{"id":61683,"date":"2023-11-20T13:49:10","date_gmt":"2023-11-20T18:49:10","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61683"},"modified":"2024-11-13T16:05:28","modified_gmt":"2024-11-13T21:05:28","slug":"promethazine-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/promethazine-interactions\/","title":{"rendered":"Promethazine interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/promethazine-hcl\/what-is\"><span style=\"font-weight: 400;\">Promethazine<\/span><\/a><span style=\"font-weight: 400;\">, often known by its brand name Phenergan, is an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antihistamines\"><span style=\"font-weight: 400;\">antihistamine<\/span><\/a><span style=\"font-weight: 400;\"> medication used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/allergy-treatment-and-medications\"><span style=\"font-weight: 400;\">allergy symptoms<\/span><\/a><span style=\"font-weight: 400;\">, such as itchy eyes, sneezing, and runny nose. It is also prescribed to reduce pain or anxiety and induce sedation in individuals undergoing surgery. In addition, it is FDA-approved to treat anaphylaxis (alongside other medications) and nausea or vomiting from <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/motion-sickness-treatment-and-medications\"><span style=\"font-weight: 400;\">motion sickness<\/span><\/a><span style=\"font-weight: 400;\">. Promethazine is part of a class of drugs called <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a682284.html\"><span style=\"font-weight: 400;\">phenothiazines<\/span><\/a><span style=\"font-weight: 400;\"> and is chemically similar to <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/chlorpromazine-hcl\/what-is\"><span style=\"font-weight: 400;\">chlorpromazine<\/span><\/a><span style=\"font-weight: 400;\">. It works by blocking the receptors and effects of histamine, dopamine, and acetylcholine chemicals. While <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/promethazine-hcl\"><span style=\"font-weight: 400;\">promethazine<\/span><\/a><span style=\"font-weight: 400;\"> can be an effective medication, it may interact with prescription drugs, over-the-counter medications, and herbal supplements. Therefore, it\u2019s important to discuss any medications being taken with a healthcare provider before taking promethazine. Read on to learn about potential drug interactions with promethazine, the possible consequences, and how to minimize the risk.\u00a0<\/span><\/p>\n<h2 id=\"promethazine-drug-interactions\"><b>Promethazine-drug interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Promethazine can interact with <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544361\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">various classes of medications<\/span><\/a><span style=\"font-weight: 400;\">, both prescription and over-the-counter drugs, that have similar effects. The main consequence of these drug interactions is an increased risk of side effects of promethazine.\u00a0<\/span><\/p>\n<h3 id=\"tricyclic-antidepressants\"><b>Tricyclic antidepressants<\/b><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> may interact with promethazine, potentially leading to increased sedation and drowsiness. This interaction could be severe and may require medical attention. Examples of tricyclic antidepressants include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elavil (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">amitriptyline<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tofranil (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/imipramine-hcl\/what-is\"><span style=\"font-weight: 400;\">imipramine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pamelor (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nortriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">nortriptyline<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If one is taking a tricyclic antidepressant and is prescribed promethazine, consult a healthcare provider to determine whether any current medications need adjustments. They may recommend an alternative to promethazine or adjust the dosage of the antidepressant.<\/span><\/p>\n<h3 id=\"benzodiazepines\"><b>Benzodiazepines<\/b><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">Benzodiazepines<\/span><\/a><span style=\"font-weight: 400;\"> are another class of medications that can interact with promethazine. This interaction may result in increased sedation, drowsiness, and potentially severe central nervous system (CNS) depression. Common benzodiazepines include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/xanax\/what-is\"><span style=\"font-weight: 400;\">Xanax<\/span><\/a><span style=\"font-weight: 400;\"> (alprazolam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/valium\/what-is\"><span style=\"font-weight: 400;\">Valium<\/span><\/a><span style=\"font-weight: 400;\"> (diazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/ativan\/what-is\"><span style=\"font-weight: 400;\">Ativan<\/span><\/a><span style=\"font-weight: 400;\"> (lorazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/klonopin\/what-is\"><span style=\"font-weight: 400;\">Klonopin<\/span><\/a><span style=\"font-weight: 400;\"> (clonazepam)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If taking a benzodiazepine and need to use promethazine, tell a healthcare provider, as the doses of one or both medications may need to be reduced. In some cases, a doctor may recommend an alternative to promethazine.<\/span><\/p>\n<h3 id=\"barbiturates\"><b>Barbiturates<\/b><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/barbiturates\"><span style=\"font-weight: 400;\">Barbiturates<\/span><\/a><span style=\"font-weight: 400;\"> can also interact with promethazine, leading to increased drowsiness, sedation, and potentially severe CNS depression. Some examples of barbiturates include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Luminal (phenobarbital)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seconal (secobarbital)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nembutal (pentobarbital)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">A healthcare provider may adjust the doses of medications or recommend an alternative to promethazine if taking promethazine with a barbiturate.