{"id":627011,"date":"2024-02-28T09:30:10","date_gmt":"2024-02-28T14:30:10","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=627011"},"modified":"2025-02-26T10:33:33","modified_gmt":"2025-02-26T15:33:33","slug":"hydroxyzine-and-alcohol","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/hydroxyzine-and-alcohol\/","title":{"rendered":"Can you drink while taking hydroxyzine?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\"><span style=\"font-weight: 400;\">Hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\"> is an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antihistamines\"><span style=\"font-weight: 400;\">antihistamine<\/span><\/a><span style=\"font-weight: 400;\"> prescribed to manage itching caused by allergic reactions, reduce anxiety, or induce sedation before or after a medical procedure. In some cases, it may even be used to treat alcohol withdrawal symptoms, such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\"> and insomnia. It works by blocking histamine and affecting other chemicals, like serotonin and dopamine, in the brain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking this medication, you might be wondering whether it\u2019s safe to have a drink with friends. Combining hydroxyzine and alcohol may result in worsened side effects, leading to increased sedation, drowsiness, or dizziness\u2014though the severity may vary from person to person. Keep reading to learn more about mixing this prescription with alcohol.<\/span><\/p>\n<h2 id=\"can-you-drink-on-hydroxyzine\"><span style=\"font-weight: 400;\">Can you drink on hydroxyzine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although hydroxyzine is sometimes prescribed for alcohol withdrawal symptoms, it\u2019s not recommended to mix hydroxyzine and alcohol. Hydroxyzine has the potential to cause several side effects that <\/span><a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/hydroxyzine\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">slow down the central nervous system (CNS)<\/span><\/a><span style=\"font-weight: 400;\">. Adding alcohol into the mix can increase these effects. Therefore, the FDA label and healthcare professionals advise that you avoid alcohol consumption altogether while on this medication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Even a single glass of wine may increase the medication&#8217;s sedative properties. As a result, driving or operating machinery could become particularly dangerous. It\u2019s generally safer to avoid alcohol use during treatment with hydroxyzine. Even occasional alcohol use, whether it\u2019s just one or a couple of drinks, could potentially worsen the side effects of hydroxyzine on the body.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you choose to drink on hydroxyzine, you\u2019ll want to be aware of these increased risks and the chance that alcohol abuse could lead to more serious health implications. If there are any doubts or questions, it&#8217;s always best to consult a healthcare provider.<\/span><\/p>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\"><span style=\"font-weight: 400;\">Hydroxyzine coupons<\/span><\/a><\/p>\n<h2 id=\"what-happens-if-you-drink-alcohol-with-hydroxyzine\"><span style=\"font-weight: 400;\">What happens if you drink alcohol with hydroxyzine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Drinking alcohol while taking hydroxyzine can increase central nervous system side effects, such as drowsiness, dizziness, and sedation. Taking hydroxyzine alone can cause these side effects, so combining the medication with alcohol can compound these effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hydroxyzine can react quickly with alcohol after ingestion. This interaction can lead to <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12867226\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">impaired motor skills<\/span><\/a><span style=\"font-weight: 400;\"> and judgment, which might last for several hours until the substances have left the bloodstream. Patients often notice hydroxyzine working within 15 to 30 minutes for allergy and anxiety symptoms, but when combined with alcohol, the usual signs of relief may become less apparent.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of mixing hydroxyzine with alcohol include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleepiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased coordination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slowed reaction times<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty concentrating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">More serious side effects can be life-threatening and require immediate medical attention. See a healthcare provider if you experience any of the following symptoms:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unexpected heart problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Extreme drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High levels of confusion or impairment<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Remember, hydroxyzine can interact with other medications as well, particularly those that also affect the central nervous system, such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">benzodiazepines<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">opioids<\/span><\/a><span style=\"font-weight: 400;\">. Consult a healthcare provider before mixing medicines with alcohol.<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-626965\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/02\/Embed_022324_Hydroxyzine_alcohol-copy.webp\" alt=\"A chart on the safety of hydroxyzine and alcohol\" width=\"1920\" height=\"900\" srcset=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/02\/Embed_022324_Hydroxyzine_alcohol-copy.webp 1920w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/02\/Embed_022324_Hydroxyzine_alcohol-copy-300x141.webp 300w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/02\/Embed_022324_Hydroxyzine_alcohol-copy-1024x480.webp 1024w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/02\/Embed_022324_Hydroxyzine_alcohol-copy-768x360.webp 768w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/02\/Embed_022324_Hydroxyzine_alcohol-copy-1536x720.webp 1536w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/span><\/p>\n<h2 id=\"are-certain-people-at-greater-risk-of-side-effects\"><span style=\"font-weight: 400;\">Are certain people at greater risk of side effects?