{"id":61069,"date":"2023-10-30T10:25:01","date_gmt":"2023-10-30T14:25:01","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61069"},"modified":"2024-12-19T12:04:48","modified_gmt":"2024-12-19T17:04:48","slug":"amoxicillin-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/amoxicillin-interactions\/","title":{"rendered":"Amoxicillin interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\/what-is\"><span style=\"font-weight: 400;\">Amoxicillin<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription-only, broad-spectrum antibiotic originally derived from penicillin that is approved by the U.S. Food and Drug Administration (FDA) to treat a wide range of respiratory bacterial infections, such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/pneumonia-treatment-and-medications\"><span style=\"font-weight: 400;\">pneumonia<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bronchitis-treatment-and-medications\"><span style=\"font-weight: 400;\">bronchitis<\/span><\/a><span style=\"font-weight: 400;\">, as well as infections of the <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ear-infection-treatment-and-medications\"><span style=\"font-weight: 400;\">ear<\/span><\/a><span style=\"font-weight: 400;\">, nose, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/strep-throat-vs-sore-throat\/\"><span style=\"font-weight: 400;\">throat<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/uti-treatment-and-medications\"><span style=\"font-weight: 400;\">urinary tract infections<\/span><\/a><span style=\"font-weight: 400;\">, and skin. It can also be used together with other medicines, such as the proton pump inhibitor <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lansoprazole\/what-is\"><span style=\"font-weight: 400;\">lansoprazole<\/span><\/a><span style=\"font-weight: 400;\">, to treat stomach ulcers (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/h-pylori-symptoms\"><i><span style=\"font-weight: 400;\">H. pylori<\/span><\/i><span style=\"font-weight: 400;\"> stomach infections<\/span><\/a><span style=\"font-weight: 400;\">). It kills bacteria by blocking their ability to make and repair their protective cell walls. Like all antibiotics, amoxicillin is not effective against viral infections.<\/span><\/p>\n<p><span data-sheets-root=\"1\" data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:6849,&quot;3&quot;:{&quot;1&quot;:0},&quot;9&quot;:1,&quot;10&quot;:2,&quot;12&quot;:0,&quot;14&quot;:{&quot;1&quot;:2,&quot;2&quot;:0},&quot;15&quot;:&quot;Arial&quot;}\" data-sheets-formula=\"=CONCATENATE(R[0]C[-2],R[0]C[-3],R[0]C[-1])\"><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Amoxicillin is generic for the brand-name products Amoxil, Trimox, and Larotid. Amoxicillin is also available combined with clavulanate, which enhances the antibacterial effect, as the generic or as brand-name <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/augmentin\/what-is\"><span style=\"font-weight: 400;\">Augmentin<\/span><\/a><span style=\"font-weight: 400;\">. Dosage forms available include amoxicillin capsules, chewable tablets, and pediatric oral suspensions. For most infections, amoxicillin is prescribed to be taken three times daily for 10 to 14 days. Those taking amoxicillin may experience <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-side-effects\/\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\">, but drug interactions taken for existing medical conditions are also possible. It is important to be aware of how amoxicillin may affect the action of other drugs and, conversely, how other drugs (and foods) may affect amoxicillin.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-on-an-empty-stomach\/\"><b>Can you take amoxicillin on an empty stomach?<\/b><\/a><\/p>\n<h2 id=\"key-takeaways\"><span style=\"font-weight: 400;\">Key takeaways:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amoxicillin interacts with oral anticoagulants, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\/what-is\"><span style=\"font-weight: 400;\">warfarin<\/span><\/a><span style=\"font-weight: 400;\">, leading to a risk of bleeding. Adjustments in the dose of the oral anticoagulant may be necessary to maintain the desired blood levels.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood level concentrations of amoxicillin can be higher if taken with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/probenecid\/what-is\"><span style=\"font-weight: 400;\">probenecid<\/span><\/a><span style=\"font-weight: 400;\">, a gout prevention pill, which could lead to increased side effects. Taking amoxicillin with probenecid is not recommended.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taking <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allopurinol\/what-is\"><span style=\"font-weight: 400;\">allopurinol<\/span><\/a><span style=\"font-weight: 400;\">, another gout-prevention medicine, and amoxicillin together may increase the incidence of skin rashes or hives.