{"id":626934,"date":"2024-02-20T16:45:58","date_gmt":"2024-02-20T21:45:58","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=626934"},"modified":"2025-09-02T10:06:21","modified_gmt":"2025-09-02T14:06:21","slug":"wegovy-vs-mounjaro","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/wegovy-vs-mounjaro\/","title":{"rendered":"Wegovy vs. Mounjaro: Comparing weight loss and diabetes treatments"},"content":{"rendered":"

Wegovy<\/span><\/a> and <\/span>Mounjaro<\/span><\/a> are brand-name injectable medications. They work similarly, mimicking natural hormones that regulate <\/span>blood sugar levels<\/span><\/a> and suppress appetite. You may have come across them as popular options for managing health conditions tied to weight and blood sugar problems. Although they\u2019re both effective medications, they\u2019re meant to be used in combination with a reduced-calorie diet and exercise plan.\u00a0<\/span><\/p>\n

Both medications share similarities in how they work, but there are some key differences to be aware of. For example, Wegovy and Mounjaro contain different active ingredients, have different approved uses, and may differ in dosage, cost, and side effects. For these reasons, it\u2019s best to work with a healthcare provider to find the most appropriate treatment option.\u00a0<\/span><\/p>\n

Read on to learn more about the differences and similarities of Wegovy and Mounjaro.\u00a0<\/span><\/p>\n

Wegovy vs. Mounjaro: Key differences<\/span><\/h2>\n

Wegovy and Mounjaro are prescription drugs that differ in various ways. One major difference is that Wegovy contains the <\/span>active ingredient semaglutide<\/span><\/a>, while Mounjaro contains the <\/span>active component tirzepatide<\/span><\/a>.\u00a0<\/span><\/p>\n

Another <\/span>main difference<\/span> is the <\/span>class of drugs<\/span> each <\/span>drug<\/span> belongs to. <\/span>Both medications activate the <\/span>glucagon-like peptide-1 (GLP-1) receptor<\/span><\/a>. However, Mounjaro also activates the glucose-dependent insulinotropic polypeptide (GIP) receptor. Therefore, while Wegovy belongs to a class of drugs called GLP-1 receptor agonists <\/span>(<\/span>GLP-1 RAs<\/span>)<\/span>, Mounjaro is classified as a dual GIP and GLP-1 receptor agonist. GIP and GLP-1 are <\/span>incretin hormones<\/span><\/a> that help control blood sugar by increasing insulin secretion and also have an effect on reducing appetite.<\/span><\/p>\n

Both Wegovy and Mounjaro are administered as once weekly injections taken with or without food. However, Wegovy is started at a dosage of 0.25 mg weekly and gradually increased to a maintenance dosage of 2.4 or 1.7 mg weekly. In comparison, Mounjaro is started at 2.5 mg weekly and gradually increased to a standard dosage of 5 mg weekly. In addition, Wegovy is FDA approved for adults and children ages 12 and older, while Mounjaro is only approved for adults 18 and older.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
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Wegovy vs. Mounjaro comparison chart<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nWegovy<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nGLP-1 receptor agonist<\/span><\/td>\nGLP-1 and GIP receptor agonist<\/span><\/td>\n<\/tr>\n
Generic name<\/b><\/td>\nSemaglutide<\/span><\/td>\nTirzepatide<\/span><\/td>\n<\/tr>\n
Forms<\/b><\/td>\nSubcutaneous injection<\/span><\/td>\nSubcutaneous injection<\/span><\/td>\n<\/tr>\n
Standard dosage<\/b><\/td>\n0.25 mg injected under the skin once weekly for 4 weeks. Then, the dosage is gradually increased to 1.7 or 2.4 mg once weekly.\u00a0<\/span><\/td>\n2.5 mg injected under the skin once weekly for 4 weeks. Then, the dosage is increased to 5 mg once weekly.\u00a0<\/span><\/p>\n

