{"id":60646,"date":"2023-10-03T12:44:02","date_gmt":"2023-10-03T16:44:02","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60646"},"modified":"2025-11-06T14:14:15","modified_gmt":"2025-11-06T19:14:15","slug":"aspirin-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/aspirin-alternatives\/","title":{"rendered":"Aspirin alternatives: What can I take instead of aspirin?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin\"><span style=\"font-weight: 400;\">Aspirin<\/span><\/a><span style=\"font-weight: 400;\"> is commonly used for fever as well as mild to moderate pain from <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/osteoarthritis-vs-rheumatoid-arthritis\/\"><span style=\"font-weight: 400;\">arthritis<\/span><\/a><span style=\"font-weight: 400;\">, headache, menstrual cramps, muscle pain, and toothaches. It is also used in <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/daily-aspirin\/\"><span style=\"font-weight: 400;\">certain people<\/span><\/a><span style=\"font-weight: 400;\"> for heart attack prevention and for its other benefits in preventing blood clots, strokes, and death after a heart attack. Aspirin works by reducing the body\u2019s production of prostaglandins, substances that cause fever, pain, inflammation (swelling), and blood clots. If you can\u2019t take aspirin, there are alternatives to discuss with your healthcare provider.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What can I take in place of aspirin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Other <\/span><span style=\"font-weight: 400;\">nonsteroidal anti-inflammatory drugs <\/span><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAIDs<\/span><\/a><span style=\"font-weight: 400;\">), such as ibuprofen, naproxen, or diclofenac, may better treat acute pain and inflammation than aspirin. Tylenol, or acetaminophen, is an effective fever reducer and is preferred in children for this purpose over aspirin. There are other options for cardiovascular protection as well, such as Plavix (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clopidogrel-bisulfate\/what-is\"><span style=\"font-weight: 400;\">clopidogrel<\/span><\/a><span style=\"font-weight: 400;\">).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The information below is not intended to be medical advice. Speak to a prescriber to determine the best treatment option for the condition.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th>\n<h2><span class=\"title\">Compare aspirin alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Uses<\/b><\/td>\n<td><b>Dosage<\/b><\/td>\n<td><b>Savings options<\/b><\/td>\n<\/tr>\n<tr>\n<td><strong>Bayer Aspirin (aspirin)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild pain, fever, stroke prophylaxis, acute myocardial infarction, and reduction in cardiovascular mortality<\/span><\/td>\n<td><span style=\"font-weight: 400;\">325 mg &#8211; 650 mg every 4 hours as needed for pain, or 81 mg by mouth daily for cardiovascular prophylaxis<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/aspirin\"><span style=\"font-weight: 400;\">Aspirin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Motrin IB (ibuprofen)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild to moderate pain, osteoarthritis, rheumatoid arthritis, dysmenorrhea, fever, migraine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">400 mg by mouth every 4 to 6 hours as needed<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/motrin-ib\"><span style=\"font-weight: 400;\">Motrin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Naprosyn (naproxen)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild to moderate pain, osteoarthritis, rheumatoid arthritis, gout, dysmenorrhea, fever<\/span><\/td>\n<td><span style=\"font-weight: 400;\">250 mg to 500 mg by mouth twice daily as needed<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/naprosyn\"><span style=\"font-weight: 400;\">Naprosyn coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Zipsor (diclofenac)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild to moderate pain\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">25 mg by mouth four times per day as needed<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/diclofenac-potassium\"><span style=\"font-weight: 400;\">Zipsor coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Lodine (etodolac)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild to moderate pain, osteoarthritis, rheumatoid arthritis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">200 mg to 400 mg by mouth every 6 to 8 hours as needed<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lodine\"><span style=\"font-weight: 400;\">Lodine coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Mobic (meloxicam)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild to moderate pain, osteoarthritis, rheumatoid arthritis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7.5 mg to 15 mg once daily\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/meloxicam\"><span style=\"font-weight: 400;\">Mobic coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Celebrex (celecoxib)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild to moderate pain, osteoarthritis, rheumatoid arthritis, migraine, dysmenorrhea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">100 mg by mouth twice daily or 200 mg by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/celebrex\"><span style=\"font-weight: 400;\">Celebrex coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Voltaren gel (diclofenac)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Osteoarthritis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4 g applied topically four times daily (knee, ankle, foot) or 2 g applied topically four times daily (elbow, wrist, hand joint)<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/voltaren-arthritis-pain\"><span style=\"font-weight: 400;\">Voltaren gel coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Tylenol (acetaminophen)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Mild to moderate pain, fever, headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">325 mg to 650 mg every 4 to 6 hours<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/tylenol\"><span style=\"font-weight: 400;\">Tylenol coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Plavix (clopidogrel)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Myocardial infarction prophylaxis, stroke prophylaxis, thrombosis prophylaxis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">75 mg by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/plavix\"><span style=\"font-weight: 400;\">Plavix coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Brilinta (ticagrelor)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Myocardial infarction prophylaxis, stroke prophylaxis, and reduction of risk after myocardial infarction<\/span><\/td>\n<td><span style=\"font-weight: 400;\">180 mg loading dose, then 90 mg by mouth twice daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(specific dosing dependent on indication)<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/brilinta\"><span style=\"font-weight: 400;\">Brilinta coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Effient (prasugrel)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Arterial thromboembolism prophylaxis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">60 mg loading dose, then 10 mg by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/effient\"><span style=\"font-weight: 400;\">Effient coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><strong>Aggrenox (aspirin\/ dipyridamole)<\/strong><\/td>\n<td><span style=\"font-weight: 400;\">Secondary stroke prophylaxis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">25 mg ASA\/ 200 mg dipyridamole by mouth twice daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/aspirin-dipyridamole-er\"><span style=\"font-weight: 400;\">Aggrenox coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><small><span style=\"font-weight: 400;\">SingleCare works with a valid prescription for over-the-counter medications.\u00a0<\/span><small><\/small><\/small><\/p>\n<h3><span style=\"font-weight: 400;\">Other alternatives to aspirin<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aleve (naproxen)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indocin (indomethacin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Relafen (nabumetone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Feldene (piroxicam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Toradol (ketorolac)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ansaid (flurbiprofen)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pennsaid (diclofenac)<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Top 5 aspirin alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following are some of the most common alternatives to aspirin.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Other oral NSAIDs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For some types of pain and inflammation, aspirin may not provide the desired symptom relief. Some last longer and do not have to be dosed as often as aspirin for inflammation and pain. Aspirin is available over the counter without a prescription. Advil, Motrin, and Aleve are OTC as well, with higher doses available by prescription. Some NSAIDs require a prescription. Long-term use of NSAIDs should only be done under the advice and supervision of a healthcare professional.<\/span><\/p>\n<p><b>Examples:<\/b> <a href=\"https:\/\/www.singlecare.com\/prescription\/motrin-ib\/what-is\"><span style=\"font-weight: 400;\">Motrin<\/span><\/a><span style=\"font-weight: 400;\"> (ibuprofen), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/naprosyn\/what-is\"><span style=\"font-weight: 400;\">Naprosyn<\/span><\/a><span style=\"font-weight: 400;\"> (naproxen), Cataflam (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/diclofenac-sodium\/what-is\"><span style=\"font-weight: 400;\">diclofenac<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lodine\/what-is\"><span style=\"font-weight: 400;\">Lodine<\/span><\/a><span style=\"font-weight: 400;\"> (etodolac), Toradol (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ketorolac-tromethamine\/what-is\"><span style=\"font-weight: 400;\">ketorolac<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Celebrex (celecoxib)\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Celebrex (celecoxib) is an NSAID, but is more specifically classified as a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/cox-2-inhibitors\"><span style=\"font-weight: 400;\">COX-2 inhibitor<\/span><\/a><span style=\"font-weight: 400;\">. It provides anti-inflammatory effects and pain relief with a lower risk of gastrointestinal side effects when compared to other NSAIDs. Celebrex is FDA-approved for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, and menstrual cramps. The dose will depend on the condition being treated.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Topical NSAIDs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If oral NSAID therapy is not desired or there is concern over potential systemic adverse events, there are topical NSAID preparations that have minimal systemic risk with topical application. These are appropriate for joint and muscle pain related to inflammation. Most products in this class contain diclofenac as the active ingredient. There are various application types, such as gels, solutions, and patches. Some items are prescription-only, while others are available over the counter without a prescription.