{"id":626479,"date":"2024-02-01T10:58:14","date_gmt":"2024-02-01T15:58:14","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626479"},"modified":"2025-02-12T18:11:50","modified_gmt":"2025-02-12T23:11:50","slug":"ibuprofen-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/","title":{"rendered":"Ibuprofen interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\/what-is\"><span style=\"font-weight: 400;\">Ibuprofen<\/span><\/a><span style=\"font-weight: 400;\"> is an over-the-counter (OTC) medication commonly used to relieve pain, reduce inflammation, and lower fever. Ibuprofen is a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">nonsteroidal anti-inflammatory drug (NSAID)<\/span><\/a><span style=\"font-weight: 400;\"> that decreases the production of prostaglandins, which cause inflammation. Ibuprofen is available under different brands and in other forms. Ibuprofen is typically used to treat various conditions like headaches, dental pain, menstrual cramps, arthritis, and muscle aches.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While the use of ibuprofen has several benefits, it does come with several precautions, especially regarding<\/span> <a href=\"https:\/\/www.singlecare.com\/blog\/ibuprofen-side-effects\/\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\"> and drug interactions. Combining ibuprofen with certain medications may increase the risk of adverse effects, some of which can be serious. It&#8217;s recommended to consult a healthcare provider about other prescribed medications before trying ibuprofen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Keep reading to learn more about ibuprofen interactions and how to prevent them.\u00a0<\/span><\/p>\n<h2 id=\"ibuprofen-drug-interactions\"><b>Ibuprofen drug interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Like most medications, ibuprofen can have serious interactions with various medications. Here are some of the most common ones that can <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/022348s005lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">interact with ibuprofen<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3 id=\"blood-thinning-medications\"><span style=\"font-weight: 400;\">Blood-thinning medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Blood thinners, such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">anticoagulants<\/span><\/a><span style=\"font-weight: 400;\"> and antiplatelet drugs, are prescribed to prevent <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/blood-clot-causes\"><span style=\"font-weight: 400;\">blood clots<\/span><\/a><span style=\"font-weight: 400;\"> and reduce the risk of heart attacks and strokes. Ibuprofen can affect the way platelets work and increase the effects of blood thinners. Taking ibuprofen with blood thinners may increase the risk of bleeding, especially in the stomach and intestines. Common blood thinners include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coumadin (warfarin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Plavix (clopidogrel)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High- and low-dose aspirin\u00a0<\/span><\/li>\n<\/ul>\n<h3 id=\"certain-antidepressants\"><span style=\"font-weight: 400;\">Certain antidepressants<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\">, particularly SSRIs, can interact with ibuprofen, increasing the risk of bleeding. If you&#8217;re taking an SSRI, a healthcare provider may recommend alternative pain relief options. Examples of SSRIs that may increase the risk of bleeding with ibuprofen include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prozac (fluoxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zoloft (sertraline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Citalopram (Celexa)<\/span><\/li>\n<\/ul>\n<h3 id=\"other-nsaids\"><span style=\"font-weight: 400;\">Other NSAIDs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Combining ibuprofen with other NSAIDs can increase the risk of side effects, such as stomach ulcers, bleeding, and kidney problems. Multiple NSAIDs can amplify each other&#8217;s effects on the stomach lining and kidneys. Therefore, it&#8217;s recommended to avoid taking multiple NSAIDs at the same time. Other common NSAIDs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aleve (naproxen)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Voltaren (diclofenac)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Celebrex (celecoxib)<\/span><\/li>\n<\/ul>\n<h3 id=\"blood-pressure-medications\"><span style=\"font-weight: 400;\">Blood pressure medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ibuprofen can interfere with the effectiveness of various blood pressure medications, including <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ace-inhibitors\"><span style=\"font-weight: 400;\">ACE inhibitors<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/angiotensin-ii-receptor-blockers\"><span style=\"font-weight: 400;\">ARBs (angiotensin II receptor blockers)<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/beta-blockers\"><span style=\"font-weight: 400;\">beta blockers<\/span><\/a><span style=\"font-weight: 400;\">. In other words, ibuprofen may reduce the blood pressure-lowering effects of these medications. In addition, combining ibuprofen with ACE inhibitors or ARBs may also increase the risk of kidney damage. Examples of blood pressure medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zestril (lisinopril)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vasotec (enalapril)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cozaar (losartan)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tenormin (atenolol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lopressor (metoprolol)<\/span><\/li>\n<\/ul>\n<h3 id=\"lanoxin-digoxin\"><span style=\"font-weight: 400;\">Lanoxin (digoxin)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The blood levels of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/digoxin\/what-is\"><span style=\"font-weight: 400;\">digoxin<\/span><\/a><span style=\"font-weight: 400;\">, a medication used to treat heart conditions like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/atrial-fibrillation-treatment-and-medications\"><span style=\"font-weight: 400;\">atrial fibrillation <\/span><\/a><span style=\"font-weight: 400;\">and heart failure, may be increased when taking ibuprofen. This interaction may increase the side effects of digoxin.<\/span><\/p>\n<h3 id=\"eskalith-lithium\"><span style=\"font-weight: 400;\">Eskalith (lithium)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/lithium\/what-is\"><span style=\"font-weight: 400;\">Lithium<\/span><\/a><span style=\"font-weight: 400;\">, a mood stabilizer for conditions like bipolar disorder, can interact with ibuprofen, leading to increased lithium levels in the blood. As a result, there may be a risk of <\/span><a href=\"https:\/\/www.nami.org\/About-Mental-Illness\/Treatments\/Mental-Health-Medications\/Types-of-Medication\/Lithium\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">lithium toxicity<\/span><\/a><span style=\"font-weight: 400;\"> while taking ibuprofen and lithium. If you&#8217;re taking these two drugs together, you may need regular blood tests to monitor lithium levels.<\/span><\/p>\n<h3 id=\"rheumatrex-methotrexate\"><span style=\"font-weight: 400;\">Rheumatrex (methotrexate)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ibuprofen can reduce the clearance of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/methotrexate\/what-is\"><span style=\"font-weight: 400;\">methotrexate<\/span><\/a><span style=\"font-weight: 400;\">, a drug often prescribed for certain cancers and autoimmune diseases like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/rheumatoid-arthritis-symptoms\"><span style=\"font-weight: 400;\">rheumatoid arthritis<\/span><\/a><span style=\"font-weight: 400;\">. As a result, taking these medications together may lead to higher levels of methotrexate in the blood. Using these medications together may require monitoring for <\/span><a href=\"https:\/\/www.arthritis.org\/health-wellness\/treatment\/treatment-plan\/disease-management\/common-pain-relievers-carry-risks\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">methotrexate toxicity<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"sandimmune-cyclosporine\"><span style=\"font-weight: 400;\">Sandimmune (cyclosporine)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclosporine\/what-is\"><span style=\"font-weight: 400;\">Cyclosporine<\/span><\/a><span style=\"font-weight: 400;\"> is an immunosuppressant commonly used in organ transplant patients. Taking it with ibuprofen may increase the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4036662\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">risk of toxic effects<\/span><\/a><span style=\"font-weight: 400;\"> on the kidneys. As a result, the interaction may lead to added strain on the kidneys and a higher risk of kidney damage.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This may not be a complete list of drugs that can interact with ibuprofen. Consult a healthcare provider for more information about potential drug interactions.\u00a0<\/span><\/p>\n<h2 id=\"ibuprofen-food-interactions\"><b>Ibuprofen food interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">It is generally safe to take ibuprofen with or without food. Taking ibuprofen on an empty stomach may lead to faster absorption and quicker pain relief. However, some people experience stomach discomfort or irritation while taking ibuprofen without food. Therefore, taking ibuprofen with food or a glass of milk may be recommended to reduce the risk of stomach irritation.<\/span><\/p>\n<h3 id=\"ibuprofen-and-alcohol\"><b>Ibuprofen and alcohol<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">It\u2019s recommended to avoid taking ibuprofen and alcohol together. Drinking alcohol, especially in large amounts over time, can increase the <\/span><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2000\/0501\/p2863.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">risk of stomach bleeding<\/span><\/a><span style=\"font-weight: 400;\"> and liver problems. Because ibuprofen can have similar effects, combining ibuprofen and alcohol may have the potential to irritate the stomach lining. Avoid the daily use of alcohol in combination with ibuprofen.