{"id":62366,"date":"2024-01-12T13:42:43","date_gmt":"2024-01-12T18:42:43","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=62366"},"modified":"2024-10-25T10:15:55","modified_gmt":"2024-10-25T14:15:55","slug":"tramadol-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tramadol-interactions\/","title":{"rendered":"Tramadol interactions to avoid"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Tramadol, commonly known by the brand names Ultram and ConZip, is approved by the Food and Drug Administration (FDA) to treat <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537060\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">moderate to severe pain<\/span><\/a><span style=\"font-weight: 400;\">. As a synthetic opioid, it works in the central nervous system (CNS) to reduce the body&rsquo;s response to pain signals. Healthcare providers may recommend an opioid analgesic or pain reliever if non-opioid drugs don&rsquo;t provide adequate pain relief.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like many other prescription drugs, tramadol has the potential to interact with other medications, which can lead to increased side effects or decreased effectiveness. For example, some interactions can increase drowsiness, seizures, or serotonin syndrome. Read on to learn more about potential tramadol interactions, including those that might involve prescription drugs and herbal supplements.<\/span><\/p>\n<h2 id=\"tramadol-drug-interactions\"><b>Tramadol-drug interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">If you&rsquo;re taking tramadol for acute or chronic pain, you might also be taking other medications for different conditions and ailments. You may want to be aware of <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/020281s040lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">tramadol drug interactions<\/span><\/a><span style=\"font-weight: 400;\"> that could lead to potentially severe adverse effects. Let&rsquo;s go over the most common ones.&nbsp;<\/span><\/p>\n<h3 id=\"medications-that-increase-serotonin\"><b>Medications that increase serotonin<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tramadol may interact with medications that increase serotonin levels, such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\">. This interaction can increase the risk of serotonin syndrome, a potentially life-threatening condition caused by high levels of serotonin in the body. Serotonin syndrome <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\"><span style=\"font-weight: 400;\">may cause<\/span><\/a><span style=\"font-weight: 400;\"> agitation, confusion, rapid heartbeat, and muscle stiffness. Examples of medications involved in this potential interaction include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\"><span style=\"font-weight: 400;\">Selective serotonin reuptake inhibitors (SSRIs)<\/span><\/a><span style=\"font-weight: 400;\">, such as Prozac (fluoxetine) and Paxil (paroxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/snris\"><span style=\"font-weight: 400;\">Serotonin and norepinephrine reuptake inhibitors (SNRIs)<\/span><\/a><span style=\"font-weight: 400;\">, such as Cymbalta (duloxetine), Effexor (venlafaxine), and Pristiq (desvenlafaxine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants (TCAs)<\/span><\/a><span style=\"font-weight: 400;\">, such as Elavil (amitriptyline), Pamelor (nortriptyline), and Tofranil (imipramine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/triptans\"><span style=\"font-weight: 400;\">Triptans<\/span><\/a><span style=\"font-weight: 400;\">, such as Imitrex (sumatriptan), Maxalt (rizatriptan), and Zomig (zolmitriptan)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors (MAOIs)<\/span><\/a><span style=\"font-weight: 400;\">, such as Nardil (phenelzine), Parnate (tranylcypromine), and Zelapar (selegiline)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In most cases, tramadol may be taken with antidepressants with close monitoring. However, tramadol should not be taken in people who are taking MAOIs or <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24153222\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">within two weeks<\/span><\/a><span style=\"font-weight: 400;\"> of stopping treatment with an MAOI due to a high risk of serotonin syndrome.&nbsp;<\/span><\/p>\n<h3 id=\"cns-depressants\"><b>CNS depressants<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tramadol can interact with other CNS depressants, including sleep medications like sedative-hypnotics and anxiety medications like benzodiazepines. These drug interactions may increase the risk of breathing problems like respiratory depression and extreme sedation. Examples of CNS depressants include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">Opioids<\/span><\/a><span style=\"font-weight: 400;\">, such as OxyContin (oxycodone), Vicodin (hydrocodone), and codeine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">Benzodiazepines<\/span><\/a><span style=\"font-weight: 400;\">, such as Valium (diazepam), Xanax (alprazolam), and Ativan (lorazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">Antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, such as