{"id":61574,"date":"2023-11-16T11:24:07","date_gmt":"2023-11-16T16:24:07","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61574"},"modified":"2024-10-25T10:25:47","modified_gmt":"2024-10-25T14:25:47","slug":"mupirocin-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/mupirocin-side-effects\/","title":{"rendered":"Mupirocin side effects and how to avoid them"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/mupirocin\"><span style=\"font-weight: 400;\">Mupirocin<\/span><\/a><span style=\"font-weight: 400;\"> is a generic topical <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-do-antibiotics-work\/\"><span style=\"font-weight: 400;\">antibiotic<\/span><\/a><span style=\"font-weight: 400;\"> that is prescribed as a cream or ointment to treat bacterial skin infections caused by streptococcal and staphylococcal bacteria. The drug works by both killing bacteria and preventing their growth. Mupirocin cream and some versions of mupirocin ointment are prescribed for bacterial infections of wounds, but only the ointment is approved by the Food and Drug Administration (FDA) for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/impetigo-treatment-and-medications\"><span style=\"font-weight: 400;\">impetigo<\/span><\/a><span style=\"font-weight: 400;\">. There are no brand-name versions on the market, though mupirocin was originally sold under the brand name Centany. A nasal mupirocin calcium ointment that was once sold under the brand name Bactroban is no longer available in the United States. People who are prescribed mupirocin will typically apply the ointment or cream to the affected skin three times a day. Side effects are rare, but they may include headaches, rashes, and nausea.<\/span><\/p>\n<h2 id=\"common-side-effects-of-mupirocin\"><span style=\"font-weight: 400;\">Common side effects of mupirocin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most people will not experience side effects when using mupirocin. In those that do, the effects are usually mild or moderate.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In clinical trials, only 8% of participants complained of side effects. According to the <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a69cd608-d2e6-4a7a-8cd7-f761bd333542\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">drug label<\/span><\/a><span style=\"font-weight: 400;\">, the most common side effects of mupirocin cream are headache, skin rash, and nausea. Other reported but less common adverse reactions include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Burning<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dermatitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itching<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Secondary infection of the wound<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mouth ulcers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bleeding or pain due to eczema<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry skin<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects-of-mupirocin\"><span style=\"font-weight: 400;\">Serious side effects of mupirocin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When applied to the skin, very little mupirocin is absorbed into the body, so serious side effects are rare. They include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Secondary infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/clostridium-difficile-treatment-and-medications\"><span style=\"font-weight: 400;\">Clostridium difficile<\/span><\/a><span style=\"font-weight: 400;\"> (C. difficile)<\/span><\/li>\n<\/ul>\n<h3 id=\"mupirocin-and-c-diff\"><span style=\"font-weight: 400;\">Mupirocin and C. diff<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">All antibiotics can cause a C. difficile overgrowth in the colon, but it is a rare side effect of topical antibiotics like mupirocin. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK501429\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Less than 1%<\/span><\/a><span style=\"font-weight: 400;\"> of mupirocin enters the bloodstream, so the system-wide exposure is minimal. Still, a C. difficile<\/span> <span style=\"font-weight: 400;\">infection is possible. The signature symptom of a C. difficile infection is severe diarrhea and abdominal bloating. These symptoms usually occur within a week of antibiotic treatment but can appear up to two months after mupirocin has been discontinued. If watery or bloody diarrhea occurs when taking antibiotics or in the weeks after taking them, seek immediate medical attention.<\/span><\/p>\n<h3 id=\"mupirocin-and-eczema\"><span style=\"font-weight: 400;\">Mupirocin and eczema<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Mupirocin is commonly prescribed for secondary infections associated with eczema. In clinical trials, some trial participants reported problems when applying mupirocin cream to the skin affected by eczema, particularly bleeding and pain.