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some people may be at a greater risk of severe side effects from hydroxyzine, especially when mixing it with alcohol. Certain situations warrant the need for extreme caution and, ultimately, avoiding mixing even a small amount of alcohol and hydroxyzine.<\/span><\/p>\n<h3 id=\"older-adults\"><span style=\"font-weight: 400;\">Older adults<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The body\u2019s liver and kidney functions, among others, tend to decline with age. As hydroxyzine is metabolized or processed by the liver and kidneys, older people may not be able to break down the medication as effectively as younger individuals. Therefore, they may be at a higher risk of side effects with hydroxyzine. Adding alcohol to this situation could amplify this risk.<\/span><\/p>\n<h3 id=\"people-with-heart-conditions\"><span style=\"font-weight: 400;\">People with heart conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Individuals with heart conditions, particularly those affecting heart rhythm or heart rate, should avoid mixing hydroxyzine with alcohol. Hydroxyzine can affect heart rhythm, increasing the risk of a heart rhythm disorder called long QT syndrome. There have also been reports of people experiencing <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27561189\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">QT prolongation after alcohol use<\/span><\/a><span style=\"font-weight: 400;\">, especially heavy alcohol consumption. Therefore, alcohol may worsen the risk of this complication of hydroxyzine.<\/span><\/p>\n<h3 id=\"individuals-with-liver-problems\"><span style=\"font-weight: 400;\">Individuals with liver problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The liver metabolizes both hydroxyzine and alcohol. Individuals who drink heavily may be at risk of liver problems, including liver disease and liver failure. Those who drink heavily and have liver problems may not be able to process hydroxyzine well, which could increase the side effects of hydroxyzine. Hydroxyzine has not been <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548128\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">associated with liver injury<\/span><\/a><span style=\"font-weight: 400;\"> on its own, however.<\/span><\/p>\n<h3 id=\"people-taking-other-cns-depressants\"><span style=\"font-weight: 400;\">People taking other CNS depressants<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In rare cases, a healthcare provider may prescribe other medications that act as CNS depressants alongside hydroxyzine. Taking other CNS depressants, such as benzodiazepines or sedative-hypnotics, with hydroxyzine can lead to severe sedation and even respiratory depression. Adding alcohol to the mix can intensify these effects, making it particularly risky for those on multiple medications for health conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you fall under any of these categories, you\u2019ll likely want to skip alcoholic beverages while taking hydroxyzine. Even if you\u2019re not drinking alcohol, you may need to avoid hydroxyzine under these conditions or consult a healthcare provider to adjust your treatment.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our allergies newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Allergies Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"how-long-after-taking-hydroxyzine-can-i-drink-alcohol\"><span style=\"font-weight: 400;\">How long after taking hydroxyzine can I drink alcohol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The effects of hydroxyzine typically wear off around six hours. However, just because the effects wear off doesn\u2019t mean you\u2019re in the clear. Instead, you\u2019ll want to take note of the medication\u2019s half-life.<\/span><\/p>\n<h3 id=\"hydroxyzine-half-life\"><span style=\"font-weight: 400;\">Hydroxyzine half-life<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The half-life of hydroxyzine is <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hup.2864\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">approximately 20 hours<\/span><\/a><span style=\"font-weight: 400;\">. This means it takes around 20 hours for half of the drug to be eliminated from your system. The exact half-life can vary depending on liver function and how fast you metabolize medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It&#8217;s generally advised to wait <\/span><i><span style=\"font-weight: 400;\">at least<\/span><\/i><span style=\"font-weight: 400;\"> 48 hours after your last dose of hydroxyzine before consuming alcohol. Still, it\u2019s safer to wait closer to three days, especially if you are taking a higher dose, as this may help reduce the risk of adverse interactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You may want to wait even longer if you\u2019ve been taking hydroxyzine long-term, especially if you were prescribed a relatively high dosage. For example, the typical dosage in adults for anxiety is 50 to 100 mg four times daily. If you&#8217;ve been prescribed hydroxyzine for alcohol withdrawal or anxiety linked to detox, you\u2019ll likely be avoiding alcohol at all costs.\u00a0 Combining it with alcohol can significantly slow recovery and may pose health risks.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It&#8217;s recommended to consult with a healthcare professional before mixing alcohol with any medication, including hydroxyzine. They can offer medical advice based on your health status and other medications you may be taking.