The dosage may be increased in 2.5 mg increments after at least 4 weeks on the present dose up to a maximum of 15 mg once weekly, depending on the treatment response.<\/span><\/td>\n<\/tr>\n

Treatment length<\/b><\/td>\nLong-term<\/span><\/td>\nLong-term<\/span><\/td>\n<\/tr>\n
Typical users<\/b><\/td>\nAdults and children 12 years and older<\/span><\/td>\nAdults 18 years and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by Wegovy and Mounjaro<\/span><\/h2>\n

Wegovy is approved by the U.S. Food & Drug Administration (FDA) for chronic weight management in adults who either have obesity or are overweight with at least one <\/span>weight-related condition<\/span><\/a>, such as high blood pressure, Type 2 diabetes mellitus, or high cholesterol. It is also approved to manage weight in children who have <\/span>obesity<\/span><\/a> and are 12 or older. While it\u2019s not approved for Type 2 diabetes, some patients may experience benefits related to their blood sugar levels.\u00a0<\/span><\/p>\n

Mounjaro is FDA approved to manage blood sugar levels in adults with <\/span>Type 2 diabetes<\/span><\/a>. Although it\u2019s not specifically approved for weight loss, some healthcare providers may prescribe Mounjaro <\/span>off-label<\/span><\/a> for this purpose. It may also be an option for people with Type 2 diabetes who may be struggling with obesity or being overweight.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n
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Comparing Wegovy vs. Mounjaro treatments<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Condition<\/b><\/td>\nWegovy<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Type 2 diabetes<\/span><\/td>\nOff-label<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Weight management for patients with a body mass index (BMI) of 30 or greater\u00a0<\/span><\/td>\nYes<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Weight management for patients with a BMI of 27 or greater with at least one weight-related health condition<\/span><\/td>\nYes<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is Mounjaro better than Wegovy?<\/span><\/h2>\n

Both Mounjaro and Wegovy are effective medications for their approved uses. The better option will depend on what is being treated and an individual\u2019s overall condition. Still, some studies suggest that the active ingredient in Mounjaro may be more effective at reducing weight and controlling blood sugar levels than Wegovy’s.\u00a0<\/span><\/p>\n

In a <\/span>68-week trial<\/span><\/a>, patients using tirzepatide at doses of 10 and 15 mg lost up to 5.92% more weight than those taking 2.4 mg of semaglutide. In addition, more patients experienced a weight reduction of 5% or more with tirzepatide. Results showed that patients taking tirzepatide were over two times more likely to lose 5% or more of their body weight than those taking semaglutide.<\/span><\/p>\n

In another clinical trial, tirzepatide was shown to lower blood sugar levels by <\/span>up to 2.3%<\/span><\/a>. It also resulted in significantly more weight loss than semaglutide, with differences ranging from 4.2 pounds (1.9 kg) to 12.1 pounds (5.5 kg) depending on the dose.<\/span><\/p>\n

Consult your healthcare provider on the most appropriate treatment option. One medication may be preferred over the other depending on overall medical history, costs, and response to treatment.\u00a0<\/span><\/p>\n

Cost and insurance coverage of Wegovy and Mounjaro<\/span><\/h2>\n

Wegovy<\/span><\/a> is not generally covered by most insurance and Medicare prescription drug plans, as they may consider weight loss medications nonessential. The average retail price is $1,850 for a month\u2019s supply containing four pens. There is currently no low-cost, generic alternative to Wegovy.<\/span><\/p>\n

RELATED: <\/b>How to save on Wegovy<\/b><\/a><\/p>\n

Mounjaro<\/span><\/a> may be covered by some insurance and Medicare prescription drug plans. However, it may come with a copay or coinsurance amount. Without insurance coverage, the typical retail price is around $1,461 for a month\u2019s supply consisting of four pens.\u00a0<\/span><\/p>\n