Haldol (haloperidol), Seroquel (quetiapine), and Risperdal (risperidone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sedative-hypnotics, such as Ambien (zolpidem), Lunesta (eszopiclone), and Sonata (zaleplon)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/barbiturates\"><span style=\"font-weight: 400;\">Barbiturates<\/span><\/a><span style=\"font-weight: 400;\">, such as Luminal (Phenobarbital), Seconal (Secobarbital), and Amytal (Amobarbital)<\/span><\/li>\n<\/ul>\n<h3 id=\"medications-that-affect-how-tramadol-is-processed-in-the-body\"><b>Medications that affect how tramadol is processed in the body<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Several drugs can alter how tramadol is processed, which may lead to increased side effects or reduced effectiveness. Examples of such medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-do-antibiotics-work\/\"><span style=\"font-weight: 400;\">antibiotics<\/span><\/a><span style=\"font-weight: 400;\">, such as Erythrocin (erythromycin) and Rifadin (rifampin). Erythrocin may increase tramadol levels, leading to increased side effects. Rifadin can decrease tramadol&#8217;s effectiveness by reducing its levels in the body.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain azole-<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antifungals\"><span style=\"font-weight: 400;\">antifungal agents<\/span><\/a><span style=\"font-weight: 400;\">, such as Nizoral (ketoconazole), may increase tramadol levels in the body, increasing the risk of side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/protease-inhibitors\"><span style=\"font-weight: 400;\">Protease inhibitors<\/span><\/a><span style=\"font-weight: 400;\">, such as Norvir (ritonavir), often used in HIV\/AIDS treatment, may increase tramadol blood levels and increase its potential side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quinidine, a medication used for heart rhythm disorders, can affect the metabolism of tramadol, potentially increasing its levels.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain antidepressants, including Prozac (fluoxetine), Paxil (paroxetine), and Wellbutrin (bupropion), may increase tramadol levels, leading to a higher risk of side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticonvulsants\"><span style=\"font-weight: 400;\">anticonvulsants<\/span><\/a><span style=\"font-weight: 400;\">, such as Tegretol (carbamazepine) and Dilantin (phenytoin), may decrease tramadol&#8217;s effectiveness by reducing its levels in the body.<\/span><\/li>\n<\/ul>\n<h3 id=\"muscle-relaxants\"><b>Muscle relaxants<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tramadol may increase the action of <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscle-relaxants\"><span style=\"font-weight: 400;\">muscle relaxants<\/span><\/a><span style=\"font-weight: 400;\"> and increase the risk of respiratory depression. Adjusting the dosage of tramadol or the muscle relaxant may be necessary. Examples of muscle relaxants include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Soma (carisoprodol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flexeril (cyclobenzaprine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Robaxin (methocarbamol)<\/span><\/li>\n<\/ul>\n<h3 id=\"anticholinergic-drugs\"><b>Anticholinergic drugs<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">The use of tramadol with anticholinergic drugs may increase the risk of urinary retention and severe constipation. This can be serious and cause your intestines to stop working correctly, leading to what&rsquo;s known as paralytic ileus. Common anticholinergic drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atropine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bentyl (dicyclomine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Detrol (tolterodine)<\/span><\/li>\n<\/ul>\n<h3 id=\"diuretics\"><b>Diuretics<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tramadol can reduce the effectiveness of water pills or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/diuretics\"><span style=\"font-weight: 400;\">diuretics<\/span><\/a><span style=\"font-weight: 400;\">. Blood pressure may need to be monitored, and the diuretic dosage may need to be increased while taking tramadol. Diuretics that may interact with tramadol include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lasix (furosemide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Microzide (hydrochlorothiazide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aldactone (spironolactone)<\/span><\/li>\n<\/ul>\n<h3 id=\"opioid-antagonists\"><b>Opioid antagonists<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tramadol&#8217;s effectiveness as a pain reliever may be reduced when combined with <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioid-antagonists\"><span style=\"font-weight: 400;\">opioid antagonists<\/span><\/a><span style=\"font-weight: 400;\">, which are medications designed to block opioid effects. These drugs can cause withdrawal symptoms in people who have been using opioids for an extended period. Commonly used opioid antagonists include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Narcan (naloxone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Revia (naltrexone)<\/span><\/li>\n<\/ul>\n<h3 id=\"warfarin\"><b>Warfarin&nbsp;<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tramadol may interfere with warfarin, a blood thinner. This interference can lead to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6705477\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increased blood clotting times<\/span><\/a><span style=\"font-weight: 400;\">. If you are taking warfarin, your doctor may need to check your blood clotting ability and adjust your dose regularly.