{"id":61090,"date":"2023-10-30T11:52:11","date_gmt":"2023-10-30T15:52:11","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61090"},"modified":"2024-10-25T10:27:32","modified_gmt":"2024-10-25T14:27:32","slug":"trazodone-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/trazodone-interactions\/","title":{"rendered":"Trazodone interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/trazodone-hcl\/what-is\"><span style=\"font-weight: 400;\">Trazodone<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription antidepressant medication approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder, or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-causes\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\">, a common mental health condition. The way trazodone works is by increasing serotonin levels in the brain. It is also sometimes prescribed <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> (for non-FDA-approved use) for conditions such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-sleep-better\/\"><span style=\"font-weight: 400;\">insomnia<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/fibromyalgia-symptoms\"><span style=\"font-weight: 400;\">fibromyalgia<\/span><\/a><span style=\"font-weight: 400;\">. Trazodone is a generic medication. It&rsquo;s often referred to by the brand names Desyrel or Oleptro, but the brand name formulations are no longer available in the United States.&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/clincalc.com\/DrugStats\/Drugs\/Trazodone\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Data as of 2020<\/span><\/a><span style=\"font-weight: 400;\"> shows that <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trazodone-hcl\"><span style=\"font-weight: 400;\">trazodone<\/span><\/a><span style=\"font-weight: 400;\"> is the 21<\/span><span style=\"font-weight: 400;\">st<\/span><span style=\"font-weight: 400;\"> most popularly prescribed medication in the U.S., with over five million patients filling more than 26 million prescriptions. When taking this medication, it is important to be aware of drug interactions that can affect how effective the medication is or cause a worsening of adverse effects. Continue reading to learn more about trazodone interactions.<\/span><\/p>\n<h2 id=\"key-takeaways\"><span style=\"font-weight: 400;\">Key takeaways:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trazodone interacts with various drugs, including other drugs that affect serotonin levels, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">blood thinners<\/span><\/a><span style=\"font-weight: 400;\">, drugs that cause central nervous system (CNS) depression, and others.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depending on the specific interaction, various effects could occur, such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/serotonin-syndrome-treatment-and-medications\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\"> or increased side effects of trazodone.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Always consult a healthcare provider regarding possible trazodone interactions to ensure this medication is taken as safely as possible.<\/span><\/li>\n<\/ul>\n<h2 id=\"trazodone-drug-interactions\"><span style=\"font-weight: 400;\">Trazodone drug interactions<\/span><\/h2>\n<p><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=71961ab1-951d-1493-f76c-2ff25cca2a85#_ae6051b9-9d2d-a9eb-273c-7cdfd31c8812\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Trazodone interacts<\/span><\/a><span style=\"font-weight: 400;\"> with various medications, and the mechanism by which they interact varies based on each category. Some of these medications are in two categories, as they can interact with trazodone in multiple ways.<\/span><\/p>\n<h3 id=\"drugs-that-increase-the-risk-of-serotonin-syndrome\"><span style=\"font-weight: 400;\">Drugs that increase the risk of serotonin syndrome<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\"><span style=\"font-weight: 400;\">Serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\"> is a condition caused by the buildup of excess serotonin levels. Serotonin syndrome may occur if one takes more than one medicine that affects serotonin levels, if too much medication that increases serotonin levels is taken, or if starting or increasing the dose of a medication that increases serotonin levels. Symptoms of serotonin syndrome may include agitation, anxiety, restlessness, mood changes, confusion, incoordination, sweating, overheating, increased heart rate or blood pressure, nausea, vomiting, diarrhea, shaking, dilated pupils, and muscle stiffness. Serotonin syndrome is a medical emergency. It may start mild but can progress quickly to death if untreated. If symptoms of serotonin syndrome occur, get emergency medical help.