{"id":60906,"date":"2023-10-18T09:30:57","date_gmt":"2023-10-18T13:30:57","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=60906"},"modified":"2024-11-13T17:26:42","modified_gmt":"2024-11-13T22:26:42","slug":"fluoxetine-side-effects-in-females","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/fluoxetine-side-effects-in-females\/","title":{"rendered":"What are the side effects of Prozac for women?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Prozac (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fluoxetine-hcl\"><span style=\"font-weight: 400;\">fluoxetine<\/span><\/a><span style=\"font-weight: 400;\">) is a selective serotonin reuptake inhibitor (SSRI) antidepressant <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459223\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">approved<\/span><\/a><span style=\"font-weight: 400;\"> by the U.S. Food and Drug Administration (FDA) to treat mental health conditions such as major depressive disorder, panic disorder, obsessive-compulsive disorder (OCD), and binge eating disorder. It works by increasing serotonin levels, a natural feel-good hormone, in the brain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like most prescription medications, Prozac can have <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/fluoxetine-side-effects\/\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\">, such as suppressed appetite, nausea, diarrhea, dry mouth, drowsiness, and trouble sleeping. However, some side effects may differ based on the patient\u2019s sex. For example, men may experience erectile dysfunction while women may see decreased libido. Read on to learn more about how this medication affects women.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/prozac-generic\/\"><b>Prozac generic availability, cost, and dosage<\/b><\/a><\/p>\n<h2 id=\"fluoxetine-side-effects-in-females\"><span style=\"font-weight: 400;\">Fluoxetine side effects in females<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In the process of treating the condition it\u2019s prescribed for, fluoxetine (known by its brand name Prozac) may also trigger some unwanted side effects. <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15744630\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Common side effects<\/span><\/a><span style=\"font-weight: 400;\"> of <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a689006.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Prozac<\/span><\/a><span style=\"font-weight: 400;\"> include gastrointestinal issues like nausea, diarrhea, and heartburn; trouble sleeping; and headaches.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, there are side effects that primarily <\/span><a href=\"https:\/\/www.jpp.krakow.pl\/journal\/archive\/10_15\/pdf\/665_10_15_article.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">affect women<\/span><\/a><span style=\"font-weight: 400;\">. They include loss of appetite, weight loss, and <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1743609515339679\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">sexual dysfunction<\/span><\/a><span style=\"font-weight: 400;\">, such as loss of sexual desire, weakened arousal and lubrication, delayed orgasm, and anorgasmia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIt is possible for individuals to notice some side effects within the first few days of starting fluoxetine as the body is getting used to the medication,\u201d says <\/span><a href=\"https:\/\/neurowellnessspa.com\/about\/care-team\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Frances Javier, MD<\/span><\/a><span style=\"font-weight: 400;\">, psychiatrist and medical director at Neuro Wellness Spa. Some of these side effects will disappear with time, though.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In some people, Prozac may also trigger serious side effects, such as swelling on the face, lips, eyes, ankles, or lower legs, difficulty breathing, irregular heartbeat, seizures, hallucinations, agitation, bleeding, and lack of coordination. Fluoxetine may also cause narrow-angle glaucoma (fluid buildup in the eye). If you experience any of these, seek medical advice from a healthcare professional and report any uncommon or worsening adverse effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h3 id=\"impact-of-fluoxetine-on-female-hormonal-balance\"><span style=\"font-weight: 400;\">Impact of fluoxetine on female hormonal balance<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">About 80% of women taking SSRIs have reported sexual dysfunction. According to a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10038119\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2022 animal study<\/span><\/a><span style=\"font-weight: 400;\">, all SSRIs\u2014including fluoxetine\u2014showed the ability to affect the production of hormones including estrogen, progesterone, and androgens when tested in the laboratory.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This very small animal study demonstrated that when mice were given high doses of fluoxetine their reproductive cycles were altered. At high doses, fluoxetine was associated with irregular cycles, fewer corpus luteum (involved in progesterone production in early pregnancy), decreased follicle development, and reduced ovulation. The study also found an association between increased estrogen concentration and taking fluoxetine\u2014which may affect other reproductive hormones including gonadotropin hormone-releasing hormone (controls the production of sex hormones), follicle-stimulating hormone (plays a role in sexual development and reproduction), and luteinizing hormone (controls the menstrual cycle in women).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The researchers recommended caution for women and girls of reproductive age using fluoxetine. However, because this research has only been performed in animals, it\u2019s uncertain if the same conclusions would apply to human subjects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThe vast majority of findings in animal studies do not translate to humans,\u201d says Bruce Bassi, MD, the medical director at <\/span><a href=\"https:\/\/www.telepsychhealth.com\/meet-our-providers\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">TelepsychHealth<\/span><\/a><span style=\"font-weight: 400;\">. \u201cI would not put a lot of weight on a study that looked at such a small sample size (6\/7 per group).\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In other words, more evidence is needed to support any conclusions about how fluoxetine affects hormonal balance in human females.<\/span><\/p>\n<h2 id=\"long-term-fluoxetine-side-effects-in-women\"><span style=\"font-weight: 400;\">Long-term fluoxetine side effects in women<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When women are on fluoxetine for six to 10 years or longer, they have reported long-term <\/span><a href=\"https:\/\/journals.lww.com\/clinicalneuropharm\/abstract\/2002\/01000\/side_effects_of_long_term_treatment_with.10.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\">, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restlessness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tension<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleep disturbances<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low sex drive (which may persist even after discontinuation)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">They also report <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/22354-low-estrogen\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">low estrogen<\/span><\/a><span style=\"font-weight: 400;\">\u2014which can trigger or contribute to painful vaginal intercourse, hot flashes, irregular periods, and more\u2014but the data on fluoxetine&#8217;s impact on estrogen is conflicting.