{"id":626601,"date":"2024-02-06T17:19:45","date_gmt":"2024-02-06T22:19:45","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626601"},"modified":"2026-03-17T15:59:36","modified_gmt":"2026-03-17T19:59:36","slug":"tadalafil-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tadalafil-interactions\/","title":{"rendered":"Tadalafil interactions to avoid"},"content":{"rendered":"

Tadalafil<\/span><\/a> (brand names Cialis, Adcirca, and Alyq) is a <\/span>phosphodiesterase type 5 (PDE5) inhibitor<\/span><\/a> that treats erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). Tadalafil is an oral tablet and suspension (brand name <\/span>Tadliq<\/span><\/a>). When used for <\/span>erectile dysfunction (ED)<\/span><\/a>, tadalafil works to help achieve erections for sexual activity. For BPH, tadalafil helps with urinary symptoms, such as <\/span>frequent urination<\/span><\/a> or the inability to empty the bladder during urination fully. Lastly, for PAH, tadalafil helps relax blood vessels and lowers the blood pressure in the lungs, which makes it easier for the heart to pump blood to the rest of the body.<\/span><\/p>\n

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Tadalafil interacts with nitrates, alpha-blockers, certain anti-infective medications, and sGC stimulators, among other drug classes. Do not take tadalafil with nitrates, sGC stimulators, and other PDE5 inhibitors without consulting a healthcare professional. Tadalafil also interacts with alcohol and grapefruit.\u2028<\/span><\/p>\n

It\u2019s important to be aware of tadalafil interactions as other drugs and foods can affect tadalafil\u2019s effectiveness and cause or worsen side effects. As a medication that can lead to serious effects, certain drug interactions are very important to avoid with tadalafil.<\/span><\/p>\n

RELATED: <\/b>Cialis (tadalafil) side effects and how to avoid them<\/b><\/a><\/p>\n

Tadalafil drug interactions<\/span><\/h2>\n

There are a variety of prescription drugs that can interact with tadalafil, including nitrates, alpha blockers, certain anti-infective medications, sGC stimulators, and other PDE5 inhibitors.<\/span><\/p>\n

Nitrates<\/span><\/h3>\n

Nitrates<\/span><\/a> are medications that are a type of <\/span>vasodilator<\/span><\/a> which means they open up blood vessels and improve blood flow. Nitrates are used for treating or preventing <\/span>chest pain<\/span><\/a> (also called angina) caused by heart disease. These medications cause relaxation within blood vessels, and this can cause several side effects. Since nitrates have serious side effects, some patients are more sensitive to these medications and do not tolerate them well. Additionally, nitrates have many serious drug interactions with other medications, including <\/span>PDE5 inhibitors<\/span><\/a> like tadalafil. In fact, people should avoid this combination.<\/span><\/p>\n

Serious <\/span>low blood pressure<\/span><\/a> can happen when a nitrate drug is taken with tadalafil, as both of these medications can lower blood pressure. <\/span>Signs of low blood pressure<\/span><\/a> include dizziness, lightheadedness, confusion, nausea, fainting, headache, blurred vision, and irregular heartbeat. In general, nitrates may be taken 24 hours after the last dose of a short-acting PDE5 inhibitor and 48 hours after the last dose of a long-acting PDE5 inhibitor. People who take nitrate medicine and would like to start a PDE5 inhibitor like tadalafil should be aware of this interaction and can talk with their doctor to determine whether nitrate treatment can be discontinued.<\/span><\/p>\n

Examples of common nitrates include:<\/span><\/p>\n