\u00a0<\/span><\/p>\n<h2 id=\"other-ibuprofen-interactions\"><b>Other ibuprofen interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Ibuprofen does not only interact with certain prescription medications but also some herbal supplements. Combining ibuprofen with certain <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6459456\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">herbal supplements that have blood-thinning effects<\/span><\/a><span style=\"font-weight: 400;\"> could increase the risk of bleeding. These herbal supplements may include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ginger<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Garlic<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ginkgo biloba<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Turmeric<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ginseng<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dong Quai<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Feverfew<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bromelain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cinnamon<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking herbal supplements and are considering the use of ibuprofen, you may want to consult a healthcare provider first. This is not a complete list of herbal supplements that can thin the blood.\u00a0<\/span><\/p>\n<h3 id=\"other-considerations\"><b>Other considerations<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Other precautions may be needed in people with <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/lookup.cfm?setid=8ea0e303-3967-4d71-8255-ac42a841ce28\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">certain health conditions<\/span><\/a><span style=\"font-weight: 400;\">. Consider the following before taking ibuprofen:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Hypersensitivity<\/b><span style=\"font-weight: 400;\">: Ibuprofen should be avoided in people with known allergies to ibuprofen or other NSAIDs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>High blood pressure<\/b><span style=\"font-weight: 400;\">: Ibuprofen may increase blood pressure and affect the blood pressure-lowering effects of medications. People with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypertension-treatments-and-medications\"><span style=\"font-weight: 400;\">hypertension<\/span><\/a><span style=\"font-weight: 400;\"> may need to use ibuprofen with caution.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Heart failure<\/b><span style=\"font-weight: 400;\">: People with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/congestive-heart-failure-treatment-and-medications\"><span style=\"font-weight: 400;\">heart failure<\/span><\/a><span style=\"font-weight: 400;\"> should use ibuprofen with caution, as it may worsen their condition. That\u2019s because ibuprofen may increase fluid retention in some people.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liver toxicity<\/b><span style=\"font-weight: 400;\">: Long-term or excessive use of ibuprofen may lead to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547845\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">liver damage<\/span><\/a><span style=\"font-weight: 400;\">. Watch for signs or symptoms of liver toxicity, such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/jaundice-symptoms\"><span style=\"font-weight: 400;\">jaundice<\/span><\/a><span style=\"font-weight: 400;\">, abdominal pain, and dark urine. Consult a healthcare provider if these symptoms occur.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Kidney toxicity<\/b><span style=\"font-weight: 400;\">: Ibuprofen may negatively affect kidney function. Monitoring for kidney issues is recommended, especially for individuals with pre-existing kidney conditions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Asthma<\/b><span style=\"font-weight: 400;\">: Those with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/asthma-treatment-and-medications\"><span style=\"font-weight: 400;\">asthma<\/span><\/a><span style=\"font-weight: 400;\"> should be aware that NSAIDs like ibuprofen may trigger asthma attacks in sensitive individuals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Pregnancy<\/b><span style=\"font-weight: 400;\">: Ibuprofen is generally not recommended during pregnancy, especially <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-recommends-avoiding-use-nsaids-pregnancy-20-weeks-or-later-because-they-can-result-low-amniotic\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">around 20 weeks or later<\/span><\/a><span style=\"font-weight: 400;\">, due to potential risks to the unborn baby.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Anemia<\/b><span style=\"font-weight: 400;\">: Ibuprofen can sometimes lower hemoglobin or hematocrit levels in your blood. These are important components that help carry oxygen. A decrease in these levels may worsen <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anemia-treatment-and-medications\"><span style=\"font-weight: 400;\">anemia<\/span><\/a><span style=\"font-weight: 400;\">, a condition in which an individual doesn\u2019t have enough red blood cells.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">With these precautions in mind, you could help prevent serious side effects and ensure ibuprofen is used safely.<\/span><\/p>\n<h2 id=\"how-to-minimize-ibuprofen-interactions\"><b>How to minimize ibuprofen interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Drug interactions with ibuprofen are generally avoidable, especially with the right knowledge and awareness. Before deciding to take ibuprofen, you can take several steps to reduce the risk of drug interactions.