{"id":626555,"date":"2024-02-02T09:30:45","date_gmt":"2024-02-02T14:30:45","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626555"},"modified":"2025-05-21T10:35:58","modified_gmt":"2025-05-21T14:35:58","slug":"which-cholesterol-drug-is-safest","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/which-cholesterol-drug-is-safest\/","title":{"rendered":"What\u2019s the safest cholesterol medication?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-treatment-and-medications\"><span style=\"font-weight: 400;\">Cholesterol medicines<\/span><\/a><span style=\"font-weight: 400;\">, such as statins, continue to play a pivotal role in helping reduce deaths from heart disease, which currently kills 1 person every 33 seconds in the United States. Statins, lauded for their cholesterol-lowering capabilities, are taken by more than 90 million Americans. Their primary function is to combat the dangerous levels of low-density lipoprotein (LDL) cholesterol, otherwise known as \u201cbad\u201d cholesterol.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&#8220;Statins are the most commonly prescribed cholesterol drugs because extensive research shows their effectiveness in reducing heart attack and stroke,&#8221; explains Renee Akers, Pharm.D., a pharmacist based in Asheville, North Carolina. &#8220;Statins help lower blood cholesterol levels by blocking your body\u2019s ability to make its own cholesterol.&#8221;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When people are diagnosed with high cholesterol (hypercholesterolemia), they often wonder what the safest cholesterol-lowering medication is. The answer, however, is not straightforward. There isn&#8217;t a universal safest statin or other cholesterol-lowering Rx. The best choice hinges on various factors, including individual side effects and interaction with other medications. The journey to finding the right cholesterol medication is as personalized as the treatment for heart disease itself.<\/span><\/p>\n<h2 id=\"which-cholesterol-drug-is-the-safest\"><span style=\"font-weight: 400;\">Which cholesterol drug is the safest?<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/lipitor\"><span style=\"font-weight: 400;\">Lipitor (atorvastatin)<\/span><\/a><span style=\"font-weight: 400;\"> is typically the first-line drug used to treat high cholesterol, says Dr. Akers. \u201cThe drug is generally well-tolerated by most people,\u201d explains <\/span><a href=\"https:\/\/www.linkedin.com\/in\/drkatebyrd\/\"><span style=\"font-weight: 400;\">Kate Byrd, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, former community pharmacist with Longs Drugs. Additionally, <\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11883-023-01124-z\"><span style=\"font-weight: 400;\">decades of research<\/span><\/a><span style=\"font-weight: 400;\"> support its long-term safety and effectiveness, reinforcing its place at the top.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Statins, in general, are the first drug class of choice for managing cholesterol due to their robust efficacy in reducing heart attack and stroke risk. The <\/span><a href=\"https:\/\/www.lipidjournal.com\/article\/S1933-2874(14)00073-7\/fulltext\"><span style=\"font-weight: 400;\">National Lipid Association\u2019s Statin Safety Task Force report<\/span><\/a><span style=\"font-weight: 400;\"> explains that the benefits of statins are closely tied to an individual&#8217;s risk for cardiovascular disease. For those with a very low risk, the risks of adverse events may outweigh the benefits.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&#8220;Overall, the key to effective statin use, as well as reducing muscle problems, is keeping doses as low as possible and avoiding drug interactions with the statin,&#8221; Dr. Akers says. It\u2019s crucial to discuss the best approach with a cardiologist, considering personal risk factors and other medical conditions to determine the best medication for you.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Atorvastatin with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAtorvastatin 40 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.33<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.33<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium#blog-cta\" class=\"coupon-see-all-btn\">See Atorvastatin prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"common-types-of-cholesterol-drugs\"><span style=\"font-weight: 400;\">Common types of cholesterol drugs\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Cholesterol management is a key aspect of preventing cardiovascular disease and stroke. Medications that can help keep levels in a healthy range include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Statins<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fibrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Niacin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bile acid sequestrants<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">PCSK9 inhibitors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zetia (ezetimibe)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Typically, statins are the first-line option in individuals with cardiovascular disease risk factors due to their proven effectiveness in lowering LDL (bad) cholesterol and reducing the risk of heart attacks and other cardiovascular events. However, the choice of medication is influenced by various factors such as individual health history, potential side effects and drug interactions, and specific cholesterol issues.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is not an exhaustive list, and other drugs may be used to treat high cholesterol depending on individual needs and health conditions. It\u2019s always best to talk with your healthcare provider about your specific circumstances.