{"id":61111,"date":"2023-11-01T09:30:12","date_gmt":"2023-11-01T13:30:12","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61111"},"modified":"2024-11-12T19:58:22","modified_gmt":"2024-11-13T00:58:22","slug":"best-antihistamine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/best-antihistamine\/","title":{"rendered":"What\u2019s the best antihistamine?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Antihistamines are medications that help alleviate allergy symptoms such as hives, itchy eyes, sneezing, sinus congestion, runny nose, and watery eyes. Allergies are the <\/span><a href=\"https:\/\/aafa.org\/allergies\/allergy-facts\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">sixth<\/span><\/a><span style=\"font-weight: 400;\"> leading cause of chronic illness, with over 100 million Americans experiencing allergies yearly. According to a 2021 <\/span><a href=\"https:\/\/www.statista.com\/statistics\/1243257\/common-allergy-medications-us\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">survey<\/span><\/a><span style=\"font-weight: 400;\">, 50% of adults with seasonal allergies in the United States reported they used over-the-counter (OTC) antihistamines to relieve their symptoms. Which one is best? It depends on a variety of factors\u2014from the specific allergy symptoms to how long you need relief. Read on to learn more.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/taking-antihistamines-daily\/\"><b>Is it safe to take an antihistamine every day?<\/b><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">What is the best antihistamine?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although their effectiveness can vary from person to person, the best oral antihistamines are <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zyrtec\"><span style=\"font-weight: 400;\">Zyrtec<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cetirizine-hcl\"><span style=\"font-weight: 400;\">cetirizine<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/claritin\"><span style=\"font-weight: 400;\">Claritin<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/loratadine\"><span style=\"font-weight: 400;\">loratadine<\/span><\/a><span style=\"font-weight: 400;\">), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allegra-allergy\"><span style=\"font-weight: 400;\">Allegra<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fexofenadine-hcl\"><span style=\"font-weight: 400;\">fexofenadine<\/span><\/a><span style=\"font-weight: 400;\">), says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/don-j-beasley-md-97a03337\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Don. J. Beasly, MD<\/span><\/a><span style=\"font-weight: 400;\">, an otolaryngologist at <\/span><a href=\"https:\/\/boiseent.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Boise ENT<\/span><\/a><span style=\"font-weight: 400;\"> in Boise, Idaho. \u201cThese are generally considered the most effective for allergy relief due to their low sedation and long-lasting effects,\u201d Dr. Beasly says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral antihistamines for allergy symptoms can be broken down into the following groups:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>First-generation antihistamines<\/b><span style=\"font-weight: 400;\"> such as Benadryl (diphenhydramine) and Chlor-Trimeton (chlorpheniramine) are effective, but they can cause central nervous system (CNS) side effects like drowsiness and impaired cognitive function. That\u2019s because they cross the <\/span><a href=\"https:\/\/www.jacionline.org\/article\/S0091-6749(00)79554-6\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">blood-brain barrier<\/span><\/a><span style=\"font-weight: 400;\">, blocking histamine and cholinergic receptors.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Second- and third-generation antihistamines<\/b><span style=\"font-weight: 400;\"> like Zyrtec (cetirizine), Claritin (loratadine), and Allegra (fexofenadine) don\u2019t cross the blood-brain barrier, so they\u2019re less likely to cause drowsiness. They have longer-lasting effects than first-generation antihistamines and are the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6771107\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recommended<\/span><\/a><span style=\"font-weight: 400;\"> first-line of treatment for mild allergic rhinitis and urticaria (hives).<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The most <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15669879\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">effective<\/span><\/a><span style=\"font-weight: 400;\"> allergy medication overall is Allegra, <\/span><span style=\"font-weight: 400;\">says <\/span><a href=\"https:\/\/www.drlorneka.co\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Lorneka Joseph, Pharm.D<\/span><\/a><span style=\"font-weight: 400;\">., a pharmacist and wellness coach based in Orlando, Florida. <\/span><span style=\"font-weight: 400;\">She says it\u2019s the least sedating of the second-generation antihistamines.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When choosing the antihistamine that\u2019s best for you, there are <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/patientinstructions\/000549.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">several considerations<\/span><\/a><span style=\"font-weight: 400;\"> to keep in mind:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Symptoms:<\/b><span style=\"font-weight: 400;\"> Dr. Beasly advises choosing an allergy medicine that targets the specific symptoms you are experiencing, such as nasal congestion, sneezing, or itching.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Side effects:<\/b><span style=\"font-weight: 400;\"> Common side effects include dry mouth, dizziness, or drowsiness. If you need to stay alert, choose a non-drowsy option, <\/span><span style=\"font-weight: 400;\">says Dr. Joseph.