{"id":627457,"date":"2024-03-28T18:23:24","date_gmt":"2024-03-28T22:23:24","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=627457"},"modified":"2026-04-17T11:09:59","modified_gmt":"2026-04-17T15:09:59","slug":"amoxicillin-and-ibuprofen","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/amoxicillin-and-ibuprofen\/","title":{"rendered":"Can you take ibuprofen with amoxicillin?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Some people don\u2019t think twice about taking a few ibuprofen when they have a headache or fever. But doing so while also taking other medications can cause adverse and even unsafe reactions. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">Ibuprofen<\/span><\/a><span style=\"font-weight: 400;\"> is the most popular nonsteroidal anti-inflammatory drug (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAID<\/span><\/a><span style=\"font-weight: 400;\">) for relieving pain and reducing fever. Meanwhile, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\"><span style=\"font-weight: 400;\">amoxicillin<\/span><\/a><span style=\"font-weight: 400;\"> is a classic member of the <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/penicillins\"><span style=\"font-weight: 400;\">penicillin antibiotic class<\/span><\/a><span style=\"font-weight: 400;\">, used in treating ear and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/sinus-infection-symptoms\"><span style=\"font-weight: 400;\">sinus infections<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/pneumonia-symptoms\"><span style=\"font-weight: 400;\">pneumonia<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/strep-throat-treatment-and-medications#:~:text=Getting%20plenty%20of%20rest%20to,pain%20associated%20with%20strep%20throat.\"><span style=\"font-weight: 400;\">strep throat,<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-for-uti\/\"><span style=\"font-weight: 400;\">urinary tract infections<\/span><\/a><span style=\"font-weight: 400;\">, and skin infections. Since those infections can generate pain and fever, ibuprofen may be an obvious quick fix for relief. Thankfully, it\u2019s generally safe for most people to take them together, but it\u2019s important to recognize the benefits and risks of doing so.<\/span><\/p>\n<h2 id=\"can-you-take-ibuprofen-with-amoxicillin\"><span style=\"font-weight: 400;\">Can you take ibuprofen with amoxicillin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Yes. Until <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=42f935ca-45ba-4b3e-8b40-9b2d4eb56281\"><span style=\"font-weight: 400;\">amoxicillin<\/span><\/a><span style=\"font-weight: 400;\"> clears up an infection, you may be experiencing fever or body aches, ear pain, sinus pressure, or headache. <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=f3f12b86-89dc-427e-a26f-728be6f73e7b\"><span style=\"font-weight: 400;\">Ibuprofen<\/span><\/a><span style=\"font-weight: 400;\">, known as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/advil\"><span style=\"font-weight: 400;\">Advil<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/motrin-ib\"><span style=\"font-weight: 400;\">Motrin<\/span><\/a><span style=\"font-weight: 400;\">, can assist with pain relief and does not interact with amoxicillin.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, ibuprofen may lessen your <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/sore-throat-treatment-and-medications#:~:text=Drinking%20warm%20liquids%20such%20as,will%20also%20help%20decrease%20scratchiness.\"><span style=\"font-weight: 400;\">sore throat<\/span><\/a><span style=\"font-weight: 400;\">, while amoxicillin treats your <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/strep-throat-treatment-without-antibiotics\/\"><span style=\"font-weight: 400;\">strep throat<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Ibuprofen with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tIbuprofen 800 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$2.76<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$2.76<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen#blog-cta\" class=\"coupon-see-all-btn\">See Ibuprofen prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2 id=\"what-happens-if-you-take-ibuprofen-and-amoxicillin-together\"><span style=\"font-weight: 400;\">What happens if you take ibuprofen and amoxicillin together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While nothing should happen, they have the potential for serious side effects that could worsen when combined. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ibuprofen-side-effects\/\"><span style=\"font-weight: 400;\">Ibuprofen\u2019s side effects<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gastrointestinal bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fluid retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypertension (high blood pressure)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart complications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney or liver function impairment<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Those are only the most notable adverse effects of ibuprofen. Others absolutely exist. Adding amoxicillin to the mix as well entails its own potential <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-side-effects\/\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\">, too, such as the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/diarrhea-from-antibiotics\/\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/antibiotics-that-cause-c-diff\/\"><span style=\"font-weight: 400;\">C. difficile-associated colitis<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe skin and allergic reactions<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">As you can see, these medications have overlapping side effects on the gastrointestinal tract. Sometimes, these may be minor, but the possibility of severe stomach bleeding or bowel infections exists. Watch for the onset of vomiting, bloody stools, severe diarrhea, and abdominal pain. Report these to a healthcare provider immediately. Ideally, you will want to limit the use of ibuprofen to a short timeframe to reduce the risk of some of these issues.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Keep in mind that antibiotics aren\u2019t always necessary, so don\u2019t assume you need amoxicillin unless a healthcare provider prescribes it. Viral infections like the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cold-vs-flu\/\"><span style=\"font-weight: 400;\">common cold<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/influenza-a-vs-influenza-b\/\"><span style=\"font-weight: 400;\">influenza<\/span><\/a><span style=\"font-weight: 400;\"> do not require antibiotic treatment, and amoxicillin won\u2019t help.<\/span><\/p>\n<h2 id=\"when-would-you-need-to-take-amoxicillin-and-ibuprofen\"><span style=\"font-weight: 400;\">When would you need to take amoxicillin and ibuprofen?