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because trazodone increases serotonin levels, other drugs that affect serotonin levels can interact with trazodone. <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> (MAO inhibitors or MAOIs), in particular, are contraindicated and should never be used in people who take trazodone. Some examples of MAOIs include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zyvox\/what-is\"><span style=\"font-weight: 400;\">Zyvox<\/span><\/a><span style=\"font-weight: 400;\"> (linezolid), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/marplan\/what-is\"><span style=\"font-weight: 400;\">Marplan<\/span><\/a><span style=\"font-weight: 400;\"> (isocarboxazid), <\/span><span style=\"font-weight: 400;\">Nardil<\/span><span style=\"font-weight: 400;\"> (phenelzine), Eldepryl (selegiline), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/parnate\/what-is\"><span style=\"font-weight: 400;\">Parnate<\/span><\/a><span style=\"font-weight: 400;\"> (tranylcypromine), and methylene blue.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other drugs can also increase serotonin levels. This does not always mean the combination needs to be avoided. However, the healthcare provider will determine if the combination with trazodone is safe. If one of these medications is taken with trazodone, the patient will be closely monitored for signs of serotonin syndrome.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of other medications that can increase serotonin levels include but are not limited to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\"><span style=\"font-weight: 400;\">Selective serotonin reuptake inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> (SSRIs) such as <\/span><span style=\"font-weight: 400;\">Lexapro<\/span><span style=\"font-weight: 400;\"> (escitalopram), <\/span><span style=\"font-weight: 400;\">Prozac<\/span><span style=\"font-weight: 400;\"> (fluoxetine), or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/\"><span style=\"font-weight: 400;\">Zoloft<\/span><\/a><span style=\"font-weight: 400;\"> (sertraline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/snris\"><span style=\"font-weight: 400;\">Serotonin and norepinephrine reuptake inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> (SNRIs) such as <\/span><span style=\"font-weight: 400;\">Cymbalta<\/span><span style=\"font-weight: 400;\"> (duloxetine) or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr\/what-is#\"><span style=\"font-weight: 400;\">Effexor<\/span><\/a><span style=\"font-weight: 400;\"> (venlafaxine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/amitriptyline-for-sleep\/\"><span style=\"font-weight: 400;\">Elavil<\/span><\/a><span style=\"font-weight: 400;\"> (amitriptyline) or <\/span><span style=\"font-weight: 400;\">Pamelor<\/span><span style=\"font-weight: 400;\"> (nortriptyline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/triptans\"><span style=\"font-weight: 400;\">Triptans<\/span><\/a><span style=\"font-weight: 400;\"> for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraine<\/span><\/a><span style=\"font-weight: 400;\">, including <\/span><span style=\"font-weight: 400;\">Imitrex<\/span><span style=\"font-weight: 400;\"> (sumatriptan)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/mood-stabilizers\"><span style=\"font-weight: 400;\">Mood stabilizers<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><span style=\"font-weight: 400;\">lithium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anxiolytics\"><span style=\"font-weight: 400;\">Anxiolytics<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/buspar-for-anxiety\/\"><span style=\"font-weight: 400;\">Buspar<\/span><\/a><span style=\"font-weight: 400;\"> (buspirone Hcl)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">Opioid<\/span><\/a><span style=\"font-weight: 400;\"> pain medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/tramadol-alternatives\/\"><span style=\"font-weight: 400;\">Ultram<\/span><\/a><span style=\"font-weight: 400;\"> (tramadol), <a href=\"https:\/\/www.singlecare.com\/prescription\/fentanyl\">fentanyl<\/a> and <\/span><span style=\"font-weight: 400;\">oxycodone<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Supplements such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/l-tryptophan\/what-is\"><span style=\"font-weight: 400;\">L-Tryptophan<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/st-johns-wort\/what-is\"><span style=\"font-weight: 400;\">St. John&rsquo;s wort<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"drugs-that-increase-bleeding-risk\"><span style=\"font-weight: 400;\">Drugs that increase bleeding risk<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/tag\/blood-thinners\/\"><span style=\"font-weight: 400;\">blood thinner<\/span><\/a><span style=\"font-weight: 400;\"> with trazodone increases the risk of bleeding. Patients who take trazodone with a blood thinner will be carefully monitored. Examples of blood thinners include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/new-blood-thinners\/\"><span style=\"font-weight: 400;\">Coumadin<\/span><\/a><span style=\"font-weight: 400;\"> (warfarin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/eliquis-alternatives\/\"><span style=\"font-weight: 400;\">Eliquis<\/span><\/a><span style=\"font-weight: 400;\"> (apixaban)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/plavix\/what-is\"><span style=\"font-weight: 