<\/span><\/p>\n<h3 id=\"mupirocin-and-allergic-reactions\"><span style=\"font-weight: 400;\">Mupirocin and allergic reactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The most likely severe side effect of mupirocin is a severe allergic reaction. Again, very little of the medicine actually enters the body, but this could be enough to set off a severe reaction. Several types of reactions have been reported in people using mupirocin, including anaphylaxis, facial swelling, and a general rash. If severe symptoms, such as trouble breathing, facial swelling, or sudden drop in blood pressure, occur when using mupirocin, seek immediate medical attention.&nbsp;<\/span><\/p>\n<h2 id=\"how-soon-do-mupirocin-side-effects-start\"><span style=\"font-weight: 400;\">How soon do mupirocin side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Site reactions like itching may happen immediately upon applying mupirocin to the skin. Others, like rash, redness, burning, itching, irritation, or pain, could start soon after applying it, if not immediately. Headache and nausea are also experienced early after starting mupirocin. Delayed side effects include secondary infections and mouth sores. Though rare, C. difficile diarrhea could take as long as two months after mupirocin treatment to appear, though it usually happens within a week of finishing antibiotic treatment.<\/span><\/p>\n<h2 id=\"how-long-do-mupirocin-side-effects-last\"><span style=\"font-weight: 400;\">How long do mupirocin side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">People experiencing adverse effects of mupirocin can expect them to end when treatment ends. Treatment for secondary infections typically lasts ten days. Impetigo treatment can last as little as seven days and as long as 14 days.<\/span><\/p>\n<h2 id=\"what-are-the-long-term-side-effects-of-mupirocin\"><span style=\"font-weight: 400;\">What are the long-term side effects of mupirocin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Though very rare, a C. difficile infection (CDI) can happen days or weeks after using mupirocin cream. A severe C. difficile infection could cause long-term or lifelong complications. Because so little mupirocin is absorbed into the body, it isn&rsquo;t an <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/antibiotics-that-cause-c-diff\/\"><span style=\"font-weight: 400;\">antibiotic that&rsquo;s most likely to cause C. diff<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"mupirocin-interactions\" style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Mupirocin interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The mupirocin drug label doesn&rsquo;t list any drug interactions. Although no drug interactions have been reported, tell your healthcare provider if you&rsquo;re taking any other medications when starting treatment with mupirocin.<\/span><\/p>\n<h2 id=\"safety-measures-while-using-mupirocin\" style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Safety measures while using mupirocin<\/span><\/h2>\n<h3 id=\"boxed-warning\"><span style=\"font-weight: 400;\">Boxed warning<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The FDA mandates <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538521\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">boxed warnings<\/span><\/a><span style=\"font-weight: 400;\"> for drugs that have a significant risk of severe side effects. The FDA has not attached a boxed warning to mupirocin products.&nbsp;<\/span><\/p>\n<h3 id=\"precautions\"><span style=\"font-weight: 400;\">Precautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Mupirocin is only contraindicated for people who have had allergic reactions to mupirocin.&nbsp;<\/span><\/p>\n<h3 id=\"children\"><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The FDA has determined that mupirocin topical ointment is safe and effective in children as young as 2 months old, and mupirocin topical cream is safe for children as young as 3 months old.&nbsp;<\/span><\/p>\n<h3 id=\"pregnancy\"><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are only a few studies on the safety of mupirocin use during pregnancy. However, healthcare providers consider it <\/span><span style=\"font-weight: 400;\"> because less than 1% of the drug is absorbed into the bloodstream when applied to the skin.<\/span><\/p>\n<h3 id=\"breastfeeding\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Absorption of topical mupirocin is minimal, so healthcare providers do not typically refrain from prescribing mupirocin cream or ointment to women who are breastfeeding. There hasn&rsquo;t been enough research on the risk to infants when using this medication during breastfeeding<\/span><span style=\"font-weight: 400;\">.<\/span><span style=\"font-weight: 400;\"> Healthcare providers advise mothers to prevent the baby&rsquo;s skin from contacting any part of the mother&rsquo;s skin where mupirocin has been applied.<\/span><\/p>\n<h3 id=\"dependence\"><span style=\"font-weight: 400;\">Dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Mupirocin use does not cause physical or psychological dependence. Discontinuing mupirocin will not cause withdrawal symptoms.