<\/span><\/p>\n<h3 id=\"opioids\"><b>Opioids<\/b><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">Opioids<\/span><\/a><span style=\"font-weight: 400;\"> are a class of strong pain-relieving medications that can interact with promethazine. The interaction may result in increased sedation, drowsiness, CNS depression, and respiratory problems. Taking promethazine with opioids may also increase the risk of seizures, especially in people with a history of seizures. Examples of opioids include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vicodin (hydrocodone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/percocet\/what-is\"><span style=\"font-weight: 400;\">Percocet<\/span><\/a><span style=\"font-weight: 400;\"> (oxycodone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kadian (morphine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Actiq (fentanyl)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Codeine<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If taking an opioid medication and are prescribed promethazine, a healthcare provider will likely reduce the dosage of the opioid.<\/span><\/p>\n<h3 id=\"antipsychotics\"><b>Antipsychotics<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Promethazine can interact with <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">antipsychotic medications<\/span><\/a><span style=\"font-weight: 400;\">, potentially leading to increased adverse effects, such as sedation, drowsiness, and CNS depression. In addition, combining promethazine with antipsychotics can increase the risk of neuroleptic malignant syndrome (NMS), a rare but serious side effect that can cause changes in blood pressure and heart rate. Examples of antipsychotics include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/abilify\/what-is\"><span style=\"font-weight: 400;\">Abilify<\/span><\/a><span style=\"font-weight: 400;\"> (aripiprazole)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Risperdal (risperidone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zyprexa (olanzapine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/seroquel\/what-is\"><span style=\"font-weight: 400;\">Seroquel<\/span><\/a><span style=\"font-weight: 400;\"> (quetiapine)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If taking an antipsychotic and are prescribed promethazine, a healthcare provider may adjust the dosage of an antipsychotic dosage or recommend an alternative to promethazine.<\/span><\/p>\n<h3 id=\"anticholinergics\"><b>Anticholinergics<\/b><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antiemetics\"><span style=\"font-weight: 400;\">Anticholinergic<\/span><\/a><span style=\"font-weight: 400;\"> drugs may interact with promethazine, leading to potential side effects like increased drowsiness, confusion, blurred vision, constipation, and dry mouth. Examples of anticholinergic medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cogentin (benztropine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">AtroPen (atropine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Toviaz (fesoterodine)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Inform a healthcare provider before using an anticholinergic drug. They may need to adjust the dosages of any current medications or suggest an alternative treatment.<\/span><\/p>\n<h3 id=\"monoamine-oxidase-inhibitors\"><b>Monoamine oxidase inhibitors<\/b><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors (MAOIs)<\/span><\/a><span style=\"font-weight: 400;\"> are a class of antidepressants that can interact with promethazine, leading to extrapyramidal side effects. Involuntary movements, tremors, and rigidity characterize these side effects. Some examples of MAOIs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nardil (phenelzine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Parnate (tranylcypromine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Marplan (isocarboxazid)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Taking promethazine along with MAOIs should be done with caution. Consult a healthcare provider for guidance on appropriate treatment options.<\/span><\/p>\n<h3 id=\"epinephrine\"><b>Epinephrine<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Promethazine may interact with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/epinephrine\/what-is\"><span style=\"font-weight: 400;\">epinephrine<\/span><\/a><span style=\"font-weight: 400;\">, a medication commonly used to treat severe allergic reactions. This interaction can decrease epinephrine&#8217;s effect, making it less effective in reversing symptoms such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/low-blood-pressure\/\"><span style=\"font-weight: 400;\">hypotension<\/span><\/a><span style=\"font-weight: 400;\"> (low blood pressure).\u00a0<\/span><\/p>\n<h2 id=\"promethazine-food-interactions\"><b>Promethazine-food interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Promethazine can be taken <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2004\/07935s030lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">before meals<\/span><\/a><span style=\"font-weight: 400;\"> to help with gastrointestinal discomfort. It is recommended that promethazine be given with food, water, or milk to decrease an upset stomach when administered by mouth.<\/span><\/p>\n<h3 id=\"promethazine-and-caffeine\"><b>Promethazine and caffeine<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">There is limited information on the interaction between promethazine and caffeine. In general, consuming moderate amounts of caffeine, like a cup of coffee, is unlikely to cause significant issues for most people. However, if taking promethazine for its sedative effects, caffeine may counteract these effects, potentially reducing the effectiveness of promethazine.