{"id":60871,"date":"2023-10-17T09:10:55","date_gmt":"2023-10-17T13:10:55","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60871"},"modified":"2024-10-25T10:28:48","modified_gmt":"2024-10-25T14:28:48","slug":"clindamycin-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/clindamycin-interactions\/","title":{"rendered":"Clindamycin interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/clindamycin-hcl\/what-is\"><span style=\"font-weight: 400;\">Clindamycin<\/span><\/a><span style=\"font-weight: 400;\"> is a generic prescription medication that is a commonly used <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-do-antibiotics-work\/\"><span style=\"font-weight: 400;\">antibiotic<\/span><\/a><span style=\"font-weight: 400;\">. Also available as a <\/span><span style=\"font-weight: 400;\">brand name<\/span><span style=\"font-weight: 400;\"> medication called <\/span><span style=\"font-weight: 400;\">Cleocin<\/span><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clindamycin-hcl\"><span style=\"font-weight: 400;\">clindamycin<\/span><\/a><span style=\"font-weight: 400;\"> can treat various <\/span><span style=\"font-weight: 400;\">bacterial infections<\/span><span style=\"font-weight: 400;\">. Some common types of infections treated with <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> include lower respiratory infections, intra-abdominal infections, gynecological infections like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/yeast-infection-treatment-and-medications\"><span style=\"font-weight: 400;\">yeast infections<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bacterial-vaginosis-treatment-and-medications\"><span style=\"font-weight: 400;\">bacterial vaginosis<\/span><\/a><span style=\"font-weight: 400;\">, bone and joint infections, and skin infections. Additionally, <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> can be used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/acne-treatment-and-medications\"><span style=\"font-weight: 400;\">acne<\/span><\/a><span style=\"font-weight: 400;\"> and pelvic inflammatory disease. <\/span><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> is also prescribed sometimes by dentists to prevent infections such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/tooth-infection-spreading-to-the-body-symptoms\"><span style=\"font-weight: 400;\">endocarditis<\/span><\/a><span style=\"font-weight: 400;\"> (an infection of the heart&#8217;s inner lining). Categorized as a lincosamide antibiotic, <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> works by preventing bacterial growth by inhibiting bacterial protein synthesis. <\/span><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> is available in various dosage forms, including capsules, oral solution, vaginal cream and gel, topical lotion and gel, and intravenous (IV) injections administered in a hospital setting.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> can be an effective treatment option for some people, there are <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> that are important to be aware of and avoid. Medications that are prescription-only and <\/span><span style=\"font-weight: 400;\">over-the-counter<\/span><span style=\"font-weight: 400;\"> (OTC) can have dangerous <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> with other medications, certain foods, alcohol, and <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Drug interactions<\/span><span style=\"font-weight: 400;\"> may cause unwanted <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, make a certain drug less effective, or increase the action of a drug. As a medication that treats infections, <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> with <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> are very important to avoid as people could be at risk of infections persisting or worsening. Some interactions may increase the amount of <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> in the body, causing increased <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> like abdominal pain, nausea, vomiting, or diarrhea. Antibiotics can increase the risk of an infection called <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/clostridium-difficile-treatment-and-medications\"><span style=\"font-weight: 400;\">C. difficile<\/span><\/a><span style=\"font-weight: 400;\"> (Clostridioides difficile\/<\/span><span style=\"font-weight: 400;\">Clostridium difficile<\/span><span style=\"font-weight: 400;\">) in the colon, the longest part of the large <\/span><span style=\"font-weight: 400;\">intestine<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> has been frequently associated with antibiotic-associated diarrhea due to an <\/span><span style=\"font-weight: 400;\">overgrowth<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">C. difficile<\/span><span style=\"font-weight: 400;\">. Although this infection has been documented with almost all antibiotics, the most frequent offenders include <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\">, ampicillin, amoxicillin, and cephalosporins.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/diarrhea-from-antibiotics\/\"><b>Can antibiotics cause diarrhea?<\/b><\/a><\/p>\n<h2 id=\"key-takeaways\"><span style=\"font-weight: 400;\">Key takeaways:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> can cause <\/span><span style=\"font-weight: 400;\">gastrointestinal<\/span><span style=\"font-weight: 400;\"> (GI) <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, including nausea, vomiting, diarrhea, and abdominal pain. Certain <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> can further increase these <\/span><span style=\"font-weight: 400;\">common side effects of clindamycin<\/span><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> is an antibiotic that treats various <\/span><span style=\"font-weight: 400;\">bacterial infections<\/span><span style=\"font-weight: 400;\">, and certain <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> can make <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> less effective, leading to possible untreated infections.