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Duration:<\/b><span style=\"font-weight: 400;\"> Some antihistamines work up to 24 hours, while others only provide relief for 4-6 hours, says<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/www.pediatrics.columbia.edu\/profile\/joyce-e-yu-md\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Joyce Yu, MD<\/span><\/a><span style=\"font-weight: 400;\">, a pediatric allergist at <\/span><a href=\"https:\/\/www.pediatrics.columbia.edu\/locations\/columbiadoctors-midtown\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Columbia Doctors Midtown<\/span><\/a><span style=\"font-weight: 400;\"> in New York, New York.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Medical conditions and drug interactions:<\/b><span style=\"font-weight: 400;\"> Consult with a healthcare provider if you have any underlying health issues or you\u2019re taking any medications, says Dr. Beasly.<\/span><\/li>\n<\/ul>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><strong><span class=\"title\">Antihistamine comparison chart <\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><span style=\"font-weight: 400;\">Medication<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Type of antihistamine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Forms\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Symptoms treated<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.benadryl.com\/benadryl-dosing-guide\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Benadryl <\/span><\/a><span style=\"font-weight: 400;\">(diphenhydramine)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">First-generation<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral liqui-gels<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Oral chewable tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral liquid suspension<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Topical cream, gel, spray, and stick<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy, watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Chlor-Trimeton (<\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a682543.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">chlorpheniramine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">First-generation<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral chewable tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral long-acting tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral liquid solution<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral long-acting capsules<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy, watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy nose\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy throat\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Unisom (<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551646\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">doxylamine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">First-generation<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nasal congestion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea &amp; vomiting during pregnancy<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Allegra (<\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a697035.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">fexofenadine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Third-generation<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral capsules<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orally disintegrating tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral liquid suspension<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral long-acting tablets<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy, watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zyrtec (<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK549776\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cetirizine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral capsules<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orally disintegrating tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral chewable tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral liquid solution<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy, watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy nose\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy throat\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Claritin (<\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a697038.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">loratadine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral capsules<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orally disintegrating tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral chewable tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral liquid solution<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy, watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy nose\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy throat\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Xyzal (<\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a607056.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">levocetirizine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Third-generation<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral liquid solution<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy, watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy nose\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy throat\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">What is the difference between antihistamines?