{"id":61862,"date":"2023-12-01T19:07:47","date_gmt":"2023-12-02T00:07:47","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=61862"},"modified":"2024-10-25T10:23:26","modified_gmt":"2024-10-25T14:23:26","slug":"paxlovid-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/paxlovid-side-effects\/","title":{"rendered":"Paxlovid side effects and how to avoid them"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/paxlovid-300-100\"><span style=\"font-weight: 400;\">Paxlovid<\/span><\/a><span style=\"font-weight: 400;\"> (nirmatrelvir-ritonavir) is a prescription medication that has been given an Emergency Use Authorization (EUA) by the Food and Drug Administration (FDA) to treat COVID-19. Paxlovid is an antiviral two-drug treatment that works by <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8933659\/\"><span style=\"font-weight: 400;\">reducing the viral load<\/span><\/a><span style=\"font-weight: 400;\"> in the body. The first drug in the treatment, nirmatrelvir, prevents the SARS-COV-2 virus from reproducing. The second drug, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ritonavir\"><span style=\"font-weight: 400;\">ritonavir<\/span><\/a><span style=\"font-weight: 400;\">, is a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/protease-inhibitors\"><span style=\"font-weight: 400;\">protease inhibitor<\/span><\/a><span style=\"font-weight: 400;\"> that prevents the liver from breaking down nirmatrelvir. This keeps nirmatrelvir at high enough levels in the bloodstream to effectively suppress the coronavirus infection. People prescribed Paxlovid will take two 150 mg nirmatrelvir tablets and one 100 mg ritonavir tablet twice per day for five days. Side effects are relatively minimal, but there are serious drug interactions that can cause severe and life-threatening problems.<\/span><\/p>\n<h2 id=\"common-side-effects-of-paxlovid\"><span style=\"font-weight: 400;\">Common side effects of Paxlovid<\/span><\/h2>\n<p><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=7bdddfba-bd31-44cb-ba9e-23a4e17a4691\"><span style=\"font-weight: 400;\">In clinical trials<\/span><\/a><span style=\"font-weight: 400;\">, the most common side effects reported were taste disturbances or bad taste (about a 6% incidence) and diarrhea (about 1%). The complete list of side effects includes:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alterations to the sense of taste (bad taste or metallic taste)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Feeling sick (malaise)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle aches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypertension-treatments-and-medications\"><span style=\"font-weight: 400;\">hypertension<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects-of-paxlovid\"><span style=\"font-weight: 400;\">Serious side effects of Paxlovid<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Possible serious side effects of Paxlovid include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions, including anaphylaxis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe skin reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.paxlovid.com\/faq\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/a><\/li>\n<\/ul>\n<h3 id=\"paxlovid-and-covid-19-rebound\"><span style=\"font-weight: 400;\">Paxlovid and COVID-19 rebound<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some people who have been treated with Paxlovid experience a relapse of COVID-19 symptoms, a phenomenon called Paxlovid rebound. <\/span><a href=\"https:\/\/emergency.cdc.gov\/han\/2022\/pdf\/CDC_HAN_467.pdf\"><span style=\"font-weight: 400;\">According to the Centers for Disease Control and Prevention<\/span><\/a><span style=\"font-weight: 400;\">, some cases of Paxlovid rebound involve a return of symptoms without testing positive, and some cases involve a return of symptoms with a positive COVID-19 test. Pfizer&rsquo;s clinical trials determined that 1% to 2% of people treated with Paxlovid had COVID-19 rebound. The median time from the end of Paxlovid treatment to rebound symptoms was nine days.&nbsp;<\/span><\/p>\n<h3 id=\"paxlovid-and-kidney-problems\"><span style=\"font-weight: 400;\">Paxlovid and kidney problems<\/span><\/h3>\n<p><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/217188s000lbl.pdf\"><span style=\"font-weight: 400;\">Paxlovid FDA-prescribing information<\/span><\/a><span style=\"font-weight: 400;\"> states that a lower dose may be needed if kidney disease is present. Paxlovid <\/span><a href=\"https:\/\/www.yalemedicine.org\/news\/13-things-to-know-paxlovid-covid-19\"><span style=\"font-weight: 400;\">isn&rsquo;t recommended<\/span><\/a><span style=\"font-weight: 400;\"> for people with serious kidney disease or those who are on dialysis.&nbsp;<\/span><\/p>\n<h3 id=\"paxlovid-and-bad-taste-in-the-mouth-paxlovid-mouth\"><span style=\"font-weight: 400;\">Paxlovid and bad taste in the mouth (Paxlovid mouth)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A foul taste in the mouth is the most commonly reported adverse effect of Paxlovid. Although clinical trials found that 5% to 6% of trial participants complained of taste disturbance (dysgeusia), a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36821807\/\"><span style=\"font-weight: 400;\">subsequent study<\/span><\/a><span style=\"font-weight: 400;\"> found the incidence to be over 17%. Whatever the incidence is, it&rsquo;s common enough that it&rsquo;s been given a name: Paxlovid mouth. Some people report taste disturbance within an hour of taking the first dose. More research is needed to identify the cause, but <\/span><a href=\"https:\/\/health.clevelandclinic.org\/paxlovid-mouth\/\"><span style=\"font-weight: 400;\">the bad taste will go away when treatment is discontinued<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"how-soon-do-paxlovid-side-effects-start\"><span style=\"font-weight: 400;\">How soon do Paxlovid side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">People may notice taste changes within hours of taking the first dose of Paxlovid. Other side effects are minor and could occur at any time during the five-day treatment regimen.