span>major depressive disorder<\/span><\/a> (MDD). The extended-release version, <\/span>Wellbutrin XL<\/span><\/a>, is also FDA-approved to treat <\/span>seasonal affective disorder<\/span><\/a> (SAD), a type of depression that comes on in certain seasons, like winter. The active ingredient is <\/span>bupropion hydrochloride<\/span><\/a>, an <\/span>atypical antidepressant<\/span><\/a> that does not affect serotonin levels, unlike other antidepressant drug classes, but rather works by blocking the reuptake of norepinephrine and dopamine in the brain. Wellbutrin comes in sustained-release and extended-release oral tablets. If Wellbutrin is not effective or side effects are a problem, prescribers have a wide range of alternative antidepressants or drug combinations that may work better.<\/span><\/p>\n\t\t

\n\t\t\t

Save up to 80% on Wellbutrin with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

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\n\t\t\t\t\tWellbutrin 150 mg (60 Tablets)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$6.20\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$6.20\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Wellbutrin prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

What can I take instead of Wellbutrin?<\/span><\/h2>\n

Wellbutrin typically isn\u2019t a first-choice depression treatment. Instead, the American Psychological Association recommends starting with <\/span>selective serotonin reuptake inhibitors<\/span><\/a> (SSRIs), such as <\/span>Prozac<\/span><\/a> (fluoxetine), or <\/span>serotonin-norepinephrine reuptake inhibitors<\/span><\/a> (SNRIs), such as <\/span>Cymbalta<\/span><\/a> (duloxetine).\u00a0<\/span><\/p>\n

Wellbutrin is typically a second choice when SSRI or SNRI treatment does not work well or side effects are a problem. Wellbutrin has a lower risk of some serious side effects of drugs that increase serotonin activity, particularly <\/span>serotonin syndrome<\/span><\/a>. However, like other antidepressants, Wellbutrin can, in rare cases, worsen depression and make patients suicidal.<\/span><\/p>\n

If Wellbutrin is not effective at improving the symptoms of depression, patients can switch back to first-line treatments like SNRI or SSRI antidepressants. Other atypical antidepressants, including <\/span>trazodone<\/span><\/a>, <\/span>mirtazapine<\/span><\/a>, <\/span>Viibryd<\/span><\/a> (vilazodone), and <\/span>Trintellix<\/span><\/a> (vortioxetine), may be a better option. For some patients\u2014particularly those with other mental health conditions, such as anxiety disorder, or pain\u2014the best treatment may involve less commonly prescribed drugs like tricyclic antidepressants (<\/span>TCAs<\/span><\/a>) or monoamine oxidase inhibitors (<\/span>MAOIs<\/span><\/a>).\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Compare Wellbutrin (bupropion) alternatives<\/span><\/th>\n<\/tr>\n<\/thead>\n
Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Wellbutrin SR<\/span><\/a>\u00a0<\/span><\/p>\n

(bupropion sustained-release)<\/span><\/a>\u00a0<\/span><\/td>\n

$563 for 60, 150 mg tablets<\/span><\/td>\n$6 for 60, 150 mg tablets of generic bupropion SR<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Wellbutrin XL<\/span><\/a>\u00a0<\/span><\/p>\n

(bupropion <\/span><\/a>extended-release<\/span><\/a>)<\/span><\/a>\u00a0<\/span><\/td>\n

$3,603 for 30, 300 mg tablets<\/span><\/td>\n$9 for 30, 300 mg tablets of generic bupropion XL<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
B<\/span>upropion HCl<\/span><\/a> i<\/span>mmediate-release\u00a0<\/span><\/a><\/td>\n$40 for 30, 75 mg tablets<\/span><\/td>\n$9 for 30, 75 mg tablets of generic bupropion<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Trazodone<\/span><\/a>\u00a0<\/span><\/td>\n$41 for 30, 50 mg tablets<\/span><\/td>\n$6 for 30, 50 mg tablets of generic trazodone<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Remeron<\/span><\/a><\/p>\n