<\/span><\/p>\n<h3 id=\"digoxin\"><b>Digoxin<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Some cases of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470568\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">digoxin toxicity<\/span><\/a><span style=\"font-weight: 400;\"> have been reported in people taking tramadol and digoxin. People taking both medications should be monitored for any adverse reactions from digoxin. Changing the digoxin dosage may also be necessary to avoid harmful effects.<\/span><\/p>\n<h2 id=\"tramadol-food-interactions\"><b>Tramadol-food interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Taking tramadol with meals does not significantly affect its absorption into the body. Therefore, tramadol can be administered with or without food. However, caution may be recommended when taking tramadol with specific food or beverages.&nbsp;<\/span><\/p>\n<h3 id=\"tramadol-and-grapefruit-juice\"><b>Tramadol and grapefruit juice<\/b><\/h3>\n<p><a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/grapefruit-juice-and-some-drugs-dont-mix\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Grapefruit juice<\/span><\/a><span style=\"font-weight: 400;\"> is known for its potential to interact with certain medications, including tramadol. It blocks how the liver breaks down tramadol, which could cause more tramadol to stay in your body and increase the chance of mild to serious side effects. Avoid grapefruit juice while taking tramadol.&nbsp;<\/span><\/p>\n<h3 id=\"tramadol-and-alcohol\"><b>Tramadol and alcohol<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol has CNS-depressant effects that can amplify those of tramadol. Combining alcohol with tramadol may lead to increased drowsiness, sedation, and dizziness. It&rsquo;s generally recommended to avoid or limit alcohol consumption while taking this medication.&nbsp;<\/span><\/p>\n<h2 id=\"other-tramadol-interactions\"><b>Other tramadol interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tramadol may also have interactions with dietary supplements and <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a695011.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">herbal remedies<\/span><\/a><span style=\"font-weight: 400;\">, which can affect the medication&#8217;s effectiveness or lead to additional side effects. These interactions include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>St. John&#8217;s wort<\/b><span style=\"font-weight: 400;\">: Often used for its potential benefits in <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/st-johns-wort\/\"><span style=\"font-weight: 400;\">alleviating symptoms of depression<\/span><\/a><span style=\"font-weight: 400;\">, St. John&#8217;s Wort can interact with tramadol. This combination may lead to an increased risk of serotonin syndrome. Therefore, it&rsquo;s recommended to use caution when combining the two.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tryptophan<\/b><span style=\"font-weight: 400;\">: This essential amino acid, sometimes taken as a supplement to support sleep or improve mood, is a precursor to serotonin. Combining tryptophan with tramadol may lead to high serotonin levels, increasing the risk of serotonin syndrome.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>5-HTP (5-Hydroxytryptophan)<\/b><span style=\"font-weight: 400;\">: Like tryptophan, 5-HTP is another supplement contributing to serotonin production. Its use alongside tramadol might increase the medication&#8217;s effect on serotonin levels, increasing the risk for serotonin syndrome.&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Discuss any dietary supplements or herbal remedies you&#8217;re taking with your healthcare provider before using tramadol.&nbsp;<\/span><\/p>\n<h3 id=\"other-considerations\"><b>Other considerations<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">While taking tramadol, it can also be helpful to be aware of the following precautions:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dependence and addiction<\/b><span style=\"font-weight: 400;\">: Tramadol is a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/controlled-substances-act\/\"><span style=\"font-weight: 400;\">controlled substance<\/span><\/a><span style=\"font-weight: 400;\"> with a potential risk for dependence or abuse, and its misuse may lead to addiction.