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cSome data supports that Prozac can decrease estrogen levels, but it is unclear why,\u201d Dr. Bassi says. \u201cThe evidence is conflicting, as other studies showed an increase.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the medication insert, when discontinuing use of Prozac, whether they\u2019ve taken it long-term or not, women should do so under the supervision of a healthcare provider. \u201cA gradual reduction in the dose rather than abrupt cessation is recommended whenever possible,\u201d says <\/span><a href=\"https:\/\/www.dralishareed.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Alisha Reed<\/span><\/a><span style=\"font-weight: 400;\">,\u00a0 Pharm.D., a pharmacist based in New Orleans, Louisiana.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients should be monitored for potential withdrawal symptoms or worsening mood. These symptoms include dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, and hypomania. \u201cWhile these reactions are generally self-limiting,\u201d Dr. Reed says, \u201cthere have been reports of serious discontinuation symptoms.\u201d\u00a0<\/span><\/p>\n<h2 id=\"how-long-do-fluoxetine-side-effects-last\"><span style=\"font-weight: 400;\">How long do fluoxetine side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some side effects are temporary and may disappear after your body adjusts to the medication. For instance, according to <\/span><a href=\"https:\/\/www.nhs.uk\/medicines\/fluoxetine-prozac\/side-effects-of-fluoxetine\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\">, the suppression of appetite experienced in the first two to three months of taking fluoxetine slowly goes away with time, such that in six months, the person\u2019s appetite returns to normal.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, Dr. Javier says that adjusting to fluoxetine is a unique experience for each individual. \u201cSome [people] may notice some mild improvement in symptoms as early as two weeks, such as changes in sleep, appetite, and energy,\u201d she says. \u201cHowever, a more common timeline is around four to eight weeks, especially for symptoms of low mood, lack of motivation, and lack of interest in activities.\u201d\u00a0<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects-of-fluoxetine-in-females\"><span style=\"font-weight: 400;\">How to treat side effects of fluoxetine in females<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">One <\/span><a href=\"https:\/\/www.health.harvard.edu\/womens-health\/when-an-ssri-medication-impacts-your-sex-life\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">common side effect of fluoxetine for women<\/span><\/a><span style=\"font-weight: 400;\"> is sexual dysfunction. If you suspect that fluoxetine is affecting your sex life, do not stop the medication without informing your healthcare provider, who may recommend reducing the dose or changing medications. Sometimes lowering the dose may be enough to alleviate the sexual side effects. You can also try planning sexual activity for moments when the effects of the medication are at their lowest. Another option is to work with a sex therapist or switch to a different drug (only if directed by your healthcare provider).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some severe side effects of Prozac will demand immediate medical attention. It is a good idea to see your healthcare provider for side effects including irregularity in the menstrual cycle, unexplained weight loss, or weight gain. If you\u2019re experiencing allergic reactions to the medication, get medical attention urgently. You should also call your doctor immediately if you experience the following: feelings of euphoria, bleeding gums, unexplained bruises, bloody sputum, or blood in your urine, stool, and vomit. If you experience suicidal thoughts, seek emergency help immediately or call 988.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some side effects may go away as your body gets used to the drug; however, it is a good idea to speak with your healthcare provider about new symptoms while using this medication.<\/span><\/p>\n<h2 id=\"how-to-avoid-fluoxetine-side-effects\"><span style=\"font-weight: 400;\">How to avoid fluoxetine side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like most prescription drugs, fluoxetine can trigger unwanted side effects. There are a number of strategies you can try to minimize the risk of fluoxetine side effects:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take fluoxetine at a certain time of day<\/b><span style=\"font-weight: 400;\">; this time will depend on the side effects you experience. For example, taking it in the morning can minimize the risk of insomnia. Then, take the medication at the same time every day.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Work with your provider to find the right dose. <\/b><span style=\"font-weight: 400;\">If you\u2019re having side effects, you may need a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prozac\/dosage\"><span style=\"font-weight: 400;\">higher or lower dosage<\/span><\/a><span style=\"font-weight: 400;\">. Fluoxetine can be taken at doses as low as 20 mg daily.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tell your provider and pharmacist about all other medications and supplements you take<\/b><span style=\"font-weight: 400;\">, which will help you avoid drug interactions. Prozac should not be taken with antidepressants such as monoamine oxidase inhibitors (MAOIs) or thioridazine serotonergic drugs (such as triptans, tricyclic antidepressants, and St. John&#8217;s Wort). Combining certain medications increases the risk of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/serotonin-syndrome-treatment-and-medications\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Inform your healthcare provider about other medical conditions you have<\/b><span style=\"font-weight: 400;\">, such as heart failure, high blood pressure, bleeding problems, stroke, diabetes, seizures, and liver or kidney disease. You should also let them know if you have low sodium, potassium, or magnesium levels.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Do not stop taking fluoxetine without your healthcare provider\u2019s advice. If you are discontinuing the medication, your provider may reduce your dosage gradually to reduce the risk of you experiencing withdrawal symptoms. It\u2019s important to stay in contact with your provider so they can help you navigate and alleviate any adverse effects of Prozac.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant approved by the U.S. Food and Drug Administration (FDA) to treat mental health conditions such as major depressive disorder, panic disorder, obsessive-compulsive disorder (OCD), and binge eating disorder. It works by increasing serotonin levels, a natural feel-good hormone, in the brain. Like most prescription medications, [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":60907,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,450,8670],"coauthors":[20915],"class_list":["post-60906","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-mental-health","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Fluoxetine side effects in females<\/title>\n<meta name=\"description\" content=\"The side effects of fluoxetine in females include loss of appetite, weight loss, and sexual dysfunction. 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