<\/span><\/p>\n<h2 id=\"which-anxiety-medications-are-not-affected-by-alcohol\"><span style=\"font-weight: 400;\">Which anxiety medications are not affected by alcohol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s generally not recommended to take any anxiety medications with alcohol. That\u2019s because many anxiety medications work in similar ways to slow the CNS. As a result, many of them share similar side effects of drowsiness, dizziness, and impaired coordination.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s important to consult a healthcare provider about drinking alcohol with your medications, as individual responses can vary. That said, some medications may be less likely to interact with alcohol than others.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\"><span style=\"font-weight: 400;\">Selective serotonin reuptake inhibitors (SSRIs)<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\"><span style=\"font-weight: 400;\">Lexapro <\/span><\/a><span style=\"font-weight: 400;\">(<\/span><a href=\"http:\/\/escitalopram\"><span style=\"font-weight: 400;\">escitalopram<\/span><\/a><span style=\"font-weight: 400;\">) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/celexa\"><span style=\"font-weight: 400;\">Celexa<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/citalopram-hydrobromide\"><span style=\"font-weight: 400;\">citalopram<\/span><\/a><span style=\"font-weight: 400;\">), and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/snris\"><span style=\"font-weight: 400;\">serotonin-noradrenaline reuptake inhibitors (SNRIs)<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pristiq\"><span style=\"font-weight: 400;\">Pristiq <\/span><\/a><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/desvenlafaxine-succinate-er\"><span style=\"font-weight: 400;\">desvenlafaxine<\/span><\/a><span style=\"font-weight: 400;\">) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cymbalta\"><span style=\"font-weight: 400;\">Cymbalta<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl\"><span style=\"font-weight: 400;\">duloxetine<\/span><\/a><span style=\"font-weight: 400;\">), may be less likely to cause drowsiness than benzodiazepines like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/xanax\"><span style=\"font-weight: 400;\">Xanax<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/alprazolam\"><span style=\"font-weight: 400;\">alprazolam<\/span><\/a><span style=\"font-weight: 400;\">) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/klonopin\"><span style=\"font-weight: 400;\">Klonopin<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clonazepam\"><span style=\"font-weight: 400;\">clonazepam<\/span><\/a><span style=\"font-weight: 400;\">).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This doesn\u2019t mean SSRIs and SNRIs can be taken with alcohol without any risk. Drinking alcohol while on these antidepressants may lead to amplified side effects, like headaches and dizziness. However, they don\u2019t generally cause the same level of CNS depression as other anti-anxiety medications, thereby reducing the risk of severe side effects with alcohol. Other anti-anxiety medications that may cause severe drowsiness, especially in combination with alcohol, include <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/barbiturates\"><span style=\"font-weight: 400;\">barbiturates<\/span><\/a><span style=\"font-weight: 400;\">, such as Luminal (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/phenobarbital\"><span style=\"font-weight: 400;\">phenobarbital<\/span><\/a><span style=\"font-weight: 400;\">) and Seconal (secobarbital).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Talk to your healthcare provider about the effects of taking alcohol with your medications. You\u2019ll also want to tell your healthcare provider about other medications you\u2019re taking, including prescription drugs, over-the-counter medicines, and herbal supplements, especially if you\u2019re considering drinking alcohol.<\/span><\/p>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\"><span style=\"font-weight: 400;\">Lexapro coupons<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/celexa\"><span style=\"font-weight: 400;\">Celexa coupons<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/pristiq\"><span style=\"font-weight: 400;\">Pristiq coupons<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cymbalta\"><span style=\"font-weight: 400;\">Cymbalta coupons<\/span><\/a><\/p>\n<h2 id=\"the-bottom-line-alcohol-and-hydroxyzine-don-t-mix\"><span style=\"font-weight: 400;\">The bottom line: Alcohol and hydroxyzine don\u2019t mix<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Mixing hydroxyzine with alcohol can significantly increase the likelihood of drowsiness and impaired coordination due to their combined effect on slowing down the central nervous system. It&#8217;s advisable to avoid alcohol for at least two to three days after taking a dose of hydroxyzine. The risk is particularly higher in older individuals and those with liver issues. Always seek medical advice before consuming alcohol if you&#8217;re using hydroxyzine.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hydroxyzine is an antihistamine prescribed to manage itching caused by allergic reactions, reduce anxiety, or induce sedation before or after a medical procedure. In some cases, it may even be used to treat alcohol withdrawal symptoms, such as anxiety and insomnia. It works by blocking histamine and affecting other chemicals, like serotonin and dopamine, in [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":626966,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[8742,554,9777],"coauthors":[8669],"class_list":["post-627011","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-alcohol-interactions","tag-allergies","tag-anxiety","franchise-the-mix-up","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Hydroxyzine and alcohol: What you should know<\/title>\n<meta name=\"description\" content=\"Discover why mixing hydroxyzine with alcohol can increase side effects, the advised caution, and safe timing for alcohol 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