{"id":62474,"date":"2024-01-10T09:30:36","date_gmt":"2024-01-10T14:30:36","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=62474"},"modified":"2025-05-07T12:47:21","modified_gmt":"2025-05-07T16:47:21","slug":"berberine-weight-loss","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/berberine-weight-loss\/","title":{"rendered":"Can berberine help with weight loss?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">With the popularity of semaglutide injectables continually growing, people are turning to medication to aid in weight loss more than ever. Although medications, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/wegovy\"><span style=\"font-weight: 400;\">Wegovy<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\">, are <\/span><a href=\"https:\/\/www.jomes.org\/journal\/view.html?doi=10.7570\/jomes22012\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">proven to help patients lose weight<\/span><\/a><span style=\"font-weight: 400;\">, they can often be prohibitively expensive as many insurance providers do not offer coverage. Enter berberine, a plant-based supplement sometimes called \u201cnature\u2019s Ozempic\u201d that is trending on social media as an alternative to weight-loss drugs. While this concept is appealing, and there are potential health benefits of taking a berberine supplement, its promise for slimming your waistline is not entirely proven.<\/span><\/p>\n<p><span data-sheets-root=\"1\" data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:6849,&quot;3&quot;:{&quot;1&quot;:0},&quot;9&quot;:1,&quot;10&quot;:2,&quot;12&quot;:0,&quot;14&quot;:{&quot;1&quot;:2,&quot;2&quot;:0},&quot;15&quot;:&quot;Arial&quot;}\" data-sheets-formula=\"=CONCATENATE(R[0]C[-2],R[0]C[-3],R[0]C[-1])\"><\/span><\/p>\n<h2 id=\"does-berberine-help-with-weight-loss\"><span style=\"font-weight: 400;\">Does berberine help with weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Berberine is a yellow alkaloid compound extracted from several plants such as goldenseal, Oregon grape, and tree turmeric. It\u2019s available in supplement form as a capsule or soft gel. Some research shows that berberine <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32690176\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">may help with weight loss<\/span><\/a><span style=\"font-weight: 400;\">, but data proving its effectiveness is limited\u2014and some benefits are shown in animal research only. As of 2022, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32353823\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">only about 40 studies<\/span><\/a><span style=\"font-weight: 400;\"> have been conducted on berberine for weight loss.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cWhile the results were promising, the studies weren\u2019t large enough to say definitively that berberine is an effective weight loss treatment,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/kathleen-jordan-md-37b6494\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Kathleen Jordan, MD<\/span><\/a><span style=\"font-weight: 400;\">, the chief medical officer at <\/span><a href=\"https:\/\/www.joinmidi.com\/post\/kathleen-jordan\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Midi Health<\/span><\/a><span style=\"font-weight: 400;\"> in San Francisco. For example, \u201can often-cited study that generated much excitement around berberine&#8217;s use for weight management had only seven enrolled patients.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Beyond that, berberine isn\u2019t as effective for weight loss as methods approved by the Food &amp; Drug Administration (FDA). People taking berberine can expect to lose about four or five pounds over one to three months, says <\/span><a href=\"https:\/\/www.memorialcare.org\/providers\/mir-b-ali\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mir Ali, MD<\/span><\/a><span style=\"font-weight: 400;\">, a bariatric surgeon and medical director of the MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California. Meanwhile, people taking <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ozempic-weight-loss\/\"><span style=\"font-weight: 400;\">Ozempic for weight loss<\/span><\/a><span style=\"font-weight: 400;\"> lost nine to 12 pounds and those taking Wegovy dropped an average of 35 pounds. People taking <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41591-023-02597-w\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> lost more than 20% of their body weight during the study period.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, there is promising research on other potential benefits of berberine. Research shows that it can:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5871262\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Lower total cholesterol<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.1015045\/full\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Improve blood sugar<\/span><\/a><span style=\"font-weight: 400;\"> (in people with Type 2 diabetes)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33740526\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Decrease insulin resistance<\/span><\/a><span style=\"font-weight: 400;\"> associated with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/what-is-pcos\/\"><span style=\"font-weight: 400;\">polycystic ovary syndrome (PCOS)<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cBerberine has been shown to reduce average blood sugar levels and HbA1C (the lab value that measures average blood sugar levels over three months), lower triglycerides and lipid levels, and positively affect metabolic syndrome,\u201d Dr. Jordan says.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Berberine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tBerberine 90 capsules, 1 bottle (90 Capsule)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$32.34<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/berberine-complex#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/berberine-complex#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$32.34<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/berberine-complex#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/berberine-complex#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/berberine-complex#blog-cta\" class=\"coupon-see-all-btn\">See Berberine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"how-long-does-it-take-for-berberine-to-work-for-weight-loss\"><span style=\"font-weight: 400;\">How long does it take for berberine to work for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As with all dietary supplements, how quickly berberine works and how much weight you lose depends on how your body reacts to it and how you change your life otherwise. <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22739410\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">One study<\/span><\/a><span style=\"font-weight: 400;\"> showed that subjects had a five-pound weight loss over the course of 12 weeks.