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cAntihistamines work by blocking the action site of a chemical in the body called histamine,\u201d says Dr. Joseph<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">The immune system releases <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/24854-histamine\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">histamine<\/span><\/a><span style=\"font-weight: 400;\"> in response to unfamiliar proteins (allergens), including pollen, mold, dust mites, and pet dander. <\/span><span style=\"font-weight: 400;\">Then, the chemical <\/span><a href=\"https:\/\/www.news-medical.net\/health\/Histamine-Mechanism.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">binds<\/span><\/a><span style=\"font-weight: 400;\"> to histamine receptors on the surface of cells, causing allergy symptoms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In severe cases, the histamine release can cause <\/span><a href=\"https:\/\/medlineplus.gov\/medlineplus-videos\/histamine-the-stuff-allergies-are-made-of\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">anaphylaxis<\/span><\/a><span style=\"font-weight: 400;\">, a severe and possibly fatal reaction causing airways to swell and blood pressure to drop. This type of reaction is more common with food allergies, such as peanuts and shellfish. But depending on the allergen and the specific person, histamine release leads to skin reactions such as itching, hives, redness, or swelling. Other people may experience typical <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/8622-allergic-rhinitis-hay-fever\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">symptoms<\/span><\/a><span style=\"font-weight: 400;\"> of allergic rhinitis such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stuffy nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sneezing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coughing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy, watery eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchy throat<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The primary mechanism of antihistamines is not to block histamine release, says Dr. Yu. Instead, the medications block histamine receptors so that histamine can\u2019t interact with them\u2014preventing an allergic response.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538188\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">two <\/span><\/a><span style=\"font-weight: 400;\">types of histamine receptors, H1 and H2. Similarly, there are two main classes of antihistamines: H1-receptor blockers and H2-receptor blockers. H1-receptor blockers prevent H1 receptor activity involved in allergic reactions, while H2-receptor blockers stop H2 receptor activity involved in triggering stomach acid production, says Dr. Yu.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cH-2 blockers are typically used for heartburn and acid reflux, not allergies,\u201d says Dr. Beasly.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When most people refer to antihistamines, they mean H1-receptor blockers, adds Dr. Yu. H1-receptor blockers are broken down further into first-, second-, and third-generation antihistamines.<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><strong><span class=\"title\">Compare types of antihistamines <\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Type of antihistamine<\/b><\/td>\n<td><b>Examples of brand names<\/b><\/td>\n<td><b>Indications<\/b><\/td>\n<td><b>Common side effects<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">First generation antihistamines<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy\"><span style=\"font-weight: 400;\">Benadryl<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/unisom-sleeptabs\"><span style=\"font-weight: 400;\">Unisom<\/span><\/a><span style=\"font-weight: 400;\">,<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/dramamine\"><span style=\"font-weight: 400;\">Dramamine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Allergy symptoms, motion sickness<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/my.clevelandclinic.org\/health\/drugs\/21223-antihistamines\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred or double vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rapid heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty urinating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Second and third generation antihistamines<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Zyrtec, Claritin, Allegra, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/xyzal-allergy-24hr\"><span style=\"font-weight: 400;\">Xyzal<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Allergy symptoms<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upset stomach<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">How quickly do antihistamines work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Though the onset of action for different antihistamines varies, these meds typically work within 30 minutes to two hours, says Dr. Joseph. A person with mild symptoms may notice their symptoms subsiding in about 30 minutes, says Dr. Yu. For seasonal allergies (also known as hay fever), it may help to take antihistamines as a <\/span><a href=\"https:\/\/familyallergy.com\/allergies\/how-to-prepare-for-spring-allergies-now\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">preventive<\/span><\/a> <span style=\"font-weight: 400;\">measure, starting a daily antihistamine about two weeks before exposure to known triggers.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Beasly says the duration of relief varies; some last 4-6 hours (first-generation), while others can provide relief for 24 hours (second-generation). For daily use, second-generation antihistamines like cetirizine, loratadine, or fexofenadine are generally preferred due to their lower sedation potential, says Dr. Beasly. He says first-generation antihistamines like diphenhydramine may provide more immediate relief but are more likely to cause drowsiness.