{"id":626472,"date":"2024-01-29T09:30:54","date_gmt":"2024-01-29T14:30:54","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626472"},"modified":"2024-10-25T10:12:20","modified_gmt":"2024-10-25T14:12:20","slug":"how-long-does-testosterone-take-to-work","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/how-long-does-testosterone-take-to-work\/","title":{"rendered":"How long does testosterone take to work?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">For men, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/testosterone\/what-is\"><span style=\"font-weight: 400;\">testosterone<\/span><\/a><span style=\"font-weight: 400;\"> plays an important role in the development of male sex characteristics, sperm cell production, regulation of sex drive, and enlargement of the testes and penis. It&rsquo;s an essential hormone for men&rsquo;s health. However, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/testosterone-levels-by-age-chart-female\/\"><span style=\"font-weight: 400;\">women also produce testosterone<\/span><\/a><span style=\"font-weight: 400;\"> in small amounts&mdash;it is a precursor to estrogen. This sex hormone also stimulates protein synthesis, thereby promoting skeletal muscle growth. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you have a testosterone deficiency, your healthcare provider might recommend a treatment called testosterone replacement therapy (TRT). TRT can help increase testosterone levels and improve <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/low-testosterone-symptoms\"><span style=\"font-weight: 400;\">symptoms like<\/span><\/a><span style=\"font-weight: 400;\"> erection problems or erectile dysfunction, low libido, and low muscle strength.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It can take testosterone a few days to a few months to work, depending on the symptom you&rsquo;re treating, the type of administration, and various health factors. For instance, one <\/span><a href=\"https:\/\/academic.oup.com\/ejendo\/article\/165\/5\/675\/6677022\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> found that it may take up to six months to see the effects of TRT on erections, while its impact on depressive mood may be detectable after three to six weeks of treatment.&nbsp;<\/span><\/p>\n<h2 id=\"how-long-does-it-take-for-trt-to-work\"><span style=\"font-weight: 400;\">How long does it take for TRT to work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">TRT works to increase testosterone levels and improve symptoms associated with low testosterone levels. &ldquo;The timeframe for experiencing the effects of TRT varies depending on individual factors and the type of administration,&rdquo; explains <\/span><a href=\"https:\/\/www.nesaz.com\/about\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Linda Khoshaba<\/span><\/a><span style=\"font-weight: 400;\">, NMD, founder of <\/span><a href=\"https:\/\/www.nesaz.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Natural Endocrinology Specialists (NES)<\/span><\/a><span style=\"font-weight: 400;\"> in Scottsdale, Arizona. Generally, TRT will begin to work gradually, with symptoms appearing over the duration of treatment. The timelines for different symptoms are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>A few days<\/b><span style=\"font-weight: 400;\"> to improve mood and energy levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>A few weeks<\/b><span style=\"font-weight: 400;\"> to begin improving muscle mass and strength<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Several months <\/b><span style=\"font-weight: 400;\">for significant improvement in sexual function and bone density<\/span><\/li>\n<\/ul>\n<h2 id=\"signs-that-testosterone-therapy-is-working\"><span style=\"font-weight: 400;\">Signs that testosterone therapy is working<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Results a person may expect from testosterone treatment <\/span><a href=\"https:\/\/www.hindawi.com\/journals\/ije\/2012\/625434\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">include<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased levels of testosterone<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Improved sexual function and increased sexual desire<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased muscle strength and lean muscle mass<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/andr.12425\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">how the body metabolizes lipids<\/span><\/a><span style=\"font-weight: 400;\"> like triglycerides and cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An increase in bone strength and density<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Better lean body mass percentage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Enhanced quality of life and overall well-being<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced body fat mass<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Improved insulin sensitivity&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">May reduce the risk of cardiovascular health issues<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Over time, and when used appropriately, testosterone hormone replacement therapy can help improve symptoms of low testosterone, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low sperm count<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced sex drive<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased body hair and sparse beard growth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced lean muscle mass<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleep problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1471489221000461\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">glycemic control<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Body fat accumulation and weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constant fatigue<\/span><\/li>\n<\/ul>\n<h2 id=\"factors-that-influence-testosterone-effectiveness\"><span style=\"font-weight: 400;\">Factors that influence testosterone effectiveness<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Different health and lifestyle factors may affect the effectiveness of TRT and how long the effects last.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Physical activity level:<\/b><span style=\"font-weight: 400;\"> An individual&rsquo;s physical activity level may influence TRT&#8217;s effectiveness. A <\/span><a href=\"https:\/\/www.mdpi.com\/2077-0383\/8\/2\/151\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2019 study<\/span><\/a><span style=\"font-weight: 400;\"> published in the <\/span><i><span style=\"font-weight: 400;\">Journal of Clinical Medicine<\/span><\/i><span style=\"font-weight: 400;\"> indicated that regular exercise may increase the chances of having a sustained TRT effect after treatment.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Type of TRT and administration method:<\/b><span style=\"font-weight: 400;\"> The efficacy of testosterone treatment may vary depending on the kind of testosterone preparation being used: injection, transdermal (patch, gel, or pellet), oral, nasal, topical, or buccal formulation. For instance, a<\/span><a href=\"https:\/\/www.npjournal.org\/article\/S1555-4155(16)30716-4\/pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\"> comparison of TRT medications<\/span><\/a><span style=\"font-weight: 400;\"> indicated that a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/testosterone-cypionate\/what-is\"><span style=\"font-weight: 400;\">Delatestryl<\/span><\/a><span style=\"font-weight: 400;\"> injection normalized testosterone levels in up to 72% of patients, while the <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/androderm\"><span style=\"font-weight: 400;\">Androderm<\/span><\/a><span style=\"font-weight: 400;\"> patch achieved normal levels in up to 92% of patients when treating hypogonadism.