{"id":626700,"date":"2024-02-08T16:51:30","date_gmt":"2024-02-08T21:51:30","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626700"},"modified":"2026-03-12T10:16:20","modified_gmt":"2026-03-12T14:16:20","slug":"lupron-depot-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lupron-depot-side-effects\/","title":{"rendered":"How to avoid Lupron Depot side effects"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/lupron-depot\"><span style=\"font-weight: 400;\">Lupron Depot<\/span><\/a><span style=\"font-weight: 400;\"> (leuprolide acetate) is a gonadotropin-releasing hormone (GnRH) agonist that can help suppress the body\u2019s production of estrogen or testosterone if they\u2019re causing certain issues. By reducing these hormones, Lupron Depot injections can <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/prostate-cancer-treatment-and-medications\"><span style=\"font-weight: 400;\">slow the growth of prostate cancer in men<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/endometriosis-treatment-and-medications\"><span style=\"font-weight: 400;\">treat endometriosis<\/span><\/a><span style=\"font-weight: 400;\"> and uterine fibroids in women, and prevent central precocious puberty in children.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, altering hormone levels can affect the body and mind, so this prescription medication comes with an array of possible side effects, ranging from mild to severe. While they\u2019re not guaranteed, it\u2019s good to understand the potential outcomes before starting treatment.\u00a0<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Lupron Depot with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tLupron Depot 3.75 mg (1 kit)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$1851.56<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/lupron-depot#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/lupron-depot#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$1851.56<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/lupron-depot#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/lupron-depot#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/lupron-depot#blog-cta\" class=\"coupon-see-all-btn\">See Lupron Depot prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"common-side-effects-of-lupron-depot\"><span style=\"font-weight: 400;\">Common side effects of Lupron Depot<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to clinical trials, the most common side effects of Lupron Depot are hot flashes and sweating. It may also cause the following adverse reactions:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Injection site reactions or pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">General pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty urinating or urinary problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Testicular shrinkage (in men)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaginal dryness, discharge, and irritation (in women)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pelvic pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased libido<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acne<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breast tenderness<\/span><\/li>\n<\/ul>\n<h3 id=\"headaches\"><span style=\"font-weight: 400;\">Headaches<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Headaches are among the most common side effects of Lupron Depot. In fact, in <\/span><a href=\"https:\/\/www.rxabbvie.com\/pdf\/lupron3_75mg.pdf\"><span style=\"font-weight: 400;\">Food and Drug Administration (FDA) trials<\/span><\/a><span style=\"font-weight: 400;\">, 32% of women who took the Lupron Depot for endometriosis reported experiencing headaches. Although headaches have many causes, the study notes that headaches may result from decreased estrogen.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Most often, headaches from Lupron Depot aren\u2019t a cause for concern, and you can treat them with <\/span><a href=\"https:\/\/www.singlecare.com\/resources\/nsaids\"><span style=\"font-weight: 400;\">NSAIDs or other over-the-counter (OTC) pain relievers<\/span><\/a><span style=\"font-weight: 400;\">. However, if they occur simultaneously with any of the serious side effects listed below, seek immediate medical attention.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/headache-causes\"><b>What causes headaches every day?<\/b><\/a><\/p>\n<h2 id=\"serious-side-effects-of-lupron-depot\"><span style=\"font-weight: 400;\">Serious side effects of Lupron Depot<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Few people who use Lupron Depot and similar drugs experience serious health problems, but they may still occur. The following are serious side effects of Lupron Depot:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High pressure in the skull<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serious allergic reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serious skin reactions, including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of bone density<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/high-blood-sugar-symptoms\"><span style=\"font-weight: 400;\">High blood sugar<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression and mood or behavior changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of heart attack and stroke<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast, pounding, or uneven heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/news\/epilepsy-statistics\/\"><span style=\"font-weight: 400;\">Seizures<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pituitary apoplexy (hemorrhage or infarction within the pituitary gland)<\/span><\/li>\n<\/ul>\n<h3 id=\"pseudotumor-cerebri-high-pressure-in-the-skull-warning-for-children\"><span style=\"font-weight: 400;\">Pseudotumor cerebri (high pressure in the skull) warning for children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In 2022, the FDA <\/span><a href=\"https:\/\/www.fda.gov\/media\/159663\/download\"><span style=\"font-weight: 400;\">issued a warning for pediatric patients<\/span><\/a><span style=\"font-weight: 400;\"> taking Lupron Depot-Ped that addressed the potential risk of pseudotumor cerebri. Literally meaning \u201cfalse brain tumor,\u201d it\u2019s an intracranial pressure that occurs without the presence of a mass. The FDA recommends that the child\u2019s healthcare provider monitor closely for headaches, optic disc swelling, blurred or double vision, pain behind the eye, tinnitus, dizziness, and nausea.<\/span><\/p>\n<h3 id=\"pre-existing-heart-conditions-especially-in-men\"><span style=\"font-weight: 400;\">Pre-existing heart conditions, especially in men<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because Lupron Depot can affect the cardiac electrical system, particularly in men taking the drug for advanced prostate cancer, people with pre-existing heart problems should take caution. The drug can cause arrhythmias by prolonging the heart\u2019s QT interval (the period when it contracts and then relaxes between beats), potentially causing serious complications. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4516188\/\"><span style=\"font-weight: 400;\">Studies show<\/span><\/a><span style=\"font-weight: 400;\"> that this kind of hormone therapy can increase the risk of cardiac complications in any patient, especially men with existing cardiovascular conditions.<\/span><\/p>\n<h3 id=\"bone-loss-risk-factors\"><span style=\"font-weight: 400;\">Bone loss risk factors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4696626\/\"><span style=\"font-weight: 400;\">a 2015 study published<\/span><\/a><span style=\"font-weight: 400;\">, those taking leuprolide acetate had significantly lower vitamin D levels than the control group, and the <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/019943s031,020011s038,020708s031lbl.pdf\"><span style=\"font-weight: 400;\">FDA drug label<\/span><\/a><span style=\"font-weight: 400;\"> confirms that studies have demonstrated a risk of bone density loss in patients.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, the FDA concludes that someone with existing risk factors for decreased bone mineral content should not use Lupron Depot longer than three months for uterine fibroids or six months for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/endometriosis-treatment-and-medications\"><span style=\"font-weight: 400;\">endometriosis<\/span><\/a><span style=\"font-weight: 400;\">. These risk factors include long-term alcohol use, tobacco use, low physical activity, poor diet, certain medications, multiple myeloma, and a family history of osteoporosis.\u00a0<\/span><\/p>\n<h3 id=\"depression\"><span style=\"font-weight: 400;\">Depression<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because Lupron Depot may cause depression and mood changes, any patient with a history of mental health issues should discuss suspending treatment with their healthcare provider if they experience severe and persistent depression or any other mental symptoms.<\/span><\/p>\n<h2 id=\"how-soon-do-lupron-depot-side-effects-start\"><span style=\"font-weight: 400;\">How soon do Lupron Depot side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cI have used monthly and 90-day preparations of Lupron Depot, and I find the side effects start more quickly with the 30-day dose than the 90-day dose,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/marchandobgyn\/\"><span style=\"font-weight: 400;\">Greg Marchand, MD<\/span><\/a><span style=\"font-weight: 400;\">, an OB-GYN and founder of <\/span><a href=\"https:\/\/marchandinstitute.org\/about-dr-marchand\/\"><span style=\"font-weight: 400;\">The Marchand Institute for Minimally Invasive Surgery<\/span><\/a><span style=\"font-weight: 400;\">. \u201cWith either dosage, you can expect side effects as soon as seven days after starting, but I find it is closer to the 14-day mark.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the drug manufacturer, <\/span><a href=\"https:\/\/www.lupron.com\/\"><span style=\"font-weight: 400;\">AbbVie<\/span><\/a><span style=\"font-weight: 400;\">, Lupron Depot causes a temporary increase of testosterone and estrogen during the first week of treatment, which could exacerbate existing symptoms.