{"id":61031,"date":"2023-10-27T09:35:42","date_gmt":"2023-10-27T13:35:42","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61031"},"modified":"2024-10-25T10:28:06","modified_gmt":"2024-10-25T14:28:06","slug":"amoxicillin-potassium-clavulanate-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/amoxicillin-potassium-clavulanate-interactions\/","title":{"rendered":"Amoxicillin-potassium clavulanate interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin-pot-clavulanate\/what-is\"><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate<\/span><\/a><span style=\"font-weight: 400;\"> is a widely used antibiotic from the <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/penicillins\"><span style=\"font-weight: 400;\">penicillin<\/span><\/a><span style=\"font-weight: 400;\"> family that is prescribed for bacterial infections of the sinuses, ears, lungs, and skin, as well as diverticulitis and urinary tract infections. Barring an allergy to penicillins, you stand a good chance of being prescribed <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin-pot-clavulanate\"><span style=\"font-weight: 400;\">amoxicillin-potassium clavulanate<\/span><\/a><span style=\"font-weight: 400;\">; its brand-name version, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/augmentin\"><span style=\"font-weight: 400;\">Augmentin<\/span><\/a><span style=\"font-weight: 400;\">; or the <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin-pot-clavulanate-er\"><span style=\"font-weight: 400;\">extended-release tablets<\/span><\/a><span style=\"font-weight: 400;\">. Although a commonly used antibiotic, it has potential drug interactions with birth control pills, tetracycline antibiotics, the gout prevention drugs probenecid and allopurinol, the autoimmune arthritis disease modifier methotrexate, and the anticoagulant warfarin. Unintended pregnancy, adverse effects, and hemorrhage could result from these interactions, so it is worth reading on to understand them better.<\/span><\/p>\n<p><span data-sheets-root=\"1\" data-sheets-value='{&quot;1&quot;:2,&quot;2&quot;:&quot;&quot;}' data-sheets-userformat='{\"2\":6849,\"3\":{\"1\":0},\"9\":1,\"10\":2,\"12\":0,\"14\":{\"1\":2,\"2\":0},\"15\":\"Arial\"}' data-sheets-formula=\"=CONCATENATE(R[0]C[-2],R[0]C[-3],R[0]C[-1])\"><\/span><\/p>\n<h2 id=\"key-takeaways\"><span style=\"font-weight: 400;\">Key takeaways:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clinical studies have raised concern that antibiotics like amoxicillin-potassium clavulanate could reduce the effectiveness of estrogen-based contraceptives, namely birth control pills, increasing the chance of unintended pregnancy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Like most antibiotics, amoxicillin-potassium clavulanate increases the effectiveness of warfarin in thinning the blood, leading to a higher likelihood of bleeding.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The drug, like all penicillins, increases the concentration of methotrexate when co-administered, which means more potential for methotrexate toxicity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tetracyclines may reduce the effectiveness of amoxicillin-potassium clavulanate, and conversely, probenecid and allopurinol can increase the antibiotic&rsquo;s side effect potential<\/span><\/li>\n<\/ul>\n<h2 id=\"amoxicillin-potassium-clavulanate-drug-interactions\"><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate-drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Drug interactions with amoxicillin-potassium clavulanic acid boil down to either diminished or heightened levels of either the antibiotic or other drug. As a result, the beneficial effects of the meds may be nullified, or negative effects may be magnified.<\/span><\/p>\n<h3 id=\"estrogen-based-contraceptives\"><span style=\"font-weight: 400;\">Estrogen-based contraceptives<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32817012\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">reviews<\/span><\/a><span style=\"font-weight: 400;\"> of the topic, antibiotic usage in women on hormonal contraceptives has been associated with an increased rate of unintended pregnancy. However, this concern has not been fully substantiated, and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12063491\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">other reviews<\/span><\/a><span style=\"font-weight: 400;\"> have found no significant interaction. A change in treatment is not usually recommended, but using a barrier method of contraception, such as a condom, may be reasonable in addition to the estrogen-based contraceptive. Of course, using a condom also provides the extra advantage of some protection against sexually transmitted diseases.