<\/span><\/p>\n<h3 id=\"promethazine-and-alcohol\"><b>Promethazine and alcohol<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Promethazine can interact with alcohol, leading to increased drowsiness and dizziness. It is not recommended to consume alcohol while taking promethazine due to the potential risk of severe drowsiness and respiratory depression. Limiting or avoiding alcohol while on promethazine could help reduce the risk of complications.<\/span><\/p>\n<h2 id=\"other-promethazine-interactions\"><b>Other promethazine interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Promethazine may interact with <\/span><a href=\"https:\/\/www.stlukes-stl.com\/health-content\/medicine\/33\/001403.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">dietary supplements and herbal remedies<\/span><\/a><span style=\"font-weight: 400;\">, which may lead to increased side effects or other complications. In addition to prescription drugs and over-the-counter medications, promethazine may interact with the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Evening primrose:<\/b><span style=\"font-weight: 400;\"> Evening primrose oil is sometimes taken for its potential benefits in reducing symptoms of conditions like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/eczema-treatment-and-medications\"><span style=\"font-weight: 400;\">eczema<\/span><\/a><span style=\"font-weight: 400;\"> or premenstrual syndrome. However, it is not recommended to mix evening primrose oil with phenothiazines like promethazine due to the increased risk of seizures.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Passionflower:<\/b><span style=\"font-weight: 400;\"> Commonly used as a natural remedy for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety <\/span><\/a><span style=\"font-weight: 400;\">or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/insomnia-treatment-and-medications\"><span style=\"font-weight: 400;\">insomnia<\/span><\/a><span style=\"font-weight: 400;\">, passionflower may have sedative effects. Combining it with promethazine, which also has sedative properties, could result in increased drowsiness or other CNS depressant effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Valerian:<\/b><span style=\"font-weight: 400;\"> Valerian root is another herbal supplement known for its calming and sleep-promoting effects. Similar to passionflower, using valerian with promethazine might intensify the sedative effects of the drug, leading to increased drowsiness or slowed responses.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Discuss any dietary supplements or herbal remedies being taken with a healthcare provider to ensure they&#8217;re safe to use alongside promethazine.<\/span><\/p>\n<h3 id=\"lab-test-interactions\"><b>Lab test interactions<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">If undergoing certain lab tests while taking promethazine, the results might be affected. Specifically, pregnancy tests based on immunological reactions might show false-negative or false-positive results. Promethazine has also been reported to increase <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/normal-blood-glucose-levels\/\"><span style=\"font-weight: 400;\">blood sugar levels<\/span><\/a><span style=\"font-weight: 400;\">, which could affect the accuracy of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/blood-tests-for-diabetes\/\"><span style=\"font-weight: 400;\">glucose tolerance tests<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our allergies newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Allergies Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h3 id=\"other-considerations\"><b>Other considerations<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">When taking promethazine, there are other factors to consider. If any of the following conditions exist, discuss them with a healthcare provider:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Respiratory disorders: <\/b><span style=\"font-weight: 400;\">Promethazine may carry an increased risk of breathing problems, especially in people with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/copd-vs-asthma\/\"><span style=\"font-weight: 400;\">chronic respiratory disorders<\/span><\/a><span style=\"font-weight: 400;\"> like asthma, chronic obstructive pulmonary disease (COPD), and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/sleep-apnea-treatment-and-medications\"><span style=\"font-weight: 400;\">sleep apnea<\/span><\/a><span style=\"font-weight: 400;\">. It\u2019s recommended to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10481760\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">avoid this medication<\/span><\/a><span style=\"font-weight: 400;\"> if any of these conditions exist.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Seizure disorders:<\/b><span style=\"font-weight: 400;\"> If a history of seizures or <\/span><span style=\"font-weight: 400;\">epilepsy<\/span><span style=\"font-weight: 400;\"> is present, there might be an increased risk of more seizures when taking promethazine. Discuss any seizure history with a healthcare provider before starting this medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bone-marrow depression:<\/b><span style=\"font-weight: 400;\"> If one has what\u2019s known as bone-marrow depression or other blood-related disorders, caution may be needed. Promethazine can further suppress bone marrow function and lead to potential problems, such as decreased platelets (thrombocytopenia) and white blood cells (leukopenia).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Heart rhythm problems:<\/b><span style=\"font-weight: 400;\"> Caution may be needed if one has a history of heart rhythm disorders. Promethazine can cause a slow or fast heart rate, which may worsen <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/signs-of-heart-problems\/\"><span style=\"font-weight: 400;\">heart rhythm problems<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liver problems:<\/b><span style=\"font-weight: 400;\"> The liver processes promethazine, so if liver conditions exist, dosages may need to be adjusted, or the medication may need to be avoided altogether. People with liver impairment may not be able to break down promethazine, which could lead to high levels of promethazine in the body. <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/jaundice-symptoms\"><span style=\"font-weight: 400;\">Jaundice<\/span><\/a><span style=\"font-weight: 400;\"> has also been reported in people taking promethazine.