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain antibacterials, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/chloramphenicol-sod-succinate\/what-is\"><span style=\"font-weight: 400;\">chloramphenicol<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin\/what-is\"><span style=\"font-weight: 400;\">erythromycin<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sulfamethoxazole\"><span style=\"font-weight: 400;\">sulfamethoxazole<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tetracycline-hcl\/what-is\"><span style=\"font-weight: 400;\">tetracycline<\/span><\/a><span style=\"font-weight: 400;\">, may interfere with the efficacy of amoxicillin and should not be taken at the same time.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">There has been concern in the past about whether taking <\/span><span style=\"font-weight: 400;\">antibiotics can interfere with the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/antibiotics-and-birth-control\/\"><span style=\"font-weight: 400;\">effectiveness of birth control pills<\/span><\/a><span style=\"font-weight: 400;\"> and lead to unexpected pregnancy. The overall risk is small and applies more to some specific antibacterials, notably <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/rifampin\/what-is\"><span style=\"font-weight: 400;\">rifampin<\/span><\/a><span style=\"font-weight: 400;\"> in the rifamycin class of drugs, than with amoxicillin.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amoxicillin can be taken without regard to meals, as the presence or absence of food does not alter its effectiveness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">When prescribed amoxicillin while taking any other medicine that may interact with it, discuss this concern with a healthcare provider.<\/span><\/li>\n<\/ul>\n<h2 id=\"amoxicillin-drug-interactions\"><span style=\"font-weight: 400;\">Amoxicillin drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most potential interactions with amoxicillin are considered mild or moderate and not dangerous, as is true of other penicillin antibiotics. There are certain prescription drugs that should be avoided when taking amoxicillin. This includes some gout medications, blood thinners (anticoagulants), and certain types of antibacterials. None of these interactions mean that they cannot be used with amoxicillin, but they do call for awareness and monitoring.<\/span><\/p>\n<h3 id=\"blood-thinners\"><span style=\"font-weight: 400;\">Blood thinners<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Amoxicillin may make it harder for the body to absorb anticoagulants (blood thinners) like warfarin (brand name Coumadin). Anticoagulants are prescribed to help prevent blood clots from forming, typically for patients at risk of clotting following surgery. Taking amoxicillin concurrently may <\/span><a href=\"https:\/\/www.mdpi.com\/2075-1729\/13\/8\/1661#:~:text=In%20particular%2C%20antibiotics%20have%20the,enzyme%20crucial%20for%20warfarin%20metabolism.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">amplify the drugs\u2019 anticoagulant effects<\/span><\/a><span style=\"font-weight: 400;\"> and even lead to dangerous conditions like warfarin toxicity or internal bleeding. However, most people who take amoxicillin short-term (10 to 14 days) while taking an anticoagulant do not experience these issues. Your healthcare professional should monitor you for symptoms of possible serious side effects.<\/span><\/p>\n<h3 id=\"gout-medications\"><span style=\"font-weight: 400;\">Gout medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Probenecid, also known by the brand name Probalan, is a medication used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/gout-treatment-and-medications\"><span style=\"font-weight: 400;\">gout<\/span><\/a><span style=\"font-weight: 400;\">. It works by raising the amount of uric acid released through the urine. This lowers uric acid levels in the blood. Taking probenecid with amoxicillin may increase the levels of amoxicillin in the blood because it makes it more difficult for the kidneys to filter antibiotics from the body. This, in turn, may increase the risk of side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Allopurinol, a common generic gout medication also known by the brand name Zyloprim, may make a person more sensitive to amoxicillin when the two drugs are taken together. This may lead to a greater chance of developing an allergic reaction to amoxicillin, particularly a skin rash.