400;\">Plavix<\/span><\/a><span style=\"font-weight: 400;\"> (clopidogrel)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pradaxa<\/span><span style=\"font-weight: 400;\"> (dabigatran)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/xarelto-savings\/\"><span style=\"font-weight: 400;\">Xarelto<\/span><\/a><span style=\"font-weight: 400;\"> (rivaroxaban)<\/span><\/li>\n<\/ul>\n<h3 id=\"enzyme-inhibitors\"><span style=\"font-weight: 400;\">Enzyme inhibitors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many drugs, including trazodone, are processed in the body by an enzyme called cytochrome P450 3A4 (CYP3A4). Certain drugs inhibit this enzyme, slowing the processing of trazodone. The effect is a higher level of trazodone in the body, which could lead to increased side effects, including blurred vision, constipation, dry mouth, priapism (prolonged, painful erection), drowsiness, lightheadedness, and heart rhythm problems. The prescribing information recommends using a lower dose of trazodone if a strong CYP3A4 inhibitor must be taken. Examples of these drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Biaxin (<\/span><span style=\"font-weight: 400;\">clarithromycin<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin\/what-is\"><span style=\"font-weight: 400;\">Erythromycin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/nizoral\/what-is\"><span style=\"font-weight: 400;\">Nizoral<\/span><\/a><span style=\"font-weight: 400;\"> (ketoconazole)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sporanox<\/span><span style=\"font-weight: 400;\"> (itraconazole)<\/span><\/li>\n<\/ul>\n<h3 id=\"enzyme-inducers\"><span style=\"font-weight: 400;\">Enzyme inducers<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While enzyme inhibitors mentioned above slow down the processing of trazodone, enzyme inducers have the opposite effect. They speed up how fast trazodone is processed in the body. This means a higher dose of trazodone may be required. The patient will be monitored carefully if an enzyme inducer is combined with trazodone. Examples of these medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/dilantin\/what-is\"><span style=\"font-weight: 400;\">Dilantin<\/span><\/a><span style=\"font-weight: 400;\"> (phenytoin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/rifampin\/what-is\"><span style=\"font-weight: 400;\">Rifampin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">St. John&rsquo;s wort (<a href=\"https:\/\/www.singlecare.com\/blog\/diet-supplements-can-interact-medications\/\">dietary supplement<\/a><\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tegretol<\/span><span style=\"font-weight: 400;\"> (carbamazepine)<\/span><\/li>\n<\/ul>\n<h3 id=\"drugs-with-a-narrow-therapeutic-index\"><span style=\"font-weight: 400;\">Drugs with a narrow therapeutic index<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some drugs have what is called a <\/span><a href=\"https:\/\/www.fda.gov\/industry\/generic-drug-user-fee-amendments\/fy2015-regulatory-science-research-report-narrow-therapeutic-index-drugs\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">narrow therapeutic index<\/span><\/a><span style=\"font-weight: 400;\">. This means that a small change in dose or blood levels can lead to toxicity or other complications. Narrow therapeutic drugs that interact with trazodone include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lanoxin\/what-is\"><span style=\"font-weight: 400;\">Lanoxin<\/span><\/a><span style=\"font-weight: 400;\"> (digoxin) and <\/span><span style=\"font-weight: 400;\">Dilantin<\/span><span style=\"font-weight: 400;\"> (phenytoin). The interactions involve trazodone acting on these narrow therapeutic drugs, increasing their blood levels, which may cause side effects or toxicity. Patients who take one of these medications with trazodone will be carefully and regularly monitored. A lower dose of digoxin or phenytoin may be required.&nbsp;<\/span><\/p>\n<h3 id=\"drugs-and-substances-that-cause-central-nervous-system-cns-depression\"><span style=\"font-weight: 400;\">Drugs and substances that cause central nervous system (CNS) depression<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Trazodone (as well as many other medications) causes central nervous system (CNS) depression, slowing down nervous system activity. While this activity helps treat certain conditions, too much <\/span><a href=\"https:\/\/nida.nih.gov\/publications\/drugfacts\/prescription-cns-depressants\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CNS depression<\/span><\/a><span style=\"font-weight: 400;\"> can cause impairment, extreme sedation, slowed breathing, loss of consciousness, coma, or even death. Trazodone combined with another CNS depressant can have an additive effect. Ask a healthcare provider about this interaction if any other CNS depressants are being taken. It&rsquo;s also a good idea to ask about safe <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/alcohol-statistics\/\"><span style=\"font-weight: 400;\">alcohol consumption<\/span><\/a><span style=\"font-weight: 400;\"> if consuming alcohol. Some