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Most commonly, estrogen-based contraceptives are taken in the form of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-birth-control-pill-contraceptive-guide\/\"><span style=\"font-weight: 400;\">birth control pills<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/birth-control-options\/\"><span style=\"font-weight: 400;\">Other varieties<\/span><\/a><span style=\"font-weight: 400;\"> include patches and rings. Examples of these various versions include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/junel-fe-1-20\/what-is\"><span style=\"font-weight: 400;\">Junel<\/span><\/a><span style=\"font-weight: 400;\"> (ethinyl estradiol and norethindrone pill)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/loestrin-fe-1-20\/what-is\"><span style=\"font-weight: 400;\">Loestrin<\/span><\/a><span style=\"font-weight: 400;\"> (ethinyl estradiol and norethindrone pill)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/xulane\/what-is\"><span style=\"font-weight: 400;\">Xulane<\/span><\/a><span style=\"font-weight: 400;\"> (ethinyl estradiol and norelgestromin weekly patch)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/zafemy\/what-is\"><span style=\"font-weight: 400;\">Zafemy<\/span><\/a><span style=\"font-weight: 400;\"> (ethinyl estradiol and norelgestromin weekly patch)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/nuvaring\/what-is\"><span style=\"font-weight: 400;\">Nuvaring<\/span><\/a><span style=\"font-weight: 400;\"> (ethinyl estradiol and etonogestrel monthly vaginal ring)<\/span><\/li>\n<\/ul>\n<h3 id=\"warfarin\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\/what-is\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/a><span style=\"font-weight: 400;\"> is an oral <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">anticoagulant<\/span><\/a><span style=\"font-weight: 400;\"> that thins the blood by blocking vitamin K-associated production of clotting proteins. Because vitamin K is absorbed after being produced by bacteria living in our intestines, antibiotics can reduce our vitamin K levels by killing these &ldquo;good&rdquo; bacteria. As a result, warfarin&#8217;s effectiveness can spike upward while taking antibiotics like amoxicillin-potassium clavulanate. This can mean more of a risk of bleeding. Your healthcare provider may want you to monitor warfarin closely while taking an antibiotic and seek immediate medical attention if you develop bleeding.<\/span><\/p>\n<h3 id=\"methotrexate\"><span style=\"font-weight: 400;\">Methotrexate<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Penicillins like amoxicillin-potassium clavulanate can increase the bodily concentrations of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/methotrexate-anti-rheumatic\/what-is\"><span style=\"font-weight: 400;\">methotrexate<\/span><\/a><span style=\"font-weight: 400;\">. Because methotrexate has a number of potentially serious <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/methotrexate-side-effects\/\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\">, you should be aware of this interaction. Methotrexate can cause adverse effects on the skin, liver, kidney, and blood cell counts. Bring this concern up to your doctor if you are prescribed both drugs, and if taking both, seek medical attention for new symptoms, such as fatigue, rash, skin color change, and change in urination.<\/span><\/p>\n<h3 id=\"tetracycline-class-antibiotics\"><span style=\"font-weight: 400;\">Tetracycline-class antibiotics<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The family of <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/tetracyclines\"><span style=\"font-weight: 400;\">tetracycline antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> is often used for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/tick-bites-prevention-treatment\/\"><span style=\"font-weight: 400;\">tick-borne illnesses<\/span><\/a><span style=\"font-weight: 400;\">, as well as skin and respiratory tract infections. In some cases, when dual antibiotic treatment is recommended, or two different infections are treated, they can be used alongside amoxicillin-potassium clavulanate. A tetracycline antibiotic could potentially lower the antibacterial efficacy of penicillins via competing mechanisms of action. To date, this has only been <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14867955\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">found to be an issue<\/span><\/a><span style=\"font-weight: 400;\"> during the treatment of meningitis. Common tetracyclines include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/doxycycline-hyclate\/what-is\"><span style=\"font-weight: 400;\">Doxycycline<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/minocin\/what-is\"><span style=\"font-weight: 400;\">Minocin<\/span><\/a><span style=\"font-weight: 400;\"> (minocycline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/tetracycline-hcl\/what-is\"><span style=\"font-weight: 400;\">Tetracycline<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"antigout-agents\"><span style=\"font-weight: 400;\">Antigout agents&nbsp;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Allopurinol and probenecid are two of the primary medicines for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/gout-triggers\/\"><span style=\"font-weight: 400;\">preventing attacks of gout<\/span><\/a><span style=\"font-weight: 400;\">. If you take allopurinol along with amoxicillin\/clavulanate potassium, your <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6458626\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">risk of developing a skin rash<\/span><\/a><span style=\"font-weight: 400;\"> may be higher.