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/high-testosterone-in-men\/\"><b>Pros and cons of high testosterone in men<\/b><\/a><\/p>\n<h2 id=\"how-long-do-side-effects-last\"><span style=\"font-weight: 400;\">How long do side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Common side effects, such as hot flashes, night sweats, and breast pain, may resolve during treatment, but Dr. Marchland says, \u201cSome patients will continue to have these symptoms the entire time they are on leuprolide therapy. Leuprolide therapy is not usually used indefinitely because of concerns about bone loss, but if it was, these symptoms would most likely completely resolve after four or five years, as they do with natural menopause.\u201d<\/span><\/p>\n<h2 id=\"what-are-the-long-term-side-effects-of-lupron-depot\"><span style=\"font-weight: 400;\">What are the long-term side effects of Lupron Depot?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While many side effects are short-lived, some are persistent. In <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5997553\/\"><span style=\"font-weight: 400;\">one clinical trial published in 2018<\/span><\/a><span style=\"font-weight: 400;\">, 80% of patients ages 15 to 22 years who received a 12-month Lupron Depot treatment, plus add-back therapy (norethindrone alone or with estrogen), reported at least one side effect lasting more than 6 months. The most common long-term side effects of Lupron Depot were migraines (35%), hot flashes (30%), joint pain (30%), and decreased libido (30%).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the drug information published on <\/span><a href=\"https:\/\/www.lupron.com\/\"><span style=\"font-weight: 400;\">AbbVie\u2019s website<\/span><\/a><span style=\"font-weight: 400;\">, \u201cThinning of the bones may occur during therapy with Lupron Depot, which may not be completely reversible in some patients.\u201d The manufacturer also notes that the drug may cause or worsen depression.\u00a0<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Use of certain medications may alter how leuprolide works, including:<\/span><\/p>\n<ul>\n<li><b>Antipsychotics<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">Combining leuprolide with drugs like mesoridazine or pimozide can increase the risk of developing a severely irregular heartbeat. This interaction is relatively rare, but a pre-existing heart disease can increase the risk.<\/span><\/li>\n<li aria-level=\"1\"><b>Antiarrhythmics<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">When taken with leuprolide, drugs designed to treat heart rhythm problems, such as amiodarone, can interfere with the cardiac electrical system, increasing the risk of QT prolongation, a heart rhythm disorder that can potentially cause rapid, chaotic heartbeats.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Tricyclic antidepressants<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">Medications like amitriptyline and clomipramine may decrease the effects of leuprolide and increase the risk of QT prolongation.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Certain antifungals<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">The \u201cazole\u201d antifungals, such as ketoconazole and itraconazole, can also increase the risk of an irregular heartbeat when combined with leuprolide.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Selective serotonin reuptake inhibitors (SSRIs)<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">Commonly prescribed for depression, these medications might also increase the risk of an irregular heartbeat when taken with leuprolide.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Diabetes medications<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">Leuprolide can decrease the efficacy of certain diabetes medicines, such as canagliflozin, glyburide, and linagliptin, when taken with them.<\/span><\/li>\n<li aria-level=\"1\"><b>Seizure medications<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">Leuprolide may slow down the excretion rate of drugs like clobazam and Valium, increasing their levels retained in the body.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Oral steroids<\/b><span style=\"font-weight: 400;\">:<\/span> <span style=\"font-weight: 400;\">When taken with Lupron Depot, certain corticosteroids, such as dexamethasone and methylprednisolone, can increase the risk of myopathy, rhabdomyolysis, and myoglobinuria.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Lupron Depot may interact with a wide range of drugs, so this isn\u2019t a comprehensive list. Anyone considering Lupron Depot should report any medications they\u2019re taking, both prescription and OTC (including vitamins, herbal supplements, and dietary supplements), to a healthcare professional before beginning treatment.<\/span><\/p>\n<h2 id=\"safety-tips-while-using-lupron-depot\"><span style=\"font-weight: 400;\">Safety tips while using Lupron Depot<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Considering all of the side effects and drug interactions associated with Lupron Depot, safety should be a priority for anyone considering the medication. It\u2019s important to discuss medical history, lifestyle, and potential risk factors with a healthcare provider before taking it.