<\/span><\/p>\n<h2 id=\"how-long-do-paxlovid-side-effects-last\"><span style=\"font-weight: 400;\">How long do Paxlovid side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most Paxlovid side effects will pass when the five-day treatment period ends. Liver problems or allergic reactions may take several days or weeks to resolve.<\/span><\/p>\n<h2 id=\"what-are-the-long-term-side-effects-of-paxlovid\"><span style=\"font-weight: 400;\">What are the long-term side effects of Paxlovid?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As of this date, there are no long-term side effects associated with Paxlovid. However, Paxlovid has only recently gone through clinical trials and is currently FDA-approved because the COVID-19 pandemic is considered a public health emergency. Healthcare providers may discover other adverse effects in the future, including long-term side effects.&nbsp;<\/span><\/p>\n<h2 id=\"paxlovid-interactions\"><span style=\"font-weight: 400;\">Paxlovid interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Paxlovid has a boxed warning that highlights significant drug-drug interactions.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The liver has several enzymes and mechanisms for breaking down drugs. The ritonavir component of Paxlovid interferes with several of them. As a result, drugs broken down through these mechanisms will build up in the body, significantly raising the risk for adverse effects. For this reason, Paxlovid cannot be taken with any medication that would cause serious or life-threatening problems due to high drug concentrations caused by an interaction. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">Statins<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Many <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antiarrhythmics\"><span style=\"font-weight: 400;\">antiarrhythmics<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">Migraine<\/span><\/a><span style=\"font-weight: 400;\"> medications classified as ergot drugs, as well as Relpax (eletriptan) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ubrelvy\"><span style=\"font-weight: 400;\">Ubrelvy<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medications used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bph-treatment-and-medications\"><span style=\"font-weight: 400;\">benign prostatic hyperplasia<\/span><\/a><span style=\"font-weight: 400;\"> (BPH), such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/alfuzosin-hcl-er\"><span style=\"font-weight: 400;\">Uroxatral<\/span><\/a><span style=\"font-weight: 400;\"> (alfuzosin) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/silodosin\"><span style=\"font-weight: 400;\">Rapaflo<\/span><\/a><span style=\"font-weight: 400;\"> (silodosin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">antipsychotic medications<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/pimozide\"><span style=\"font-weight: 400;\">pimozide<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/latuda\"><span style=\"font-weight: 400;\">Latuda<\/span><\/a><span style=\"font-weight: 400;\"> (lurasidone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The pulmonary hypertension drug <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/revatio\"><span style=\"font-weight: 400;\">Revatio<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sildenafil-citrate\"><span style=\"font-weight: 400;\">sildenafil citrate<\/span><\/a><span style=\"font-weight: 400;\">), as well as the <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/erectile-dysfunction-treatment-and-medications\"><span style=\"font-weight: 400;\">erectile dysfunction<\/span><\/a><span style=\"font-weight: 400;\"> version of sildenafil, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/viagra\"><span style=\"font-weight: 400;\">Viagra<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">benzodiazepines<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/triazolam\"><span style=\"font-weight: 400;\">triazolam<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/midazolam\"><span style=\"font-weight: 400;\">midazolam<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The chest pain (angina) medication Ranexa <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ranolazine-er\"><span style=\"font-weight: 400;\">(ranolazine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The gout medications Colcrys and Mitigare <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/colchicine\"><span style=\"font-weight: 400;\">(colchicine)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The blood pressure medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/eplerenone\"><span style=\"font-weight: 400;\">eplerenone<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The heart failure medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/corlanor\"><span style=\"font-weight: 400;\">Corlanor<\/span><\/a><span style=\"font-weight: 400;\"> (ivabradine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The lupus nephritis medication Lupkynis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The cholesterol medication