{"id":626244,"date":"2024-01-23T13:34:09","date_gmt":"2024-01-23T18:34:09","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626244"},"modified":"2024-10-25T10:13:36","modified_gmt":"2024-10-25T14:13:36","slug":"black-seed-oil-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/black-seed-oil-side-effects\/","title":{"rendered":"What are the side effects of black seed oil?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">For thousands of years, black seed, known also as black cumin and black caraway, has been used as an herbal remedy in traditional medicine. Presently, science is still trying to prove black seed oil&rsquo;s potential <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-seed-oil-benefits\/\"><span style=\"font-weight: 400;\">benefits<\/span><\/a><span style=\"font-weight: 400;\"> and therapeutic role in modern medicine, and of equal importance, research is needed on its safety. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7501064\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Preliminary studies<\/span><\/a><span style=\"font-weight: 400;\"> have fueled hope for its <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6535880\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">use in various health conditions<\/span><\/a><span style=\"font-weight: 400;\">, including <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/adult-onset-allergies\/\"><span style=\"font-weight: 400;\">allergies<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/infertility-statistics\/\"><span style=\"font-weight: 400;\">infertility<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypertension-causes\"><span style=\"font-weight: 400;\">high blood pressure<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-causes\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\">, cancer, and weight loss for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/obesity-and-health-insurance\/\"><span style=\"font-weight: 400;\">obesity<\/span><\/a><span style=\"font-weight: 400;\">. While those applications still need to be confirmed, the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8225153\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">evidence of black seed oil&rsquo;s side effects<\/span><\/a><span style=\"font-weight: 400;\"> is being uncovered, too. We will update you on what we currently know.<\/span><\/p>\n<h2 id=\"common-side-effects-of-black-seed-oil\"><span style=\"font-weight: 400;\">Common side effects of black seed oil<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The chance of having an adverse effect from taking black cumin seed oil is largely undefined. Gastrointestinal symptoms with oral ingestion and skin and nasal reactions to topical application seem to be most common.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal bloating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nasal dryness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects-of-black-seed-oil\"><span style=\"font-weight: 400;\">Serious side effects of black seed oil<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Limited research and isolated <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7331904\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">case reports<\/span><\/a><span style=\"font-weight: 400;\"> have raised <\/span><a href=\"https:\/\/health.clevelandclinic.org\/black-seed-oil\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">concern for possible side effects<\/span><\/a><span style=\"font-weight: 400;\"> of a severe nature from the use of black seed oil. Other researchers have not confirmed these severe side effects.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypoglycemia (low blood sugar levels)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated liver enzymes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney function decline<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Overdose toxicity<\/span><\/li>\n<\/ul>\n<h2 id=\"how-soon-do-black-seed-oil-side-effects-start\"><span style=\"font-weight: 400;\">How soon do black seed oil side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The onset time of adverse reactions to black cumin seed oil has not been elucidated to date. Based on the short timeframe of most studies on black seed supplements, an onset within days to weeks would be predicted. Long-term, large-scale clinical studies are needed to establish this, however.<\/span><\/p>\n<h2 id=\"how-long-do-black-seed-oil-side-effects-last\"><span style=\"font-weight: 400;\">How long do black seed oil side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Clinical trials have not firmly nailed down the duration of side effects from black cumin oil after the herbal remedy is stopped. Extrapolating from other medications with similar side effects could provide a reasonable guesstimate. Typically, drug-induced hypoglycemia resolves within hours and skin and intestinal symptoms improve within days of stopping an inciting drug.&nbsp;<\/span><\/p>\n<h2 id=\"what-are-the-long-term-side-effects-of-black-seed-oil\"><span style=\"font-weight: 400;\">What are the long-term side effects of black seed oil?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most alarming findings bring up kidney and liver toxicity questions. No proof exists to substantiate those worries, but if black seed oil truly can cause harm to these organs, the potential exists for some degree of permanent damage.<\/span><\/p>\n<h2 id=\"who-should-not-take-black-seed-oil\"><span style=\"font-weight: 400;\">Who should not take black seed oil?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some would question whether any individuals should take black seed oil since it has not been sufficiently tested with peer-reviewed, placebo-controlled studies and is not approved for use by the Food and Drug Administration (FDA). Nonetheless, most would agree that until the serious adverse effect concerns are refuted, the following conditions could be considered contraindications to black seed oil.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upcoming surgery<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">Anticoagulant therapy<\/span><\/a><span style=\"font-weight: 400;\"> or high risk of bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Advanced kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Advanced liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/hypoglycemia-without-diabetes\/\"><span style=\"font-weight: 400;\">Hypoglycemia<\/span><\/a><span style=\"font-weight: 400;\"> (low blood sugar) risk<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypotension (low blood pressure) risk<\/span><\/li>\n<\/ul>\n<h2 id=\"black-seed-oil-warnings\"><span style=\"font-weight: 400;\">Black seed oil warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Based on findings thus far, people with a history of bleeding, hypoglycemia, hypotension, renal impairment, or hepatic impairment should avoid black seed oil or at least discuss it with their healthcare provider prior to starting, although this is advisable for everyone.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If black seed oil is taken, dosing decisions could be very important. Animal studies have found high doses to be toxic and life-threatening. High-quality human studies are still needed.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dosing guidelines have not been established, so it is difficult to determine starting, typical, and maximum doses. Studies have often used 1 to 2 grams per day of product from the seeds of Nigella sativa and limited duration to 3 months or less.<\/span><\/p>\n<h2 id=\"black-seed-oil-interactions\"><span style=\"font-weight: 400;\">Black seed oil interactions<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Black seed oil can interact with medications for diabetes mellitus by amplifying the risk of hypoglycemia. Additional blood sugar monitoring may be necessary.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taking black seed oil concurrently with antihypertensive drugs could result in hypotension. Watching for symptoms of lightheadedness and checking for lower blood pressure readings could be advised.