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Pregnant or breastfeeding: <\/b><span style=\"font-weight: 400;\">Animal studies have shown that promethazine may cause harm to an unborn baby. It is not known whether promethazine passes into breast milk. Promethazine should only be taken while <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/safe-medication-during-pregnancy\/\"><span style=\"font-weight: 400;\">pregnant<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/breastfeeding-and-medications\/\"><span style=\"font-weight: 400;\">breastfeeding<\/span><\/a><span style=\"font-weight: 400;\"> if the benefits outweigh the risks.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Use in children: <\/b><span style=\"font-weight: 400;\">Promethazine tablets and suppositories are not recommended for children under the age of two due to the risk of fatal respiratory depression. In addition, antiemetics like promethazine are not recommended to treat vomiting in children, according to the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black box warnings<\/span><\/a><span style=\"font-weight: 400;\"> on the FDA label.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Be certain to tell a healthcare provider if conditions such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">narrow-angle glaucoma<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bph-treatment-and-medications\"><span style=\"font-weight: 400;\">enlarged prostate<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ulcer-treatment-and-medications\"><span style=\"font-weight: 400;\">certain stomach ulcers<\/span><\/a><span style=\"font-weight: 400;\">, or problems with bladder blockage exist, as promethazine may worsen these conditions. Medication regimens may need to be adjusted, or additional precautions may be needed if any medical conditions are present. A complete medical history should be discussed with a healthcare provider before taking promethazine.\u00a0<\/span><\/p>\n<h2 id=\"how-to-minimize-promethazine-interactions\"><b>How to minimize promethazine interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Consulting a healthcare provider before taking promethazine, especially if taking other medications, is the first step in minimizing interactions. The healthcare provider can assess the potential risks and benefits of taking promethazine alongside other medications to determine if it\u2019s safe. Always keep a complete list of all medicines being taken, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prescription medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Over-the-counter drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Herbal supplements<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vitamins and minerals<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The healthcare provider may adjust dosages, discontinue medications, or recommend alternative treatment options if there is a risk for promethazine drug interactions. People should closely follow medical advice from a healthcare provider to avoid potential complications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is also essential to be aware of warning signs of drug interactions while taking promethazine. Common warning signs may include unexpected side effects, changes in the effectiveness of promethazine, and the onset of new symptoms or worsening of existing symptoms. Should one experience any of these signs, contact a healthcare provider immediately.<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-promethazine-interactions\"><b>When to talk to a healthcare provider about promethazine interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Consult with a healthcare provider if concerns about using promethazine alongside other sedatives, substances that might increase drowsiness or drugs that could affect its efficacy are present. In addition, tell a healthcare provider if unusual reactions are experienced, such as intense drowsiness or trouble breathing while using promethazine, as these may indicate an adverse interaction.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other reasons to speak with healthcare professionals about promethazine interactions include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prescription or over-the-counter medications are being taken<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dietary supplements or herbal products are being used<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any existing medical conditions or a history of certain illnesses exist<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any unexpected side effects are being experienced, or changes in health that occur during treatment<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Keep in mind that there may be other promethazine interactions not discussed here. Always follow the healthcare provider\u2019s guidance and directions for using promethazine safely and effectively.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Promethazine, often known by its brand name Phenergan, is an antihistamine medication used to treat allergy symptoms, such as itchy eyes, sneezing, and runny nose. It is also prescribed to reduce pain or anxiety and induce sedation in individuals undergoing surgery. In addition, it is FDA-approved to treat anaphylaxis (alongside other medications) and nausea or [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":61688,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,814],"coauthors":[8669],"class_list":["post-61683","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Promethazine interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Promethazine (Phenergan) interacts with barbiturates, benzodiazepines, MAOIs, and other medications.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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