<\/span><\/p>\n<h3 id=\"statins\"><span style=\"font-weight: 400;\">Statins<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Statins are the most commonly prescribed drugs for cholesterol management. \u201cThey work by helping the liver reduce the amount of cholesterol produced and also help the liver remove cholesterol that is already in the bloodstream,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/alexanderolumese\/\"><span style=\"font-weight: 400;\">Alexander Olumese, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, a clinical pharmacist with the University of Maryland Medical Center in Baltimore, Maryland. \u201cThis is important because, in situations where cholesterol is high, plaque (atherosclerosis) begins to form in the blood vessels. Increased plaque can lead to the narrowing of arteries and the blockage of blood flow.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of the most <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">common statins<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium\"><span style=\"font-weight: 400;\">Lipitor (atorvastatin)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/rosuvastatin-calcium\"><span style=\"font-weight: 400;\">Crestor (rosuvastatin)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/simvastatin\"><span style=\"font-weight: 400;\">Zocor (simvastatin)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/fluvastatin-sodium\"><span style=\"font-weight: 400;\">Lescol XL (fluvastatin)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\"><span style=\"font-weight: 400;\">Pravastatin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/lovastatin\"><span style=\"font-weight: 400;\">Lovastatin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/pitavastatin-calcium\"><span style=\"font-weight: 400;\">Livalo (pitavastatin)<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Statin therapy is generally safe, and most tolerate it fine. However, it may cause side effects, which may lead to treatment cessation for some. Statin side effects may be mild or severe. According to the <\/span><a href=\"https:\/\/academic.oup.com\/cardiovascres\/article\/118\/17\/3288\/6541634?login=false\"><span style=\"font-weight: 400;\">most recent<\/span><\/a><span style=\"font-weight: 400;\"> studies, these are some of the possible side effects and adverse events:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain, muscle aches, and muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">General abdominal discomfort<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Memory loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased liver enzyme levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of Type 2 diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Damage to the kidneys<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleep problems<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">It\u2019s important to note that some statin medication holds specific warnings related to adverse events and drug interactions. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/simvastatin\/what-is\"><span style=\"font-weight: 400;\">Simvastatin<\/span><\/a><span style=\"font-weight: 400;\">, one of the most commonly used statin drugs, <\/span><a href=\"https:\/\/health.clevelandclinic.org\/statins-grapefruit-safely-mix\"><span style=\"font-weight: 400;\">interacts with grapefruit juice<\/span><\/a><span style=\"font-weight: 400;\">, leading to increased levels of simvastatin in the body, which can, in turn, lead to more side effects. Lovastatin is another statin that may interact with grapefruit juice. Typically, these types of interactions occur with high doses of a statin. Some statins require you to completely avoid grapefruit products, while others warn not to consume large quantities. If you enjoy vitamin C through grapefruit or grapefruit juice, check with your healthcare provider about any possible restrictions.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are also warnings of a rare side effect of statins called rhabdomyolysis. \u201cSometimes, muscle aches develop into muscle breakdown, which may lead to kidney failure,\u201d Dr. Akers says. \u201cIt\u2019s important to notify your doctor if you develop severe muscle pain, dark brown urine, and fever while taking a statin.\u201d<\/span><\/p>\n<h3 id=\"zetia-ezetimibe\"><span style=\"font-weight: 400;\">Zetia (ezetimibe)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/zetia\"><span style=\"font-weight: 400;\">Zetia (ezetimibe)<\/span><\/a><span style=\"font-weight: 400;\"> is a commonly used non-statin anti-lipid medicine that works by reducing cholesterol absorption in the small intestine, thus lowering LDL cholesterol. While statins are the backbone of cholesterol-lowering treatments, millions of individuals can still have elevated LDL levels despite taking statins. Therefore, it is common for ezetimibe to be used in <\/span><a href=\"https:\/\/www.acc.org\/latest-in-cardiology\/articles\/2016\/03\/09\/06\/50\/ezetimibe-the-lower-the-ldlc-the-better\"><span style=\"font-weight: 400;\">combination<\/span><\/a><span style=\"font-weight: 400;\"> with statins to elicit a better effect.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ezetimibe has fewer side effects than other cholesterol-lowering medicines. \u201cDiarrhea is the most common side effect, affecting up to 10% of people taking ezetimibe,\u201d Dr. Byrd says. However, increasing water and fiber in one\u2019s diet can often help manage this gastrointestinal upset.