Juxtapid<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The chronic kidney disease medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/kerendia\"><span style=\"font-weight: 400;\">Kerendia<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The medication used to treat opioid-induced constipation, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/movantik\"><span style=\"font-weight: 400;\">Movantik<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The hypoactive sexual desire disorder (HSDD) treatment Addyi <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/flibanserin\"><span style=\"font-weight: 400;\">(flibanserin)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The treatment for low sodium (hyponatremia), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tolvaptan\"><span style=\"font-weight: 400;\">tolvaptan<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Paxlovid should not be taken with any drugs that speed up the mechanisms that break down nirmatrelvir, as those drugs will significantly reduce Paxlovid&rsquo;s ability to fight the virus that causes COVID-19. These drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Many types of <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticonvulsants\"><span style=\"font-weight: 400;\">anticonvulsants<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/tuberculosis-treatment-and-medications\"><span style=\"font-weight: 400;\">tuberculosis<\/span><\/a><span style=\"font-weight: 400;\"> drugs Rifadin (rifampin) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/priftin\/what-is\"><span style=\"font-weight: 400;\">Priftin<\/span><\/a><span style=\"font-weight: 400;\"> (rifapentine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/cystic-fibrosis-treatment-and-medications\"><span style=\"font-weight: 400;\">cystic fibrosis<\/span><\/a><span style=\"font-weight: 400;\"> medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/orkambi\/what-is\"><span style=\"font-weight: 400;\">Orkambi<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The anticancer drug <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/erleada\/what-is\"><span style=\"font-weight: 400;\">Erleada<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The herbal supplement <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/st-johns-wort\/\"><span style=\"font-weight: 400;\">St. John&rsquo;s wort<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The FDA also warns that Paxlovid interferes with the effectiveness of hormonal birth control, so women are urged to use alternative contraception when taking Paxlovid.<\/span><\/p>\n<h2 id=\"safety-measures-while-using-paxlovid\"><span style=\"font-weight: 400;\">Safety measures while using Paxlovid<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because of its emergency authorization, Paxlovid is only prescribed to adults and children 12 years and older with mild-to-moderate COVID-19 who are at high risk of developing severe COVID-19, including hospitalization or death. The safety of Paxlovid is fairly well-established, but more safety data may become available as more people take the drug.<\/span><\/p>\n<h3 id=\"precautions\"><span style=\"font-weight: 400;\">Precautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid cannot be used by anyone who has had a severe hypersensitivity reaction to nirmatrelvir or ritonavir.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Several medical conditions may require dosage restrictions. People with moderate kidney disease may need to take a reduced dose. People with severe kidney disease may not be able to take the drug at all. Those with liver disorders can take the drug if liver dysfunction is mild or moderate, but Paxlovid should be avoided in people with severe liver dysfunction.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ritonavir is used to treat HIV, the virus that causes AIDS. Giving Paxlovid to someone with both COVID-19 and HIV can increase the risk of developing resistance to the protease inhibitor drug class to treat HIV. Therefore, it is very important that anyone with HIV speaks to their infectious disease specialist before taking Paxlovid.<\/span><\/p>\n<h3 id=\"children\"><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid has FDA approval for use in children as young as 12 years old who weigh at least 88 pounds. As with adults, children are only prescribed Paxlovid if they have a high risk of developing severe COVID-19.<\/span><\/p>\n<h3 id=\"pregnancy\"><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because Paxlovid is an emergency-approved drug that is still early in its formal approval process, there is limited information on the safety of taking it while pregnant. However, prior studies of its individual components, nirmatrelvir and ritonavir, show that it is<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9866309\/\"><span style=\"font-weight: 400;\"> considered safe to take during pregnancy<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"breastfeeding\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is a lack of research on the effects of Paxlovid on lactation and nursing. Women who are breastfeeding should ask for medical advice about the risks and benefits of taking Paxlovid.&nbsp;<\/span><\/p>\n<h3 id=\"dependence\"><span style=\"font-weight: 400;\">Dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid does not cause dependency. There are no known withdrawal symptoms when the drug is discontinued.<\/span><\/p>\n<h3 id=\"overdose\"><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is a lack of information about the consequences or symptoms of a Paxlovid overdose. If too much Paxlovid is taken, call the prescribing healthcare provider or get emergency medical care.