{"id":626599,"date":"2024-02-06T17:24:20","date_gmt":"2024-02-06T22:24:20","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626599"},"modified":"2024-10-25T10:10:53","modified_gmt":"2024-10-25T14:10:53","slug":"pseudoephedrine-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/pseudoephedrine-interactions\/","title":{"rendered":"Pseudoephedrine interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/pseudoephedrine-hcl\/what-is\"><span style=\"font-weight: 400;\">Pseudoephedrine<\/span><\/a><span style=\"font-weight: 400;\"> is a <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a682619.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">nasal decongestant<\/span><\/a><span style=\"font-weight: 400;\"> and the active ingredient in the brand-name drug Sudafed. It is taken by mouth to treat a stuffy nose associated with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/common-cold-treatment-and-medications\"><span style=\"font-weight: 400;\">colds<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/allergy-treatment-and-medications\"><span style=\"font-weight: 400;\">allergies<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/spring-allergies\/\"><span style=\"font-weight: 400;\">hay fever<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/sinus-infection-treatment-and-medications\"><span style=\"font-weight: 400;\">sinus congestion<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-relieve-sinus-pressure\/\"><span style=\"font-weight: 400;\">pressure<\/span><\/a><span style=\"font-weight: 400;\">. It is not an antibiotic and does not treat bacterial infections; however, it may reduce some associated symptoms.&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/pseudoephedrine-hcl\"><span style=\"font-weight: 400;\">Pseudoephedrine<\/span><\/a><span style=\"font-weight: 400;\"> is available in several formulations, such as immediate-release tablets, extended-release tablets, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sudafed-childrens\"><span style=\"font-weight: 400;\">liquid<\/span><\/a><span style=\"font-weight: 400;\"> (version for children). Pseudoephedrine is available as a single-ingredient product and in various cough and cold medicine types. This article will focus on the single ingredient product.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because pseudoephedrine can be <\/span><a href=\"https:\/\/nida.nih.gov\/publications\/drugfacts\/over-counter-medicines\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">used to make methamphetamine<\/span><\/a><span style=\"font-weight: 400;\">, medications that contain this drug are sold &ldquo;behind the counter.&rdquo; Most states do not require a prescription for pseudoephedrine, but people who want to purchase it must ask the pharmacy staff for the product, which is kept behind the pharmacy counter. Other limitations vary by state, such as the amount of pseudoephedrine a person can buy each month or how old you have to be to purchase pseudoephedrine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of the most common side effects of this medication include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restlessness<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some of the most serious side effects of pseudoephedrine include dizziness, trouble sleeping, stomach pain, difficulty breathing, or a fast, pounding, or irregular heartbeat. Signs of an allergic reaction may include hives, difficulty swallowing or breathing, or swelling of the face, lips, tongue, or throat. If you have any of these symptoms, immediately get emergency medical attention. This is a partial list of side effects, and others may occur. Ask your healthcare provider for a complete list of possible side effects associated with the use of pseudoephedrine.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pseudoephedrine interacts with various drugs, including monoamine oxidase inhibitors (MAOIs or MAO inhibitors), tricyclic antidepressants, phentermine, and others. For those who take pseudoephedrine, it&rsquo;s important to be aware of possible interactions that can cause potential complications.<\/span><\/p>\n<h2 id=\"pseudoephedrine-drug-interactions\"><span style=\"font-weight: 400;\">Pseudoephedrine drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Pseudoephedrine (PSE) interacts with various drugs and classes of drugs, which can result in different complications. Note that when pseudoephedrine should not be taken with a certain drug, you can check with your healthcare provider or pharmacist to help you find a more appropriate drug. You can also try <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-get-rid-of-a-stuffy-nose\/\"><span style=\"font-weight: 400;\">other methods<\/span><\/a><span style=\"font-weight: 400;\"> to relieve a stuffy nose, such as using nasal saline sprays, neti pot rinses, or running a cool-mist humidifier.&nbsp;<\/span><\/p>\n<h3 id=\"monoamine-oxidase-inhibitors-maois\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors (MAOIs)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors (MAOIs)<\/span><\/a><span style=\"font-weight: 400;\"> are a group of older medications that treat depression and other neurological conditions like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/parkinsons-symptoms\"><span style=\"font-weight: 400;\">Parkinson&rsquo;s disease<\/span><\/a><span style=\"font-weight: 400;\">.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MAOIs are no longer the first choice in treating <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\"> because there are dietary restrictions, potentially serious side effects, and many drug interactions associated with them.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both pseudoephedrine and MAOIs can increase the heart rate and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/blood-pressure-levels\/\"><span style=\"font-weight: 400;\">blood pressure<\/span><\/a><span style=\"font-weight: 400;\">.