With a <\/span>SingleCare discount card<\/span><\/a>, you may be able to save on the cash price of Wegovy or Mounjaro.\u00a0<\/span><\/p>\n

RELATED: How to save on <\/b>Mounjaro<\/b><\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n
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Insurance and cost comparisons<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nWegovy<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nNo<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n4 prefilled injection pens<\/span><\/td>\n4 prefilled injection pens<\/span><\/td>\n<\/tr>\n
Typical Medicare copay<\/b><\/td>\nVaries<\/span><\/td>\nVaries<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$1,233<\/span><\/td>\n$950<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Wegovy and Mounjaro side effects<\/span><\/h2>\n

Wegovy<\/span><\/a> and <\/span>Mounjaro<\/span><\/a> share several similar side effects, including gastrointestinal ones. The most common side effects include nausea, vomiting, diarrhea, constipation, and stomach or <\/span>abdominal pain<\/span><\/a>. In addition to these side effects, Wegovy may cause dizziness and common cold symptoms like runny nose or sore throat.\u00a0<\/span><\/p>\n

RELATED: <\/b>Does Wegovy make you tired?<\/b><\/a><\/p>\n

Severe side effects are rare but possible while taking Wegovy or Mounjaro. Both medications may cause inflammation of the pancreas (pancreatitis), low blood sugar (hypoglycemia), kidney problems, or serious allergic reactions.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Wegovy vs. Mounjaro side effects comparison<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nWegovy<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Side Effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nYes<\/span><\/td>\n44%<\/span><\/td>\nYes<\/span><\/td>\n12%<\/span><\/td>\n<\/tr>\n
Vomiting<\/span><\/td>\nYes<\/span><\/td>\n24%<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n
Constipation<\/span><\/td>\nYes<\/span><\/td>\n24%<\/span><\/td>\nYes<\/span><\/td>\n6%<\/span><\/td>\n<\/tr>\n
Diarrhea<\/span><\/td>\nYes<\/span><\/td>\n30%<\/span><\/td>\nYes<\/span><\/td>\n12%<\/span><\/td>\n<\/tr>\n
Indigestion<\/span><\/td>\nYes<\/span><\/td>\n9%<\/span><\/td>\nYes<\/span><\/td>\n8%<\/span><\/td>\n<\/tr>\n
Stomach pain<\/span><\/td>\nYes<\/span><\/td>\n20%<\/span><\/td>\nYes<\/span><\/td>\n6%<\/span><\/td>\n<\/tr>\n
Headache<\/span><\/td>\nYes<\/span><\/td>\n14%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Sore throat and runny nose<\/span><\/td>\nYes<\/span><\/td>\n12%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Dizziness<\/span><\/td>\nYes<\/span><\/td>\n8%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.<\/span><\/i><\/p>\n

Sources: DailyMed (<\/span>Wegovy<\/span><\/a>, <\/span>Mounjaro<\/span><\/a>)<\/span><\/p>\n

Wegovy and Mounjaro interactions<\/span><\/h2>\n

Wegovy and Mounjaro can both decrease blood sugar levels. Taking Wegovy or Mounjaro with insulin or other diabetes medications may lead to an increased <\/span>risk of hypoglycemia<\/span><\/a>. Therefore, the dosage of insulin or diabetes medications may need to be reduced while taking Wegovy or Mounjaro.\u00a0<\/span><\/p>\n

Wegovy and Mounjaro can slow down how quickly the stomach empties food. As a result, they may slow down how the body absorbs other drugs taken by mouth. In addition, the drug label for Mounjaro specifically states that it may interfere with the absorption of oral birth control pills. A non-oral <\/span>birth control method<\/span><\/a> should be used for four weeks after starting treatment with Mounjaro, and for four weeks after each time the dosage is increased.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
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Wegovy vs. Mounjaro drug interactions chart<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nWegovy<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
NovoLog (insulin aspart)<\/span><\/p>\n