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin sensitivities can occur with various antibiotics, and potential <\/span><span style=\"font-weight: 400;\">clindamycin<\/span> <span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> include <\/span><span style=\"font-weight: 400;\">skin rashes<\/span><span style=\"font-weight: 400;\"> and itchy <\/span><span style=\"font-weight: 400;\">skin reactions<\/span><span style=\"font-weight: 400;\">. Some <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> can further increase the skin <\/span><span style=\"font-weight: 400;\">side effects of clindamycin<\/span><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dose adjustments may be necessary to avoid or lessen the effects of certain <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> with <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain <\/span><span style=\"font-weight: 400;\">vaccines<\/span><span style=\"font-weight: 400;\"> interact with <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\">, which can cause a diminished <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\"> effect.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If a dangerous mixture of medications has been consumed, seek immediate medical help or contact <\/span><a href=\"https:\/\/www.poison.org\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Poison Control <\/span><\/a><span style=\"font-weight: 400;\">for help.<\/span><\/li>\n<\/ul>\n<h2 id=\"clindamycin-drug-interactions\"><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\">&#8211;<\/span><span style=\"font-weight: 400;\">drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are a variety of drugs that can interact with <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> and cause different unwanted effects. While some drugs may worsen <\/span><span style=\"font-weight: 400;\">clindamycin<\/span> <span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, others may make <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> less effective.<\/span><\/p>\n<h3 id=\"cyp3a4-inducers\"><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inducers<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drug metabolism can undergo various pathways, and cytochrome P450 (CYP) enzymes play an important role in this process. CYP enzymes can affect drug responses by influencing drug action, safety, bioavailability, and drug resistance through metabolism. There are a variety of CYP enzymes, and drugs may inhibit or induce the enzymes. <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inducers are medications that speed up the metabolism of a drug and can make it less effective in the body. When <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> is mixed with a <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inducer, the levels of <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> in the body can go down and lead to an untreated infection. <\/span><span style=\"font-weight: 400;\">Prescribers<\/span><span style=\"font-weight: 400;\"> may suggest pausing or lowering the dose of certain <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> medications while people undergo <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> treatment. If taken together, people should be aware of symptoms of their infection not improving and contact their <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> if symptoms worsen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inducers:<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticonvulsants\"><span style=\"font-weight: 400;\">Seizure Medications<\/span><\/a><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/tegretol\"><span style=\"font-weight: 400;\">Tegretol (carbamazepine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/phenobarbital\"><span style=\"font-weight: 400;\">Phenobarbital<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/dilantin\"><span style=\"font-weight: 400;\">Dilantin (phenytoin)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/mysoline\"><span style=\"font-weight: 400;\">Mysoline (primidone)<\/span><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/prostate-cancer-treatment-and-medications\"><span style=\"font-weight: 400;\">Prostate Cancer Medications<\/span><\/a><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erleada (apalutamide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xtandi (enzalutamide)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Supplements<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/st-johns-wort\"><span style=\"font-weight: 400;\">St. John&rsquo;s Wort<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"cyp3a4-inhibitors\"><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inhibitors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">On the other hand, <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inhibitors are medications that slow down the metabolism of a drug and can cause higher plasma <\/span><span style=\"font-weight: 400;\">concentrations<\/span><span style=\"font-weight: 400;\"> of drugs. This inhibition can increase the chances of adverse drug reactions and affect therapeutic responses. When <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> is mixed with a <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inhibitor, the levels of <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> in the body can increase and lead to worsened <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Prescribers<\/span><span style=\"font-weight: 400;\"> may suggest pausing or lowering the dose of certain <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> medications while people undergo <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> treatment. If taken together, people should be aware of the <\/span><span style=\"font-weight: 400;\">potential <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> of clindamycin<\/span><span style=\"font-weight: 400;\"> and contact their doctor if <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> worsen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inhibitors:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/emend\"><span style=\"font-weight: 400;\">Emend (aprepitant<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orladeyo (berotralstat)&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/cardizem\"><span style=\"font-weight: 400;\">Cardizem (diltiazem)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/multaq\"><span style=\"font-weight: 400;\">Multaq (dronedarone)&nbsp;<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin\"><span style=\"font-weight: 400;\">Erythromycin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/diflucan\"><span style=\"font-weight: 400;\">Diflucan (fluconazole<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/lexiva\"><span style=\"font-weight: 400;\">Lexiva (fosamprenavir<\/span><\/a><a href=\"https:\/\/www.singlecare.com\/prescription\/cresemba\"><span style=\"font-weight: 400;\">Isavuconazonium sulfate)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/kisqali-200-mg-dose\"><span style=\"font-weight: 400;\">Kisqali (ribociclib)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/verelan\"><span style=\"font-weight: 400;\">Verelan (verapamil)<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"certain-vaccines\"><span style=\"font-weight: 400;\">Certain <\/span><span style=\"font-weight: 400;\">vaccines<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Certain <\/span><span style=\"font-weight: 400;\">vaccines<\/span><span style=\"font-weight: 400;\"> should not be administered while taking antibiotics like <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\">, as the effect of the <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\"> can be diminished. The cholera <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\"> (Vaxchora) should be avoided in people receiving antibiotics and for another 14 days following oral antibiotics. The BCG <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\"> is used for tuberculosis prevention and should be used cautiously in people receiving antibiotics like <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> because there is the potential for diminished <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\"> effect. Another <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\"> affected by a <\/span><span style=\"font-weight: 400;\">drug interaction<\/span><span style=\"font-weight: 400;\"> with <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> is the oral typhoid <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\">, Vivotif. When getting <\/span><span style=\"font-weight: 400;\">vaccines<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">healthcare professionals<\/span><span style=\"font-weight: 400;\"> will screen people for any contraindications or precautions people may have before getting their <\/span><span style=\"font-weight: 400;\">vaccine<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of <\/span><span style=\"font-weight: 400;\">vaccines<\/span><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/bcg-vaccine\"><span style=\"font-weight: 400;\">BCG <\/span><span style=\"font-weight: 400;\">vaccine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/vaxchora\"><span style=\"font-weight: 400;\">Vaxchora<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/vivotif\"><span style=\"font-weight: 400;\">Vivotif<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"nerve-blocking-medications\"><span style=\"font-weight: 400;\">Nerve blocking medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nerve-blocking medications are used during procedures to help prevent and manage pain. <\/span><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> may enhance the nerve-blocking effect of these drugs and cause them to last longer than expected. This could unexpectedly affect the <\/span><span style=\"font-weight: 400;\">healthcare<\/span><span style=\"font-weight: 400;\"> team, so providing a full list of prescription medications, OTC drugs, and <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\"> to the <\/span><span style=\"font-weight: 400;\">healthcare providers<\/span><span style=\"font-weight: 400;\"> before any procedure is important.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of nerve-blocking medications:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atracurium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nimbex (cisatracurium)&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rocuronium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anectine (succinylcholine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vecuronium<\/span><\/li>\n<\/ul>\n<h2 id=\"clindamycin-food-interactions\"><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\">-food interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Sometimes interactions with food are an unexpected warning with medications. Grapefruit is a food that commonly interacts with medications like <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"clindamycin-and-grapefruit-juice\"><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> and Grapefruit Juice<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While part of a healthy diet, grapefruit juice is a common culprit of <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> as it is a <\/span><span style=\"font-weight: 400;\">CYP3A4<\/span><span style=\"font-weight: 400;\"> inhibitor and can increase the amount of certain drugs in the body. This inhibition could increase the chances of adverse drug reactions and affect therapeutic responses. When <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> is mixed with grapefruit juice, <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> in the body can increase and worsen <\/span><span style=\"font-weight: 400;\">adverse effects<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Prescribers<\/span><span style=\"font-weight: 400;\"> may suggest pausing daily use of grapefruit juice while people undergo <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> treatment or monitor for increased <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">. Talking with a <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> or pharmacist about potential grapefruit juice interactions is important.