{"id":626286,"date":"2024-01-23T14:06:11","date_gmt":"2024-01-23T19:06:11","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626286"},"modified":"2025-10-06T15:02:14","modified_gmt":"2025-10-06T19:02:14","slug":"amlodipine-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/amlodipine-interactions\/","title":{"rendered":"Amlodipine interactions to avoid"},"content":{"rendered":"

Amlodipine<\/span><\/a> is one of the most frequently used antihypertensives, often chosen because its action as a <\/span>calcium channel blocker<\/span><\/a> is quite effective for <\/span>lowering high blood pressure<\/span><\/a>. Unfortunately, it and its brand-name version, <\/span>Norvasc<\/span><\/a>, are not without their faults, namely side effects like lower leg swelling and constipation, and a penchant for drug interactions. You should know some important interactions between amlodipine and other medications and certain health problems. We will cover key ones involving antifungals, erectile dysfunction medications, immunosuppressants, and cholesterol-lowering agents. By gaining this knowledge, you can reach out to your healthcare providers if you find an interaction between amlodipine and one of your other meds or medical conditions.<\/span><\/p>\n

Amlodipine drug interactions<\/span><\/h2>\n

The issues with drug interactions involving amlodipine relate to either magnified amlodipine adverse effects or amplified side effects of the other medication. Knowing the interaction’s existence and the symptoms to watch for is helpful.<\/span><\/p>\n

Statins<\/span><\/h3>\n

Statins<\/span><\/a> are a mainstay of hyperlipidemia management, providing lower cholesterol levels and reductions in heart attack and stroke rates. Often, <\/span>high cholesterol<\/span><\/a> and <\/span>hypertension<\/span><\/a> coexist, so it is not uncommon to have both a statin and amlodipine on one\u2019s med list. This is perfectly fine most times, but <\/span>Zocor<\/span><\/a> (simvastatin) and <\/span>lovastatin<\/span><\/a> are two members of the statin class that can be problematic. In both cases, amlodipine can escalate the risk of muscle pains when taking simvastatin or lovastatin. Talk to your doctor about reducing your statin dose or changing to a different statin.<\/span><\/p>\n

Phosphodiesterase-5 inhibitors<\/span><\/h3>\n

Inhibiting the <\/span>enzyme phosphodiesterase-5 (PDE-5)<\/span><\/a> leads to dilated blood vessels and greater penile blood flow, which improves erectile function. If one of these pills for <\/span>impotence<\/span><\/a> is taken along with amlodipine, a drop in blood pressure can occur, creating a sense of dizziness or fainting. Anyone prescribed this combination should talk to the prescribing professional right away. The PDE-5 inhibitors to watch out for include:<\/span><\/p>\n