Humalog (insulin lispro)<\/span><\/p>\n

Lantus (insulin glargine)<\/span><\/td>\n

Insulin\u00a0<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Glucotrol (glipizide)<\/span><\/p>\n

Amaryl (glimepiride)<\/span><\/td>\n

Sulfonylureas<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Januvia (sitagliptin)<\/span><\/p>\n

Tradjenta (linagliptin)<\/span><\/p>\n

Onglyza (saxagliptin)<\/span><\/td>\n

DPP-4 inhibitors<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Prandin (repaglinide)<\/span><\/p>\n

Starlix (nateglinide)<\/span><\/td>\n

Glinides<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Consult a healthcare professional for other possible drug interactions.<\/span><\/i><\/p>\n

Wegovy and Mounjaro drug warnings<\/span><\/h2>\n

Both Wegovy and Mounjaro carry a <\/span>boxed warning<\/span><\/a>, the most serious warning issued by the FDA. The warning states that, based on animal studies, these drugs may increase the risk of thyroid tumors. Therefore, people with a personal or family history of <\/span>medullary thyroid carcinoma (MTC)<\/span><\/a> or those with multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid Wegovy and Mounjaro.\u00a0<\/span><\/p>\n

In addition, Wegovy and Mounjaro may cause serious side effects, such as acute pancreatitis, hypoglycemia, acute kidney injury, and acute gallbladder disease. These medications may also cause vision problems, such as <\/span>diabetic retinopathy<\/span><\/a>, in people with diabetes.\u00a0<\/span><\/p>\n

There\u2019s a risk of allergic reactions while taking either drug. Seek medical attention immediately if signs or symptoms of an allergic reaction develop, such as hives, rash, swelling of the face or throat, and trouble breathing.\u00a0<\/span><\/p>\n

Consult a healthcare provider before starting Wegovy or Mounjaro if you\u2019re pregnant or breastfeeding. Wegovy and Mounjaro may cause harm to an unborn baby. If pregnancy is suspected, the medications should be discontinued.<\/span><\/p>\n

Frequently asked questions about Wegovy vs. Mounjaro<\/span><\/h2>\n

Is Wegovy or Mounjaro more effective?<\/span><\/h3>\n

Wegovy and Mounjaro can both reduce blood sugar levels and support weight management. However, Wegovy is only FDA approved for weight management, while Mounjaro is only FDA approved to treat Type 2 diabetes. Some studies suggest that the active ingredient in Mounjaro, tirzepatide, is more effective for blood sugar control and aiding weight loss than the active ingredient in Wegovy, semaglutide. However, the efficacy of either drug can depend on other factors, such as the dose given and the person\u2019s overall condition.\u00a0<\/span><\/p>\n

Will insurance pay for Wegovy or Mounjaro for weight loss?<\/span><\/h3>\n

Insurance coverage for Wegovy and Mounjaro may depend on the health insurance policy and whether the prescription is for FDA approved or off-label use. Many health insurance plans don\u2019t consider weight loss drugs essential medications, and they may require <\/span>prior authorization<\/span><\/a> before covering a weight-loss medication. Some insurance companies may cover Mounjaro if it\u2019s prescribed for Type 2 diabetes.\u00a0<\/span><\/p>\n

Is it okay to switch from Wegovy to Mounjaro?<\/span><\/h3>\n

In some cases, a healthcare provider may recommend switching from Wegovy to Mounjaro<\/a>. Switching medication from Wegovy to Mounjaro should be done under the guidance of a healthcare provider. They can assess the overall condition<\/span>, individual <\/span>weight<\/span> loss goals,<\/span> and recommend the appropriate dosage. They can also provide guidance on potential side effects and any changes that may affect blood glucose levels.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Wegovy and Mounjaro are brand-name injectable medications. They work similarly, mimicking natural hormones that regulate blood sugar levels and suppress appetite. You may have come across them as popular options for managing health conditions tied to weight and blood sugar problems. 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