<\/span><\/p>\n<h3 id=\"antibacterials\"><span style=\"font-weight: 400;\">Antibacterials<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Certain antibacterials, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/chloramphenicol-sod-succinate\/what-is\"><span style=\"font-weight: 400;\">chloramphenicol<\/span><\/a><span style=\"font-weight: 400;\">, macrolides (e.g., <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin-base\/what-is\"><span style=\"font-weight: 400;\">erythromycin<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\/what-is\"><span style=\"font-weight: 400;\">clarithromycin<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/azithromycin\/what-is\"><span style=\"font-weight: 400;\">azithromycin<\/span><\/a><span style=\"font-weight: 400;\">), sulfonamides (e.g., <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/bactrim\/what-is\"><span style=\"font-weight: 400;\">Bactrim<\/span><\/a><span style=\"font-weight: 400;\">), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tetracycline-hcl\/what-is\"><span style=\"font-weight: 400;\">tetracyclines<\/span><\/a><span style=\"font-weight: 400;\"> (e.g., Sumycin, doxycycline), may interfere with and reduce the bactericidal effects of amoxicillin. Always consult a healthcare professional before combining amoxicillin with other antibiotics or antibacterial medicines.<\/span><\/p>\n<h3 id=\"birth-control-pills\"><span style=\"font-weight: 400;\">Birth control pills<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In the past, it was thought that taking antibiotics with hormonal birth control pills or patches might make them less effective, increasing the risk of pregnancy. It has since been determined that only antibacterials that speed up the metabolism of hormonal contraceptives, such as rifampin (brand names Rifadin and Rimactane) in the rifamycin class, can potentially interact and reduce their effectiveness. According to a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28694152\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2017 database review<\/span><\/a><span style=\"font-weight: 400;\">, no evidence of drug interactions between hormonal contraception and non-rifamycin antibiotics was found.\u00a0<\/span><\/p>\n<h2 id=\"amoxicillin-food-interactions\"><span style=\"font-weight: 400;\">Amoxicillin food interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to the <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2008\/050760s11,050761s11,050754s12,050542s25lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">amoxicillin product labeling<\/span><\/a><span style=\"font-weight: 400;\">, there are no drug-food interactions of concern. Taking amoxicillin with or without food has minimal effects on the absorption of amoxicillin into the bloodstream, therefore, it can be taken without regard to meals. Amoxicillin combined with clavulanate may cause some gastrointestinal (GI) discomfort, so it is recommended to be taken before meals to minimize possible GI side effects.\u00a0<\/span><\/p>\n<h2 id=\"other-amoxicillin-interactions\"><span style=\"font-weight: 400;\">Other amoxicillin interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following interactions with amoxicillin are not as consequential as the previously mentioned drug-drug interactions. Any concerns or questions one may have about specific foods, over-the-counter (OTC) medications, or vitamins or herbal supplements should be discussed with a healthcare professional.\u00a0<\/span><\/p>\n<h3 id=\"amoxicillin-and-alcohol\"><span style=\"font-weight: 400;\">Amoxicillin and alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Although <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-and-alcohol\/\"><span style=\"font-weight: 400;\">drinking alcohol while taking amoxicillin<\/span><\/a><span style=\"font-weight: 400;\"> is not prohibited, most healthcare professionals recommend avoiding alcohol because it may increase common amoxicillin side effects such as nausea and abdominal discomfort. Alcohol may also weaken the immune system and lead to dehydration which may make the infection more difficult to treat.<\/span><\/p>\n<h3 id=\"amoxicillin-and-oral-live-vaccines\"><span style=\"font-weight: 400;\">Amoxicillin and oral live vaccines<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Antibacterial drugs such as amoxicillin can impact the effectiveness of the <\/span><a href=\"https:\/\/wwwnc.cdc.gov\/travel\/yellowbook\/2024\/preparing\/interactions-travel-vaccines-drugs\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">oral typhoid and cholera vaccines<\/span><\/a><span style=\"font-weight: 400;\">. It is recommended to delay vaccination with oral typhoid vaccine by more than three days (72 hours) and delay oral cholera vaccine by more than 14 days following a course of therapy of amoxicillin.