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Probenecid, on the other hand, directly increases levels of amoxicillin-potassium clavulanate in the body, an effect that could be thought of as positive or negative. Limited studies on the topic have not been conclusive, with some demonstrating an <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7191790\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">advantage<\/span><\/a><span style=\"font-weight: 400;\"> in treating infection, others an <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27169296\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">adverse outcome<\/span><\/a><span style=\"font-weight: 400;\"> from side effects, and still others showing <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC352859\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">no difference<\/span><\/a><span style=\"font-weight: 400;\">. At this point, if you find yourself on one of these drug combinations, you should discuss the interaction with your prescribing healthcare professional.<\/span><\/p>\n<h2 id=\"amoxicillin-potassium-clavulanate-food-interactions\"><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate-food interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate is actually best taken with food and can even be mixed with milk or juice to facilitate a pediatric dose of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/augmentin-es-600\"><span style=\"font-weight: 400;\">oral suspension liquid<\/span><\/a><span style=\"font-weight: 400;\">. Significant food interactions are not a concern.<\/span><\/p>\n<h2 id=\"other-amoxicillin-potassium-clavulanate-interactions\"><span style=\"font-weight: 400;\">Other amoxicillin-potassium clavulanate interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fortunately, this member of the penicillin family does not have many other interactions or contraindications. Nonetheless, a few are important to note.<\/span><\/p>\n<h3 id=\"amoxicillin-potassium-clavulanate-and-phenylketonuria\"><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate and phenylketonuria<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Phenylalanine can be present in some preparations of amoxicillin-potassium clavulanate. Accordingly, those with the metabolic disorder phenylketonuria should ask their pharmacists if phenylalanine is present to determine whether to avoid the drug.<\/span><\/p>\n<h3 id=\"amoxicillin-potassium-clavulanate-and-renal-impairment\"><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate and renal impairment<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The drug is excreted in the urine, and if kidney function is severely impaired, the drug&rsquo;s concentration could be too high. If you have kidney disease, you should get the medical advice of your healthcare team when prescribed amoxicillin-potassium clavulanate, or any new drug for that matter, to see if the dose should be adjusted for you.<\/span><\/p>\n<h3 id=\"amoxicillin-potassium-clavulanate-and-liver-disease\"><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate and liver disease<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While this antibiotic does not need to be avoided or adjusted in general with liver disease, amoxicillin-potassium clavulanate has been associated with some cases of drug-induced liver problems, specifically cholestatic hepatitis. These reactions are particular only to certain individuals, but enough cases occur to make amoxicillin-potassium clavulanate the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4945382\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most common cause<\/span><\/a><span style=\"font-weight: 400;\"> of idiosyncratic drug-included liver injury. If you develop symptoms such as fatigue, dark urine, or jaundice, you should swiftly get medical care.<\/span><\/p>\n<h3 id=\"amoxicillin-potassium-clavulanate-and-mononucleosis\"><span style=\"font-weight: 400;\">Amoxicillin-potassium clavulanate and mononucleosis<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Besides the chance of an allergic reaction, a rash can also result if amoxicillin products are taken in the setting of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-mono-last\/\"><span style=\"font-weight: 400;\">mononucleosis<\/span><\/a><span style=\"font-weight: 400;\">, better known as mono. You can imagine that this is not uncommon, given that antibiotics are sometimes prescribed for sore throat, a symptom that can be from mono. To best avoid this, your healthcare provider may recommend a throat swab to determine if a bacterial infection, namely <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/strep-throat-vs-sore-throat\/\"><span style=\"font-weight: 400;\">strep throat<\/span><\/a><span style=\"font-weight: 400;\">, is the cause of sore throat or not before prescribing any antibiotic.