(<\/span>mirtazapine<\/span><\/a>)\u00a0<\/span><\/td>\n

$243 for 30, 15 mg tablets<\/span><\/td>\n$9 for 30, 15 mg tablets of generic mirtazapine<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Viibryd<\/span><\/a>\u00a0<\/span><\/p>\n

(<\/span>vilazodone<\/span><\/a>)<\/span><\/td>\n

$434 for 30, 40 mg tablets<\/span><\/td>\n$36 for 30, 40 mg tablets of generic vilazodone<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Trintellix<\/span><\/a>\u00a0<\/span><\/p>\n

(vortioxetine)<\/span><\/td>\n

$679 for 30, 20 mg tablets<\/span><\/td>\n$466 for 30, 20 mg tablets of brand-name Trintellix<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Zoloft<\/span><\/a><\/p>\n

(<\/span>sertraline<\/span><\/a>)<\/span><\/td>\n

$543 for 30, 50 mg tablets<\/span><\/td>\n$9 for 30, 50 mg tablets of generic sertraline<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Prozac <\/span><\/a>(<\/span>fluoxetine<\/span><\/a>)<\/span><\/td>\n$650 for 30, 20 mg capsules<\/span><\/td>\n$6 for 30, 20 mg capsules of generic fluoxetine<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Duloxetine<\/span><\/a><\/td>\n$217 for 30, 60 mg capsules<\/span><\/td>\n$8 for 30, 60 mg capsules of generic duloxetine<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Lexapro<\/span><\/a> (<\/span>escitalopram<\/span><\/a>)<\/span><\/td>\n$560 for 30, 10 mg tablets<\/span><\/td>\n$9 for 30, 10 mg tablets of generic escitalopram<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Effexor XR <\/span><\/a>(<\/span>venlafaxine extended-release<\/span><\/a>)<\/span><\/td>\n$766 for 30, 150 mg capsules<\/span><\/td>\n$6 for 30, 150 mg capsules of generic venlafaxine ER<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Celexa<\/span><\/a> (<\/span>citalopram<\/span><\/a>)<\/span><\/td>\n$368 for 30, 20 mg tablets<\/span><\/td>\n$6 for 30, 20 mg tablets of generic citalopram<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Paxil<\/span><\/a><\/p>\n

(<\/span>paroxetine<\/span><\/a>)<\/span><\/td>\n

$749 for 30, 20 mg tablets<\/span><\/td>\n$4 for 30, 20 mg tablets of generic paroxetine<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the \u201cSavings options\u201d link to see the latest drug prices.<\/span><\/i><\/p>\n

Top 5 Wellbutrin alternatives<\/span><\/h2>\n

The most common treatment options when Wellbutrin or first-line antidepressant medications are not effective are other atypical antidepressants, including:<\/span><\/p>\n

1. Trazodone<\/span><\/h3>\n

Trazodone<\/span><\/a> is an atypical antidepressant that affects serotonin levels in the brain. Doses are usually taken twice daily. <\/span>Adverse effects<\/span><\/a> associated with trazodone include drowsiness, dry mouth, headache, dizziness, and weight loss. Trazodone also carries a <\/span>black box warning<\/span><\/a> that the drug can worsen depression and bring on suicidal thoughts and behavior.<\/span><\/p>\n

2. Remeron (mirtazapine)\u00a0<\/span><\/h3>\n

Remeron<\/span><\/a> is a tetracyclic antidepressant that affects serotonin and norepinephrine levels in the brain. The tablet or orally disintegrating tablet is usually taken once daily at bedtime. The orally disintegrating tablets dissolve in the mouth and can be swallowed with or without liquid.<\/span><\/p>\n

The most common <\/span>side effects of Remeron<\/span><\/a> include increased appetite, weight gain, dry mouth, drowsiness, and dizziness. Remeron also carries the boxed warning about worsening depression and suicidal thoughts or behavior.<\/span><\/p>\n

3. Trintellix (vortioxetine)<\/span><\/h3>\n

Trintellix<\/span><\/a> blocks serotonin reuptake in the brain but also acts like serotonin, increasing the overall serotonin activity in the brain. Doses are taken once daily. The most common<\/span> adverse effects<\/span><\/a> of Trintellix are digestive system side effects (nausea, diarrhea, constipation, vomiting, flatulence), dry mouth, dizziness, abnormal dreams, itching, and sexual dysfunction. Trintellix also carries a black box warning about worsening depression and suicidal thoughts or behavior.<\/span><\/p>\n