cough and cold medications contain an antihistamine (or a small amount of alcohol), which can cause CNS depression, so check with the pharmacist or healthcare provider before taking any prescription or over-the-counter (OTC) cough and cold medications. Examples of drugs and substances that cause CNS depression include:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alcohol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/a><span style=\"font-weight: 400;\"> medications like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/xanax\/dosage\"><span style=\"font-weight: 400;\">Xanax (alprazolam)<\/span><\/a><span style=\"font-weight: 400;\"> or Valium (diazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Barbiturates such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phenobarbital-without-insurance\/\"><span style=\"font-weight: 400;\">phenobarbital<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/taking-antihistamines-daily\/\"><span style=\"font-weight: 400;\">antihistamines<\/span><\/a><span style=\"font-weight: 400;\">, like <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/benadryl-vs-claritin\/\"><span style=\"font-weight: 400;\">Benadryl<\/span><\/a><span style=\"font-weight: 400;\"> (diphenhydramine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/best-muscle-relaxers\/\"><span style=\"font-weight: 400;\">Muscle relaxants<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/skelaxin-vs-flexeril\/\"><span style=\"font-weight: 400;\">Flexeril<\/span><\/a><span style=\"font-weight: 400;\"> (cyclobenzaprine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioid pain medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/oxycodone-acetaminophen-without-insurance\/\"><span style=\"font-weight: 400;\">Percocet<\/span><\/a><span style=\"font-weight: 400;\"> (oxycodone\/acetaminophen)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/news\/sleep-statistics\/\"><span style=\"font-weight: 400;\">Sleep<\/span><\/a><span style=\"font-weight: 400;\"> medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/trazodone-vs-ambien\/\"><span style=\"font-weight: 400;\">Ambien<\/span><\/a><span style=\"font-weight: 400;\"> (zolpidem)<\/span><\/li>\n<\/ul>\n<h3 id=\"drugs-that-can-affect-heart-rhythm\"><span style=\"font-weight: 400;\">Drugs that can affect heart rhythm<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Trazodone can affect the heart rhythm, causing <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK441860\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">QT prolongation<\/span><\/a><span style=\"font-weight: 400;\">, and if taken with another drug that affects heart rhythm, it could increase the risk of irregular heartbeat. Patients at high risk for heart rhythm conditions should not take trazodone. Trazodone should not be taken with drugs that affect the heart rhythm. Examples of medications that can affect heart rhythm when combined with trazodone include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Betapace<\/span><span style=\"font-weight: 400;\"> (sotalol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/chlorpromazine-hcl\/what-is\"><span style=\"font-weight: 400;\">Chlorpromazine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cordarone (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/amiodarone-alternatives\/\"><span style=\"font-weight: 400;\">amiodarone<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/geodon\/what-is\"><span style=\"font-weight: 400;\">Geodon<\/span><\/a><span style=\"font-weight: 400;\"> (ziprasidone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/norpace\/what-is\"><span style=\"font-weight: 400;\">Norpace<\/span><\/a><span style=\"font-weight: 400;\"> (disopyramide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Procainamide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quinidine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thioridazine<\/span><\/li>\n<\/ul>\n<h2 id=\"trazodone-food-interactions\"><span style=\"font-weight: 400;\">Trazodone-food interactions<\/span><\/h2>\n<h3 id=\"trazodone-and-grapefruit\"><span style=\"font-weight: 400;\">Trazodone and grapefruit&nbsp;<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/grapefruit-juice-with-medicine-other-foods\/\"><span style=\"font-weight: 400;\">Grapefruit and grapefruit juice<\/span><\/a><span style=\"font-weight: 400;\"> products (including any type of juice that contains grapefruit) act as an enzyme inhibitor, which can increase trazodone levels in the body. Ask a healthcare provider how much, if any, grapefruit can be consumed while taking trazodone.<\/span><\/p>\n<h2 id=\"trazodone-and-other-interactions\"><span style=\"font-weight: 400;\">Trazodone and other interactions<\/span><\/h2>\n<h3 id=\"trazodone-and-alcohol\"><span style=\"font-weight: 400;\">Trazodone and alcohol&nbsp;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">As discussed above, trazodone and alcohol both cause CNS depression. Combining the two can increase the risk of serious side effects or complications, including impairment, extreme sedation, slowed breathing, loss of consciousness, coma, or even death. Consult a healthcare professional about alcohol consumption.