{"id":627778,"date":"2024-04-14T16:20:19","date_gmt":"2024-04-14T20:20:19","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=627778"},"modified":"2026-03-04T14:21:13","modified_gmt":"2026-03-04T19:21:13","slug":"metronidazole-dosage-for-dogs","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/metronidazole-dosage-for-dogs\/","title":{"rendered":"How many days should I give my dog metronidazole?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Whether it\u2019s from an infection or finding something rotten in the backyard, dogs are no strangers to stomach or bowel issues. When they show signs of intestinal distress, the solution may be to give the dog <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole\/\"><span style=\"font-weight: 400;\">metronidazole<\/span><\/a><span style=\"font-weight: 400;\"> for 5 to 10 days. Metronidazole is a nitroimidazole <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/pet-antibiotics\/\"><span style=\"font-weight: 400;\">antibiotic<\/span><\/a><span style=\"font-weight: 400;\"> that not only kills bacteria but also kills some protozoans and reduces inflammation. Veterinarians commonly use it to treat Giardia intestinal infections, anaerobic bacterial infections, non-specific intestinal and stomach inflammatory conditions, and diarrhea. Here\u2019s everything you need to know about how you should give metronidazole to your furry companion.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Metronidazole with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tMetronidazole 500 mg (14 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.01<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.01<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\" class=\"coupon-see-all-btn\">See Metronidazole prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/metronidazole-for-dogs\/\"><b>Metronidazole for dogs: What you need to know<\/b><\/a><\/p>\n<h2 id=\"metronidazole-dosage-for-dogs\"><span style=\"font-weight: 400;\">Metronidazole dosage for dogs<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole\/what-is\"><span style=\"font-weight: 400;\">Metronidazole<\/span><\/a><span style=\"font-weight: 400;\"> dosages vary by condition, but usually range between 5\u201310 mg for every pound of body weight (10-25 mg\/kg) given two and sometimes three times a day, depending on the condition. \u201cDosing based on a pet\u2019s size is extremely important since we treat anything from kittens to Great Danes,\u201d says Dr. Emily Seidel, DVM, DACVIM, a <\/span><a href=\"https:\/\/coloradoanimalspecialty.com\/\"><span style=\"font-weight: 400;\">Colorado Animal Specialty &amp; Emergency<\/span><\/a><span style=\"font-weight: 400;\"> veterinarian. \u201cWe have certain thresholds at which we see toxicity, and we use doses lower than this to mitigate these adverse effects.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For specific conditions, the <\/span><a href=\"https:\/\/www.merckvetmanual.com\/pharmacology\/antibacterial-agents\/nitroimidazoles-use-in-animals\"><span style=\"font-weight: 400;\">Merck Veterinary Manual<\/span><\/a><span style=\"font-weight: 400;\"> says the safest and most effective doses are as follows:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Giardiasis:<\/b><span style=\"font-weight: 400;\"> 25 mg\/kg every 12 hours for five days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Inflammatory bowel disease (IBD): <\/b><span style=\"font-weight: 400;\">10\u201315 mg\/kg every 12 hours<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Complications of severe liver disease (hepatic encephalopathy):<\/b><span style=\"font-weight: 400;\"> 7.5 mg\/kg, every eight to 12 hours<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Plumb\u2019s Veterinary Drug Handbook gives the following common dosages:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Amoeba intestinal infections:<\/b><span style=\"font-weight: 400;\"> 25 mg\/kg every 12 hours for eight days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Large bowel diarrhea: <\/b><span style=\"font-weight: 400;\">20\u201325 mg\/kg every 12 hours for five to 10 days<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Because metronidazole may affect the liver and kidneys, vets usually give it in lower doses or avoid it entirely for dogs with pre-existing kidney and liver disease. It\u2019s also unsafe for pregnant or nursing dogs and young puppies, per the <\/span><a href=\"https:\/\/www.akc.org\/expert-advice\/health\/metronidazole-for-dogs\/\"><span style=\"font-weight: 400;\">American Kennel Club<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Metronidazole also has <\/span><a href=\"https:\/\/www.wedgewoodpharmacy.com\/medications\/metronidazole\/\"><span style=\"font-weight: 400;\">drug interactions<\/span><\/a><span style=\"font-weight: 400;\"> with several other medications, including cyclosporine, phenobarbital, and phenytoin. Certain supplements, flea medications, and chemotherapy drugs may also cause adverse reactions.