<\/span><\/p>\n<h3 id=\"overdose\"><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A mupirocin overdose is not considered dangerous since so little of the drug is absorbed into the bloodstream when applied to the skin. However, swallowing mupirocin cream or ointment is a different matter. In that case, call 911 or seek emergency treatment.&nbsp;<\/span><\/p>\n<h2 id=\"how-to-avoid-mupirocin-side-effects\" style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">How to avoid mupirocin side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Children and adults using mupirocin don&rsquo;t often have side effects from it. When they do, those effects are often mild. Even so, there are ways to reduce or minimize the risk of mupirocin side effects:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Give the doctor a complete medical history.<\/b><span style=\"font-weight: 400;\"> Just to be safe, make sure your prescribing healthcare provider knows about any past and present medical conditions as well as any prescription drugs, over-the-counter remedies, and dietary supplements you&rsquo;re taking.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take mupirocin as directed. <\/b><span style=\"font-weight: 400;\">Follow all of the dosing instructions given by your healthcare provider. Even if the skin improves, continue applying mupirocin for the full length of treatment to cure the infection completely. Only apply it to affected areas of the skin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Don&rsquo;t apply mupirocin with your hands.<\/b><span style=\"font-weight: 400;\"> Apply mupirocin with a cotton swab or gauze pad to ensure that none of the medicine gets on your hands or fingers. This will minimize exposure to the drug.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Don&rsquo;t use other medications on the same area of the treated skin.<\/b><span style=\"font-weight: 400;\"> Avoid putting other topical medications, such as non-prescription anti-itch remedies, on the treated area unless instructed by a healthcare professional.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Don&rsquo;t apply mupirocin to mucus membranes or the eyes. <\/b><span style=\"font-weight: 400;\">If mupirocin cream gets in the mouth, nose, or eyes, rinse the area with water.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dress the treated area with sterile gauze.<\/b><span style=\"font-weight: 400;\"> A dressing isn&rsquo;t required after applying mupirocin to the skin, but it will prevent accidental exposure to others. This is especially important for infants. Do not use a bandage or any other covering that will not allow airflow to the affected area.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Keep the mupirocin tube out of reach of children. <\/b><span style=\"font-weight: 400;\">Accidental ingestion of mupirocin is more likely to cause side effects and severe problems. The tube does not have a childproof cap, so make sure children have no possible access to the medicine.<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-treat-side-effects-of-mupirocin\"><span style=\"font-weight: 400;\">How to treat side effects of mupirocin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Call your healthcare provider if you experience side effects. If you have signs of an allergic reaction, stop using the medicine and get medical help. While a C. difficile infection is rare, side effects like watery or bloody diarrhea could show up weeks after mupirocin treatment has ended. If that happens, get immediate medical attention.<\/span><\/p>\n<h2 id=\"bottom-line-is-mupirocin-safe\"><span style=\"font-weight: 400;\">Bottom line: Is mupirocin safe?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Healthcare providers consider mupirocin to be a safe and well-tolerated medication. As a topical antibiotic, only minimal amounts of the drug are absorbed into the body. Possible side effects are not very common and tend to be mild or moderate if they do occur. Severe side effects are rare and mainly limited to allergic reactions. Mupirocin does not interact with other drugs or supplements. Accidental ingestion is possible, so this medicine needs to be kept well out of reach of children and pets.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mupirocin is a generic topical antibiotic that is prescribed as a cream or ointment to treat bacterial skin infections caused by streptococcal and staphylococcal bacteria. The drug works by both killing bacteria and preventing their growth. Mupirocin cream and some versions of mupirocin ointment are prescribed for bacterial infections of wounds, but only the ointment [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":61593,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752],"coauthors":[8861],"class_list":["post-61574","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mupirocin side effects and how to avoid them<\/title>\n<meta name=\"description\" content=\"Mupirocin side effects are uncommon but may include headaches, skin irritation, and nausea.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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