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take the lowest effective dose<\/b><span style=\"font-weight: 400;\">: Starting with the lowest <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\/dosage\"><span style=\"font-weight: 400;\">dose<\/span><\/a><span style=\"font-weight: 400;\"> that provides relief may help decrease the risk of side effects from interactions. It\u2019s typically recommended to use ibuprofen at the lowest effective dose for the shortest possible duration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Keep a regular schedule<\/b><span style=\"font-weight: 400;\">: Taking ibuprofen as directed by the label or a healthcare provider can help ensure the drug is taken effectively and safely. If the dosage is once every four to six hours, don\u2019t take another dose sooner than recommended.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Read labels on nonprescription products: <\/b><span style=\"font-weight: 400;\">Check the labels of OTC cold and pain medications. Many products contain ibuprofen and other NSAIDs as added ingredients. Therefore, you\u2019ll want to avoid taking medications with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/flu-cold-medicine-interactions\/\"><span style=\"font-weight: 400;\">overlapping ingredients<\/span><\/a><span style=\"font-weight: 400;\"> that can increase the risk of an interaction.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Be alert for any unusual symptoms<\/b><span style=\"font-weight: 400;\">: Watch for any unusual symptoms of an interaction, such as dizziness, bleeding or bruising more easily, or severe headaches.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Consult a healthcare provider<\/b><span style=\"font-weight: 400;\">: Before starting ibuprofen, especially when taking other medications, you may want to consult a healthcare provider. They can recommend any necessary changes to current medications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Keep a medication list<\/b><span style=\"font-weight: 400;\">: A detailed <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/medication-list-template\/\"><span style=\"font-weight: 400;\">list of all medications<\/span><\/a><span style=\"font-weight: 400;\">, including dosages and frequencies, can help your healthcare provider review and manage potential interactions.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">By taking proactive steps and closely monitoring your health, you can often reduce the risk of drug interactions with ibuprofen.\u00a0<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-ibuprofen-interactions\"><b>When to talk to a healthcare provider about ibuprofen interactions<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">While ibuprofen can be a helpful and effective medication, knowing when to consult a healthcare provider may be beneficial. Here are some general situations where you should speak with a healthcare provider before taking ibuprofen.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>You take other medications:<\/b><span style=\"font-weight: 400;\"> If you\u2019re taking other drugs, including OTC products and prescription medications, you can review potential interactions with a doctor or pharmacist to prevent an interaction.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>You take supplements:<\/b><span style=\"font-weight: 400;\"> Using supplements or herbal products with ibuprofen could increase the risk of side effects. If you regularly take supplements, discuss them with your healthcare provider.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>You have pre-existing Conditions:<\/b><span style=\"font-weight: 400;\"> Those with conditions involving the liver or kidneys may need to consult a healthcare provider before taking ibuprofen. In addition, individuals with a personal or family history of heart disease should consult their healthcare provider before taking ibuprofen or other NSAIDs.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This overview is not exhaustive. Different factors can affect the severity and risk of a drug interaction with ibuprofen. Always consult a healthcare provider before taking ibuprofen if you take other medications. Seek medical attention if you experience serious side effects that develop or worsen.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ibuprofen is an over-the-counter (OTC) medication commonly used to relieve pain, reduce inflammation, and lower fever. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that decreases the production of prostaglandins, which cause inflammation. Ibuprofen is available under different brands and in other forms. Ibuprofen is typically used to treat various conditions like headaches, dental pain, menstrual [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":626480,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[814,808],"coauthors":[8669],"class_list":["post-626479","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-interactions","tag-pain-management","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ibuprofen interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Ibuprofen (Advil) interacts with blood thinners, other NSAIDs, and certain antidepressants, foods, and alcohol. Here\u2019s what you should not take with ibuprofen to avoid side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ibuprofen interactions to avoid\" \/>\n<meta property=\"og:description\" content=\"Watch out for these combinations\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2024-02-01T15:58:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-12T23:11:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/01\/ibuprofen-interactions.