<\/span><\/p>\n<h2 id=\"how-much-metronidazole-can-i-give-my-dog\"><span style=\"font-weight: 400;\">How much metronidazole can I give my dog?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to the <\/span><a href=\"https:\/\/vetmeds.org\/pet-poison-control-list\/metronidazole\/\"><span style=\"font-weight: 400;\">American College of Veterinary Pharmacists<\/span><\/a><span style=\"font-weight: 400;\">, much of the literature on metronidazole toxicity says it can occur at around 60 mg\/kg\/day. However, they also say some research has shown toxicity at lower doses, such as <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30478843\/\"><span style=\"font-weight: 400;\">this 2018 study<\/span><\/a><span style=\"font-weight: 400;\">, which recommended caution with doses greater than 40 mg\/kg\/day. Plumb\u2019s Veterinary Drug Handbook also cautions that prolonged use of metronidazole can lead to toxicity in dogs even at clinically-recommended moderate to high dosages. In conclusion, metronidazole has a low threshold for side effects, and dosage is calculated on a case-by-case basis. Doses usually start around 10-15mg\/kg of body weight twice daily and do not typically exceed 25mg\/kg of body weight twice daily. Your veterinarian will factor in the condition being treated, length of treatment, additional medications your pet is taking, and your pet\u2019s coexisting medical conditions when prescribing a metronidazole dose.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/where-to-fill-pet-prescriptions\/\"><b>Where to fill your pet\u2019s prescriptions<\/b><\/a><\/p>\n<h2 id=\"how-long-should-i-give-my-dog-metronidazole\"><span style=\"font-weight: 400;\">How long should I give my dog metronidazole?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">After you\u2019ve answered, \u201cHow much?\u201d The next important question is, \u201cHow long?\u201d Most often, metronidazole is used for a short time, typically 5 to 10 days.<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32856349\/\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">\u201cMetronidazole is a very effective medication; however, overuse can be dangerous,\u201d says <\/span><a href=\"https:\/\/www.dramyattas.com\/\"><span style=\"font-weight: 400;\">Dr. Amy Attas<\/span><\/a><span style=\"font-weight: 400;\">, veterinarian and author of <\/span><i><span style=\"font-weight: 400;\">Pets and the City: True Tales of a Manhattan House Call Veterinarian<\/span><\/i><span style=\"font-weight: 400;\">. \u201cProlonged use may disrupt the gut microbiota, which can negatively affect a dog\u2019s digestive health.\u201d <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7517498\/\"><span style=\"font-weight: 400;\">One study has demonstrated<\/span><\/a><span style=\"font-weight: 400;\"> significant changes to a dog\u2019s gut biome and suggests a cautious approach when prescribing the drug.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aside from dysregulation of the bacteria found in the GI tract, Dr. Seidel says long-term use \u201ccan also contribute to antibiotic resistance, which is an important topic in an increasingly antibiotic-resistant world.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But there are less common risks, too. Per Dr. Attas, \u201cIn rare instances, high doses or prolonged use can lead to liver toxicity, even if initial doses are well-tolerated,\u201d and metronidazole can cause neurologic side effects as well, such as disorientation, inability to walk, and seizures. A veterinarian may ask the pet\u2019s parent to watch for neurological effects if metronidazole is used for too long.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The exact duration depends on the condition being treated. However, dogs should only take the medication for longer than a week if the vet specifically directs it.<\/span><\/p>\n<h2 id=\"overdose-of-metronidazole-in-dogs\"><span style=\"font-weight: 400;\">Overdose of metronidazole in dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dogs may experience common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metronidazole-side-effects\/\"><span style=\"font-weight: 400;\">side effects of metronidazole<\/span><\/a><span style=\"font-weight: 400;\">, including vomiting, diarrhea, drooling, gagging, fatigue, loss of appetite, and urine discoloration. Usually, these adverse effects are relatively harmless. Yet it\u2019s also possible for a dog to overdose on metronidazole, no matter their size and condition, so owners have to be careful not to give them too much.