{"id":627118,"date":"2024-03-04T13:10:08","date_gmt":"2024-03-04T18:10:08","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=627118"},"modified":"2024-10-25T10:06:03","modified_gmt":"2024-10-25T14:06:03","slug":"sucralfate-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/sucralfate-interactions\/","title":{"rendered":"Sucralfate interactions to avoid"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/sucralfate\/what-is\"><span style=\"font-weight: 400;\">Sucralfate<\/span><\/a><span style=\"font-weight: 400;\"> is approved by the U.S. Food and Drug Administration (FDA) for the short-term treatment of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ulcer-treatment-and-medications\"><span style=\"font-weight: 400;\">stomach ulcers<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Also known by its brand name, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/carafate\/what-is\"><span style=\"font-weight: 400;\">Carafate<\/span><\/a><span style=\"font-weight: 400;\">, sucralfate comes in two dosage forms: an oral tablet and oral suspension. Sucralfate is composed of a sucrose sulfate-aluminum. It belongs to a class of medications called protectants, which create a protective layer over the ulcer and intestines to shield it from bile salts, acids, and enzymes to speed up healing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although sucralfate is considered a safe and effective treatment option, it can interact with other medications, including certain antibiotics, HIV medications, and levothyroxine. It&rsquo;s important to be aware of sucralfate interactions as they can interfere with other drugs&rsquo; effectiveness and cause or worsen side effects, such as constipation, dry mouth, skin rash, or hives.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Let&rsquo;s explore potential sucralfate interactions.<\/span><\/p>\n<h2 id=\"sucralfate-drug-interactions\"><span style=\"font-weight: 400;\">Sucralfate drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The interactions are the same whether you take sucralfate tablets or the suspension. Sucralfate can interact with several drugs.&nbsp;<\/span><\/p>\n<h3 id=\"certain-antibiotics\"><span style=\"font-weight: 400;\">Certain antibiotics<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/how-do-antibiotics-work\/\"><span style=\"font-weight: 400;\">Antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> are drugs used to treat bacterial infections. There are many different classes of antibiotics, such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/quinolones\"><span style=\"font-weight: 400;\">fluoroquinolones<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/tetracyclines\"><span style=\"font-weight: 400;\">tetracyclines<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/penicillins\"><span style=\"font-weight: 400;\">penicillins<\/span><\/a><span style=\"font-weight: 400;\">. Each class of antibiotics works differently to kill bacteria.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sucralfate <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=4350b771-76a9-4e00-93f0-a18c71288f83&amp;type=display\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">can interact with certain antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> by interfering with their absorption into the body. This is most likely due to sucralfate binding to the antibiotic in the digestive tract, which prevents the antibiotic from being fully absorbed into the bloodstream. This can make the antibiotic less effective.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of antibiotics that may interact with sucralfate include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Levaquin (levofloxacin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tetracycline<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avelox (moxifloxacin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cipro (ciprofloxacin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ofloxacin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ketoconazole<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Due to these interactions, doctors may recommend separating the administration of sucralfate and your antibiotic.&nbsp;<\/span><\/p>\n<h3 id=\"certain-proton-pump-inhibitors\"><span style=\"font-weight: 400;\">Certain proton pump inhibitors<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/proton-pump-inhibitors\"><span style=\"font-weight: 400;\">Proton pump inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> (PPIs) are drugs used to treat various conditions, such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-heartburn-medicine\/\"><span style=\"font-weight: 400;\">heartburn<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/gerd-treatment-and-medications\"><span style=\"font-weight: 400;\">gastroesophageal reflux disease<\/span><\/a><span style=\"font-weight: 400;\"> (GERD), and certain types of ulcers. Sucralfate <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/?drugLabelId=2243\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">can interact<\/span><\/a><span style=\"font-weight: 400;\"> with some PPIs, potentially interfering with their absorption. This interaction can cause the PPI to be less effective, which may result in unmanaged heartburn, GERD, or stomach ulcers.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of proton pump inhibitors include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prilosec (omeprazole)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nexium (esomeprazole)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lansoprazole<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Although some proton pump inhibitors interact with sucralfate, they can still be taken together as long as their administration is separated. Before starting sucralfate, let your healthcare provider know if you take a proton pump inhibitor so they can properly manage the potential interaction.