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/clindamycin-and-alcohol\/\"><b>Can you drink while taking <\/b><b>clindamycin<\/b> <b>HCL<\/b><b>?<\/b><\/a><\/p>\n<h2 id=\"how-to-minimize-clindamycin-interactions\"><span style=\"font-weight: 400;\">How to minimize <\/span><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It&rsquo;s important that <\/span><span style=\"font-weight: 400;\">healthcare providers<\/span><span style=\"font-weight: 400;\"> are aware of all <\/span><span style=\"font-weight: 400;\">medical conditions<\/span><span style=\"font-weight: 400;\"> and have a medication list, including <\/span><span style=\"font-weight: 400;\">prescription drugs<\/span><span style=\"font-weight: 400;\">, OTC medications, herbal products, and <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\">. Even OTC and <\/span><span style=\"font-weight: 400;\">supplement<\/span><span style=\"font-weight: 400;\"> products can have dangerous <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\">. People can also turn to pharmacists as they are great resources and can provide additional <\/span><span style=\"font-weight: 400;\">drug information<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">medical advice<\/span><span style=\"font-weight: 400;\"> when picking up medication from the pharmacy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Certain <\/span><span style=\"font-weight: 400;\">medical conditions<\/span><span style=\"font-weight: 400;\"> can impact whether a drug will be safe or not for a person. <\/span><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> should be used cautiously in people with GI diseases such as <\/span><span style=\"font-weight: 400;\">colitis<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">liver disease<\/span><span style=\"font-weight: 400;\"> or impairment, or kidney impairment. Caution should also be used in older adults as they may be unable to tolerate diarrhea&#8217;s potentially <\/span><span style=\"font-weight: 400;\">serious side effects<\/span><span style=\"font-weight: 400;\">. People who have had <\/span><span style=\"font-weight: 400;\">allergic reactions<\/span><span style=\"font-weight: 400;\"> (such as <\/span><span style=\"font-weight: 400;\">hives<\/span><span style=\"font-weight: 400;\"> or swelling of the face) to <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> or a similar medication called <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lincomycin-hcl\"><span style=\"font-weight: 400;\">lincomycin<\/span><\/a><span style=\"font-weight: 400;\"> should not use <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> due to potential <\/span><span style=\"font-weight: 400;\">life-threatening<\/span><span style=\"font-weight: 400;\"> effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> is present in breast milk, so the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/breastfeeding-and-medications\/\"><span style=\"font-weight: 400;\">decision to breastfeed<\/span><\/a><span style=\"font-weight: 400;\"> will be determined by a doctor. Several considerations include the risk of infant exposure, the benefits of <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><span style=\"font-weight: 400;\"> to the infant, and the benefits of treatment to the <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><span style=\"font-weight: 400;\"> mother. Other antibiotics may be safer options while a woman is <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><span style=\"font-weight: 400;\">. It&rsquo;s important to look for potential <\/span><span style=\"font-weight: 400;\">clindamycin<\/span> <span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> in an infant, such as GI disturbances, diarrhea, and bloody stools.<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-clindamycin-interactions\"><span style=\"font-weight: 400;\">When to talk to a <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> about <\/span><span style=\"font-weight: 400;\">Clindamycin<\/span><span style=\"font-weight: 400;\"> interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While many serious <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> associated with <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> are included, several other potential <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> are not. To ensure safe drug management, people should communicate openly with their <\/span><span style=\"font-weight: 400;\">healthcare providers<\/span><span style=\"font-weight: 400;\"> about all <\/span><span style=\"font-weight: 400;\">medical conditions<\/span><span style=\"font-weight: 400;\">, medications, and <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\">. Alternative medication options to <\/span><span style=\"font-weight: 400;\">clindamycin<\/span><span style=\"font-weight: 400;\"> may be better treatment options for some people.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clindamycin is a generic prescription medication that is a commonly used antibiotic. Also available as a brand name medication called Cleocin, clindamycin can treat various bacterial infections. Some common types of infections treated with clindamycin include lower respiratory infections, intra-abdominal infections, gynecological infections like yeast infections or bacterial vaginosis, bone and joint infections, and skin [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":60872,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,814],"coauthors":[20740],"class_list":["post-60871","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Clindamycin interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Clindamycin interacts with CYP3A4 inducers, CYP3A4 inhibitors, certain vaccines, nerve-blocking medications, and grapefruit. 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