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When pseudoephedrine is <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8152226\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">combined<\/span><\/a><span style=\"font-weight: 400;\"> with an MAOI, the result can be severely <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypertension-treatments-and-medications\"><span style=\"font-weight: 400;\">high blood pressure<\/span><\/a><span style=\"font-weight: 400;\"> (hypertension), hypertensive crisis (a medical emergency where there is a sudden and severe increase in blood pressure, which could lead to a heart attack or stroke), and a slowed heart rate. At least 14 days should elapse between taking pseudoephedrine and an MAOI. If you take an MAOI, you should not take pseudoephedrine. Consult your healthcare provider for medical advice.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of MAOIs include the following medicines:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Azilect (rasagiline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nardil (phenelzine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Parnate (tranylcypromine)&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This drug class also includes Zyvox (linezolid), the only <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-do-antibiotics-work\/\"><span style=\"font-weight: 400;\">antibiotic<\/span><\/a><span style=\"font-weight: 400;\"> classified as an MAOI.&nbsp;<\/span><\/p>\n<h3 id=\"tricyclic-antidepressants\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants (TCAs)<\/span><\/a><span style=\"font-weight: 400;\"> are a group of antidepressant medications that include drugs such as Elavil (amitriptyline) and Pamelor (nortriptyline). TCAs should not be combined with PSE. This is because their combined effect could result in high blood pressure and irregular heartbeat. If you take a TCA, you should not take pseudoephedrine. Consult your healthcare professional for medical advice.<\/span><\/p>\n<h3 id=\"ergots\"><span style=\"font-weight: 400;\">Ergots<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ergot medications, sometimes used for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraine<\/span><\/a><span style=\"font-weight: 400;\">, should not be combined with pseudoephedrine. The combination could result in vasoconstriction (narrowing of blood vessels, which slows blood flow) and increased blood pressure. Examples of ergots include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drugs containing ergotamine such as Migergot (ergotamine\/caffeine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Migranal (dihydroergotamine) nasal spray<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you take an ergot medication, you should not take pseudoephedrine. Consult your healthcare provider for medical advice.<\/span><\/p>\n<h3 id=\"caffeine\"><span style=\"font-weight: 400;\">Caffeine<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Combining caffeine with pseudoephedrine can increase body temperature and high blood sugar. Caffeine can also intensify certain side effects of pseudoephedrine, like <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/caffeine-and-anxiety\/\"><span style=\"font-weight: 400;\">nervousness<\/span><\/a><span style=\"font-weight: 400;\">, shaking, trouble sleeping, and irritability. Caffeine products may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dietary caffeine, such as in coffee, tea, energy drinks, and others<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Caffeine found in prescription medications such as Fioricet or OTC medications (nonprescription products) like Excedrin Migraine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Caffeine found in supplements, such as alertness aids like Vivarin and NoDoz<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">While taking pseudoephedrine, you should avoid caffeine or limit consumption.&nbsp;<\/span><\/p>\n<h3 id=\"phentermine\"><span style=\"font-weight: 400;\">Phentermine<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/phentermine-hcl\/what-is\"><span style=\"font-weight: 400;\">Phentermine<\/span><\/a><span style=\"font-weight: 400;\">, also known by the brand name <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/adipex-p\/what-is\"><span style=\"font-weight: 400;\">Adipex-P<\/span><\/a><span style=\"font-weight: 400;\">, is a prescription weight-loss medication. Combining pseudoephedrine and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phentermine-alternatives\/\"><span style=\"font-weight: 400;\">phentermine<\/span><\/a><span style=\"font-weight: 400;\"> can lead to increased blood pressure and heart rate. If you take phentermine, ask your healthcare provider about an alternative to pseudoephedrine and try some non-medicinal methods to relieve your cold symptoms.&nbsp;<\/span><\/p>\n<h3 id=\"phenylephrine\"><span style=\"font-weight: 400;\">Phenylephrine&nbsp;<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/phenylephrine-hcl\/what-is\"><span style=\"font-weight: 400;\">Phenylephrine<\/span><\/a><span style=\"font-weight: 400;\">, like pseudoephedrine, is an oral medication used for nasal congestion. Because it is not used to make methamphetamine, it can be found over-the-counter (rather than behind the counter) in products such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sudafed-pe-sinus-congestion\"><span style=\"font-weight: 400;\">Sudafed-PE<\/span><\/a><span style=\"font-weight: 400;\"> and many combination cough and cold medications. Recently, this medication has been in the news <\/span><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/afp-community-blog\/entry\/FDA-advisory-panel-rules-that-oral-phenylephrine-is-ineffective.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">for being ineffective<\/span><\/a><span style=\"font-weight: 400;\"> (although not dangerous). Pseudoephedrine and phenylephrine are similar and should not be used together, not only because they have the same use but also because the combination could cause narrowing of blood vessels and increased blood pressure.