<\/span><\/p>\n<h2 id=\"how-to-minimize-amoxicillin-potassium-clavulanate-interactions\"><span style=\"font-weight: 400;\">How to minimize amoxicillin-potassium clavulanate interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Your best bet to avoid drug-drug interactions involving amoxicillin-potassium clavulanate is to communicate well with your medical providers. Keep an updated, accurate prescription drug list, including over-the-counter medications and supplements too, and review this list with your provider at each visit. Make sure that any provider who&rsquo;s prescribing meds for you is aware of all of your underlying medical conditions. Periodically and when a new medication is prescribed, ask about any interactions with your existing therapies.&nbsp;<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-amoxicillin-potassium-clavulanate-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about amoxicillin-potassium clavulanate interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you are worried about a potential drug interaction, the time is now to ask about it. Taking an active role in your own care is essential for the best outcomes. By bringing up a potential interaction with amoxicillin-potassium clavulanate, you could avoid an adverse reaction or, at the very least, have peace of mind and a better understanding of why it is being prescribed for you.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amoxicillin-potassium clavulanate is a widely used antibiotic from the penicillin family that is prescribed for bacterial infections of the sinuses, ears, lungs, and skin, as well as diverticulitis and urinary tract infections. Barring an allergy to penicillins, you stand a good chance of being prescribed amoxicillin-potassium clavulanate; its brand-name version, Augmentin; or the extended-release tablets. [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":61037,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,814],"coauthors":[20732],"class_list":["post-61031","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Amoxicillin-potassium clavulanate interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Amoxicillin-potassium clavulanate (Augmentin) interacts with certain birth control, warfarin, methotrexate, tetracycline antibiotics, and antigout agents. Here\u2019s what you should not take with amoxicillin-potassium clavulanate to avoid side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-potassium-clavulanate-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Amoxicillin-potassium clavulanate interactions to avoid\" \/>\n<meta property=\"og:description\" content=\"Amoxicillin-potassium clavulanate (Augmentin) interacts with certain birth control, warfarin, methotrexate, tetracycline antibiotics, and antigout agents. Here\u2019s what you should not take with amoxicillin-potassium clavulanate to avoid side effects.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-potassium-clavulanate-interactions\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2023-10-27T13:35:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-25T14:28:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2023\/10\/amoxicillin-potassium-clavulanate-interactions-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Chad Shaffer, MD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Chad Shaffer, MD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"Amoxicillin-potassium clavulanate interactions to avoid\",\"datePublished\":\"2023-10-27T13:35:42+00:00\",\"dateModified\":\"2024-10-25T14:28:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/\"},\"wordCount\":1253,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/10\\\/amoxicillin-potassium-clavulanate-interactions-1.png\",\"keywords\":[\"Antibiotics\",\"Drug interactions\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/\",\"name\":\"Amoxicillin-potassium clavulanate interactions to avoid | SingleCare\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/amoxicillin-potassium-clavulanate-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/10\\\/amoxicillin-potassium-clavulanate-interactions-1.png\",\"datePublished\":\"2023-10-27T13:35:42+00:00\",\"dateModified\":\"2024-10-25T14:28:06+00:00\",\"description\":\"Amoxicillin-potassium clavulanate (Augmentin) interacts with certain birth control, warfarin, methotrexate, tetracycline antibiotics, and antigout agents. 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