&nbsp;<\/span><\/p>\n<h3 id=\"trazodone-and-caffeine\"><span style=\"font-weight: 400;\">Trazodone and caffeine&nbsp;<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Trazodone causes increased sedation, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/caffeine-and-anxiety\/\"><span style=\"font-weight: 400;\">caffeine<\/span><\/a><span style=\"font-weight: 400;\"> causes decreased sedation. While the effect is unclear, check with a healthcare provider about caffeine consumption while taking trazodone.<\/span><\/p>\n<h3 id=\"trazodone-and-dietary-supplements\"><span style=\"font-weight: 400;\">Trazodone and dietary supplements<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Combining trazodone with certain dietary supplements, such as St. John&rsquo;s wort or tryptophan, can increase the risk of serotonin syndrome. Check with the pharmacist or healthcare provider before starting any dietary supplement.<\/span><\/p>\n<h3 id=\"trazodone-and-marijuana\"><span style=\"font-weight: 400;\">Trazodone and marijuana<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Marijuana may increase the trazodone levels and effects. Both cause sedation. Consult a healthcare provider if marijuana is also being used.<\/span><\/p>\n<h3 id=\"trazodone-and-illicit-drugs\"><span style=\"font-weight: 400;\">Trazodone and illicit drugs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Combining trazodone with an illicit drug such as LSD or cocaine could increase the risk of toxicity and serotonin syndrome.&nbsp;<\/span><\/p>\n<h2 id=\"how-to-minimize-trazodone-interactions\"><span style=\"font-weight: 400;\">How to minimize trazodone interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Trazodone has many potential interactions but can still be taken safely with some precautions.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Always talk to a healthcare provider before starting a new medication. Before taking trazodone, make sure the provider is aware of any medical conditions, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver or kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart problems (such as heart disease or a heart rhythm condition) or a recent heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A blood clotting disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/epilepsy-treatment-and-medications\"><span style=\"font-weight: 400;\">Seizures<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suicidal thoughts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Substance use disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/bipolar-disorder-treatment-and-medications\"><span style=\"font-weight: 400;\">Bipolar disorder<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If pregnant or breastfeeding, always consult a healthcare provider. Inform the doctor of any medical history, history of any allergic reaction to medicine, and all medications being taken, including Rx and OTC drugs, vitamins, and supplements.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A healthcare provider may need to change the medication or adjust a dosage in case of a possible interaction. Always take the medication as directed by a healthcare provider.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While taking trazodone, be aware of potential warning signs of drug interactions, such as the serotonin syndrome symptoms described above or symptoms of CNS depression. Ask a healthcare provider if there are any questions about drug interactions.&nbsp;<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-trazodone-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about trazodone interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">This article lists various drug interactions but is not a complete list of all possible trazodone interactions. It is important to tell a healthcare provider about all medications being taken (including prescription drugs, OTC medicines, vitamins, and supplements) and medical conditions to ensure proper management and monitoring. While taking trazodone, do not start any new medications unless a healthcare provider approves.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trazodone is a prescription antidepressant medication approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder, or depression, a common mental health condition. The way trazodone works is by increasing serotonin levels in the brain. It is also sometimes prescribed off-label (for non-FDA-approved use) for conditions such as insomnia, anxiety, or [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":61091,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[9777,451,814],"coauthors":[10668],"class_list":["post-61090","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-anxiety","tag-depression","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Trazodone interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Trazodone (Desyrel) interacts with MAOIs such as Zyvox, Marplan, Nardil, grapefruit juice, alcohol, and dietary supplements. 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