<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><strong><span class=\"title\">How quickly do antihistamines work? <\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<th><span style=\"font-weight: 400;\">Antihistamine<\/span><\/th>\n<th><span style=\"font-weight: 400;\">How quickly does it take to work?<\/span><\/th>\n<th><span style=\"font-weight: 400;\">Duration of action<\/span><\/th>\n<th><span style=\"font-weight: 400;\">How often should it be taken?<\/span><\/th>\n<\/tr>\n<tr>\n<th><span style=\"font-weight: 400;\">Zyrtec\u00a0<\/span><\/th>\n<th><span style=\"font-weight: 400;\">20 to 60 minutes<\/span><\/th>\n<th><span style=\"font-weight: 400;\">24 hours<\/span><\/th>\n<th><span style=\"font-weight: 400;\">Once daily<\/span><\/th>\n<\/tr>\n<tr>\n<th><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542278\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Claritin<\/span><\/a><\/th>\n<th><span style=\"font-weight: 400;\">1 to 3 hours<\/span><\/th>\n<th><span style=\"font-weight: 400;\">24 hours<\/span><\/th>\n<th><span style=\"font-weight: 400;\">Once daily<\/span><\/th>\n<\/tr>\n<tr>\n<th><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK556104\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Allegra<\/span><\/a><\/th>\n<th><span style=\"font-weight: 400;\">1 hour<\/span><\/th>\n<th><span style=\"font-weight: 400;\">12-24 hours<\/span><\/th>\n<th><span style=\"font-weight: 400;\">Once daily<\/span><\/th>\n<\/tr>\n<tr>\n<th><a href=\"https:\/\/www.singlecare.com\/prescription\/benadryl-allergy\/dosage\"><span style=\"font-weight: 400;\">Benadryl<\/span><\/a><\/th>\n<th><span style=\"font-weight: 400;\">15 to 30 minutes<\/span><\/th>\n<th><span style=\"font-weight: 400;\">4 to 6 hours<\/span><\/th>\n<th><span style=\"font-weight: 400;\">Every 4 to 6 hours<\/span><\/th>\n<\/tr>\n<tr>\n<th><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3048603\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Xyzal<\/span><\/a><\/th>\n<th><span style=\"font-weight: 400;\">1 hour<\/span><\/th>\n<th><span style=\"font-weight: 400;\">24 hours<\/span><\/th>\n<th><span style=\"font-weight: 400;\">Once daily\u00a0<\/span><\/th>\n<\/tr>\n<tr>\n<th><a href=\"https:\/\/www.nhs.uk\/medicines\/chlorphenamine-including-piriton\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Chlor-trimeton<\/span><\/a><\/th>\n<th><span style=\"font-weight: 400;\">30 minutes to 1 hour<\/span><\/th>\n<th><span style=\"font-weight: 400;\">4 to 6 hours<\/span><\/th>\n<th><span style=\"font-weight: 400;\">Every 4 to 8 hours<\/span><\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>RELATED <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/xyzal-vs-allegra\/\"><b>Xyzal vs. Allegra<\/b><\/a><b> | <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/allegra-vs-claritin\/\"><b>Allegra vs. Claritin<\/b><\/a><b> | <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/zyrtec-vs-benadryl\/\"><b>Zyrtec vs. Benadryl<\/b><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">Who can take antihistamines?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most adults and older children can use antihistamines, says Dr. Beasly. However, it&#8217;s essential to consult a healthcare provider, especially if you have underlying medical conditions or are taking other medications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antihistamines can <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4264760\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cause<\/span><\/a> <span style=\"font-weight: 400;\">central nervous system (CNS) depression, especially when combined with other sedating drugs, says Dr. Joseph. <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/patientinstructions\/000549.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Caution is advised<\/span><\/a><span style=\"font-weight: 400;\"> in patients with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000381.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Enlarged prostate<\/span><\/a><span style=\"font-weight: 400;\"> or difficulty passing urine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000694.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Epilepsy<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart disease\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma (increased pressure in the eye)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Overactive thyroid<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">According to Dr. Beasly, children younger than 2 should not use most antihistamines. Pregnant or breastfeeding women and seniors should consult with their providers before using them.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><strong><span class=\"title\">Child vs. adult antihistamine dosage <\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><span style=\"font-weight: 400;\">Antihistamine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Age restrictions<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Child dosage<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adult dosage<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.healthychildren.org\/English\/safety-prevention\/at-home\/medication-safety\/Pages\/Diphenhydramine-Benadryl-Antihistamine.