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThe amount of weight loss [with berberine] definitely varies,\u201d says <\/span><a href=\"https:\/\/forumhealth.com\/provider\/traci-eliszewski-np\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Traci Eliszewski<\/span><\/a><span style=\"font-weight: 400;\">, a nurse practitioner with Forum Health in Fitchburg, Wisconsin. \u201cOther factors such as an individual\u2019s diet, exercise routine, and overall health play a role. While berberine may support weight loss efforts, it is important to remember that it is not a magic pill and should be used in conjunction with a healthy lifestyle.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our weight management newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Weight Management Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"berberine-dosage-for-weight-loss\"><span style=\"font-weight: 400;\">Berberine dosage for weight loss<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/natural\/1126.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recommended dosage of berberine<\/span><\/a><span style=\"font-weight: 400;\"> is between 400 mg to 1,500 mg daily. Dr. Jordan notes that the most convincing evidence for berberine-related weight loss suggests taking a 500 mg tablet three times per day for a total of 1,500 mg a day. You may need to take the higher end of the dose range if you are attempting to regulate your blood glucose levels with berberine and no other medication, according to Eliszewski.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s considered safe to take berberine daily for up to two years. \u201cIt is generally recommended to take it with meals to enhance absorption and minimize potential digestive discomfort,\u201d Eliszewski says. In fact, taking it 30 minutes before a meal can enhance its effectiveness as it\u2019s already in your system when you start eating. Just keep a watchful eye on how you\u2019re feeling and if you\u2019re having any adverse effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As with any new supplement, talk to your healthcare provider and see what they recommend before starting berberine so they can keep you informed about how you may react to it based on your medical history.<\/span><\/p>\n<h2 id=\"side-effects-of-berberine\"><span style=\"font-weight: 400;\">Side effects of berberine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most people take berberine without incident. The side effects of berberine are mostly digestion-related and include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach upset<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These issues can often be resolved by taking the supplement with food. If you are concerned about new or increased gastrointestinal issues, stop taking berberine and talk to your healthcare provider.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Neurological side effects are rare but can occur.<\/span><\/p>\n<h2 id=\"who-should-not-take-berberine-for-weight-loss\"><span style=\"font-weight: 400;\">Who should not take berberine for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Women who are pregnant or breastfeeding should not take berberine, Dr. Ali says. The supplement can pass to your fetus or child and cause harm.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, if you have <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-symptoms\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\">, you must watch your blood sugar closely. \u201cBerberine can lower your blood sugars and decrease your insulin needs,\u201d Dr.\u00a0 Jordan says. \u201cAdjustments can be made under the advice of your diabetes physician.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Berberine also interacts with a number of medicines, so check with your healthcare provider and pharmacist before starting it if you\u2019re taking any other medications or supplements. Some examples of drug interactions include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cyclosporine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Plavix (clopidogrel)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eliquis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pradaxa<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xarelto<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cozaar (losartan) and other medications that lower blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metformin and other medicines that lower blood sugar<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tacrolimus<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pentobarbital<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Versed (midazolam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dextromethorphan (a cough suppressant found in medications such as Robitussin DM)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sedatives (such as medications for sleep or anxiety)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Dr. Jordan also warns \u201cnot to confuse it with Berberine Complex, which has a different use, with lower amounts of berberine combined with other vitamins and minerals.\u201d<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/best-weight-loss-pills\/\"><b>Alternatives to berberine for weight loss<\/b><\/a><\/p>\n<h2 id=\"the-bottom-line-berberine-can-help-with-minimal-weight-loss\"><span style=\"font-weight: 400;\">The bottom line: Berberine can help with minimal weight loss<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Overall, berberine is a potential weight-loss aid that\u2019s safe for most people. However, because studies have been limited and quite small, physicians say it cannot be definitively called a weight-loss supplement. It\u2019s also important to note that berberine is an over-the-counter supplement with limited regulation by the Food and Drug Administration, so there may be side effects and risk factors that are still unknown. Carefully monitor how you feel when you take it, and stop taking it immediately if any adverse side effects occur.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>With the popularity of semaglutide injectables continually growing, people are turning to medication to aid in weight loss more than ever. Although medications, Wegovy and Mounjaro, are proven to help patients lose weight, they can often be prohibitively expensive as many insurance providers do not offer coverage. Enter berberine, a plant-based supplement sometimes called \u201cnature\u2019s [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":62475,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[812,9825],"coauthors":[8371],"class_list":["post-62474","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-wellness","tag-supplements","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Berberine for weight loss: Efficacy, dosage, and side effects<\/title>\n<meta name=\"description\" content=\"The plant-based supplement berberine has shown promise in early studies for its weight-loss properties. 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