<\/span><\/p>\n<h3 id=\"antacids\"><span style=\"font-weight: 400;\">Antacids<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Antacids neutralize stomach acid to relieve symptoms of heartburn and indigestion. According to The Prescribers&rsquo; Digital Reference (PDR), combining antacids with sucralfate can decrease the effects of sucralfate by interfering with its binding to the stomach wall. A healthcare provider may recommend separating sucralfate and antacids to prevent this from happening.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of antacids include:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Maalox<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tums<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alka-Seltzer<\/span><\/li>\n<\/ul>\n<h3 id=\"certain-hiv-medications\"><span style=\"font-weight: 400;\">Certain HIV medications<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/hiv-treatment-and-medications\"><span style=\"font-weight: 400;\">Human immunodeficiency virus<\/span><\/a><span style=\"font-weight: 400;\"> (HIV) is treated with antiretroviral drugs. However, according to PDR, the aluminum component of sucralfate can bind to certain antiretrovirals in the digestive tract and prevent the antiretroviral from being fully absorbed. This can make the HIV medication less effective, which can lead to an increased HIV viral load.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of antiretrovirals include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tivicay (dolutegravir)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Genvoya (elvitegravir\/cobicistat\/emtricitabine\/tenofovir alafenamide)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Healthcare providers may monitor you more closely if these drugs are taken together, and they will likely advise you to separate the administration of the two drugs.&nbsp;<\/span><\/p>\n<h3 id=\"alendronate\"><span style=\"font-weight: 400;\">Alendronate<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/alendronate-sodium\/what-is\"><span style=\"font-weight: 400;\">Alendronate<\/span><\/a><span style=\"font-weight: 400;\"> (Fosamax) is a bisphosphonate drug used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/osteoporosis-treatment-and-medications\"><span style=\"font-weight: 400;\">osteoporosis<\/span><\/a><span style=\"font-weight: 400;\">. Similar to other interactions, taking sucralfate with alendronate can disrupt alendronate&rsquo;s absorption. To avoid this, your medical team will likely recommend separating your dose of sucralfate and alendronate.<\/span><\/p>\n<h3 id=\"levothyroxine\"><span style=\"font-weight: 400;\">Levothyroxine<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium\/what-is\"><span style=\"font-weight: 400;\">Levothyroxine<\/span><\/a><span style=\"font-weight: 400;\"> (Synthroid) is a medication used to treat an underactive thyroid gland (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypothyroidism-treatment-and-medications\"><span style=\"font-weight: 400;\">hypothyroidism<\/span><\/a><span style=\"font-weight: 400;\">). Sucralfate can interact with levothyroxine by delaying or preventing its absorption. This can lead to reduced effectiveness of the thyroid drug, which can worsen hypothyroidism. Due to this interaction, a healthcare professional may not prescribe sucralfate if you take levothyroxine. But if these drugs are prescribed together, their administration should be separated by at least four hours, according to the Prescribers&rsquo; Digital Reference (PDR). Doctors may also monitor your thyroid function more closely.&nbsp;<\/span><\/p>\n<h3 id=\"quinidine\"><span style=\"font-weight: 400;\">Quinidine<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/quinidine-sulfate\/what-is\"><span style=\"font-weight: 400;\">Quinidine<\/span><\/a><span style=\"font-weight: 400;\"> is a drug prescribed for certain types of irregular heartbeats. If taken with sucralfate, the two medications can bind in the gastrointestinal tract, leading to decreased quinidine absorption. As a result, quinidine may be less effective at maintaining a healthy heart rhythm.&nbsp;<\/span><\/p>\n<h3 id=\"digoxin\"><span style=\"font-weight: 400;\">Digoxin<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/digoxin\/what-is\"><span style=\"font-weight: 400;\">Digoxin<\/span><\/a><span style=\"font-weight: 400;\"> (Lanoxin) is used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/congestive-heart-failure-treatment-and-medications\"><span style=\"font-weight: 400;\">heart failure<\/span><\/a><span style=\"font-weight: 400;\"> and certain types of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/atrial-fibrillation-treatment-and-medications\"><span style=\"font-weight: 400;\">irregular heartbeats<\/span><\/a><span style=\"font-weight: 400;\">. Like its interaction with quinidine, sucralfate can bind to digoxin in the digestive tract, impeding its absorption into the bloodstream. Because of this, a healthcare provider will likely recommend separating the administration of the medications. They may also adjust your digoxin dose and measure your digoxin blood levels before and during sucralfate treatment.&nbsp;<\/span><\/p>\n<h3 id=\"theophylline\"><span style=\"font-weight: 400;\">Theophylline<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/theophylline\/what-is\"><span style=\"font-weight: 400;\">Theophylline<\/span><\/a><span style=\"font-weight: 400;\"> (Theo-24) is prescribed for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/asthma-treatment-and-medications\"><span style=\"font-weight: 400;\">asthma<\/span><\/a><span style=\"font-weight: 400;\"> and other lung problems. Combining theophylline and sucralfate can reduce the effectiveness of theophylline. Similar to other interactions, this occurs because theophylline can bind to theophylline in the digestive tract and impede its absorption.