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Benadryl<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/diphenhydramine-hcl\"><span style=\"font-weight: 400;\">diphenhydramine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Do not use in children younger than 6 unless your pediatrician tells you to; not for use in children younger than 2<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Dosage (by weight, not age) is every 4-6 hours for children older than 2 years old:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>20-24 lbs:<\/b><span style=\"font-weight: 400;\"> 4 ml of 12.5 mg\/5ml oral suspension or\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>25-37 lbs<\/b><span style=\"font-weight: 400;\">: 5 ml of 12.5 mg\/5ml oral suspension or one 12.5g mg tablet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>38-49 lbs<\/b><span style=\"font-weight: 400;\">: 7.5 ml of 12.5 mg\/5ml oral suspension or one and one-half 12.5 mg tablets (18.75 mg)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>50-99 lbs<\/b><span style=\"font-weight: 400;\">: 10 ml of 12.5 mg\/5ml oral suspension or two 12.5 mg tablets (25 mg)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>100 lbs or more<\/b><span style=\"font-weight: 400;\">: 2-4, 12.5 mg tablets (25-50 mg)<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">25-50 mg every 4-6 hours<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Claritin (<\/span><a href=\"https:\/\/www.childrenscolorado.org\/conditions-and-advice\/conditions-and-symptoms\/dosagetables\/pediatric\/loratadine-claritin-dose-table\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">loratadine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Do not use in children younger than 6 unless your healthcare provider advise it; not for use in children younger than 2<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 2-5:<\/b><span style=\"font-weight: 400;\"> 2.5 ml of 5 mg\/5 ml oral suspension\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 6-11:<\/b><span style=\"font-weight: 400;\"> 5 ml of 5 mg\/5 ml oral suspension, or one 5 mg chewable tablet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 12+:<\/b><span style=\"font-weight: 400;\"> 10 ml of 5 mg\/5 ml oral suspension, two 5 mg chewable tablets, or one 10 mg tablet<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">10 mg every 24 hours<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Allegra (<\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/fexofenadine-oral-route\/proper-use\/drg-20067082\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">fexofenadine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Do not use in children younger than 6 months<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 6 months to 2 years:<\/b><span style=\"font-weight: 400;\"> 2.5 ml of 30 mg\/5 ml oral suspension twice a day for hives, other uses not recommended<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 2 to 11 years: <\/b><span style=\"font-weight: 400;\">5 ml of 30 mg\/5 ml oral suspension twice daily for hives or allergic rhinitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 12+:<\/b><span style=\"font-weight: 400;\"> 10 ml of 30 mg\/5 ml oral suspension twice daily<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">60 mg twice daily, or 180 mg once daily\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zyrtec (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=ee8695ac-1293-4e43-ac7c-a64e21a0ca0a&amp;type=display\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cetirizine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Do not use in children younger than 6 months; ask your provider before giving Zyrtec to children younger than 2<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 2-6: <\/b><span style=\"font-weight: 400;\">2.5 ml of 5 mg\/5 ml solution once a day\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 6+: <\/b><span style=\"font-weight: 400;\">5 or 10 ml of 5 mg\/5 ml solution or one 5 or 10 mg tablet, not to exceed 10 mg daily<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">5 or10 mg taken once daily\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Chlor-Trimeton (<\/span><a href=\"https:\/\/www.childrenscolorado.org\/conditions-and-advice\/conditions-and-symptoms\/dosagetables\/pediatric\/chlorpheniramine-dose-table\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">chlorpheniramine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Do not use in children younger than 4<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Dosage every 4-8 hours for children over 2 years old is by weight, not age:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>22-32 lbs:<\/b><span style=\"font-weight: 400;\"> 2.5 ml of 2 mg\/5 ml oral suspension\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>33-43 lbs:<\/b><span style=\"font-weight: 400;\"> 4 ml of 2 mg\/5 ml oral suspension\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>44-54 lbs: <\/b><span style=\"font-weight: 400;\">5 ml of 2 mg\/5 ml oral suspension or one-half 4 mg tablet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>55-65 lbs:<\/b><span style=\"font-weight: 400;\"> 5 ml of 2 mg\/5 ml oral suspension or one-half 4 mg tablet\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>66-76 lbs:<\/b><span style=\"font-weight: 400;\"> 7.5 ml of 2 mg\/5 ml oral suspension or one-half 4 mg tablet<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>77-87 lbs:<\/b><span style=\"font-weight: 400;\"> 7.5 ml of 2 mg\/5 ml oral suspension or one 4 mg tablet\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>88 lb+:<\/b><span style=\"font-weight: 400;\"> 10 ml of 2 mg\/5 ml oral suspension or one 4 mg tablet\u00a0<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">4 mg every 4-6 hours<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Xyzal (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=a33f2704-d350-428b-b467-91f4775ce17f&amp;type=display\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">levocetirizine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Do not use in children younger than 2<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 2-5:<\/b><span style=\"font-weight: 400;\"> 2.5 ml of 2.5 mg\/5 ml solution at night every 24 hours<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 6-11: <\/b><span