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When enduring the pain and discomfort of an ear, sinus, or throat infection, taking some ibuprofen to lessen the discomfort can be greatly beneficial, considering that it can take two or three days of antibiotic therapy to see improvement. However, not everyone should reach for ibuprofen. Ibuprofen can exacerbate various underlying medical conditions. Stomach ulcers, kidney disease, liver disease, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypertension-causes\"><span style=\"font-weight: 400;\">hypertension<\/span><\/a><span style=\"font-weight: 400;\">, congestive heart failure, and heart disease are among the health problems that can worsen with ibuprofen use.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Amoxicillin with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAmoxicillin 500 mg (21 Capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.22<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.22<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\" class=\"coupon-see-all-btn\">See Amoxicillin prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2 id=\"ibuprofen-and-amoxicillin-drug-interactions\"><span style=\"font-weight: 400;\">Ibuprofen and amoxicillin drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s important to ask your healthcare provider or pharmacist before taking any medication, since they can identify potential interactions. Although ibuprofen and amoxicillin are generally safe together, either may interact with other medications or supplements you may be taking.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, ibuprofen alone interacts with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin-low-dose\/what-is\"><span style=\"font-weight: 400;\">aspirin<\/span><\/a><span style=\"font-weight: 400;\"> and other blood thinners. And both amoxicillin and ibuprofen interact with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\/what-is\"><span style=\"font-weight: 400;\">warfarin<\/span><\/a><span style=\"font-weight: 400;\">, an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">anticoagulant<\/span><\/a><span style=\"font-weight: 400;\">, so taking both of them while taking warfarin carries a major risk of bleeding.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A combination cough and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-cold-medicine\/\"><span style=\"font-weight: 400;\">cold medicine<\/span><\/a><span style=\"font-weight: 400;\"> can also be problematic in these situations because these medications include multiple active ingredients. It can be all too easy to mistakenly use two products with the same drug component, leading to an overdose. For example, someone could take ibuprofen along with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/advil-cold-sinus\/what-is\"><span style=\"font-weight: 400;\">Advil Cold and Sinus<\/span><\/a><span style=\"font-weight: 400;\"> (pseudoephedrine and ibuprofen), which may exceed the recommended dose of ibuprofen.\u00a0<\/span><\/p>\n<h2 id=\"ibuprofen-alternatives\"><span style=\"font-weight: 400;\">Ibuprofen alternatives<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/tylenol\"><span style=\"font-weight: 400;\">Tylenol<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/acetaminophen\/what-is\"><span style=\"font-weight: 400;\">acetaminophen<\/span><\/a><span style=\"font-weight: 400;\">) is an alternative for pain and fever, and for some, it may be a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ibuprofen-vs-tylenol\/\"><span style=\"font-weight: 400;\">better choice<\/span><\/a><span style=\"font-weight: 400;\"> since it does not negatively impact the stomach and kidneys like NSAIDs do. Nevertheless, NSAIDs sometimes work better, which is why they are more often chosen for joint sprains, muscle strains, or menstrual pain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Acetaminophen is in lots of cold remedies, and taking Tylenol with a product like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vicks-dayquil-nyquil-cld-flu\"><span style=\"font-weight: 400;\">DayQuil Cold and Flu<\/span><\/a><span style=\"font-weight: 400;\"> (acetaminophen, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dextromethorphan-hbr\"><span style=\"font-weight: 400;\">dextromethorphan<\/span><\/a><span style=\"font-weight: 400;\">, and phenylephrine) can lead to overdose. The issue has become enough of a problem to warrant an <\/span><a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/dont-overuse-acetaminophen\"><span style=\"font-weight: 400;\">advisory<\/span><\/a><span style=\"font-weight: 400;\"> from the Food and Drug Administration (FDA).<\/span><\/p>\n<h2 id=\"amoxicillin-alternatives\"><span style=\"font-weight: 400;\">Amoxicillin alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Amoxicillin is not the only antibiotic for various bacterial infections, nor the only antibiotic that can be coupled with ibuprofen. Each medication combination must be looked at, but most antibiotics can be taken with this NSAID. However, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/quinolones\"><span style=\"font-weight: 400;\">quinolones<\/span><\/a><span style=\"font-weight: 400;\"> like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cipro\/what-is\"><span style=\"font-weight: 400;\">Cipro<\/span><\/a><span style=\"font-weight: 400;\"> (ciprofloxacin) could increase seizure risk when taken with ibuprofen.<\/span><\/p>\n<h2 id=\"bottom-line-it-is-safe-to-take-ibuprofen-with-amoxicillin\"><span style=\"font-weight: 400;\">Bottom line: It is safe to take ibuprofen with amoxicillin\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although using ibuprofen with amoxicillin is generally safe for most individuals, exceptions may include those with kidney, liver, and heart disease. Aside from these examples, everyone should be aware of additive side effects and drug interactions when taking multiple medicines. For ibuprofen and amoxicillin, that means gastrointestinal effects. Staying safe with the use of these medications means running the decision to take them together past your medical provider and limiting ibuprofen use as much as possible.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Some people don\u2019t think twice about taking a few ibuprofen when they have a headache or fever. But doing so while also taking other medications can cause adverse and even unsafe reactions. Ibuprofen is the most popular nonsteroidal anti-inflammatory drug (NSAID) for relieving pain and reducing fever. Meanwhile, amoxicillin is a classic member of the [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":627458,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,808],"coauthors":[20732],"class_list":["post-627457","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-pain-management","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can you take ibuprofen with amoxicillin? | SingleCare<\/title>\n<meta name=\"description\" content=\"Ibuprofen can be taken with amoxicillin to treat pain and fever from an infection. Here\u2019s what you should know about mixing amoxicillin and ibuprofen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-and-ibuprofen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can you take ibuprofen with amoxicillin?\" \/>\n<meta property=\"og:description\" content=\"Ibuprofen can be taken with amoxicillin to treat pain and fever from an infection. 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