&nbsp;<\/span><\/p>\n<h2 id=\"other-pseudoephedrine-interactions\"><span style=\"font-weight: 400;\">Other pseudoephedrine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In addition to drug interactions, certain health conditions are not compatible with pseudoephedrine.<\/span><\/p>\n<h3 id=\"pseudoephedrine-and-certain-medical-conditions\"><span style=\"font-weight: 400;\">Pseudoephedrine and certain medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Pseudoephedrine is not safe for everyone to take. General contraindications of pseudoephedrine (situations where you should not take this medication) include people who:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are allergic to pseudoephedrine or any ingredient in the medication<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have high blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have coronary artery disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/hypothyroidism-vs-hyperthyroidism\/\"><span style=\"font-weight: 400;\">hyperthyroidism<\/span><\/a><span style=\"font-weight: 400;\"> (overactive thyroid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have narrow-angle <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">glaucoma<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bph-treatment-and-medications\"><span style=\"font-weight: 400;\">benign prostatic hyperplasia<\/span><\/a><span style=\"font-weight: 400;\"> (BPH)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have taken an MAOI in the past 14 days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are you pregnant or breastfeeding<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">However, in some cases, a healthcare provider may give the green light for a short course of pseudoephedrine if no other options are available. For example, a healthcare provider may recommend a low dose of pseudoephedrine for a short period for an individual with high blood pressure that is well-controlled.&nbsp;<\/span><\/p>\n<h2 id=\"how-to-minimize-pseudoephedrine-interactions\"><span style=\"font-weight: 400;\">How to minimize pseudoephedrine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although pseudoephedrine has some potential interactions, in many cases, it can still be taken safely with some precautions.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Before beginning a new medicine, consult your healthcare provider for more information and medical advice. Before you start taking pseudoephedrine, make your provider aware of all of your medical conditions, <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/drugs\/20768-pseudoephedrine-capsules-and-tablets\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">especially if you<\/span><\/a><span style=\"font-weight: 400;\">:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are pregnant or trying to become pregnant<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are breastfeeding&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have heart disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have high blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have prostate problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have kidney problems or trouble urinating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take an MAOI<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have thyroid problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have had an unusual or allergic reaction to pseudoephedrine<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Tell your physician about all your medicines, including prescription drugs, OTC drugs, vitamins, supplements, or herbal products. While taking pseudoephedrine, do not start any new medication unless approved by your healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It&rsquo;s also important to note that extended-release pseudoephedrine tablets (long-acting tablets) should not be used in anyone less than 12 years of age. Older people may be more sensitive to the adverse effects of pseudoephedrine and may require lower doses. Always follow the dosage directions on the label and ask a healthcare provider or pharmacist if you have questions about the appropriate dose. The best way to measure liquid medication is to use a medicinal measuring device, as household measuring devices are not as accurate.<\/span><\/p>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-pseudoephedrine-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about pseudoephedrine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">This article outlines various pseudoephedrine interactions but lacks a complete list of every possible interaction. Tell your healthcare provider about all your medical conditions and medicines, including prescription medications, over-the-counter (OTC) drugs, vitamins, and dietary supplements. Doing so helps ensure proper management and monitoring of your medical condition.&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pseudoephedrine is a nasal decongestant and the active ingredient in the brand-name drug Sudafed. It is taken by mouth to treat a stuffy nose associated with colds, allergies, hay fever, sinus congestion, and pressure. It is not an antibiotic and does not treat bacterial infections; however, it may reduce some associated symptoms.&nbsp; Pseudoephedrine is available [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":626600,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,11169,814],"coauthors":[10668],"class_list":["post-626599","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-cold-flu","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Pseudoephedrine interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Pseudoephedrine interacts with MAOIs, tricyclic antidepressants, phentermine, and caffeine. 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