\u00a0<\/span><\/p>\n<h3 id=\"amoxicillin-and-bromelain\"><span style=\"font-weight: 400;\">Amoxicillin and bromelain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Certain antibiotics, including amoxicillin, may <\/span><a href=\"https:\/\/www.healthline.com\/health\/bromelain#interactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">interact with bromelain<\/span><\/a><span style=\"font-weight: 400;\">, an enzyme extract derived from pineapples. Taking bromelain might increase how much amoxicillin is absorbed, which may increase the effects, and side effects, such as stomach pain, of the drug.<\/span><\/p>\n<h3 id=\"amoxicillin-and-guar-gum\"><span style=\"font-weight: 400;\">Amoxicillin and guar gum<\/span><\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3931889\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Guar gum<\/span><\/a><span style=\"font-weight: 400;\">, fiber from the seed of the guar plant, is used to treat diarrhea, irritable bowel syndrome (IBS), constipation, high blood pressure, and high cholesterol. <\/span><a href=\"https:\/\/www.drugs.com\/drug-interactions\/amoxicillin-with-guar-gum-187-0-1221-0.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Guar gum may reduce the absorption of amoxicillin<\/span><\/a>,<span style=\"font-weight: 400;\"> and it is recommended it be taken two hours before or two hours after taking the amoxicillin.<\/span><\/p>\n<h2 id=\"how-to-minimize-amoxicillin-interactions\"><span style=\"font-weight: 400;\">How to minimize amoxicillin interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While many medications can be taken at the same time as amoxicillin safely, there are several medications that can have potentially serious negative outcomes when taken with amoxicillin. To avoid potential problems before starting a new prescription, it\u2019s always best to give the prescribing healthcare provider a list of all prescription and over-the-counter medications, vitamins, herbs, and supplements being taken, as well as any existing medical conditions. By sharing this information, it is much easier to prevent any interactions before they occur. It may result in a different antibiotic, such as the cephalosporin antibiotics <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cefaclor\/what-is\"><span style=\"font-weight: 400;\">cefaclor<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cephalexin\/what-is\"><span style=\"font-weight: 400;\">cephalexin<\/span><\/a><span style=\"font-weight: 400;\">, or a macrolide, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\/what-is\"><span style=\"font-weight: 400;\">clarithromycin<\/span><\/a>,<span style=\"font-weight: 400;\"> being prescribed.\u00a0<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-amoxicillin-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about amoxicillin interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Severe drug interactions are rare when taking amoxicillin. Overall, the drug is very safe. Tell your healthcare provider about any adverse effects experienced, even if they may not be related to amoxicillin. This article doesn\u2019t provide a complete list of all of the potential interactions, so it\u2019s important to be conscious of any untoward effects from taking amoxicillin with another drug and to seek medical advice if any occur.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Contact the prescribing healthcare provider immediately if any of the following symptoms occur while taking amoxicillin with another drug:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A persistently high fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sudden sweats or chills<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unexplained fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New or worsening pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New or worsening gastrointestinal symptoms like nausea, vomiting, and diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rashes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sudden weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Numbness or tingling in your hands and feet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion and lightheadedness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood in your stool or urine<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Amoxicillin is a prescription-only, broad-spectrum antibiotic originally derived from penicillin that is approved by the U.S. Food and Drug Administration (FDA) to treat a wide range of respiratory bacterial infections, such as pneumonia and bronchitis, as well as infections of the ear, nose, throat, urinary tract infections, and skin. It can also be used together [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":61076,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,814],"coauthors":[20733],"class_list":["post-61069","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Amoxicillin interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Amoxicillin interacts with anticoagulants, such as warfarin, gout prevention medications, and antibacterials. 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