{"id":627226,"date":"2024-03-08T15:36:10","date_gmt":"2024-03-08T20:36:10","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=627226"},"modified":"2024-10-25T10:04:37","modified_gmt":"2024-10-25T14:04:37","slug":"digoxin-interactions","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/digoxin-interactions\/","title":{"rendered":"Digoxin interactions to avoid"},"content":{"rendered":"

Digoxin<\/span><\/a> has a <\/span>long history<\/span><\/a>, beginning over 200 years ago when its cardiac effects were first described as a digitalis or foxglove plant component. Current use is fading as other options for heart disease and the treatment of <\/span>atrial fibrillation<\/span><\/a> (irregular heartbeat) and congestive heart failure (CHF) are <\/span>more highly recommended<\/span><\/a>. One reason for waning enthusiasm for digoxin and its brand-name counterpart, <\/span>Lanoxin<\/span><\/a>, is that their levels in the body are notoriously disturbed by other drugs or health conditions. These interactions can push digoxin levels out of a safe and effective range and into a danger zone where adverse effects predominate. Despite these features, the cardiac glycoside drug remains in use. Digoxin can be taken safely if you know the potential interactions and take steps to avoid them.<\/span><\/p>\n

Digoxin drug interactions<\/span><\/h2>\n

Digoxin is said to have a narrow therapeutic range, meaning that its dosing needs to hit the sweet spot between an ineffective amount and a toxic dose. All too often, other drugs can push it out of that range.<\/span><\/p>\n

P-glycoprotein inhibitors<\/span><\/h3>\n

An assortment of medications can inhibit the P-glycoprotein transporter. Without the action of that transporter, we have trouble eliminating digoxin, and toxicity can ensue. Because there is a wide assortment, there is no single drug class to remember to avoid. Examples include:<\/span><\/p>\n