style=\"font-weight: 400;\">5 ml of 2.5 mg\/5 ml solution at night every 24 hours<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ages 12+<\/b><span style=\"font-weight: 400;\">: 5 or 10 ml of 2.5 mg\/5 ml solution once daily<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">2.5-5 mg once daily<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">Alternatives to antihistamines<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cSome individuals may not respond well to antihistamines and may need other allergy treatments,\u201d says Dr. Beasly. He adds that some people might prefer natural remedies or have concerns about antihistamines\u2019 side effects. In some cases, a healthcare provider may recommend a combination of medications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our allergies newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Allergies Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other <\/span><a href=\"https:\/\/aafa.org\/allergies\/allergy-treatments\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">treatments<\/span><\/a><span style=\"font-weight: 400;\"> that may be recommended include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergy shots, or immunotherapy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye drops, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pataday\"><span style=\"font-weight: 400;\">Pataday<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/olopatadine-hcl\"><span style=\"font-weight: 400;\">olopatadine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nasal sprays, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/flonase-allergy-relief\"><span style=\"font-weight: 400;\">Flonase<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fluticasone-propionate\"><span style=\"font-weight: 400;\">fluticasone propionate<\/span><\/a><span style=\"font-weight: 400;\">) and Astepro (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/astepro\"><span style=\"font-weight: 400;\">azelastine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mast cell stabilizers, like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/singulair\"><span style=\"font-weight: 400;\">Singulair<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/montelukast-sodium\"><span style=\"font-weight: 400;\">montelukast<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decongestants like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sudafed-sinus-congestion-24hr\"><span style=\"font-weight: 400;\">Sudafed (pseudoephedrine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral steroids like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone\"><span style=\"font-weight: 400;\">prednisone<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Corticosteroid creams or ointments<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Additionally, the following home remedies and lifestyle changes may help reduce allergy symptoms:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use a neti pot to rinse your nasal passages.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take a shower when you get home to wash off allergens.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drink extra fluids to loosen congestion.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stay <\/span><a href=\"https:\/\/aafa.org\/allergies\/prevent-allergies\/control-indoor-allergens\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">indoors<\/span><\/a><span style=\"font-weight: 400;\"> during allergy season when pollen levels are high.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vacuum once or twice a week.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Keep your doors and windows closed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Invest in a high-efficiency particulate air (<\/span><a href=\"https:\/\/allergyasthmanetwork.org\/news\/hepa-help-hype\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">HEPA<\/span><\/a><span style=\"font-weight: 400;\">) filter.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Choosing an antihistamine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When choosing the best antihistamine, keep in mind your symptoms, whether or not side effects like drowsiness are an issue, how long you want the medication to last, and any health conditions or medications that may be problematic when combined with an antihistamine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It&#8217;s best to seek medical advice from a healthcare professional to determine your best choice. Dr. Beasly urges discussing new medications with a healthcare provider to check for potential contraindications or interactions.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/mixing-allergy-medicine\/\"><b>RELATED: Learn how to combine antihistamines for a sneeze-free season<\/b><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antihistamines are medications that help alleviate allergy symptoms such as hives, itchy eyes, sneezing, sinus congestion, runny nose, and watery eyes. Allergies are the sixth leading cause of chronic illness, with over 100 million Americans experiencing allergies yearly. According to a 2021 survey, 50% of adults with seasonal allergies in the United States reported they [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":61125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8029],"tags":[554,802],"coauthors":[20608],"class_list":["post-61111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-education","tag-allergies","tag-seasonal-allergies","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What is the best antihistamine? Antihistamine comparison charts<\/title>\n<meta name=\"description\" content=\"The best oral antihistamines are Zyrtec, Claritin, and Allegra because of their low sedation and long-lasting effects. 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