{"id":61780,"date":"2023-11-30T20:10:40","date_gmt":"2023-12-01T01:10:40","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61780"},"modified":"2025-12-17T15:25:28","modified_gmt":"2025-12-17T20:25:28","slug":"lisinopril-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lisinopril-interactions\/","title":{"rendered":"Lisinopril interactions to avoid"},"content":{"rendered":"

Lisinopril<\/span><\/a> is a member of the drug class called angiotensin-converting enzyme inhibitors, or <\/span>ACE inhibitors<\/span><\/a>. It is approved by the Food and Drug Administration (FDA) to treat <\/span>hypertension<\/span><\/a> (high blood pressure) in adults and children 6 years and older. Known by the brand names Zestril and Qbrelis, <\/span>lisinopril<\/span><\/a> can also be used in adults to treat heart failure and improve survival after a myocardial infarction (<\/span>heart attack<\/span><\/a>). For those who take lisinopril, it\u2019s essential to be aware of interactions that can affect lisinopril\u2019s effectiveness and cause or worsen <\/span>side effects<\/span><\/a>, including serious side effects such as high potassium levels.<\/span><\/p>\n

Lisinopril drug interactions<\/span><\/h2>\n

Lisinopril interacts with various drugs, including prescription and over-the-counter medications. Continue reading to learn more about lisinopril interactions.<\/span><\/p>\n

Diuretics\u00a0<\/span><\/h3>\n

Sometimes, healthcare providers prescribe lisinopril and a <\/span>diuretic<\/span><\/a>. For example, the medication <\/span>Zestoretic<\/span><\/a> is a combination pill containing lisinopril and hydrochlorothiazide (HCTZ), a diuretic. Or, some individuals may take lisinopril along with a separate diuretic pill (as two separate pills). In these cases, additional blood pressure-lowering effects are needed.\u00a0<\/span><\/p>\n

However, people who already take a diuretic and then start taking lisinopril may have an excessive lowering of blood pressure, causing blood pressure to become too low. People who take a specific type of diuretic, called a <\/span>potassium-sparing diuretic<\/span><\/a> (such as spironolactone), in combination with lisinopril have a higher risk of <\/span>hyperkalemia<\/span><\/a> (high potassium levels in the blood). <\/span>Symptoms<\/span><\/a> of hyperkalemia may include tiredness, weakness, nausea, muscle cramps, chest pain, an irregular heartbeat, and trouble breathing, although some individuals have no symptoms. Too much potassium can lead to a heart attack, so if any of these symptoms arise, call 911 for emergency medical help.\u00a0<\/span><\/p>\n

People who take both lisinopril and a diuretic will require regular monitoring of their potassium levels and blood pressure.\u00a0<\/span><\/p>\n

Insulin and sulfonylureas<\/span><\/h3>\n

People who use insulin for diabetes or take oral diabetes medication in the sulfonylurea drug class should consult their healthcare provider about a potential lisinopril interaction. The combination could cause an increased blood sugar-lowering effect, resulting in <\/span>hypoglycemia<\/span><\/a> (low blood sugar). Examples of these medications include:<\/span><\/p>\n