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Gastrointestinal obstruction, including <\/b><a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/paralytic-ileus\" target=\"_blank\" rel=\"noopener\"><b>paralytic ileus<\/b><\/a><span style=\"font-weight: 400;\">: Tramadol should be used with caution in people with a history of gastrointestinal issues, as it may worsen symptoms or cause complications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Hypersensitivity<\/b><span style=\"font-weight: 400;\">: Individuals with a known hypersensitivity or previous allergic reaction to tramadol or any of its ingredients should avoid this medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Seizure disorder<\/b><span style=\"font-weight: 400;\">: As tramadol may increase the likelihood of seizures, individuals with a history of seizures should discuss this risk with a healthcare professional.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Serotonin syndrome<\/b><span style=\"font-weight: 400;\">: Taking high doses of tramadol or combining it with other medications that affect serotonin levels may lead to a potentially life-threatening condition known as serotonin syndrome.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Brain tumors or <\/b><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26330713\/\" target=\"_blank\" rel=\"noopener\"><b>head injuries<\/b><\/a><span style=\"font-weight: 400;\">: People with these or similar conditions should exercise caution when taking tramadol, as it may worsen symptoms. Tramadol should be avoided in people with impaired consciousness or coma.&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Consult a healthcare provider about any medical conditions you have before taking tramadol.&nbsp;<\/span><\/p>\n<h2 id=\"how-to-minimize-tramadol-interactions\"><b>How to minimize tramadol interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tell your healthcare provider about any medical conditions and additional medications you take to minimize interactions. A complete, updated list of all your medications might include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prescription medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Over-the-counter drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Herbal supplements<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vitamins and minerals<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Recognizing the potential warning signs of drug interactions can also help you detect potential issues early on. Some common warning signs may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unexpected side effects<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New symptoms&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsening of existing symptoms&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Always follow the prescribing instructions provided by your healthcare provider. They may suggest using the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2386353\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">extended-release form<\/span><\/a><span style=\"font-weight: 400;\"> of tramadol, adjusting the dosage, or changing the schedule of your medications to minimize potential tramadol interactions and side effects.<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-tramadol-interactions\"><b>When to talk to a healthcare provider about tramadol interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">You should speak with a healthcare provider about tramadol interactions during the initial visit when they prescribe the medication. You can also consult your local pharmacist if you have concerns about drug interactions. In general, you should seek medical advice about tramadol interaction if you:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take any prescription or over-the-counter medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use any dietary supplements or herbal products<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have any medical conditions or a history of certain illnesses<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Experience any unexpected side effects or changes in health<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not a complete list of tramadol interactions. Discuss your overall medical history, including medical conditions and other medications you take, with your healthcare provider before starting treatment. A healthcare provider can assess the risks and benefits of tramadol, especially if you&#8217;re taking other medications.&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tramadol, commonly known by the brand names Ultram and ConZip, is approved by the Food and Drug Administration (FDA) to treat moderate to severe pain. As a synthetic opioid, it works in the central nervous system (CNS) to reduce the body&rsquo;s response to pain signals. Healthcare providers may recommend an opioid analgesic or pain reliever [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":62368,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[814,808],"coauthors":[8669],"class_list":["post-62366","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-interactions","tag-pain-management","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tramadol interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Tramadol (Ultram) interacts with antidepressants, CNS depressants, muscle relaxants, grapefruit juice, and alcohol. 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