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Underlying medical conditions and adverse effects:<\/b><span style=\"font-weight: 400;\"> TRT may worsen pre-existing health problems like certain cardiovascular diseases and obstructive sleep apnea. Also, <\/span><a href=\"https:\/\/www.npjournal.org\/article\/S1555-4155(16)30716-4\/pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">adverse effects, such as<\/span><\/a><span style=\"font-weight: 400;\"> urinary retention, reduced sperm production, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/tag\/acne\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">acne<\/span><\/a><span style=\"font-weight: 400;\">, may occur during testosterone treatment, causing some people to discontinue treatment.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Duration of treatment:<\/b><span style=\"font-weight: 400;\"> The duration of TRT treatment may vary depending on the type of TRT and the goal of the treatment. However, for people receiving the same treatment type (oral, gels, and injectables), <\/span><a href=\"https:\/\/www.mdpi.com\/2077-0383\/8\/2\/151\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">evidence suggests<\/span><\/a><span style=\"font-weight: 400;\"> that longer treatment periods may sustain the treatment response compared to shorter treatment periods.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Individual body response:<\/b><span style=\"font-weight: 400;\"> Some individuals may respond more dramatically to TRT than others due to genetics and other factors.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Diet:<\/b><span style=\"font-weight: 400;\"> Dietary factors can influence serum testosterone levels and impact androgen response. In a 2021 <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0960076021000716\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">systemic review and meta-analysis of studies<\/span><\/a><span style=\"font-weight: 400;\">, a low-fat diet appeared to reduce testosterone levels in men. The effects of proteins on testosterone are also being studied. Very high-protein foods (more than 3.4&#8197;g\/kg\/day) may reduce testosterone levels, while moderate-to-high protein (1.25&ndash;3.4&#8197;g\/kg\/day) diets may not, according to a <\/span><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/02601060221132922\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recent study<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><a href=\"https:\/\/www.mdpi.com\/2072-6643\/13\/10\/3375\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Micronutrients like<\/span><\/a><span style=\"font-weight: 400;\"> vitamin D, zinc, and magnesium may also affect testosterone concentrations and synthesis.<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-maximize-the-effectiveness-of-testosterone-therapy\"><span style=\"font-weight: 400;\">How to maximize the effectiveness of testosterone therapy<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/www.providence.org\/doctors\/urologic-oncology\/ca\/burbank\/ramkishen-narayanan-1215296348\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Ramkishen Narayanan<\/span><\/a><span style=\"font-weight: 400;\">, MD, a board-certified urologist at Providence Saint Joseph Medical Center in Burbank, California, lifestyle modifications can <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-increase-testosterone\/\"><span style=\"font-weight: 400;\">increase testosterone<\/span><\/a><span style=\"font-weight: 400;\"> and possibly relieve hypogonadism symptoms enough before formal TRT is even considered. Steps to maximize the effectiveness of your testosterone treatment plan include:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reducing stress and getting enough sleep<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6571549\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Avoiding recreational drug use<\/span><\/a><span style=\"font-weight: 400;\"> and limiting alcohol intake<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Losing weight if your BMI falls within the overweight or obese range<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/does-working-out-increase-testosterone\/\"><span style=\"font-weight: 400;\">Exercising regularly<\/span><\/a><span style=\"font-weight: 400;\">, especially by doing weight- or resistance-based training<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Being compliant with the treatment of existing medical conditions and the underlying cause of hypogonadism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Going for regular checkups after the TRT prescription so your healthcare provider can follow up with blood tests to know your progress<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Working with a registered dietitian to ensure your diet consists of foods that promote testosterone and its effects<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">&ldquo;Consult a qualified and experienced naturopathic endocrinologist or other healthcare professionals; focus on a holistic approach to wellness, address underlying issues, and optimize overall health alongside TRT,&rdquo; Khoshaba advises.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It&rsquo;s also crucial to understand that TRT is not a magic bullet, and its effectiveness and how long it takes to work depend on individual circumstances. It may not be the best treatment approach for everyone with low T, and like all medications, it is also <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/testosterone-side-effects\/\"><span style=\"font-weight: 400;\">associated with side effects<\/span><\/a><span style=\"font-weight: 400;\">. It is also essential to work with a licensed prescriber to ensure safe use because misuse or abuse may lead to an <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-approves-new-changes-testosterone-labeling-regarding-risks-associated-abuse-and-dependence\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increased risk of<\/span><\/a><span style=\"font-weight: 400;\"> stroke, heart attack, depression, and liver damage.&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>For men, testosterone plays an important role in the development of male sex characteristics, sperm cell production, regulation of sex drive, and enlargement of the testes and penis. It&rsquo;s an essential hormone for men&rsquo;s health. However, women also produce testosterone in small amounts&mdash;it is a precursor to estrogen. This sex hormone also stimulates protein synthesis, [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":626478,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[17777,8905,8670],"coauthors":[20970],"class_list":["post-626472","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-mens-health","tag-seasonal","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How long does testosterone take to work?<\/title>\n<meta name=\"description\" content=\"Testosterone can take up to a few months to fully work, depending on the type of TRT, the symptoms it\u2019s treating, and a patient\u2019s health condition.\" \/>\n<meta name=\"robots\" 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