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Gerardo Sison, Pharm.D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Ibuprofen interactions to avoid\" \/>\n<meta name=\"twitter:description\" content=\"Watch out for these combinations\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gerardo Sison, Pharm.D.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"Ibuprofen interactions to avoid\",\"datePublished\":\"2024-02-01T15:58:14+00:00\",\"dateModified\":\"2025-02-12T23:11:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/\"},\"wordCount\":1521,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ibuprofen-interactions.png\",\"keywords\":[\"Drug interactions\",\"Pain management\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/\",\"name\":\"Ibuprofen interactions to avoid | SingleCare\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ibuprofen-interactions.png\",\"datePublished\":\"2024-02-01T15:58:14+00:00\",\"dateModified\":\"2025-02-12T23:11:50+00:00\",\"description\":\"Ibuprofen (Advil) interacts with blood thinners, other NSAIDs, and certain antidepressants, foods, and alcohol. Here\u2019s what you should not take with ibuprofen to avoid side effects.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ibuprofen-interactions.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ibuprofen-interactions.png\",\"width\":1920,\"height\":1080,\"caption\":\"Rx pill and pill bottles: Ibuprofen interactions to avoid\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/ibuprofen-interactions\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ibuprofen interactions to avoid\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\",\"name\":\"Christie Falzone\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"caption\":\"Christie Falzone\"},\"description\":\"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/cfalzone\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Ibuprofen interactions to avoid | SingleCare","description":"Ibuprofen (Advil) interacts with blood thinners, other NSAIDs, and certain antidepressants, foods, and alcohol. Here\u2019s what you should not take with ibuprofen to avoid side effects.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/","og_locale":"en_US","og_type":"article","og_title":"Ibuprofen interactions to avoid","og_description":"Watch out for these combinations","og_url":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2024-02-01T15:58:14+00:00","article_modified_time":"2025-02-12T23:11:50+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/01\/ibuprofen-interactions.png","type":"image\/png"}],"author":"Gerardo Sison, Pharm.D.","twitter_card":"summary_large_image","twitter_title":"Ibuprofen interactions to avoid","twitter_description":"Watch out for these combinations","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Gerardo Sison, Pharm.D.","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/"},"author":{"name":"Christie Falzone","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e"},"headline":"Ibuprofen interactions to avoid","datePublished":"2024-02-01T15:58:14+00:00","dateModified":"2025-02-12T23:11:50+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/"},"wordCount":1521,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/01\/ibuprofen-interactions.png","keywords":["Drug interactions","Pain management"],"articleSection":["Drug Info"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/","url":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/","name":"Ibuprofen interactions to avoid | SingleCare","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/01\/ibuprofen-interactions.png","datePublished":"2024-02-01T15:58:14+00:00","dateModified":"2025-02-12T23:11:50+00:00","description":"Ibuprofen (Advil) interacts with blood thinners, other NSAIDs, and certain antidepressants, foods, and alcohol. Here\u2019s what you should not take with ibuprofen to avoid side effects.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/01\/ibuprofen-interactions.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/01\/ibuprofen-interactions.png","width":1920,"height":1080,"caption":"Rx pill and pill bottles: Ibuprofen interactions to avoid"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/ibuprofen-interactions\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Ibuprofen interactions to avoid"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e","name":"Christie Falzone","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7","url":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","caption":"Christie Falzone"},"description":"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.","url":"https:\/\/www.singlecare.com\/blog\/author\/cfalzone\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/626479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/133"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=626479"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/626479\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/626480"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=626479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=626479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=626479"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=626479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}