&nbsp;<\/span><\/p>\n<h3 id=\"recalls\"><span style=\"font-weight: 400;\">Recalls<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid has not been recalled for any reason.&nbsp;<\/span><\/p>\n<h2 id=\"how-to-avoid-paxlovid-side-effects\"><span style=\"font-weight: 400;\">How to avoid Paxlovid side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As a prescription medication, Paxlovid can be risky to take. The risks of side effects can be reduced by following some fundamental rules:<\/span><\/p>\n<h3 id=\"1-tell-the-prescriber-about-all-medical-conditions\"><span style=\"font-weight: 400;\">1. Tell the prescriber about all medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The prescribing healthcare provider needs to know about all past and present medical conditions&mdash;particularly kidney problems, liver problems, hepatitis, or an HIV infection.<\/span><\/p>\n<h3 id=\"2-tell-the-prescriber-and-pharmacist-about-all-drugs-and-supplements-youre-taking\"><span style=\"font-weight: 400;\">2. Tell the prescriber and pharmacist about all drugs and supplements you&rsquo;re taking<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The riskiest aspect of taking Paxlovid involves drug interactions. Give your prescriber or pharmacist a complete list of all prescription drugs, over-the-counter medications, and dietary supplements you&rsquo;re taking. A healthcare professional can tell you which of those drugs are unsafe to take with Paxlovid.<\/span><\/p>\n<h3 id=\"3-take-paxlovid-as-instructed\"><span style=\"font-weight: 400;\">3. Take Paxlovid as instructed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Paxlovid is a complicated medicine to take, requiring three pills to be taken for each dose in order for it to be effective. Never take an extra dose or tablet to make up for a missed dose.&nbsp;<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects-of-paxlovid\"><span style=\"font-weight: 400;\">How to treat side effects of Paxlovid<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most Paxlovid side effects are minimal. A few can be more problematic. Here&rsquo;s how to handle some of the most unpleasant or serious side effects of Paxlovid:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bad taste<\/b><span style=\"font-weight: 400;\">: Getting a persistent, bad taste in the mouth is among the least pleasant side effects a drug can have. Fortunately, an unpleasant taste in the mouth is not a health threat unless someone stops eating or drinking. Although there&rsquo;s little to do about it, a few things may help. Don&rsquo;t eat foods with a bitter taste. Don&rsquo;t put metal in your mouth; use plastic utensils instead. Brushing your teeth or eating candies may also help.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liver problems<\/b><span style=\"font-weight: 400;\">: Paxlovid can injure the liver. If you notice symptoms of liver dysfunction, such as pale stools, jaundice (yellowing of the eyes or skin), dark-colored urine, upper abdominal pain, itchy skin, or loss of appetite, immediately contact a healthcare provider. You may need to stop taking the drug.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>COVID-19 rebound<\/b><span style=\"font-weight: 400;\">: If COVID-19 symptoms return in the days or weeks following Paxlovid treatment, begin isolation at home just as you would with a new infection. Many people with Paxlovid rebound get over their symptoms quickly. In that case, isolation can end five days after the fever recedes. People with Paxlovid rebound do not need further treatment with the drug.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Hypersensitivity reactions<\/b><span style=\"font-weight: 400;\">: Immediately stop taking Paxlovid and get immediate medical help if you notice symptoms of hypersensitivity, such as a skin rash, hives, blisters, peeling skin, trouble breathing, facial swelling, difficulty swallowing, or tightness in the throat. These are all signs of a potentially severe allergic reaction or drug reaction.<\/span><\/li>\n<\/ul>\n<h2 id=\"bottom-line-is-paxlovid-safe\"><span style=\"font-weight: 400;\">Bottom line: Is Paxlovid safe?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">At this time, Paxlovid is only used in people infected with mild-to-moderate COVID-19 who are at risk of developing severe and potentially life-threatening COVID-19. That means the risks of Paxlovid must be weighed against the risk of hospitalization or death. Paxlovid has relatively few possible side effects. Most side effects are mild and not commonly experienced. The most significant warnings about taking Paxlovid are in regard to its potentially severe or fatal drug interactions.&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paxlovid (nirmatrelvir-ritonavir) is a prescription medication that has been given an Emergency Use Authorization (EUA) by the Food and Drug Administration (FDA) to treat COVID-19. Paxlovid is an antiviral two-drug treatment that works by reducing the viral load in the body. The first drug in the treatment, nirmatrelvir, prevents the SARS-COV-2 virus from reproducing. The [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":61868,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752],"coauthors":[8861],"class_list":["post-61862","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Paxlovid side effects and how to avoid them<\/title>\n<meta name=\"description\" content=\"COVID-19 rebound and a bad taste in the mouth, are common Paxlovid side effects. 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