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anticoagulants coupled with black seed oil could magnify the risk of hemorrhage.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The cough suppressant <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dextromethorphan-polistirex-er\/what-is\"><span style=\"font-weight: 400;\">dextromethorphan<\/span><\/a><span style=\"font-weight: 400;\"> was not metabolized as readily when taken with black seed oil in a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20201775\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\">. This interaction could lead to higher levels of the drug and more adverse effects. The cause was noted to be black seed-inhibited CYP3A4 and CYP2D6 enzyme metabolism.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The findings of impeded CYP3A4 and CYP2D6 enzyme metabolism by black seed have created concern that other drugs could be affected too. This could mean that black seed oil interacts with numerous meds, including some from such common drug classes as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/calcium-channel-blockers\"><span style=\"font-weight: 400;\">calcium channel blockers<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/macrolides\"><span style=\"font-weight: 400;\">macrolide antibiotics<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">statins<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drug levels of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sildenafil-citrate\/what-is\"><span style=\"font-weight: 400;\">sildenafil<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/neoral\/what-is\"><span style=\"font-weight: 400;\">cyclosporine<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/phenytoin-sodium-extended\/what-is\"><span style=\"font-weight: 400;\">phenytoin<\/span><\/a><span style=\"font-weight: 400;\"> were reduced when taken concurrently with black seed oil. As a result, the drugs could be ineffective, a dangerous proposition considering that cyclosporine is an immunosuppressant and phenytoin is an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticonvulsants\"><span style=\"font-weight: 400;\">anticonvulsant<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-avoid-black-seed-oil-side-effects\"><span style=\"font-weight: 400;\">How to avoid black seed oil side effects<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">First and foremost, before starting an N. sativa plant product for any of your medical conditions or for a protective effect, ask your healthcare provider if you should take this supplement, what potential negative or positive effects you may experience, and what dosing or monitoring is advised.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Monitor your blood glucose when taking black seed oil.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Monitor your blood pressure when taking black seed oil.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Black seed oil can be taken with food, which could reduce stomach upset.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Limit intake to no more than 2 grams of black seed oil per day and duration to no more than 3 months.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Recognize the potential side effects of this herbal dietary supplement, including rash, abdominal pain, and bleeding, and discontinue it immediately if any are noted.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoid black seed oil if you take blood thinners or have a history of bleeding, hypoglycemia, hypotension, or advanced kidney or liver disease.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnant women should avoid products from the seeds of the Nigella sativa plant.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take your list of prescription drugs and over-the-counter meds, remembering to report any dietary supplements as well to your medical team of providers and pharmacists, and ask them if one could interact with black seed oil, specifically if any are CYP2D6 or CYP3A4 substrates.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you are looking into alternative medications due to cost concerns with your prescriptions, try a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare discount card<\/span><\/a><span style=\"font-weight: 400;\"> to see how much money you could save.<\/span><\/li>\n<\/ol>\n<h2 id=\"how-to-treat-side-effects-of-black-seed-oil\"><span style=\"font-weight: 400;\">How to treat side effects of black seed oil<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Considering the unproven benefits of the oil from these tiny black seeds, any side effects that are experienced should lead to its discontinuation. You should then call your doctor to ask if any other actions are recommended to alleviate symptoms of the adverse reaction. Treatment may be available for nausea, bloating, or skin irritation. Quick-acting sugary food or drink could correct hypoglycemia. If the side effects of black seed oil are severe, such as in the case of bleeding, you should seek emergency medical attention. Before and during the use of any supplement, communication with your care providers is key.&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>For thousands of years, black seed, known also as black cumin and black caraway, has been used as an herbal remedy in traditional medicine. Presently, science is still trying to prove black seed oil&rsquo;s potential benefits and therapeutic role in modern medicine, and of equal importance, research is needed on its safety. Preliminary studies have [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":626245,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8029],"tags":[12752],"coauthors":[20732],"class_list":["post-626244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-education","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Black seed oil side effects: What to expect | SingleCare<\/title>\n<meta name=\"description\" content=\"The side effects of black seed oil include nausea, vomiting, bloating, stomach pain, nasal dryness, and rash. Learn how long the side effects of black seed oil last.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/black-seed-oil-side-effects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What are the side effects of black seed oil?\" \/>\n<meta property=\"og:description\" content=\"The side effects of black seed oil include nausea, vomiting, bloating, stomach pain, nasal dryness, and rash. Learn how long the side effects of black seed oil last.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/black-seed-oil-side-effects\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-23T18:34:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-25T14:13:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/01\/black-seed-oil-side-effects.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Chad Shaffer, MD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Chad Shaffer, MD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"What are the side effects of black seed oil?\",\"datePublished\":\"2024-01-23T18:34:09+00:00\",\"dateModified\":\"2024-10-25T14:13:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/\"},\"wordCount\":1153,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/black-seed-oil-side-effects.png\",\"keywords\":[\"Medication side effects\"],\"articleSection\":[\"Health Education\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/\",\"name\":\"Black seed oil side effects: What to expect | SingleCare\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/black-seed-oil-side-effects\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/black-seed-oil-side-effects.png\",\"datePublished\":\"2024-01-23T18:34:09+00:00\",\"dateModified\":\"2024-10-25T14:13:36+00:00\",\"description\":\"The side effects of black seed oil include nausea, vomiting, bloating, stomach pain, nasal dryness, and rash. 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