4. Viibryd (vilazodone)<\/span><\/h3>\n

Viibryd<\/span><\/a> is an antidepressant that works like an SSRI but also imitates serotonin in the brain, so overall serotonin activity is increased. Doses are taken once daily. The most common <\/span>adverse effects<\/span><\/a> of Viibryd include digestive system complaints (diarrhea, nausea, vomiting, and stomach pain), insomnia, and headache. Viibryd also carries a black box warning about worsening depression and suicidal thoughts or behavior.<\/span><\/p>\n

5. Lexapro (escitalopram) plus Wellbutrin SR (bupropion sustained-release)<\/span><\/h3>\n

Although the combination of <\/span>Lexapro<\/span><\/a> and Wellbutrin SR is <\/span>not approved by the Food and Drug Administration<\/span><\/a>, <\/span>clinical trials<\/span><\/a> show that this combination can be highly effective in helping people with treatment-resistant depression. The use of both medications impacts the three major neurotransmitters (serotonin, norepinephrine, and dopamine) that are important in the treatment of depression. Although combining Wellbutrin SR and Lexapro has had positive results, it may not be recommended for some because the combination may have too strong an effect, leading to increased physical, mental, or sexual side effects. Wellbutrin SR can cause blood levels of Lexapro to increase, leading to increased <\/span>side effects<\/span><\/a> of that drug.<\/span><\/p>\n

Over-the-counter antidepressants<\/span><\/h2>\n

There are no over-the-counter antidepressants. Some over-the-counter dietary supplements and vitamins can complement antidepressant treatment or improve mood in people who feel down. These include St. John\u2019s wort, probiotics, vitamin D, vitamin B12, folate, vitamin B, niacin, magnesium, zinc, calcium, and iron. No over-the-counter medication or supplement can substitute for prescription antidepressants in the treatment of major depressive disorder.<\/span><\/p>\n

Natural alternatives to Wellbutrin<\/span><\/h2>\n

Antidepressants are effective and often necessary for treating major depressive symptoms. Natural alternatives to Wellbutrin can help, but should not take the place of prescription medications in people diagnosed with major depressive disorder. The most effective nonpharmaceutical treatment for depression is cognitive behavioral therapy (CBT), which helps people change the way they think and react. In addition, <\/span>exercise<\/span><\/a>, sunlight or light therapy, and <\/span>diets<\/span><\/a> that include omega-3 fats and tryptophan (e.g., fish, nuts, poultry, and whole grains) can help improve mood. Obtaining medical advice from a healthcare professional before trying any of these alternatives is important.\u00a0<\/span><\/p>\n

How to switch to a Wellbutrin alternative<\/span><\/h2>\n

Switching from Wellbutrin to another antidepressant may be necessary due to a poor response or unacceptable side effects. However, there are risks such as withdrawal symptoms if the transition isn\u2019t managed correctly. A healthcare professional must manage any discontinuation or change in medicines.<\/span><\/p>\n

A <\/span>common switching strategy<\/span><\/a> involves tapering the currently prescribed antidepressant, followed by the appropriate washout period before prescribing the new treatment. Gradual dose reduction, as recommended by a healthcare provider, reduces the chance of withdrawal complications.<\/span><\/p>\n

Choosing the right path for depression treatment<\/span><\/h2>\n

Always consult with a healthcare provider or other mental health professional about what types of drugs and treatments are best to resolve depression. If Wellbutrin does not work, there are many other antidepressants to choose from, including antidepressants that work differently from standard antidepressants. Consult with the healthcare provider about possible side effects and any adjunctive therapies.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Wellbutrin is a brand-name prescription drug that treats major depressive disorder (MDD). The extended-release version, Wellbutrin XL, is also FDA-approved to treat seasonal affective disorder (SAD), a type of depression that comes on in certain seasons, like winter. 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