<\/span><\/p>\n<h3 id=\"age-restrictions\"><span style=\"font-weight: 400;\">Age restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Since Lupron Depot-Ped has proven to be <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10274571\/\"><span style=\"font-weight: 400;\">effective in treating early puberty<\/span><\/a><span style=\"font-weight: 400;\">, it\u2019s approved for the treatment of children, but only as a puberty blocker. For endometriosis or advanced prostate cancer treatment, patients should be at least 18 years old.\u00a0<\/span><\/p>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lupron-depot-ped\"><b>Lupron Depot Ped coupons<\/b><\/a><\/p>\n<h3 id=\"pregnancy\"><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Women who are pregnant or may become pregnant <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551662\/#article-24223.s6\"><span style=\"font-weight: 400;\">should avoid leuprolide<\/span><\/a><span style=\"font-weight: 400;\"> since it can harm the fetus and cause congenital disabilities. \u201cWhile premenopausal women are on GnRH agonists, the treatment usually stops ovulation and menstruation; however, pregnancies have occurred in patients on GnRH therapy, including the Depot version,\u201d <\/span><span style=\"font-weight: 400;\">says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/alex-juusela-md-mph-facog\/\"><span style=\"font-weight: 400;\">Alexander Juusela, MD,<\/span><\/a><span style=\"font-weight: 400;\"> a maternal-fetal medicine physician at Newark Beth Israel Medical Center<\/span><span style=\"font-weight: 400;\">. \u201cThis is why a pregnancy test is mandatory prior to starting GnRH treatment in premenopausal patients.\u201d<\/span><\/p>\n<h3 id=\"breastfeeding\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There\u2019s little data on whether Lupron Depot gets excreted during breastfeeding or if it can harm an infant. Since human milk often contains medications from the mother and there\u2019s a potential for serious adverse effects, Lupron Depot\u2019s manufacturer <\/span><a href=\"https:\/\/www.lupronprostatecancer.com\/content\/dam\/lupron\/hcp\/pdf\/UROLCHFlashcardDecember2018.pdf\"><span style=\"font-weight: 400;\">updated its prescribing information<\/span><\/a><span style=\"font-weight: 400;\"> in 2018 to warn against using Lupron Depot while breastfeeding.<\/span><\/p>\n<h3 id=\"allergies\"><span style=\"font-weight: 400;\">Allergies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Anyone who is allergic or hypersensitive to GnRH agonists should not take Lupron Depot since it may cause an anaphylactic reaction. Women with a history of asthma, sinusitis, and environmental or drug allergies have also developed asthma while taking leuprolide. Patients should seek medical attention if they experience any signs of an allergic reaction, such as a rash, itching, hives, trouble breathing, or swelling of the face, lips, or hands.\u00a0<\/span><\/p>\n<h2 id=\"how-to-avoid-lupron-depot-side-effects\"><span style=\"font-weight: 400;\">How to avoid Lupron Depot side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Sometimes, side effects might seem inevitable, and for some people, they might be. However, just like with many other medications, certain measures can help prevent side effects of Lupron Depot:<\/span><b><\/b><\/p>\n<ol>\n<li aria-level=\"1\"><b>Report medical history, other medications, and lifestyle habits to the prescribing healthcare provider<\/b><span style=\"font-weight: 400;\">.<\/span> <span style=\"font-weight: 400;\">Particular diseases, drugs, and habits can cause or worsen Lupron Depot\u2019s side effects. Anyone with a personal or family history of cardiovascular conditions, osteoporosis, seizures, depression, or diabetes should tell their healthcare provider and seek medical advice before beginning treatment. They should also be honest about their sex life, alcohol consumption, and diet.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Attend regular check-ups<\/b><span style=\"font-weight: 400;\">.<\/span> <span style=\"font-weight: 400;\">Healthcare providers are aware of potential complications associated with leuprolide treatment that may lead to side effects. By scheduling routine checkups, you\u2019re giving them opportunities to find and address any issues that may arise.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Exercise regularly<\/b><span style=\"font-weight: 400;\">.<\/span> <span style=\"font-weight: 400;\">This is important for everyone, whether or not they\u2019re taking Lupron Depot. However, certain studies (like <\/span><a href=\"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/23\/2\/101.xml\"><span style=\"font-weight: 400;\">this one from 2016<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8846498\/\"><span style=\"font-weight: 400;\">this one from 2022<\/span><\/a><span style=\"font-weight: 400;\">) showed that regular aerobic and resistance exercise may ameliorate side effects and improve the quality of life in men receiving androgen deprivation therapy for prostate cancer.<\/span><\/li>\n<li aria-level=\"1\"><b>Maintain a healthy diet<\/b><span style=\"font-weight: 400;\">.