&nbsp;<\/span><\/p>\n<h3 id=\"warfarin\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\/what-is\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/a><span style=\"font-weight: 400;\"> (Coumadin) is a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">blood thinner<\/span><\/a><span style=\"font-weight: 400;\"> used to prevent blood clots. There is some evidence that sucralfate can interact with warfarin by interfering with its absorption into the bloodstream. If these two drugs are prescribed together, your healthcare provider will likely monitor your prothrombin time (PT) and international normalized ratio (INR) more closely.&nbsp;<\/span><\/p>\n<h2 id=\"sucralfate-food-interactions\"><span style=\"font-weight: 400;\">Sucralfate food interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Foods can sometimes interact with medications. However, sucralfate isn&rsquo;t known to interact with any foods. Sucralfate is most effective if it&rsquo;s taken on an empty stomach.&nbsp;<\/span><\/p>\n<h2 id=\"other-sucralfate-interactions\"><span style=\"font-weight: 400;\">Other sucralfate interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In addition to prescription drugs, sucralfate can interact with certain vitamins and diseases.&nbsp;<\/span><\/p>\n<h3 id=\"sucralfate-and-alcohol\"><span style=\"font-weight: 400;\">Sucralfate and alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There aren&rsquo;t any known interactions between the use of sucralfate and alcohol. However, it&rsquo;s typically recommended to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/alcohol-and-heartburn-medication\/\"><span style=\"font-weight: 400;\">avoid alcohol<\/span><\/a><span style=\"font-weight: 400;\"> if you have an ulcer, which sucralfate is used to treat. This is because alcohol can worsen the symptoms of an ulcer, including stomach bleeding.&nbsp;<\/span><\/p>\n<h3 id=\"sucralfate-and-vitamins\"><span style=\"font-weight: 400;\">Sucralfate and vitamins<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Sucralfate can interact with certain vitamins, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-d-ergocalciferol\/what-is\"><span style=\"font-weight: 400;\">vitamin D<\/span><\/a><span style=\"font-weight: 400;\"> (cholecalciferol, ergocalciferol). Taking these medications together can increase the levels of aluminum in the body and increase the risk of aluminum toxicity. This can lead to serious side effects, such as muscle weakness, mental changes, and seizures.&nbsp;<\/span><\/p>\n<h3 id=\"sucralfate-and-disease\"><span style=\"font-weight: 400;\">Sucralfate and disease<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Certain health conditions or health factors can increase your risk of sucralfate interactions.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Past allergic reaction to sucralfate or any other ingredients in the drug<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dialysis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Age 65 years or older<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-minimize-sucralfate-interactions\"><span style=\"font-weight: 400;\">How to minimize sucralfate interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although sucralfate has several potential interactions, it may still be taken safely with certain precautions.&nbsp;<\/span><b><\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Consult a healthcare provider. <\/b><span style=\"font-weight: 400;\">Before starting any new prescription or over-the-counter drugs, vitamins, supplements, or herbal products, consult a healthcare professional so they can screen for interactions and provide additional drug information.<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Keep a list of medications and medical conditions. <\/b><span style=\"font-weight: 400;\">Include all drugs and medical conditions <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/medication-list-template\/\"><span style=\"font-weight: 400;\">on your list<\/span><\/a><span style=\"font-weight: 400;\">.&nbsp;<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Understand warning signs. <\/b><span style=\"font-weight: 400;\">Potential warning signs of a sucralfate interaction include new or worsening adverse effects, changes in a drug&rsquo;s effectiveness, and changes in your condition. Report any of these signs to a healthcare professional.&nbsp;<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Adhere to prescribed dosing. <\/b><span style=\"font-weight: 400;\">Take sucralfate only as directed. If a dose is missed, take the missed dose as soon as possible. Avoid taking additional or twice the recommended dosage.<\/span><\/li>\n<\/ul>\n<h2 id=\"when-to-talk-to-a-healthcare-provider-about-sucralfate-interactions\"><span style=\"font-weight: 400;\">When to talk to a healthcare provider about sucralfate interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although several sucralfate interactions were discussed in this article, this is only a partial list of all possible interactions. Share a list of all your medications and medical conditions with your healthcare provider before you start sucralfate. This way, they can help prevent interactions before they occur.&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sucralfate is approved by the U.S. Food and Drug Administration (FDA) for the short-term treatment of stomach ulcers. Also known by its brand name, Carafate, sucralfate comes in two dosage forms: an oral tablet and oral suspension. Sucralfate is composed of a sucrose sulfate-aluminum. It belongs to a class of medications called protectants, which create [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":627119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[16414,814],"coauthors":[20969],"class_list":["post-627118","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-digestive-health","tag-drug-interactions","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sucralfate interactions to avoid | SingleCare<\/title>\n<meta name=\"description\" content=\"Sucralfate (Carafate) interacts with antibiotics, proton pump inhibitors, HIV medications, vitamin D, and certain health conditions. 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D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ashley Wong, Pharm. 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