<\/span><\/p>\n<p><b>Examples:<\/b> <a href=\"https:\/\/www.singlecare.com\/prescription\/voltaren-arthritis-pain\/what-is\"><span style=\"font-weight: 400;\">Voltaren gel<\/span><\/a><span style=\"font-weight: 400;\"> (diclofenac), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pennsaid\/what-is\"><span style=\"font-weight: 400;\">Pennsaid solution<\/span><\/a><span style=\"font-weight: 400;\"> (diclofenac), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/flector\/what-is\"><span style=\"font-weight: 400;\">Flector patch<\/span><\/a><span style=\"font-weight: 400;\"> (diclofenac)<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Tylenol (acetaminophen)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In treating fever, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tylenol\/what-is\"><span style=\"font-weight: 400;\">Tylenol<\/span><\/a><span style=\"font-weight: 400;\"> is an excellent alternative to aspirin and other NSAIDs. It is the preferred product in children due to the potential for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/reyes-syndrome\/\"><span style=\"font-weight: 400;\">Reye\u2019s syndrome<\/span><\/a><span style=\"font-weight: 400;\">. Tylenol is not an anti-inflammatory drug, but it does have some analgesic properties and can be useful for some pain types, such as arthritis and headaches. Tylenol is available without a prescription in various dosage forms, including pills and oral liquids.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Platelet inhibitors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Aspirin causes platelet inhibition, slowing and decreasing the formation of clots in the blood. This makes it useful in treating and preventing stroke and other cardiac conditions. For patients who need this protection but are not good candidates for aspirin therapy, other platelet inhibitors do not carry the NSAID-related risk profile of aspirin. These other platelet inhibitors are available by prescription. All platelet inhibitors carry some risk with the potential for serious bleeding and blood loss, bruising, and bleeding gums.<\/span><\/p>\n<p><b>Examples:<\/b> <a href=\"https:\/\/www.singlecare.com\/prescription\/plavix\/what-is\"><span style=\"font-weight: 400;\">Plavix<\/span><\/a><span style=\"font-weight: 400;\"> (clopidogrel), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/effient\/what-is\"><span style=\"font-weight: 400;\">Effient<\/span><\/a><span style=\"font-weight: 400;\"> (prasugrel)<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Natural alternatives to aspirin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3011108\/\"><span style=\"font-weight: 400;\">natural supplements<\/span><\/a><span style=\"font-weight: 400;\"> have anti-inflammatory properties. Fish oil (omega-3 fatty acids) is a natural blood thinner and may reduce cholesterol. White willow bark, curcumin (turmeric), and green tea are other natural alternatives. As mentioned previously, aspirin is derived from the white willow bark. It is a non-selective inhibitor of COX-1 and COX-2, functioning similarly to aspirin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Green tea is a natural antioxidant used for its cardioprotective properties to reduce the risk of cardiovascular diseases. If you are interested in trying natural alternatives, know that they are not a substitute for treatment recommended by your healthcare provider, especially when recommended for their protective effects on the heart and blood vessels. There is also a potential for drug interactions, so it is important to check with your healthcare provider before adding any supplement to your routine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">See also: <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/home-remedies-for-pain-relief\/\"><span style=\"font-weight: 400;\">13 home remedies for pain relief<\/span><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">How to switch to an aspirin alternative<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Whether one has a drug allergy to aspirin or another NSAID, is concerned about potential or existing side effects, or has another reason for wanting an aspirin alternative, the first step is to speak to a healthcare provider. Let the provider know if conditions such as stomach ulcers or high blood pressure exist, as aspirin may not be the right choice. The primary consideration in finding an aspirin alternative is determining what indication it will be used to treat and then looking at appropriate and safe alternatives for that indication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Switching therapies should not be done alone, even between two over-the-counter options. Consult a prescriber or pharmacist to get acceptable alternatives. If switching to a prescription-only drug, it would also be helpful to consult the insurance <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/what-is-a-formulary\/\"><span style=\"font-weight: 400;\">formulary<\/span><\/a><span style=\"font-weight: 400;\"> while deciding. The formulary status of the drug will determine out-of-pocket costs. If uninsured, consult the <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare<\/span><\/a><span style=\"font-weight: 400;\"> webpage to compare the discounted cash prices SingleCare offers across multiple pharmacies at once.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aspirin is commonly used for fever as well as mild to moderate pain from arthritis, headache, menstrual cramps, muscle pain, and toothaches. It is also used in certain people for heart attack prevention and for its other benefits in preventing blood clots, strokes, and death after a heart attack. Aspirin works by reducing the body\u2019s [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":60648,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[737,808],"coauthors":[10437],"class_list":["post-60646","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-heart-health","tag-pain-management","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Top aspirin alternatives<\/title>\n<meta name=\"description\" content=\"Other NSAIDs, COX-2 Inhibitors, Tylenol, and platelet inhibitors are some aspirin alternatives. 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