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Metronidazole can pass through the blood-brain barrier, which means toxicity might manifest in terms of central nervous system symptoms. The signs of metronidazole toxicity include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ataxia (difficulty balancing)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rapid eye movements (nystagmus)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Problems with body position and movement (clumsiness, falls, bumping into things)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Head tilt<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dilated pupils<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lethargy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint knuckling (walking on the top of a paw)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rigidity and stiffness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tremors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you notice any of these serious side effects, contact the vet immediately. Dogs can fully recover from a metronidazole overdose, but only if they receive the proper medical attention and treatment.<\/span><\/p>\n<h2 id=\"guidelines-for-administering-metronidazole-in-dogs\"><span style=\"font-weight: 400;\">Guidelines for administering metronidazole in dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The best way to administer metronidazole is by mouth, with or without food. Technically, dogs can take it without food, but a full belly can reduce the chances of gastrointestinal side effects. Of course, that\u2019s easier said than done since dogs don\u2019t always like taking medications. Plus, metronidazole is bitter, says Dr. Attas, so dogs might not want to take it.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cFind a food that is irresistible to the dog and try molding it around the pill,\u201d she suggests. \u201cGive the dog a few small treats of this food without pills inside, so they are excited for the next treat. After eating the treat-wrapped pill, follow up with a few empty treats so they are not suspicious for the next treatment.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If that doesn\u2019t work, she says you can approach the dog from behind, lift the head, open the dog\u2019s mouth, and put the pill as far back as possible, then quickly remove your hand, since even friendly dogs may mistakenly bite in an attempt to get a hand out of their mouth.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Alternatively, you can give the dog a liquid version of metronidazole called <\/span><a href=\"https:\/\/vet-us.virbac.com\/home\/products\/antibiotics\/ayradia-oral-suspension.html\"><span style=\"font-weight: 400;\">Ayradia<\/span><\/a><span style=\"font-weight: 400;\">. FDA-approved to treat giardiasis in dogs, Ayradia is more expensive than generic metronidazole tablets or capsules. The expense may be worth it, because it\u2019s easier to administer. It\u2019s also harder for a dog to spit out a liquid medicine than a pill.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you miss a dose of metronidazole, give it as soon as possible. However, if the dog\u2019s next dose is only a few hours away, just wait. Never give a dog a double dose to make up for a missed one because it could cause an accidental overdose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Metronidazole\u2019s half-life in dogs is 3-<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/B9781455707171000612\"><span style=\"font-weight: 400;\">13 hours<\/span><\/a><span style=\"font-weight: 400;\">, so it can remain in their system for up to 26 hours after treatment. Any side effects should subside within around a day after stopping treatment.<\/span><\/p>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/resources\/pet-meds\"><strong>Discount pet meds &amp; resources<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Whether it\u2019s from an infection or finding something rotten in the backyard, dogs are no strangers to stomach or bowel issues. When they show signs of intestinal distress, the solution may be to give the dog metronidazole for 5 to 10 days. Metronidazole is a nitroimidazole antibiotic that not only kills bacteria but also kills [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":627780,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7956],"tags":[7969],"coauthors":[8861],"class_list":["post-627778","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pets","tag-dogs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Metronidazole dosage for dogs: What you should know<\/title>\n<meta name=\"description\" content=\"Metronidazole is typically prescribed for 5-10 days, depending on the condition being treated and its severity. 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