<\/span><\/p>\n<h3 id=\"fibrates\"><span style=\"font-weight: 400;\">Fibrates<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fibrates, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/gemfibrozil\"><span style=\"font-weight: 400;\">Lopid (gemfibrozil)<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fenofibrate\"><span style=\"font-weight: 400;\">fenofibrate<\/span><\/a><span style=\"font-weight: 400;\">, are another class of cholesterol-lowering drugs. They mainly target triglycerides\u2014another type of fat in the blood\u2014by decreasing the liver\u2019s release of triglycerides and increasing the production of an enzyme that breaks down triglycerides.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&#8220;Fibrates increase your body&#8217;s ability to break down and remove triglycerides from your bloodstream; they also slightly raise &#8216;good&#8217; high-density lipoprotein (HDL) cholesterol levels, which statins don\u2019t typically affect,&#8221; Dr. Byrd says. \u201cSide effects of fibrates can include stomach pain, gallstones, and muscle damage, especially when taken with statins. Muscle aches (myalgia) are the most frequent side effect of fibrates, affecting up to 10% of patients.\u201d<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547756\/\"><span style=\"font-weight: 400;\">Studies report<\/span><\/a><span style=\"font-weight: 400;\"> that the most common adverse effects of fibrates include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in kidney or liver function<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gallstones<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain (especially when combined with statins)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">However, fibrates are generally safe to use and do not need frequent monitoring unless a patient is susceptible to any of the known side effects.<\/span><\/p>\n<h3 id=\"niacin\"><span style=\"font-weight: 400;\">Niacin<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Niacin, or nicotinic acid, is a B vitamin that boosts HDL (good) cholesterol and lowers triglycerides and LDL cholesterol. However, unlike statins and fibrates, it takes slightly longer to exert its effects. Niacin is naturally found in many foods, like fish, beef, chicken, and turkey. In the body, niacin is converted to nicotinamide adenine dinucleotide (NAD), a vital molecule used for energy production and numerous other physiological functions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Niacin has been studied both as a standalone treatment and in combination with statin therapy for cholesterol management. However, despite <\/span><a href=\"https:\/\/medscimonit.com\/abstract\/index\/idArt\/893619\"><span style=\"font-weight: 400;\">studies<\/span><\/a><span style=\"font-weight: 400;\"> proving its effectiveness in managing cholesterol levels, it&#8217;s important to note that results have varied, and some individuals have experienced adverse effects such as flushing, itching, increased blood sugar, and, in rare cases, liver damage.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Therefore, the <\/span><a href=\"https:\/\/www.acc.org\/Latest-in-Cardiology\/ten-points-to-remember\/2022\/08\/25\/13\/13\/2022-ACC-ECDP-on-Nonstatin\"><span style=\"font-weight: 400;\">American College of Cardiology<\/span><\/a><span style=\"font-weight: 400;\"> and the American Heart Association have provided guidance indicating a preference for statins over non-statin therapies like niacin in reducing cardiovascular risk. This advisory is primarily based on the <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30716508\/\"><span style=\"font-weight: 400;\">consistent and significant benefits statins<\/span><\/a><span style=\"font-weight: 400;\"> have shown in large-scale clinical trials compared to the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559137\/\"><span style=\"font-weight: 400;\">mixed results and potential side effects<\/span><\/a><span style=\"font-weight: 400;\"> associated with niacin.<\/span><\/p>\n<h3 id=\"bile-acid-sequestrants\"><span style=\"font-weight: 400;\">Bile acid sequestrants<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">&#8220;Bile acid sequestrants like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cholestyramine\"><span style=\"font-weight: 400;\">cholestyramine<\/span><\/a><span style=\"font-weight: 400;\"> \u2026 bind to bile acids in your digestive system, preventing them from being reabsorbed into your bloodstream,&#8221; Dr. Byrd explains. \u201cThese medicines force your liver to use cholesterol to make new bile acids, thus lowering your overall cholesterol levels.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bile acid sequestrants can help lower LDL cholesterol but may cause gastrointestinal issues and reduce the absorption of other medications. Dr. Byrd says that \u201cconstipation, bloating, and gas can affect up to 20% of users.\u201d<\/span><\/p>\n<h3 id=\"pcsk9-inhibitors\"><span style=\"font-weight: 400;\">PCSK9 Inhibitors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Newer to the scene are PCSK9 inhibitors like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/praluent\"><span style=\"font-weight: 400;\">Praluent (alirocumab)<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/repatha\"><span style=\"font-weight: 400;\">Repatha (evolocumab)<\/span><\/a><span style=\"font-weight: 400;\">. &#8220;These injectable medications block the PCSK9 protein, which removes LDL receptors from your liver,\u201d Dr. Byrd says. \u201cThis leads to more LDL receptors available to remove LDL cholesterol from your bloodstream.&#8221; They are typically used in patients with genetic conditions leading to <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-causes\"><span style=\"font-weight: 400;\">high cholesterol<\/span><\/a><span style=\"font-weight: 400;\"> or those who don&#8217;t respond to statins.