{"id":61794,"date":"2023-11-30T21:16:44","date_gmt":"2023-12-01T02:16:44","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61794"},"modified":"2025-08-27T10:36:34","modified_gmt":"2025-08-27T14:36:34","slug":"gabapentin-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/gabapentin-interactions\/","title":{"rendered":"Gabapentin interactions to avoid"},"content":{"rendered":"

Gabapentin<\/span><\/a> is a generic medication approved by the U.S. Food and Drug Administration (FDA) to treat postherpetic neuralgia (nerve pain after shingles), <\/span>epilepsy<\/span><\/a>, other seizure disorders, and <\/span>restless leg syndrome<\/span><\/a>. Available under the brand names <\/span>Neurontin<\/span><\/a>, <\/span>Gralise<\/span><\/a>, and <\/span>Horizant<\/span><\/a>, gabapentin is also commonly prescribed <\/span>off-label<\/span><\/a> for general nerve pain, <\/span>migraines<\/span><\/a>, and <\/span>bipolar disorder<\/span><\/a>. <\/span>Off-label use<\/span><\/a> is when a drug is used for a purpose other than what it is approved for. Gabapentin belongs to a class of drugs called <\/span>anticonvulsants<\/span><\/a>, also known as antiepileptics, and it is <\/span>thought to work<\/span><\/a> by blocking chemicals in the brain that cause excitation.\u00a0<\/span><\/p>\n

While <\/span>gabapentin<\/span><\/a> is used to treat many different conditions, like most other drugs, it has a risk of drug interactions. Drug interactions may affect how well gabapentin works, or it can worsen the side effects of gabapentin. It\u2019s essential to be aware of gabapentin interactions to avoid them before they occur. This way, the treatment will be as safe and effective as possible.<\/span><\/p>\n

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\n\t\t\t\t\tGabapentin 300 mg (90 Capsules)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t
\n\t\t\t\t\t$8.98\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t
\n\t\t\t\t\t$8.98\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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Gabapentin interactions<\/span><\/h2>\n

Gabapentin can interact with various prescription and over-the-counter medications. Specifically, it may interact with opioid medications and some heartburn medications. Below are some of the potential drugs that gabapentin can interact with.\u00a0<\/span><\/p>\n\n\n\n\n\n\n
Drug class or group name<\/b><\/td>\nDrug name<\/b><\/td>\nInteractions\/side effects<\/b><\/td>\n<\/tr>\n
Opioids<\/span><\/td>\n\n
    \n
  • Vicodin, Norco, Lortab (hydrocodone\/acetaminophen)<\/span><\/li>\n
  • Vicoprofen (hydrocodone\/ibuprofen)<\/span><\/li>\n
  • Zohydro ER, Hysingla ER (hydrocodone<\/span>)<\/span><\/li>\n
  • Roxicodone (oxycodone)<\/span><\/li>\n
  • Percocet (oxycodone\/acetaminophen)<\/span><\/li>\n
  • Tussionex, Pennkinetic ER (hydrocodone\/chlorpheniramine)<\/span><\/li>\n
  • Hycofenix (hydrocodone\/pseudoephedrine\/guaifenesin)<\/span><\/li>\n
  • Tussigon (hydrocodone\/homatropine)<\/span><\/li>\n
  • Avinza, Kadian, MS Contin, Oramorph, Roxanol (morphine)<\/span><\/li>\n<\/ul>\n<\/td>\n
Intensifies CNS depression, leading to drowsiness, dizziness, and slowed breathing\u00a0<\/span><\/td>\n<\/tr>\n
Aluminum hydroxide or magnesium hydroxide antacids<\/span><\/td>\n\n
    \n
  • Alternagel, Amphojel, Dialume, Nephrox (aluminum hydroxide)<\/span><\/li>\n
  • Milk of Magnesia, Pedia-Lax (magnesium hydroxide)<\/span><\/li>\n
  • Maalox, Mylanta, and Gelusil (aluminum hydroxide\/magnesium hydroxide)<\/span><\/li>\n<\/ul>\n<\/td>\n
Decreased efficacy of gabapentin; reduces the amount of gabapentin that can be absorbed into the bloodstream<\/span><\/td>\n<\/tr>\n
CNS depressants<\/span><\/td>\n\n
    \n
  • Xanax (alprazolam)<\/span><\/li>\n
  • Ativan (lorazepam)<\/span><\/li>\n
  • Klonopin (clonazepam)<\/span><\/li>\n
  • Benadryl (diphenhydramine)<\/span><\/li>\n
  • Vistaril (hydroxyzine)<\/span><\/li>\n
  • Ambien (zolpidem)<\/span><\/li>\n
  • Lunesta (eszopiclone)<\/span><\/li>\n
  • Flexeril (cyclobenzaprine)<\/span><\/li>\n
  • Lioresal (baclofen)<\/span><\/li>\n<\/ul>\n<\/td>\n
Intensifies CNS depression, leading to drowsiness, dizziness, and slowed breathing\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Opioids<\/span><\/h3>\n

Opioids<\/span><\/a> are a group of drugs used to treat pain. They share some of the same side effects as gabapentin, such as sleepiness and respiratory depression. Taking these medications together can worsen these side effects and increase the risk of severe sleepiness, difficulty breathing, coma, and even death.\u00a0<\/span><\/p>\n

If possible, gabapentin should not be taken with opioid medications. Talk to a healthcare provider about alternative pain treatments if taking gabapentin. If both medications are prescribed, call for emergency medical help immediately if extreme sleepiness or slow or shallow breathing occurs.<\/span><\/p>\n

Examples of opioids include:<\/span><\/p>\n