<\/span> <span style=\"font-weight: 400;\">Staying hydrated and eating healthy foods can always help you feel your best. This is especially true for people who take medications that alter their hormones. The <\/span><a href=\"https:\/\/www.lupronprostatecancer.com\/your-experience\/taking-care-of-yourself\"><span style=\"font-weight: 400;\">Lupron Depot for prostate cancer website<\/span><\/a><span style=\"font-weight: 400;\"> recommends a <a href=\"https:\/\/www.singlecare.com\/blog\/foods-for-prostate-health\/\">plant-based diet that\u2019s low in salt and fat<\/a>. Increasing consumption of <a href=\"https:\/\/www.singlecare.com\/prescription\/calcium-carb-cholecalciferol\">vitamin D and calcium<\/a> might also help prevent bone loss.<\/span><\/li>\n<li aria-level=\"1\"><b>Ask about add-back therapy<\/b><span style=\"font-weight: 400;\">.<\/span> <span style=\"font-weight: 400;\">In women, Dr. Marchland says, \u201cLeuprolide therapy works by bringing about an artificial menopausal state, so by adding back the hormones that are being suppressed, you can sometimes prevent menopausal symptoms without compromising the relief received. [However], this is not always successful, and I have seen patients have endometriosis pain return or have their fibroids grow when adding estrogen or progesterone therapy to leuprolide.\u201d<\/span><\/li>\n<\/ol>\n<h2 id=\"how-to-treat-side-effects\"><span style=\"font-weight: 400;\">How to treat side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some common Lupron Depot side effects may respond well to at-home treatments. For example, many people deal with hot flashes by exercising, wearing loose-fitting clothing, and avoiding triggers like hot showers, spicy food, alcohol, and caffeine. Headaches and general soreness may subside with OTC painkillers like ibuprofen and acetaminophen, while ice packs and anti-itch medications may help with injection site redness, swelling, or irritation.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Certain serious symptoms require medical help, such as new or worsening bone pain, irregular heartbeat, depression, mood swings, difficulty breathing, blood in urine, extreme thirst, fainting, seizures, and signs of myocardial infarction (e.g., chest pain, shortness of breath, cold sweat, and fatigue) or stroke (e.g., sudden numbness, trouble speaking, dizziness, vision problems, trouble walking, and loss of balance).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Add-back therapy can also help relieve adverse effects after they begin, according to Dr. Juusela, adding that it can significantly decrease the unpleasant side effects of the drop in sex steroid hormones. She explains, \u201cIn my experience, add-back therapy with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/norethindrone-acetate\"><span style=\"font-weight: 400;\">norethindrone acetate<\/span><\/a><span style=\"font-weight: 400;\"> is the most effective method of managing side effects.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Marchand agrees. For his patients, he says, \u201cI would begin by adding back some <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/progesterone\"><span style=\"font-weight: 400;\">progesterone<\/span><\/a><span style=\"font-weight: 400;\">, and if that didn\u2019t work, you could add some <\/span><a href=\"https:\/\/www.singlecare.com\/resources\/estrogen\"><span style=\"font-weight: 400;\">estrogen<\/span><\/a><span style=\"font-weight: 400;\"> as well to reverse some of the side effects. Other medications that are nonhormonal and could also help these side effects include SSRIs, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\"><span style=\"font-weight: 400;\">Lexapro<\/span><\/a><span style=\"font-weight: 400;\"> (escitalopram oxalate) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">Zoloft<\/span><\/a><span style=\"font-weight: 400;\"> (sertraline), or the anti-seizure medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/neurontin\"><span style=\"font-weight: 400;\">Neurontin<\/span><\/a><span style=\"font-weight: 400;\"> (gabapentin).\u201d<\/span><\/p>\n<h2 id=\"bottom-line-is-lupron-depot-safe\"><span style=\"font-weight: 400;\">Bottom line: Is Lupron Depot safe?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lupron Depot is effective for health conditions driven by high estrogen or testosterone, but it can cause side effects ranging from mild to serious. Most are manageable with monitoring, lifestyle changes, or add-back therapy. Anyone taking Lupron Depot should stay in close communication with their healthcare provider and report new or worsening symptoms right away.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lupron Depot (leuprolide acetate) is a gonadotropin-releasing hormone (GnRH) agonist that can help suppress the body\u2019s production of estrogen or testosterone if they\u2019re causing certain issues. By reducing these hormones, Lupron Depot injections can slow the growth of prostate cancer in men, treat endometriosis and uterine fibroids in women, and prevent central precocious puberty in [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":626702,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752],"coauthors":[8861],"class_list":["post-626700","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How does Lupron Depot make you feel?<\/title>\n<meta name=\"description\" content=\"Hot flashes and sweating are the most common side effects of Lupron Depot, but serious complications can occur. 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