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, like all medicines, they come with their own side effects. Some using PCSK9 inhibitors may experience injection site reactions, which range from mild redness and swelling to pain and itching. Side effects such as fatigue, chills, muscle aches, and headaches may occur, but these effects usually resolve within a day or two.<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><strong><span class=\"title\">Save on cholesterol medications<\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Lipitor (atorvastatin)<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Crestor (rosuvastatin)<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/rosuvastatin-calcium\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/rosuvastatin-calcium\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zocor (simvastatin)<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/simvastatin\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/simvastatin\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fluvastatin<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/fluvastatin-sodium-er\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/fluvastatin-sodium-er\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Pravastatin<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lovastatin<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lovastatin\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lovastatin\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Livalo (pitavastatin)<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/pitavastatin-calcium\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/livalo\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zetia (ezetimibe)\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zetia\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zetia\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lopid (gemfibrozil)\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/gemfibrozil\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/gemfibrozil\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fenofibrate<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/fenofibrate\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/fenofibrate\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Niacin<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/niacin-antihyperlipidemic\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/niacin-antihyperlipidemic\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cholestyramine<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cholestyramine\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cholestyramine\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Praluent (alirocumab)\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/praluent\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/praluent\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Repatha (evolocumab)<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/repatha\"><span style=\"font-weight: 400;\">Coupons<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/repatha\/what-is\"><span style=\"font-weight: 400;\">Learn more<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"the-bottom-line-take-statins-with-lifestyle-changes\"><span style=\"font-weight: 400;\">The bottom line: Take statins with lifestyle changes<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While statins are generally considered the safest and effective cholesterol medications, there is no one-size-fits-all approach. Choosing the right cholesterol medication involves considering several factors:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Individual health profile: A person&#8217;s overall health, including any existing conditions and whether they have a high risk of cardiovascular disease, plays a crucial role in determining the most suitable cholesterol medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Side effects and drug interactions: Patients should discuss the potential side effects of different medications with their healthcare providers and weigh them against their benefits.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lifestyle modifications: Integrating <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-lower-cholesterol\/\"><span style=\"font-weight: 400;\">lifestyle changes<\/span><\/a><span style=\"font-weight: 400;\"> as part of cholesterol management is crucial.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">&#8220;The best way to lower cholesterol without having to take medication is to stop smoking, exercise, follow a healthy diet, and limit alcohol intake,&#8221; Dr. Akers says. Consulting with a cardiologist for medical advice is essential to tailor a plan that suits individual health needs and risks. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cholesterol medicines, such as statins, continue to play a pivotal role in helping reduce deaths from heart disease, which currently kills 1 person every 33 seconds in the United States. Statins, lauded for their cholesterol-lowering capabilities, are taken by more than 90 million Americans. Their primary function is to combat the dangerous levels of low-density [&hellip;]<\/p>\n","protected":false},"author":106,"featured_media":626500,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,737,20952],"coauthors":[20977],"class_list":["post-626555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-heart-health","tag-high-cholesterol","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What\u2019s the safest cholesterol medication?<\/title>\n<meta name=\"description\" content=\"Statins are the safest for most, but other cholesterol medications may have fewer side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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